Celecoxib induces heme oxygenase-1 expression in macrophages and vascular smooth muscle cells via ROS-dependent signaling pathway

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 383, Issue 2, 2011, Pages 159-168

  Wang, Jang Shiun ^a   Ho, Feng Ming ^b,c   Kang, Hao Cheng ^a   Lin, Wan Wan ^a   Huang, Kuo Chin ^d,e  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b TAO YUAN GENERAL HOSPITAL   (Taiwan)

^c CHUNG YUAN CHRISTIAN UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Celecoxib; Heme oxygenase 1; Macrophages; Signal pathway; Vascular smooth muscle cells

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE; CELECOXIB; COBALT CHLORIDE; CYCLOOXYGENASE 2; HEME OXYGENASE 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR FACTOR; PROSTAGLANDIN E2; PROSTAGLANDIN J2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SYNAPTOPHYSIN; WORTMANNIN;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STRAIN; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPOXIA; MACROPHAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR SMOOTH MUSCLE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AORTA, THORACIC; CELL HYPOXIA; CELL LINE; CYCLOOXYGENASE 2 INHIBITORS; ENDOTHELIAL CELLS; ENZYME INDUCTION; HEME OXYGENASE-1; HUMANS; IMMUNOBLOTTING; MACROPHAGES; MALE; MICE; MUSCLE, SMOOTH, VASCULAR; PYRAZOLES; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SULFONAMIDES; UP-REGULATION;

EID: 79954434352     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-010-0586-6     Document Type: Article

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