Pyrimidinedione: Pharmacophore optimization of selective thymidine monophosphate kinase inhibitors using group QSAR studies as potential antitubercular agents

Journal of Chemical and Pharmaceutical Research

Volumn 3, Issue 2, 2011, Pages 479-488

  Chitre, T S ^a   Bothara, K G ^a  

^a AISSMS COLLEGE OF PHARMACY   (India)

Author keywords

G QSAR; Genetic algorithm (GA); Pharmacophore optimization; Simulating annealing (SA); Thymidine monophosphate kinase of m. tuberculosis (TMPKmt)

Indexed keywords

THYMIDINE KINASE; THYMIDINE KINASE INHIBITOR; THYMIDINE PHOSPHATE; TUBERCULOSTATIC AGENT;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SELECTIVITY; ENZYME INHIBITION; FRAGMENTATION REACTION; IC 50; MATHEMATICAL MODEL; MYCOBACTERIUM TUBERCULOSIS; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE METABOLISM; PHARMACOPHORE; PREDICTION; PROCESS OPTIMIZATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; TUBERCULOSIS;

EID: 79954499569     PISSN: None     EISSN: 09757384     Source Type: Journal    
DOI: None     Document Type: Article

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