Modification of a receptor-binding surface of epidermal growth factor (EGF): Analogs with enhanced receptor affinity at low pH or at neutrality

Protein Engineering

Volumn 11, Issue 6, 1998, Pages 473-480

  Mullenbach, Guy T ^a,b   Chiu, Choi Ying ^a   Gyenes, Alex ^a   Blaney, Jeffrey ^a,c   Rosenberg, Steve ^a   Marlowe, Charles K ^a,d   Brown, Suzy ^a   Stratton Thomas, Jennifer ^a   Montelione, Gaetano T ^a,e   George Nascimento, Carlos ^a   Stauber, Gregory ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Indus Biomolecular Group   (United States)

^c Metaphorics LLC   (United States)

^d MILLENNIUM PHARMACEUTICALS INC   (United States)

^e RUTGERS UNIVERSITY   (United States)

Author keywords

EGF; Engineering; Epidermal growth factor; pH dependence; Protein; Site directed mutagenesis; Urogastrone

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUTAMINE; HISTIDINE;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; PH; POINT MUTATION; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR AFFINITY; RECEPTOR BINDING;

EID: 0031871572     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/11.6.473     Document Type: Article

References (77)

1. Aaronson, S. (1991) Science, 254, 1146-1153.
2. Bennet, N. and Schultz, G. (1993) Am. J. Surg., 155, 75-81.
3. Bishop, J. (1987) Science, 235, 305.
4. Boonstra, J., Rijken, P., Humbel, B., Cremers, F., Verkleij, A. and van Bergen en Henegouwen, P. (1995) Cell Biol. Int., 19, 413-430.
5. Brake, A., Merryweather, J., Coit, D., Heberlein, U., Masiazr, E. Mullenbach, G., Urdea, M., Valenzuela, P. and Barr, P.J. (1984) Proc. Natl Acad. Sci. USA, 81, 4642-4646.
6. Calabro, A., Milani, S., Paladini, I., Orsini, B., Salvadori, G. and Surrenti, C. (1995) Dig. Dis. Sci., 40, 2497-2504.
7. Campion, S. and Niyogi, S. (1994) Prog. Nucleic Acid Res. Mol. Biol., 49, 353-383.
8. Campbell, I., Cooke, R., Baron, M., Harvey, T. and Tappin, M. (1989) Prog. Growth Factor Res., 1, 13-22.
9. Campbell, I., Baron, M., Cooke, R., Dudgeon, T., Fallon, A., Harvey, T. and Tappin, M. (1990) Biochem. Pharrn., 40, 35-40.
10. Campion, S., Geck, M. and Niyogi, S. (1993) J. Biol. Chem., 268, 1742-1748.
11. Carpenter, G. (1987) Annu. Rev. Biochem., 56, 881-914.
12. Carpenter, G. and Cohen, S. (1979) Annu. Rev. Biochem., 48, 193-216.
13. Carpenter, G., King, L. and Cohen, S. (1978) Nature, 276, 409-410.
14. Chang, W., Upton, C., Hu, S.-L., Purchio, A.F., McFadden, G. (1987) Mol. Cell. Biol., 7, 535-540.
15. Cooke, R., Wilkinson, A., Baron, M., Pastore, A., Tappin, M., Campbell, I., Gregory H. and Sheard, B. (1987) Nature, 327, 339-341.
16. Davies, D. and Chamberlin, S. (1996) Biochem. Pharm., 51, 1101-1110.
17. Defeo-Jones, D., Tai, J.-Y., Wegrzyn, R., Vuocolo, G., Baker, A., Payne, L., Garsky, V., Oliff, A. and Riemen, M. (1988) Mol. Cell. Biol., 8, 2999-3007.
18. Defeo-Jones, D., Tai, J.-Y. and Oliff, A. (1991) Meth. Enzymol. 198, 191-200.
19. Ebner, R. and Derynck, R. (1991) Cell Reg., 2, 599-612.
