A Highly Variable Region in Members of the Streptococcal M Protein Family Binds the Human Complement Regulator C4BP

Journal of Immunology

Volumn 157, Issue 7, 1996, Pages 3021-3029

  Johnsson, Eskil ^a   Thern, Anette ^a   Dahlbäck, Björn ^a   Hedén, Lars Olof ^a   Wikström, Mats ^a,b   Lindahl, Gunnar ^a  

^a LUND UNIVERSITY   (Sweden)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARP4 PROTEIN, STREPTOCOCCUS PYOGENES; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; CARRIER PROTEIN; GLYCOPROTEIN P 15095; OUTER MEMBRANE PROTEIN; STREPTOCOCCAL M PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHEMISTRY; COMPARATIVE STUDY; HUMAN; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; STREPTOCOCCUS PYOGENES;

AMINO ACID SEQUENCE; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; BASE SEQUENCE; BINDING SITES; CARRIER PROTEINS; HUMANS; INTEGRIN ALPHAXBETA2; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; STREPTOCOCCUS PYOGENES;

EID: 0030267784     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Bisno, A. L. 1991. Group A streptococcal infections and acute rheumatic fever. N. Engl. J. Med. 325:783.
2. Stevens, D. L. 1992. Invasive group A streptococcus infections. Clin. Infect. Dis. 14:2.
3. Fischetti, V. A. 1989. Streptococcal M protein: molecular design and biological behavior. Clin. Microbiol. Rev. 2:285.
4. Okada, N., M. K. Liszewski, J. P. Atkinson, and M. Caparon. 1995. Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus. Proc. Natl. Acad. Sci. USA 92:2489.
5. Hollingshead, S. K., V. A. Fischetti, and J. R. Scott. 1986. Complete nucleotide sequence of type 6 M protein of the group A streptococcus: repetitive structure and membrane anchor. J. Biol. Chem. 261:1677.
6. O'Toole, P., L. Stenberg, M. Rissler, and G. Lindahl. 1992. Two major classes in the M protein family in group A streptococci. Proc. Natl. Acad. Sci. USA 89: 8661.
7. Kehoe, M. A. 1994. Cell-wall-associated proteins in Gram-positive bacteria. N. Compr. Biochem. 27:217.
8. Manjula, B. N., A. S. Acharya, T. Fairwell, and V. A. Fischetti. 1986. Antigenic domains of the streptococcal Pep M5 protein: localization of epitopes crossreactive with type 6 M protein and identification of a hypervariable region of the M molecule. J. Exp. Med. 163:129.
9. Hedén, L. O., and G. Lindahl. 1993. Conserved and variable regions in protein Arp, the IgA receptor of Streptococcus pyogenes. J. Gen. Microbiol. 139:2067.
10. Harbaugh, M. P., A. Podbielski, S. Hügl, and P. P. Cleary. 1993. Nucleotide substitutions and small-scale insertion produce size and antigenic variation in group A streptococcal M1 protein. Mol. Microbiol. 8:981.
11. Whatmore, A. M., and M. A. Kehoe. 1994. Horizontal gene transfer in the evolution of group A streptococcal emnm-like genes: gene mosaics and variation in Vir regulons. Mol. Microbiol. 11:363.
12. Whitnack, E., J. B. Dale, and E. H. Beachey. 1984. Common protective antigens of group A streptococcal M proteins masked by fibrinogen. J. Exp. Med. 159: 1201.
13. Frithz, E., L. O. Hedén, and G. Lindahl. 1989. Extensive sequence homology between IgA receptor and M proteins in Streptococcus pyogenes. Mol. Microbiol. 3:1111.
14. Berge, A., and U. Sjöbring. 1993. PAM, a novel plasminogen-binding protein from Streptococcus pyogenes. J. Biol. Chem. 268:25417.
15. Frick, I. M., P. Åkesson, J. Cooney, U. Sjöbring, K. H. Schmidt, H. Gomi, S. Hattori, C. Tagawa, F. Kishimoto, and L. Björck. 1994. Protein H-a surface protein of Streptococcus pyogenes with separate binding sites for IgG and albumin. Mol. Microbiol. 12:143.
