Parathyroid hormone treatment increases fixation of orthopedic implants with gap healing: A biomechanical and histomorphometric canine study of porous coated titanium alloy implants in cancellous bone

Calcified Tissue International

Volumn 88, Issue 4, 2011, Pages 294-303

  Daugaard, Henrik ^a   Elmengaard, Brian ^a   Andreassen, Troels ^b   Bechtold, Joan ^c   Lamberg, Anders ^a   Soballe, Kjeld ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c MINNEAPOLIS MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

Biomechanics; Canine; Histomorphometry; Parathyroid hormone; Prostheses and implants

Indexed keywords

PARATHYROID HORMONE[1-34]; TITANIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE MASS; BONE STRUCTURE; CANCELLOUS BONE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENERGY ABSORPTION; EQUIPMENT DESIGN; FRACTURE FIXATION; FRACTURE HEALING; GAP HEALING; IMPLANT; MALE; MATERIAL COATING; MORNING DOSAGE; NONHUMAN; PRIORITY JOURNAL; RIGIDITY; SHEAR STRENGTH; TIBIA;

ALLOYS; ANIMALS; BIOMECHANICS; BONE AND BONES; COATED MATERIALS, BIOCOMPATIBLE; DOGS; HORMONES; MALE; MATERIALS TESTING; ORTHOPEDICS; PARATHYROID HORMONE; POROSITY; PROSTHESES AND IMPLANTS; STRESS, MECHANICAL; TIBIA;

EID: 79954425811     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-010-9458-9     Document Type: Article

References (52)

