Extracts of Magnoliae flos inhibit inducible nitric oxide synthase via ERK in human respiratory epithelial cells

Nitric Oxide - Biology and Chemistry

Volumn 20, Issue 2, 2009, Pages 122-128

  Baek, Jin Ah ^a,b   Lee, Yang Deok ^a   Lee, Chan Bog ^b   Go, Hyeon Kyu ^c   Kim, Jin Pyo ^b   Seo, Jeong Ju ^b   Rhee, Yang Keun ^d   Kim, A Mi ^c   Na, Dong Jib ^a  

^a Eulji University School of Medicine   (South Korea)

^b Ja Kwang Research Institute   (South Korea)

^c Chonbuk National University   (South Korea)

^d Chonbuk National University Medical School   (South Korea)

Author keywords

Asthma; Epimagnolin; Fargesin; Intracellular signaling; Magnoliae flos; Nitric oxide

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ENZYME INHIBITOR; EPIMAGNOLIN; FARGESIN; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MAGNOLIA EXTRACT; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CELL VIABILITY; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; MAGNOLIACEAE; MAGNOLIAE FLOS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYNTHESIS;

ANALYSIS OF VARIANCE; ANIMALS; BENZODIOXOLES; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; GENE EXPRESSION; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-1BETA; LIGNANS; MAGNOLIA; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; RESPIRATORY MUCOSA; RNA, MESSENGER; SEEDS; STATISTICS, NONPARAMETRIC; TUMOR NECROSIS FACTOR-ALPHA;

FLOS; MAGNOLIA;

EID: 59049104836     PISSN: 10898603     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.niox.2008.10.003     Document Type: Article

References (33)

