Pharmacokinetics of magnolin in rats

Archives of Pharmacal Research

Volumn 33, Issue 6, 2010, Pages 933-938

  Kim, Nam Jin ^a   Song, Won Young ^a   Yoo, Sun Dong ^b   Oh, Sei Ryang ^c   Lee, Hyeong Kyu ^c   Lee, Hye Suk ^a  

^a Wonkwang University   (South Korea)

^b Sungkyunkwan University   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology   (South Korea)

Author keywords

Magnolia fargesii; Magnolin; Pharmacokinetics; Plasma protein binding; Rats

Indexed keywords

MAGNOLIN; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG PROTEIN BINDING; DRUG STABILITY; DRUG URINE LEVEL; FLOWER; LIVER MICROSOME; MAGNOLIA FARGESII; MAGNOLIACEAE; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PLASMA PROTEIN BINDING; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOLOGICAL AVAILABILITY; BIOTRANSFORMATION; CARRIER PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HALF-LIFE; HISTAMINE ANTAGONISTS; INJECTIONS, INTRAVENOUS; INTESTINAL ABSORPTION; LIGNANS; MALE; METABOLIC CLEARANCE RATE; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 77954522647     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-010-0617-3     Document Type: Article

References (13)

1. K. S. Ahn K. Y. Jung J. H. Kim S. R. Oh H. K. Lee 2001 Inhibitory activity of lignan components from the flower buds of Magnoliae fargesii on the expression of cell adhesion molecules Biol. Pharm. Bull. 24 1085 1087 10.1248/bpb.24.1085 1:CAS:528:DC%2BD3MXmsFyksLo%3D 11558575 (Pubitemid 32894134)
2. J. A. Baek Y. D. Lee C. B. Lee H. K. Go J. P. Kim J. J. Seo Y. K. Rhee A. M. Kim D.J. Na 2009 Extracts of Magnoliae flos inhibit inducible nitric oxide synthase via ERK in human respiratory epithelial cells Nitric Oxide 20 122 128 10.1016/j.niox.2008.10.003 1:CAS:528:DC%2BD1MXhsFKnt7k%3D 18976718
3. V. A. Bhattaram U. Graefe C. Kohlert M. Veit H. Derendorf 2002 Pharmacokinetics and bioavailability of herbal medicinal products Phytomedicine 9 Suppl. 3 1 33 10.1078/1433-187X-00210 1:CAS:528:DC%2BD38XnvV2qtrg%3D 12222652
4. S. H. Chae P. S. Kim J. Y. Cho J. S. Park J. H. Lee E. S. Yoo K. U. Baik J. S. Lee M. H. Park 1998 Isolation and identification of inhibitory compounds on TNF-alpha production from Magnolia fargesii Arch. Pharm. Res. 21 67 69 1:CAS:528:DyaK1cXhtlGgu7c%3D 9875517
5. FDA/Center for Drug Evaluation and Research, Guidance for industry: Botanical drug products (2004). Available at: http://www.fda.gov/cder/guidance/ index.htm.
6. K. Y. Jung D. S. Kim S. R. Oh S. H. Park I. S. Lee J. J. Lee D. H. Shin H. K. Lee 1998 Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii J. Nat. Prod. 61 808 811 10.1021/np970445+ 1:CAS:528:DyaK1cXjs1GhsrY%3D 9644071 (Pubitemid 28317148)
7. J. Y. Kim H. J. Lim D. Y. Lee J. S. Kim D. H. Kim H. J. Lee H. D. Kim R. Jeon J. H. Ryu 2009 In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii Bioorg. Med. Chem. Lett. 19 937 940 10.1016/j.bmcl.2008.11. 103 1:CAS:528:DC%2BD1MXhtF2itLc%3D 19110419
8. N. J. Kim S. R. Oh H. K. Lee H. S. Lee 2009 Simultaneous determination of magnolin and epimagnolin A in rat plasma by liquid chromatography with tandem mass spectrometry: application to pharmacokinetic study of a purified extract of the dried flower buds of Magnolia fargesii, NDC-052 in rats J. Pharm. Biomed. Anal. 50 53 57 10.1016/j.jpba.2009.03.036 1:CAS:528:DC%2BD1MXmsVGjtbw%3D 19409747
9. Lee, H. K., Jung, K. Y., Ahn, K. S., Oh, S. R., Lee, I. S., Park, S. H., Kim, J. H., Jang, H. W., and Hong, N. D. (inventors), Korea Institute of Science & Technology (assignee), New lignans isolated from Magnolia flos with leukotriene synthesis inhibitory activity. Korea Patent 10-0321313-0000 (2002).
10. M. Miyazawa H. Kasahara H. Kameoka 1993 Biotransformation of (+)-magnolin and (+)-yangabin in rat Phytochemistry 32 1421 1424 10.1016/0031-9422(93)85150- P 1:CAS:528:DyaK3sXkvFWqtbw%3D
11. Y. Shen E. C. Pang C. C. Xue Z. Z. Zhao J. G. Lin C. G. Li 2008 Inhibitions of mast cell-derived histamine release by different Flos Magnoliae species in rat peritoneal mast cells Phytomedicine 15 808 814 10.1016/j.phymed.2008.04.012 1:CAS:528:DC%2BD1cXhsVKmtrrK 18585022
12. Tang, W. and Eisenbrand, G., Chinese Drugs of Plant Origin: Chemistry, Pharmacology and Use in Traditional and Modern Medicine. Springer-Verlag: Berlin (1992).
13. W. Zhao T. Zhou G. Fan Y. Chai Y. Wu 2007 Isolation and purification of lignans from Magnolia biondii Pamp by isocratic reversed-phase two-dimensional liquid chromatography following microwave-assisted extraction J. Sep. Sci. 30 2370 2381 10.1002/jssc.200700098 1:CAS:528:DC%2BD2sXht1Kqs77O 17628872 (Pubitemid 350020034)