Characterization of the basal core promoter and precore regions in anti-HBe-positive inactive carriers of hepatitis B virus

International Journal of Infectious Diseases

Volumn 15, Issue 5, 2011, Pages

  Ledesma, María Mora González López ^a   Galdame, Omar ^b   Bouzas, Belén ^c   Tadey, Luciana ^a   Livellara, Beatriz ^b   Giuliano, Silvina ^c   Viaut, Marcela ^b   Paz, Silvia ^c   Fainboim, Hugo ^c   Gadano, Adrian ^b   Campos, Rodolfo ^a   Flichman, Diego ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b HOSPITAL ITALIANO DE BUENOS AIRES   (Argentina)

^c HOSPITAL F J MUÑIZ   (Argentina)

Author keywords

Anti HBe positive; Basal core promoter; Genotypes; Inactive carriers; Precore region

Indexed keywords

HEPATITIS B(E) ANTIBODY; HEPATITIS B(E) ANTIGEN;

ADULT; AGED; ARTICLE; DNA FINGERPRINTING; FEMALE; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; MAJOR CLINICAL STUDY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PREVALENCE; PROMOTER REGION;

ADULT; AGED; BASE SEQUENCE; CARRIER STATE; DNA, VIRAL; FEMALE; FOLLOW-UP STUDIES; GENOTYPE; HEPATITIS B ANTIBODIES; HEPATITIS B E ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; PHYLOGENY; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; SEQUENCE ANALYSIS, DNA; STATISTICS AS TOPIC;

EID: 79954467888     PISSN: 12019712     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijid.2010.12.009     Document Type: Article

References (57)

1. Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 2004, 11:97-107.
2. Maddrey W.C. Hepatitis B: an important public health issue. J Med Virol 2000, 61:362-366.
3. Ocama P., Opio C.K., Lee W.M. Hepatitis B virus infection: current status. Am J Med 2005, 118. 1413.e15-22.
4. Perz J.F., Armstrong G.L., Farrington L.A., Hutin Y.J., Bell B.P. The contribution of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol 2006, 45:529-538.
5. Lok A.S., McMahon B.J. Chronic hepatitis B. Hepatology 2001, 34:1225-1241.
6. Hollinger F.B., Liang T.J. Hepatitis B virus. Fields virology. 2001, 2971-3036. Lippincott-Raven Publishers, Philadelphia, PA. 4th ed. D.M. Knipe, P.M. Howley, D.E. Griffin, R.A. Lamb, M.A. Martin, B. Roizman (Eds.).
7. Ganem D., Prince A.M. Hepatitis B virus infection-natural history and clinical consequences. N Engl J Med 2004, 350:1118-1129.
8. Hadziyannis S.J., Vassilopoulos D. Hepatitis B e antigen-negative chronic hepatitis B. Hepatology 2001, 34:617-624.
9. Hadziyannis S.J. Hepatitis B e antigen negative chronic hepatitis B. From clinical recognition to pathogenesis and treatment. Viral Hepat Rev 1995, 1:7-36.
10. McMahon B.J. The natural history of chronic hepatitis B virus infection. Hepatology 2009, 49:S45-55.
11. Fattovich G., Bortolotti F., Donato F. Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors. J Hepatol 2008, 48:335-352.
12. Liang T.J. Hepatitis B: the virus and disease. Hepatology 2009, 49:S13-21.
13. Pungpapong S., Kim W.R., Poterucha J.J. Natural history of hepatitis B virus infection: an update for clinicians. Mayo Clin Proc 2007, 82:967-975.
14. Brunetto M.R., Rodriguez U.A., Bonino F. Hepatitis B virus mutants. Intervirology 1999, 42:69-80.
15. Kramvis A., Kew M.C. The core promoter of hepatitis B virus. J Viral Hepat 1999, 6:415-427.
16. Buckwold V.E., Xu Z., Chen M., Yen T.S., Ou J.H. Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J Virol 1996, 70:5845-5851.
17. Baumert T.F., Marrone A., Vergalla J., Liang T.J. Naturally occurring mutations define a novel function of the hepatitis B virus core promoter in core protein expression. J Virol 1998, 72:6785-6795.
18. Moriyama K., Okamoto H., Tsuda F., Mayumi M. Reduced precore transcription and enhanced core-pregenome transcription of hepatitis B virus DNA after replacement of the precore-core promoter with sequences associated with e antigen-seronegative persistent infections. Virology 1996, 226:269-280.
19. Scaglioni P.P., Melegari M., Wands J.R. Biologic properties of hepatitis B viral genomes with mutations in the precore promoter and precore open reading frame. Virology 1997, 233:374-381.
20. Hunt C.M., McGill J.M., Allen M.I., Condreay L.D. Clinical relevance of hepatitis B viral mutations. Hepatology 2000, 31:1037-1044.
21. Kreutz C. Molecular, immunological and clinical properties of mutated hepatitis B viruses. J Cell Mol Med 2002, 6:113-143.
22. Chu C.M., Yeh C.T., Lee C.S., Sheen I.S., Liaw Y.F. Precore stop mutant in HBeAg-positive patients with chronic hepatitis B: clinical characteristics and correlation with the course of HBeAg-to-anti-HBe seroconversion. J Clin Microbiol 2002, 40:16-21.
23. Tong M.J., Blatt L.M., Kao J.H., Cheng J.T., Corey W.G. Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma. World J Gastroenterol 2006, 12:6620-6626.
24. Brunetto M.R., Giarin M., Oliveri F., Chiaberge E., Baldi M., Alfarano A., et al. Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis. Proc Natl Acad Sci U S A 1999, 88:4186-4190.
25. Bonino F., Brunetto M.R., Hepatitis B virus heterogeneity, one of many factors influencing the severity of hepatitis B. J Hepatol 1993, 18:5-8.
26. Baumert T.F., Barth H., Blum H.E. Genetic variants of hepatitis B virus and their clinical relevance. Minerva Gastroenterol Dietol 2005, 51:95-108.
27. Bedossa P., Poynard T. An algorithm for grading activity in chronic hepatitis C. Hepatology 1996, 24:289-293. The French METAVIR Cooperative Study Group.
28. Thompson J.D., Gibson T.J., Plewniak F., Jeanmougin F., Higgins D.G. The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 1997, 25:4876-4882.
29. Posada D., Crandall K.A. MODELTEST: testing the model of DNA substitution. Bioinformatics 1998, 14:817-818.
30. *and other methods). Version 4.0b10. Sunderland, MA: Sinauer Associates; 2003.
31. Lok A.S., Akarca U., Greene S. Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal. Proc Natl Acad Sci U S A 1994, 91:4077-4081.
32. Tong S.P., Li J.S., Vitvitski L., Kay A., Treépo C. Evidence for a base-paired region of hepatitis B virus pregenome encapsidation signal which influences the patterns of precore mutations abolishing HBe protein expression. J Virol 1993, 67:5651-5655.
33. Lindh M., Andersson A.S., Gusdal A. Genotypes, nt 1858 variants, and geographic origin of hepatitis B virus-large-scale analysis using a new genotyping method. J Infect Dis 1997, 175:1285-1293.
34. Piñeiro y Leone F.G., Pezzano S.C., Torres C., Rodríguez C.E., Eugenia Garay M., Fainboim H.A., et al. Hepatitis B virus genetic diversity in Argentina: dissimilar genotype distribution in two different geographical regions; description of hepatitis B surface antigen variants. J Clin Virol 2008, 42:381-388.
