Engineered epidermal growth factor mutants with faster binding on-rates correlate with enhanced receptor activation

FEBS Letters

Volumn 585, Issue 8, 2011, Pages 1135-1139

  Lahti, Jennifer L ^a   Lui, Bertrand H ^a   Beck, Stayce E ^a   Lee, Stephen S ^a   Ly, Daphne P ^b   Longaker, Michael T ^b   Yang, George P ^b   Cochran, Jennifer R ^a,c  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

Epidermal growth factor; Kinetic binding rate; Protein engineering; Receptor activation; Receptor tyrosine kinase

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CELL SURFACE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIGAND BINDING; MOUSE; MUTANT; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CELL LINE; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; FIBROBLASTS; IMMUNOBLOTTING; KINETICS; MICE; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION; PROTEIN BINDING; PROTEIN ENGINEERING; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; SEQUENCE HOMOLOGY, AMINO ACID; SURFACE PLASMON RESONANCE;

EID: 79954427245     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.03.044     Document Type: Article

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