Emergence of the precore mutant late in chronic hepatitis B infection correlates with the severity of liver injury and mutations in the core region

American Journal of Gastroenterology

Volumn 95, Issue 10, 2000, Pages 2894-2904

  Maruyama, Toshiyuki ^a,c   Mitsui, Hiroshi ^a   Maekawa, Hisato ^a   Yamada, Haruki ^a   Hirayama, Miki ^a   Iino, Shiro ^b   Yasuda, Kiyomi ^b   Koike, Kazuhiko ^a   Kimura, Satoshi ^a   Milich, David R ^c,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d Vaccine Research Institute of San Diego   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; DNA; GAMMA INTERFERON; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; GENE MUTATION; GENOME; HEPATITIS B; HUMAN; LIVER INJURY; MALE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEROCONVERSION; T LYMPHOCYTE; VIRUS INFECTION;

ADOLESCENT; ADULT; DISEASE PROGRESSION; DNA MUTATIONAL ANALYSIS; FEMALE; HEPATITIS B ANTIBODIES; HEPATITIS B E ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMAN; LIVER CIRRHOSIS; LIVER FUNCTION TESTS; MALE; MIDDLE AGE; SUPPORT, U.S. GOV'T, P.H.S.; VIRAL CORE PROTEINS; VIRULENCE;

EID: 0033791696     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9270(00)01994-8     Document Type: Article

References (37)

1. Hepatocellular carcinoma and hepatitis B virus
2. Hepatitis B virus gene function: The precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen
3. Formation of transmembraneous hepatitis B e-antigen by cotranslational in vitro processing of the viral precore protein
4. Immune response to hepatitis B virus core antigen (HBcAg): Localization of T cell recognition sites within HBcAg/HBeAg
5. DNA immunization induces antibody and cytotoxic T cell responses to hepatitis B core antigen in H-2(B) mice
6. Selective sensitization of peripheral blood T lymphocytes to hepatitis B core antigen in patients with chronic active hepatitis type B
7. + T cell population during seroconversion to anti-HBs in hepatitis B virus infection
8. HLA class I-restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen
9. New specificities in Australia antigen positive sera distinct from the Le Bouvier determinants
10. Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection
11. Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen
12. Chronic active hepatitis with hepatitis B virus DNA and antibody against e antigen in the serum
13. Wild-type, and e antigen-minus hepatitis B viruses, and course of chronic hepatitis
14. Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis
15. A hepatitis B virus mutant associated with an epidemic of fulminant hepatitis
16. Precore wild-type DNA, and immune complexes persist in chronic hepatitis B after seroconversion. No association between genome conversion and serconversion
17. Hepatitis B virus precore/core variation, and interferon therapy
18. Genomic variations in the hepatitis B core gene: A possible factor influencing response to interferon alfa treatment
19. High rate of mutations in the hepatitis B core gene during the immune clearance phase of chronic hepatitis B virus infection
20. Nucleotide sequence analysis of precore and proximal core regions in patients with chronic hepatitis B treated with interferon
21. The serology of chronic hepatitis B infection revisited
22. The secreted hepatitis B precore antigen can modulate the immune response to the nucleocapsid: A mechanism for persistence
23. Extrathymic expression of the intracellular hepatitis B core antigen results in T cell tolerance in transgenic mice
24. Variations in codons 84-101 in the core nucleotide sequence correlate with hepatocellular injury in chronic hepatitis B virus infection
25. Mutations in core nucleotide sequence of hepatitis B virus correlate with fulminant and severe hepatitis
26. Precore/core mutations of hepatitis B virus in hepatocellular carcinomas developed on noncirrhotic livers
27. + cytotoxic T lymphocytes
28. Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis
29. Hepatitis B virus mutants with precore-region defects in two babies with fulminant hepatitis, and their mothers positive for antibody to hepatitis B e antigen
30. Precore-mediated inhibition of hepatitis virus progeny DNA synthesis
31. The hepatitis B virus (HBV) precore protein inhibitis HBV replication in transgenic mice
32. The precore gene of the woodchuck hepatitis virus genome is not essential for viral replication in the natural host
33. Enrichment of a precore-minus mutant of duck hepatitis B vires in experimental mixed infection
34. + cytotoxic T-lymphocyte responses after genetic immunization with retrovirus vectors expressing different forms of the hepatitis B vires core, and e antigens
35. Characterization of self-reactive T cells that evade tolerance in hepatitis B e antigen transgenic mice
36. + cell repertoire in chronic HBV infection
37. Differential antigen processing pathways of the hepatitis B virus e core proteins