In vitro metabolism of magnolin and characterization of cytochrome P450 enzymes responsible for its metabolism in human liver microsomes

Xenobiotica

Volumn 41, Issue 5, 2011, Pages 358-371

  Kim, Dong Kyun ^a   Liu, Kwang Hyeon ^b   Jeong, Ji Hyun ^a   Ji, Hye Young ^a   Oh, Sei Ryang ^c   Lee, Hyeong Kyu ^c   Lee, Hye Suk ^a,d  

^a Wonkwang University   (South Korea)

^b Inje University   (South Korea)

^c Korea Research Institute of Biology and Biotechnology   (South Korea)

^d The Catholic University of Korea   (South Korea)

Author keywords

CYPs; hydroxylation; Magnolin metabolism; O demethylation

Indexed keywords

ANTIINFLAMMATORY AGENT; CYTOCHROME P450; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; DRUG METABOLITE; HYDROXYMAGNOLIN; MAGNOLIN; O DESMETHYL MAGNOLIN; UNCLASSIFIED DRUG;

ARTICLE; DEMETHYLATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG TRANSFORMATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER MICROSOME;

BIOTRANSFORMATION; COMPUTER SIMULATION; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; ISOENZYMES; KINETICS; LIGNANS; MASS SPECTROMETRY; METABOLIC NETWORKS AND PATHWAYS; MICROSOMES, LIVER; NADP; RECOMBINANT PROTEINS;

MAGNOLIA FARGESII;

EID: 79954486652     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2010.549968     Document Type: Article

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