High-throughput screening of chromatographic separations: III. monoclonal antibodies on ceramic hydroxyapatite

Biotechnology and Bioengineering

Volumn 100, Issue 5, 2008, Pages 839-854

  Wensel, David L ^a   Kelley, Brian D ^a,b   Coffman, Jon L ^a  

^a Purification Process Development   (United States)

^b GENENTECH INC   (United States)

Author keywords

Aggregate; Ceramic hydroxyapatite; Chromatography; High throughput screening; Monoclonal antibody

Indexed keywords

AGGREGATE; CERAMIC HYDROXYAPATITE; CHROMATOGRAPHIC SEPARATIONS; HIGH THROUGHPUT SCREENINGS; HIGH-THROUGHPUT SCREENING; INDUSTRIAL PROCESS DEVELOPMENT; INTEGRAL PART; MONOCLONAL ANTIBODY; PARTITION COEFFICIENTS; PROTEIN PURIFICATION;

APATITE; CERAMIC MATERIALS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; ELECTRIC BATTERIES; HIGH TEMPERATURE SUPERCONDUCTORS; HYDROXYAPATITE; LIQUID CHROMATOGRAPHY; MONOCLONAL ANTIBODIES; RESINS; SEPARATION; SURFACE PLASMON RESONANCE; THROUGHPUT;

ANTIBODIES;

HYDROXYAPATITE; MONOCLONAL ANTIBODY; PHOSPHATE; SODIUM CHLORIDE;

ANALYSIS OF VARIANCE; ANIMAL CELL; ANTIGEN BINDING; ARTICLE; CHEMICAL INTERACTION; CHROMATOGRAPHY; DIAGNOSTIC ACCURACY; HIGH THROUGHPUT SCREENING; NONHUMAN; PH MEASUREMENT; STATISTICAL MODEL; ALGORITHM; CERAMICS; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; INSTRUMENTATION; ISOLATION AND PURIFICATION; METHODOLOGY; SENSITIVITY AND SPECIFICITY;

ALGORITHMS; ANTIBODIES, MONOCLONAL; CERAMICS; CHROMATOGRAPHY; COMPUTER SIMULATION; DURAPATITE; MICROCHEMISTRY; MODELS, CHEMICAL; SENSITIVITY AND SPECIFICITY;

EID: 46249087945     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21906     Document Type: Article

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