35. França P.H., González J.E., Munné M.S., Brandão L.H., Gouvea V.S., Sablon E., et al. Strong association between genotype F and hepatitis B virus (HBV) e antigen-negative variants among HBV-infected Argentinean blood donors. J Clin Microbiol 2004, 42:5015-5021.
36. Cooksley W.G. Do we need to determine viral genotype in treating chronic hepatitis B?. J Viral Hepat 2010, 17:601-610.
37. Guettouche T., Hnatyszyn H.J. Chronic hepatitis B and viral genotype: the clinical significance of determining HBV genotypes. Antivir Ther 2005, 10:593-604.
38. Kay A., Zoulim F. Hepatitis B virus genetic variability and evolution. Virus Res 2007, 127:164-176.
39. Datta S., Biswas A., Chandra P.K., Banerjee A., Panigrahi R., Mahapatra P.K., et al. Molecular epidemiology and clinical significance of hepatitis B virus genotypes, core promoter and precore mutations in eastern India. Intervirology 2008, 51:275-284.
40. Livingston S.E., Simonetti J.P., McMahon B.J., Bulkow L.R., Hurlburt K.J., Homan C.E., et al. Hepatitis B virus genotypes in Alaska Native people with hepatocellular carcinoma: preponderance of genotype F. J Infect Dis 2007, 195:5-11.
41. Raimondo G., Rodino G., Brancatelli S., Sardo M.A., Campo S., Smedile V., et al. HBe antibody unrelated to 'e minus' hepatitis B virus variant infection in patients with chronic type D hepatitis. J Hepatol 1991, 13(Suppl 4):S87-S89.
42. Tu H., Li P.Y., Wen Y.M. Anti-HBe titre in patients infected with wild-type and e-minus variant of hepatitis B virus. Res Virol 1996, 147:39-43.
43. Kawabe N., Hashimoto S., Harata M., Nitta Y., Murao M., Nakano T., et al. The loss of HBeAg without precore mutation results in lower HBV DNA levels and ALT levels in chronic hepatitis B virus infection. J Gastroenterol 2009, 44:751-756.
44. Jardi R., Rodriguez F., Buti M., Costa X., Valdes A., Allende H., et al. Mutations in the basic core promoter region of hepatitis B virus. Relationship with precore variants and HBV genotypes in a Spanish population of HBV carriers. J Hepatol 2004, 40:507-514.
45. Fouillot N., Rossignol J.M. Translational stop codons in the precore sequence of hepatitis B virus pre-C RNA allow translation reinitiation at downstream AUGs. J Gen Virol 1996, 77:1123-1127.
46. Okamoto H., Yotsumoto S., Akahane Y., Yamanaka T., Miyazaki Y., Sugai Y., et al. Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J Virol 1990, 64:1298-1303.
47. Santantonio T., Jung M.C., Miska S., Pastore G., Pape G.R., Will H. Prevalence and type of pre-C HBV mutants in anti-HBe positive carriers with chronic liver disease in a highly endemic area. Virology 1991, 183:840-844.
48. Laras A., Koskinas J., Avgidis K., Hadziyannis S.J. Incidence and clinical significance of hepatitis B virus precore gene translation initiation mutations in e antigen-negative patients. J Viral Hepat 1998, 5:241-248.
49. Raimondo G., Schneider R., Stemler M., Smedile V., Rodino G., Will H. A new hepatitis B virus variant in a chronic carrier with multiple episodes of viral reactivation and acute hepatitis. Virology 1990, 179:64-68.
50. Fiordalisi G., Cariani E., Mantero G., Zanetti A., Tanzi E., Chiaramonte M., et al. High genomic variability in the pre-C region of hepatitis B virus in anti-HBe, HBV DNA-positive chronic hepatitis. J Med Virol 1990, 31:297-300.
51. Zampino R., Lobello S., Chiaramonte M., Venturi-Pasini C., Dumpis U., Thursz M., et al. Intra-familial transmission of hepatitis B virus in Italy: phylogenetic sequence analysis and amino-acid variation of the core gene. J Hepatol 2002, 36:248-253.
52. Huy T.T., Ushijima H., Quang V.X., Ngoc T.T., Hayashi S., Sata T., et al. Characteristics of core promoter and precore stop codon mutants of hepatitis B virus in Vietnam. J Med Virol 2004, 74:228-236.
53. Yeh C.T., Shen C.H., Tai D.I., Chu C.M., Liaw Y.F. Identification and characterization of a prevalent hepatitis B virus X protein mutant in Taiwanese patients with hepatocellular carcinoma. Oncogene 2000, 19:5213-5220.
54. Maruyama T., Mitsui H., Maekawa H., Yamada H., Hirayama M., Iino S., et al. Emergence of the precore mutant late in chronic hepatitis B infection correlates with the severity of liver injury and mutations in the core region. Am J Gastroenterol 2000, 95:2894-2904.
55. Ito K., Tanaka Y., Orito E., Sugiyama M., Fujiwara K., Sugauchi F., et al. T1653 mutation in the box alpha increases the risk of hepatocellular carcinoma in patients with chronic hepatitis B virus genotype C infection. Clin Infect Dis 2006, 42:1-7.
56. Shinkai N., Tanaka Y., Ito K., Mukaide M., Hasegawa I., Asahina Y., et al. Influence of hepatitis B virus X and core promoter mutations on hepatocellular carcinoma among patients infected with subgenotype C2. J Clin Microbiol 2007, 45:3191-3197.
57. Choi C.S., Cho E.Y., Park R., Kim S.J., Cho J.H., Kim H.C. X gene mutations in hepatitis B patients with cirrhosis, with and without hepatocellular carcinoma. J Med Virol 2009, 81:1721-1725.