Molecular biological characteristics of differentiated early gastric cancer on the basis of mucin expression

Korean Journal of Pathology

Volumn 45, Issue 1, 2011, Pages 69-78

  Shin, Nari ^a   Kim, Hye Yeon ^a   Kim, Woo Kyung ^a   Park, Min Gyung ^a   Kim, Kyung Bin ^a   Shin, Dong Hoon ^a   Choi, Kyung Un ^a   Kim, Jee Yeon ^a   Lee, Chang Hun ^a   Huh, Gi Young ^a   Sol, Mee Young ^a   Park, Do Youn ^a  

^a Pusan National University Hospital   (South Korea)

Author keywords

Beta catenin; Comparative genomic hybridization; Microsatellite instability; Mucins; Stomach neoplasms; Tumor suppressor protein p53

Indexed keywords

EID: 79954483087     PISSN: 17381843     EISSN: None     Source Type: Journal    
DOI: 10.4132/KoreanJPathol.2011.45.1.69     Document Type: Article

References (30)

1. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An atempt at a histoclinical classification. Acta Pathol Microbiol Scand 1965; 64: 31-49.
2. Schlemper RJ, Riddell RH, Kato Y, et al. The Vienna classification of gastrointestinal epithelial neoplasia. Gut 2000; 47:251-5.
3. Tatematsu M, Ichinose M, Miki K, Hasegawa R, Kato T, Ito N. Gastric and intestinal phenotypic expression of human stomach cancers as revealed by pepsinogen immunohistochemistry and mucin histochemistry. Acta Pathol Jpn 1990; 40:494-504.
4. Saito A, Shimoda T, Nakanishi Y, Ochiai A, Toda G. Histologic heterogeneity and mucin phenotypic expression in early gastric cancer. Pathol Int 2001; 51:165-71.
5. Koseki K, Takizawa T, Koike M, Ito M, Nihei Z, Sugihara K Distinction of differentiated type early gastric carcinoma with gastric type mucin expression. Cancer 2000; 89: 724-32.
6. Tajima Y, Yamazaki K, Makino R, et al. Gastric and intestinal phenotypic marker expression in early differentiated-type tumors of the stomach: clinicopathologic significance and genetic background. Clin Cancer Res 2006; 12: 6469-79.
7. Bamba M, Sugihara H, Kushima R, et al. Time-dependent expression of intestinal phenotype in signet ring cell carcinomas of the human stomach. Virchows Arch 2001; 438:49-56.
8. Yamachika T, Inada K, Fujimitsu Y, et al. Intestinalization of gastric signet ring cell carcinomas with progression. Virchows Arch 1997; 431:103-10.
9. Yoshikawa A, Inada Ki K, Yamachika T, Shimizu N, Kaminishi M, Tatematsu M. Phenotypic shift in human differentiated gastric cancers from gastric to intestinal epithelial cell type during disease progression. Gastric Cancer 1998; 1:134-41.
10. Utsunomiya T, Yonezawa S, Sakamoto H, et al. Expression of MUC1 and MUC2 mucins in gastric carcinomas: its relationship with the prognosis of the patients. Clin Cancer Res 1998; 4:2605-14.
11. Baldus SE, Zirbes TK, Engel S, et al. Correlation of the immunohis-tochemical reactivity of mucin peptide cores MUC1 and MUC2 with the histopathological subtype and prognosis of gastric carcinomas. Int J Cancer 1998; 79:133-8.
12. Lee HS, Lee HK, Kim HS, Yang HK, Kim YI, Kim WH. MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas: their roles as prognostic indicators. Cancer 2001; 92:1427-34.
13. Pinto-de-Sousa J, David L, Reis CA, Gomes R, Silva L, Pimenta A. Mucins MUC1, MUC2, MUC5AC and MUC6 expression in the evaluation of differentiation and clinico-biological behaviour of gastric carcinoma. Virchows Arch 2002; 440:304-10.
14. Pinkel D, Segraves R, Sudar D, et al. High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays. Nat Genet 1998; 20:207-11.
15. Sumiyoshi Y Kakeji Y, Egashira A, Mizokami K, Orita H, Maehara Y Overexpression of hypoxia-inducible factor 1alpha and p53 is a marker for an unfavorable prognosis in gastric cancer. Clin Cancer Res 2006; 12: 5112-7.
16. Jin Z, Tamura G, Honda T, Motoyama T. Molecular and cellular phenotypic profiles of gastric noninvasive neoplasia. Lab Invest 2002; 82:1637-45.
17. Ohmura K, Tamura G, Endoh Y, Sakata K, Takahashi T, Motoyama T. Microsatellite alterations in differentiated-type adenocarcinomas and precancerous lesions of the stomach with special reference to cellular phenotype. Hum Pathol 2000; 31:1031-5.
18. Kim GH, Song GA, Park DY, et al. CDX2 expression is increased in gastric cancers with less invasiveness and intestinal mucin phenotype. Scand J Gastroenterol 2006; 41:880-6.
19. Fan Z, Li J, Dong B, Huang X. Expression of Cdx2 and hepatocyte antigen in gastric carcinoma: correlation with histologic type and implications for prognosis. Clin Cancer Res 2005; 11:6162-70.
20. Peifer M. Cell adhesion and signal transduction: the Armadillo connection. Trends Cell Biol 1995; 5:224-9.
21. Resnik E. Beta-catenin: one player, two games. Nat Genet 1997; 16: 9-11.
22. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996; 87:159-70.
23. Bienz M, Clevers H. Linking colorectal cancer to Wnt signaling. Cell 2000; 103:311-20.
24. Miyazawa K, Iwaya K, Kuroda M, et al. Nuclear accumulation of beta-catenin in intestinal-type gastric carcinoma: correlation with early tumor invasion. Virchows Arch 2000; 437:508-13.
25. Aihara R, Mochiki E, Nakabayashi T, Akazawa K, Asao T, Kuwano H. Clinical significance of mucin phenotype, beta-catenin and matrix metalloproteinase 7 in early undifferentiated gastric carcinoma. Br J Surg 2005; 92:454-62.
26. Lee HS, Choi SI, Lee HK, et al. Distinct clinical features and outcomes of gastric cancers with microsatellite instability. Mod Pathol 2002; 15:632-40.
27. Myllykangas S, Junnila S, Kokkola A, et al. Integrated gene copy number and expression microarray analysis of gastric cancer highlights potential target genes. Int J Cancer 2008; 123:817-25.
28. Hou Q, Wu YH, Grabsch H, et al. Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer. Cancer Res 2008; 68:4623-30.
29. Weiss MM, Snijders AM, Kuipers EJ, et al. Determination of amplicon boundaries at 20q13.2 in tissue samples of human gastric adenocarcinomas by high-resolution microarray comparative genomic hybridization. J Pathol 2003; 200:320-6.
30. Morohara K, Tajima Y, Nakao K, et al. Gastric and intestinal pheno-typic cell marker expressions in gastric differentiated-type carcinomas: association with E-cadherin expression and chromosomal changes. J Cancer Res Clin Oncol 2006; 132: 363-75.