16. Bessen, D. E. 1994. Localization of immunoglobulin A-binding sites within M or M-like proteins of group A streptococci. Infect. Immun. 62:1968.
17. Johnsson, E., G. Andersson, G. Lindahl, and L. O. Hedén. 1994. Identification of the IgA-binding region in streptococcal protein Arp. J. Immunol. 153:3557.
18. Heath, D. G., M. D. Boyle, and P. P. Cleary. 1990. Isolated DNA repeat region from fcrA76, the Fc-binding protein gene from an M-type 76 strain of group A streptococci, encodes a protein with Fc-binding activity. Mol. Microbiol. 4:2071.
19. Carlsson Wistedt, A., U. Ringdahl, W. Müller-Esterl, and U. Sjöbring. 1995. Identification of a plasminogen-binding motif in PAM, a bacterial surface protein. Mol. Microbiol. 18:569.
20. Retnoningrum, D. S., and P. P. Cleary. 1994. M12 protein from Streptococcus pyogenes is a receptor for immunoglobulin G3 and human albumin. Infect. Immun. 62:2387.
21. Fischetti, V. A., R. D. Horstmann, and V. Pancholi. 1995. Location of the complement factor H binding site on streptococcal M6 protein. Infect. Immun. 63:149.
22. Dale, J. B., and E. H. Beachey. 1986. Localization of protective epitopes of the amino terminus of type 5 streptococcal M protein. J. Exp. Med. 163:1191.
23. Jones, K. F., and V. A. Fischetti. 1988. The importance of the location of antibody binding on the M6 protein for opsonization and phagocytosis of group A M6 streptococci. J. Exp. Med. 167:1114.
24. Robinson, J. H., and M. A. Kehoe. 1992. Group A streptococcal M proteins: virulence factors and protective antigens. Immunol. Today 13:362.
25. Thern, A., L. Stenberg, B. Dahlback, and G. Lindahl. 1995. Ig-binding surface proteins of Streptococcus pyogenes also bind human C4b-binding protein (C4BP), a regulatory component of the complement system. J. Immunol. 154: 375.
26. Stenberg, L., P. W. O'Toole, J. Mestecky, and G. Lindahl. 1994. Molecular characterization of protein Sir, a streptococcal cell surface protein that binds both immunoglobulin A and immunoglobulin G. J. Biol. Chem. 269:13458.
27. Miller, L., L. Gray, E. Beachey, and M. Kehoe. 1988. Antigenic variation among group A streptococcal M proteins: nucleotide sequence of the serotype 5 M protein gene and its relationship with genes encoding types 6 and 24 M proteins. J. Biol. Chem. 263:5668.
28. Messing, J. 1983. New M13 vectors for cloning. Methods Enzymol. 101:20.
29. Carter, P., H. Bedouelle, and G. Winter. 1985. Improved oligonucleotide site-directed mutagenesis using M13 vectors. Nucleic Acids Res. 13:4431.
30. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual, 2nd Ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
31. Gomi, H., T. Hozumi, S. Hattori, C. Tagawa, F. Kishimoto, and L. Björck. 1990. The gene sequence and some properties of protein H. A novel IgG-binding protein. J. Immunol. 144:4046.
32. Åkesson, P., J. Cooney, F. Kishimoto, and L. Björck. 1990. Protein H-a novel IgG binding bacterial protein. Mol. Immunol. 27:523.
33. Jeppson, H., E. Frithz, and L. O. Hedén. 1992. Duplication of a DNA sequence homologous to genes for immunoglobulin receptors and M proteins in Streptococcus pyogenes. FEMS Microbiol. Lett. 71:139.
34. Stenberg, L., P. O'Toole, and G. Lindahl. 1992. Many group A streptococcal strains express two different immunoglobulin-binding proteins, encoded by closely linked genes: characterization of the proteins expressed by four strains of different M-type. Mol. Microbiol. 6:1185.
35. Dahlbäck, B. 1983. Purification of human C4b-binding protein and formation of its complex with vitamin K-dependent protein S. Biochem. J. 209:847.
36. Hillarp, A., and B. Dahlbäck. 1988. Novel subunit in C4b-binding protein required for protein S binding. J. Biol. Chem. 263:12759.