20. Ennis, B., Lippman, M. and Dickson, R. (1991) Cancer Invest., 9, 553-562.
21. Eppstein, D., Varsh, Y., Schreiber, A., Newman, S., Todaro, G. and Nestor, J. (1985) Nature, 318, 663-665.
22. George-Nascimento, C., Gyenes, A., Halloran, S., Merry weather, J., Valenzuela, P. Steimer, K., Masiarz, F. and Randolph, A. (1988) Biochemistry, 27, 797-802.
23. Getzoff, E., Cabelli, D., Fisher, C., Parge, H., Viezzoli, M., Banci, L. and Hallewell, R. (1992) Nature, 358, 347-351.
24. Gill, G., Kawamoto, T., Cochet, C., Le, A., Sato, J., Masui, H., McLeod, C. and Mendelsohn, J. (1984) J. Biol. Chem., 259, 7755-7760.
25. Greenfield, C., Hiles, I., Waterfield, M., Federwisch, M., Wollmer, A., Blundell, T. and McDonald, N. (1989) EMBO J., 8, 4115-4123.
26. Groenen, L., Nice, E. and Burgess, A. (1994) Growth Factors, 11, 235-257.
27. Guenther, N., Betzel, C. and Weber, W. (1990) J. Biol. Chem., 265, 22082-22085.
28. Harvey, T., Wilkinson, A., Tappin, M., Cooke, R. and Campbell, I. (1991) Eur. J. Biochem., 198, 555-562.
29. Heath, W. and Merrifield, R. (1986) Proc. Natl Acad. Sci. USA, 83, 6367-6371.
30. Higashiyama, S., Abraham, J., Miller, J., Fiddes, J. and Klagsbrun, M. (1991) Science, 251, 936-939.
31. Hommel, U., Dudgeon, T., Fallon, A., Edwards, M. and Campbell, I. (1991) Biochemistry, 30, 8891-8898.
32. Hommel, U., Harvey, T., Driscoll, P. and Campbell, I. (1992) J. Mol. Biol., 227, 271-282.
33. Hopp, T., Prickett, K., Price, V. Libby, R., March, C., Cerretti, D., Urdal, D. and Conlon, P. (1988) Biotechnology, 6, 1204-1210.
34. Kimura, H., Fischer, W. and Schubert, D. (1990) Nature, 348, 257-260.
35. Kohda, D. and Inagaki, F. (1988) J. Biochem., 103, 554-571.
36. Kohda, D. and Inagaki, F. (1992) Biochemistry, 31, 11928-11939.
37. Kohda, D., Go, N., Hayashi, K. and Inagaki, F. (1988) J. Biochem., 103, 741-743.
38. Kohda, D., Shimada, I., Miyake, T., Fuwa, T. and Inagaki, F. (1989) Biochemistry, 28, 953-958.
39. Komoriya, A., Hortsch, M., Meyers, C., Smith, M., Kanety, H. and Schlessinger, J. (1984) Proc. Natl Acad. Sci. USA, 81, 1351-1355.
40. Kramer, R., Lenferink, A., van Bueren-Koornneef, I., van der Meer, A., van de Poll, L. and van Zoelen, E. (1994) J. Biol. Chem., 269, 8708-8711.
41. Lax, I., Johnson, A., Howk, R., Sap, J., Bellot, F., Winkler, M., Ullrich, A., Vennstrom, B., Schlessinger, J. and Givol, D. (1988) Mol. Cell. Biol., 8, 1970-1978.
42. Lax, I., Mitra, A., Ravera, C., Hurwitz, D., Rubinstein, M., Ullrich, A., Stroud, R. and Schlessinger, J. (1991) J. Biol. Chem., 266, 13828-13833.
43. Lazar, E., Watanabe, S., Dalton, S. and Sporn, M.B. (1988) Mol. Cell. Biol., 8, 1247-1253.
44. Lazar, E., Vicenzi, E., Van Obberghen-Schilling, E., Wolff, B., Dalton, S., Watanabe, S. and Sporn, M. (1989) Mol. Cell. Biol., 9, 860-864.
45. Lin, Y-Z., Caporaso, G., Chang, P.-Y., Ke, X.-H. and Tam J. (1988) Biochemistry, 27, 5640-5645.
46. Lin, Y.-Z., Ke, X.-H. and Tam, J. (1990) J. Biol. Chem., 265, 18884-18890.
47. Lin, Y.-Z., Ke, X.-H. and Tam, J.-P. (1991) Biochemistry, 30, 3310-3314.