1. Belvisi M.G., Ward J.K., Mitchell J.A., and Barnes P.J. Nitric oxide as a neurotransmitter in human airways. Arch. Int. Pharmacodyn. Ther. 329 (1995) 97-110
2. Jain B., Rubinstein I., Robbins R.A., Leise K.L., and Sisson J.H. Modulation of airway epithelial cell ciliary beat frequency by nitric oxide. Biochem. Biophys. Res. Commun. 191 (1993) 83-88
3. Belvisi M.G., Stretton C.D., Yacoub M., and Barnes P.J. Nitric oxide is the endogenous neurotransmitter of bronchodilator nerves in humans. Eur. J. Pharmacol. 210 (1992) 221-222
4. Marletta M.A. Nitric oxide synthase: aspects concerning structure and catalysis. Cell 78 (1994) 927-930
5. Nathan C., and Xie Q.W. Nitric oxide synthases: roles, tolls, and controls. Cell 78 (1994) 915-918
6. Hamid Q., Springall D.R., Riveros-Moreno V., Chanez P., Howarth P., Redington A., Bousquet J., Godard P., Holgate S., and Polak J.M. Induction of nitric oxide synthase in asthma. Lancet 342 (1993) 1510-1513
7. Zhang Y., Brovkovych V., Brovkovych S., Tan F., Lee B.S., Sharma T., and Skidgel R.A. Dynamic receptor-dependent activation of inducible nitric-oxide synthase by ERK-mediated phosphorylation of Ser745. J. Biol. Chem. 282 (2007) 32453-32461
8. Kröncke K.D., Fehsel K., and Kolb-Bachofen V. Inducible nitric oxide synthase in human diseases. Clin. Exp. Immunol. 113 (1998) 147-156
9. Delclaux C., Malinvaud D., Chevalier-Bidaud B., Callens E., Mahut B., and Bonfils P. Nitric oxide evaluation in upper and lower respiratory tracts in nasal polyposis. Clin. Exp. Allergy 38 (2008) 1140-1147
10. Pijnenburg M.W., and De Jongste J.C. Exhaled nitric oxide in childhood asthma: a review. Clin. Exp. Allergy 38 (2008) 246-259
11. Kharitonov S.A., Yates D., Robbins R.A., Logan-Sinclair R., Shinebourne E.A., and Barnes P.J. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 343 (1994) 133-135
12. Watkins D.N., Peroni D.J., Basclain K.A., Garlepp M.J., and Thompson P.J. Expression and activity of nitric oxide synthases in human airway epithelium. Am. J. Respir. Cell Mol. Biol. 16 (1997) 629-639
13. Kobzik L., Bredt D.S., and Lowenstein C.J. Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. Am. J. Respir. Cell Mol. Biol. 9 (1993) 371-377
14. Giaid A., and Saleh D. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N. Engl. J. Med. 21 (1995) 214-221
15. Diamond G., Legarda D., and Ryan L.K. The innate immune response of the respiratory epithelium. Immunol. Rev. 173 (2000) 27-38
16. Xatzipsalti M., Psarros F., Konstantinou G., Gaga M., Gourgiotis D., Saxoni-Papageorgiou P., and Papadopoulos N.G. Modulation of the epithelial inflammatory response to rhinovirus in an atopic environment. Clin. Exp. Allergy 38 (2008) 466-472
17. ++-antagonistic principles of the flower buds of Magnolia fargesii. Planta Med. 54 (1988) 438-440
18. Yu H.J., Chen C.C., and Shieh B.J. Two new constituents from the leaves of Magnolia coco. J. Nat. Prod. 61 (1998) 1017-1019
19. Chen J.J., Ishikawa T., Duh C.Y., Tsai I.L., and Chen I.S. New dimeric aporphine alkaloids and cytotoxic constituents of Hernandia nymphaeifolia. Planta Med. 62 (1996) 528-533
20. Giovannoni G., Land J.M., Keir G., Thompson E.J., and Heales S.J. Adaptation of the nitrate reductase and Griess reaction methods for the measurement of serum nitrate plus nitrite levels. Ann. Clin. Biochem. 34 (1997) 193-198
21. Porsbjerg C., Brannan J.D., Anderson S.D., and Backer V. Relationship between airway responsiveness to mannitol and to methacholine and markers of airway inflammation, peak flow variability and quality of life in asthma patients. Clin. Exp. Allergy 38 (2008) 43-50
22. Sade K., Schwartz I., Schwartz D., Wolman Y., Chernichovski T., Fireman E., Iaina A., and Kivity S. Effect of montelukast pretreatment on inducible nitric oxide synthase mRNA expression in the lungs of antigen-challenged allergic mice. Clin. Exp. Allergy 33 (2003) 1741-1746
23. Chibana K., Trudeau J.B., Mustovitch A.T., Hu H., Zhao J., Balzar S., Chu H.W., and Wenzel S.E. IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells. Clin. Exp. Allergy 38 (2008) 936-946
24. Guo F.H., De Raeve H.R., Rice T.W., Stuehr D.J., Thunnissen F.B., and Erzurum S.C. Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo. Proc. Natl. Acad. Sci. USA 92 (1995) 7809-7813
25. Chu S.C., Marks-Konczalik J., Wu H.P., Banks T.C., and Moss J. Analysis of the cytokine-stimulated human inducible nitric oxide synthase (iNOS) gene: characterization of differences between human and mouse iNOS promoters. Biochem. Biophys. Res. Commun. 248 (1998) 871-878
26. Guo F.H., Uetani K., Haque S.J., Williams B.R., Dweik R.A., Thunnissen F.B., Calhoun W., and Erzurum S.C. Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators. J. Clin. Invest. 100 (1997) 829-838
27. Kwon S., Newcomb R.L., and George S.C. Mechanisms of synergistic cytokine-induced nitric oxide production in human alveolar epithelial cells. Nitric oxide 5 (2001) 534-546
28. Kohan M., Bader R., Puxeddu I., Levi-Schaffer F., Breuer R., and Berkman N. Enhanced osteopontin expression in a murine model of allergen-induced airway remodeling. Clin. Exp. Allergy 37 (2007) 1444-1454
29. Ying S., Robinson D.S., Varney V., Meng Q., Tsicopoulos A., Moqbel R., Durham S.R., Kay A.B., and Hamid Q. TNF alpha mRNA expression in allergic inflammation. Clin. Exp. Allergy 21 (1991) 745-750
30. Gutierrez H.H., Pitt B.R., and Schwarz M. Pulmonary alveolar epithelial inducible NO synthase gene expression: regulation by inflammatory mediators. Am. J. Physiol. 268 (1995) L501-L508
31. Kwon S., and George S.C. Synergistic cytokine-induced nitric oxide production in human alveolar epithelial cells. Nitric oxide 3 (1999) 348-357
32. Janssen-Heininger Y.M., Poynter M.E., and Baeuerle P.A. Recent advances towards understanding redox mechanisms in the activation of nuclear factor Κb. Free Radic. Biol. Med. 28 (2000) 1317-1327
33. Redington A.E. Modulation of nitric oxide pathways: therapeutic potential in asthma and chronic obstructive pulmonary disease. Eur. J. Pharmacol. 533 (2006) 263-276