37. Åkerström, B., A. Lindqvist, and G. Lindahl. 1991. Binding properties of protein Arp, a bacterial IgA-receptor. Mol. Immunol. 28:349.
38. Scatchard, G. 1949. The attractions of proteins for small molecules and ions. Ann. NY Acad. Sci. 51:660.
39. Schägger, H., and G. von Jagow. 1987. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal. Biochem. 166:368.
40. 125I)-labelled human growth hormone of high specific activity. Biochem. J. 89: 114.
41. Manjula, B. N., and V. A. Fischetti. 1980. Tropomyosin-like seven residue periodicity in three immunologically distinct streptococcal M proteins and its implications for the antiphagocytic property of the molecule. J. Exp. Med. 151:695.
42. Phillips, G., Jr., P. F. Flicker, C. Cohen, B. N. Manjula, and V. A. Fischetti. 1981. Streptococcal M protein: alpha-helical coiled-coil structure and arrangement on the cell surface. Proc. Natl. Acad. Sci. USA 78:4689.
43. Åkerström, B., G. Lindahl, L. Björck, and A. Lindqvist. 1992. Protein Arp and protein H from group A streptococci: Ig binding and dimerization are regulated by temperature. J. Immunol. 148:3238.
44. Nilson, B. H. K., I. M. Frick, P. Åkesson, S. Forsén, L. Björck, B. Åkerström, and M. Wikström. 1995. Structure and stability of protein H and the M1 protein from Streptococcus pyogenes: implications for other surface proteins of Gram-positive bacteria. Biochemistry 34:13688.
45. Genetics Computer Group. 1994. Program Manual for the Wisconsin Package, Version 8. University of Wisconsin, Madison, WI.
46. Rost, B., and C. Sander. 1993. Prediction of protein secondary structure at better than 70% accuracy. J. Mol. Biol. 232:584.
47. Berger, B., D. B. Wilson, E. Wolf, T. Tonchev, M. Milla, and P. S. Kim. 1995. Predicting coiled coils by use of pairwise residue correlations. Proc. Natl. Acad. Sci. USA 92:8259.
48. Lupas, A., M. Van Dyke, and I. Stock. 1991. Predicting coiled coils from protein sequences. Science 252:1162.
49. Rost, B., and C. Sander. 1994. Conservation and prediction of solvent accessibility in protein families. Proteins 20:216.
50. Horstmann, R. D., H. J. Sievertsen, J. Knobloch, and V. A. Fischetti. 1988. Antiphagocytic activity of streptococcal M protein: selective binding of complement control protein factor H. Proc. Natl. Acad. Sci. USA 85:1657.
51. Cleary, P., and D. Retnoningrum. 1994. Group A streptococcal immunoglobulin-binding proteins: adhesins, molecular mimicry or sensory proteins? Trends Microbiol. 2:131.
52. Hourcade, D., V. M. Holers, and J. P. Atkinson. 1989. The regulators of complement activation (RCA) gene cluster. Adv. Immunol. 45:381.
53. Barnum, S. R. 1991. C4b-binding protein, a regulatory protein of complement. Immunol. Res. 10:28.
54. Dahlbäck, B. 1991. Protein S and C4b-binding protein: components involved in the regulation of the protein C anticoagulation system. Thromb. Haemost. 66:49.
55. Perez-Casal, J., N. Okada, M. G. Caparon, and J. R. Scott. 1995. Role of the conserved C-repeat region of the M protein of Streptococcus pyogenes. Mol. Microbiol. 15:907.
56. Gerlier, D., G. Varior-Krishnan, and P. Devaux. 1995. CD46-mediated measles virus entry: a first key to host-range specificity. Trends Microbiol. 3:338.
57. Whatmore, A. M., V. Kapur, D. J. Sullivan, J. M. Musser, and M. A. Kehoe. 1994. Non-congruent relationships between variation in emm gene sequences and the population genetic structure of group A streptococci. Mol. Microbiol. 14:619.
58. Dahlbäck, B., C. A. Smith, and H. J. Müller-Eberhard. 1983. Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b. Proc. Natl. Acad. Sci. USA 80:3461.