48. Matsunami, R., Campion, S., Niyogi, S. and Stevens, A. (1990) FEBS Lett., 264, 105-108
49. Modjtahedi, H., Styles, J. and Dean, C. (1993) Br. J. Cancer, 67, 247-253.
50. Montelione, G., Wuthrich, K., Nice, E., Burgess, A. and Scheraga, H. (1987) Proc. Natl Acad. Sci. USA, 84, 5226-5230.
51. Montelione, G., Winkler, M., Rinderknecht, E., Burton, L., Sporn, M. and Wagner, G. (1989) Proc. Natl Acad. Sci. USA, 86, 1519-1523.
52. Montelione, G., Wuthrich, K., Burgess, A., Nice, E., Wagner, G., Gibson, K. and Scheraga, H. (1992) Biochemistry, 31, 236-249.
53. Moy, F., Li, Y.-C., Rauenbuehler, P. Winkler, M., Scheraga, H. and Montelione, G. (1993) Biochemistry, 32, 7334-7353.
54. Mullenbach, G., Tabrizi, A., Blacher, R., Steimer, K. (1986) J. Biol. Chem., 27, 719-722 .
55. Nelson, J., Stewart, R., McGivern, M., Bailie, J., Walker, B., Murphy, R. and Wilson, D. (1991) Carcinogenesis, 12, 1823-1829.
56. Nunez, M., Mayo, K., Starbuck, C. and Lauffenburger, D. (1993) J. Cell. Biochem., 51, 312-321.
57. Read, L. and George-Nascimento, C. (1990) Biotech. Ther., 1, 237-272.
58. Richter, A., Drummond, D., MacGarvie, J., Puddicombe, S., Chamberlin, S. and Davies, D. (1995) J. Biol. Chem., 270, 1612-1616.
59. Salacinski, P., McLean, C., Sykes, J., Clement-Jones, V. and Lowry, P. (1981) Anal. Biochem., 117, 136-146.
60. Salomon, D., Brandt, R., Ciardiello, F. and Normanno, N. (1995) Crit. Rev. Onc. Hematology, 19, 183-232.
61. Schultz, G. and Twardzik, D. (1991) Meth. Enzymol., 198, 200-213.
62. Shiah, H.-S., Chen, T.-Y., Chang, C.-M., Chow, J.-T., Kung, J.-J. and Hwang, J. (1992) J. Biol. Chem., 267, 24034-24040.
63. Shin, S..-Y., Watanabe, M., Kako, K., Ohtaki, T. and Munekata, E. (1994) Life Sci., 55, 131-139.
64. Shing, Y., Christofori, G., Hanahan, D., Ono, Y., Sasada, R., Igarashi, K. and Folkman, T. (1993) Science, 259, 1604-1607.
65. Shoyab, M., Plowman, G., McDonald, V., Bradley, J. and Todaro, G. (1989) Science, 243, 1074-1078.
66. Simpson, R., Smith, J., Moritz, R., O'Hare, M., Rudland, P., Morrison, J., Lloyd, C., Grego, B., Burgess, A. and Nice, E. (1985) Eur. J. Biochem., 153, 629-637.
67. Steinman, H. (1987) J. Biol. Chem., 262, 1882-1887.
68. Tadaki, D. and Niyogi, S. (1993) J. Biol. Chem., 268, 10114-10119.
69. Tadaki, D., Campion, S. and Niyogi, S. (1994) FASEB J., 8, A1459.
70. Toyoda, H., Komurasaki, T., Uchida, D., Takayama, Y., Isobe, T., Okuyama, T. and Hanada, K. (1995) J. Biol. Chem., 31, 7495-7500.
71. Ullrich, A. and Schlessinger, J. (1990) Cell, 61, 203-212.
72. Ushiro, H. and Cohen, S. (1980) J. Biol. Chem., 255, 8363-8365.
73. van de Poll, M., Lenferink, A., van Vugt, M., Jacobs, J., Janssen, J., Joldersma, M. and van Zoelen, E. (1995) J. Biol. Chem., 270, 22337-22343.
74. Willingham, M. Maxfield, F. and Pastan, I. (1979) J. Cell Biol., 82, 614-625.
75. Winkler, M.E., O'Connor, L., Winget, M. and Fendly, B. (1989) Biochemistry, 28, 6373-6378.
76. Yarden, Y. (1988) Annu. Rev. Biochem., 57, 443-478.
77. Yarden, Y. and Schlessinger, J. (1987) Biochemistry, 26, 1443-1451.