1. CA Engh D O'Connor M Jasty TF McGovern JD Bobyn WH Harris 1992 Quantification of implant micromotion, strain shielding, and bone resorption with porous-coated anatomic medullary locking femoral prostheses Clin Orthop Relat Res 285 13 29 1446429
2. J Karrholm B Borssen G Lowenhielm F Snorrason 1994 Does early micromotion of femoral stem prostheses matter? 4-7-year stereoradiographic follow-up of 84 cemented prostheses J Bone Joint Surg Br 76 912 917 7983118 1:STN:280: DyaK2M%2FnsVahtg%3D%3D (Pubitemid 24368446)
3. J Inoue H Takahashi T Konno 1985 Histomorphometric evaluation on ilium of beagle dogs with long-term administration of low-dose 1-34 PTH Bone 6 401 402 10.1016/8756-3282(85)90341-2
4. M Li H Liang Y Shen TJ Wronski 1999 Parathyroid hormone stimulates cancellous bone formation at skeletal sites regardless of marrow composition in ovariectomized rats Bone 24 95 100 9951776 10.1016/S8756-3282(98)00167-7 1:CAS:528:DyaK1MXnt12ht7o%3D (Pubitemid 29070799)
5. H Dobnig RT Turner 1995 Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells Endocrinology 136 3632 3638 7628403 10.1210/en.136.8.3632 1:CAS:528:DyaK2MXntFKntbs%3D
6. S Nishida A Yamaguchi T Tanizawa N Endo T Mashiba Y Uchiyama T Suda S Yoshiki HE Takahashi 1994 Increased bone formation by intermittent parathyroid hormone administration is due to the stimulation of proliferation and differentiation of osteoprogenitor cells in bone marrow Bone 15 717 723 7873302 10.1016/8756-3282(94)90322-0 1:CAS:528:DyaK2MXitFSkt7Y%3D (Pubitemid 24332666)
7. CP Jerome DB Burr BT Van JM Hock R Brommage 2001 Treatment with human parathyroid hormone (1-34) for 18 months increases cancellous bone volume and improves trabecular architecture in ovariectomized cynomolgus monkeys (Macaca fascicularis) Bone 28 150 159 11182372 10.1016/S8756-3282(00)00430-0 1:CAS:528:DC%2BD3MXhtFehu7w%3D (Pubitemid 32140971)
8. H Oxlund M Dalstra C Ejersted TT Andreassen 2002 Parathyroid hormone induces formation of new cancellous bone with substantial mechanical strength at a site where it had disappeared in old rats Eur J Endocrinol 146 431 438 11888851 10.1530/eje.0.1460431 1:CAS:528:DC%2BD38Xis1OhsbY%3D (Pubitemid 34257655)
9. L Zhang HE Takahashi T Tanizawa N Endo N Yamamoto M Hori 1998 Low dose of human PTH(1-34) improved tibial subcortical bone mass without further cortical bone loss in adult intact beagles J Bone Miner Metab 16 96 99 10.1007/s007740050032 1:CAS:528:DyaK1cXltlCjtrw%3D (Pubitemid 28313296)
10. TT Andreassen C Ejersted H Oxlund 1999 Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures J Bone Miner Res 14 960 968 10352105 10.1359/jbmr.1999.14.6.960 1:CAS:528:DyaK1MXjvFKqurw%3D (Pubitemid 29262891)
11. K Nozaka N Miyakoshi Y Kasukawa S Maekawa H Noguchi Y Shimada 2008 Intermittent administration of human parathyroid hormone enhances bone formation and union at the site of cancellous bone osteotomy in normal and ovariectomized rats Bone 42 90 97 17997377 10.1016/j.bone.2007.08.041 1:CAS:528: DC%2BD2sXhsVOrtrbM (Pubitemid 350297177)
12. YM Alkhiary LC Gerstenfeld E Krall M Westmore M Sato BH Mitlak TA Einhorn 2005 Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34) J Bone Joint Surg Am 87 731 741 15805200 10.2106/JBJS.D.02115 (Pubitemid 40489347)
13. T Manabe S Mori T Mashiba Y Kaji K Iwata S Komatsubara A Seki YX Sun T Yamamoto 2007 Human parathyroid hormone (1-34) accelerates natural fracture healing process in the femoral osteotomy model of cynomolgus monkeys Bone 40 1475 1482 17369013 10.1016/j.bone.2007.01.015 1:CAS:528:DC%2BD2sXlsF2ntbs%3D (Pubitemid 46756411)
14. P Aspenberg HK Genant T Johansson AJ Nino K See K Krohn PA Garcia-Hernandez CP Recknor TA Einhorn GP Dalsky BH Mitlak A Fierlinger MC Lakshmanan 2009 Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures J Bone Miner Res 25 404 414 10.1359/jbmr.090731
15. Y Gabet R Muller J Levy R Dimarchi M Chorev I Bab D Kohavi 2006 Parathyroid hormone 1-34 enhances titanium implant anchorage in low-density trabecular bone: a correlative micro-computed tomographic and biomechanical analysis Bone 39 276 282 16617039 10.1016/j.bone.2006.02.004 1:CAS:528:DC%2BD28Xls1ejt7Y%3D (Pubitemid 43851377)
16. T Shirota M Tashiro K Ohno A Yamaguchi 2003 Effect of intermittent parathyroid hormone (1-34) treatment on the bone response after placement of titanium implants into the tibia of ovariectomized rats J Oral Maxillofac Surg 61 471 480 12684966 10.1053/joms.2003.50093 (Pubitemid 36396977)
17. Y Ohkawa K Tokunaga N Endo 2008 Intermittent administration of human parathyroid hormone (1-34) increases new bone formation on the interface of hydroxyapatite-coated titanium rods implanted into ovariectomized rat femora J Orthop Sci 13 533 542 19089541 10.1007/s00776-008-1275-x 1:CAS:528: DC%2BD1cXhsFSrurnK
18. R Skripitz HR Johansson SD Ulrich A Werner P Aspenberg 2009 Effect of alendronate and intermittent parathyroid hormone on implant fixation in ovariectomized rats J Orthop Sci 14 138 143 19337803 10.1007/s00776-008-1311-x 1:CAS:528:DC%2BD1MXjvV2ntbw%3D
19. R Skripitz TT Andreassen P Aspenberg 2000 Strong effect of PTH (1-34) on regenerating bone: a time sequence study in rats Acta Orthop Scand 71 619 624 11145391 10.1080/000164700317362271 1:STN:280:DC%2BD3M%2Fos1GlsA%3D%3D
20. R Skripitz P Aspenberg 2001 Implant fixation enhanced by intermittent treatment with parathyroid hormone J Bone Joint Surg Br 83 437 440 11341434 10.1302/0301-620X.83B3.10256 1:STN:280:DC%2BD3MzgvFKnug%3D%3D (Pubitemid 32390361)
21. R Skripitz P Aspenberg 2001 Early effect of parathyroid hormone (1-34) on implant fixation Clin Orthop Relat Res 392 427 432 11716418 10.1097/00003086-200111000-00056 (Pubitemid 33054976)
22. R Skripitz S Bohling W Ruther P Aspenberg 2005 Stimulation of implant fixation by parathyroid hormone (1-34)-a histomorphometric comparison of PMMA cement and stainless steel J Orthop Res 23 1266 1270 15964166 1:CAS:528:DC%2BD2MXhtFWht73J (Pubitemid 41554656)
23. Y Gabet D Kohavi R Voide TL Mueller R Muller I Bab 2009 Endosseous implant anchorage is critically dependent on mechanostructural determinants of peri-implant bone trabeculae J Bone Miner Res 25 575 583 10.1359/jbmr.090808
24. MS Corsini FN Faraco AA Castro T Onuma WR Sendyk JA Shibli 2008 Effect of systemic intermittent administration of human parathyroid hormone (rhPTH[1-34]) on the resistance to reverse torque in rabbit tibiae J Oral Implantol 34 298 302 19133483 10.1563/1548-1336-34.6.298
25. P Aspenberg K Wermelin P Tengwall A Fahlgren 2008 Additive effects of PTH and bisphosphonates on the bone healing response to metaphyseal implants in rats Acta Orthop 79 111 115 18283582 10.1080/17453670710014851 (Pubitemid 351271892)
26. B Mair S Tangl J Feierfeil D Skiba G Watzek R Gruber 2009 Age-related efficacy of parathyroid hormone on osseointegration in the rat Clin Oral Implants Res 20 400 405 19298294 10.1111/j.1600-0501.2008.01658.x
27. HR Johansson R Skripitz P Aspenberg 2008 Bisphosphonates can block the deterioration in implant fixation after withdrawal of intermittent doses of parathyroid hormone J Bone Joint Surg Br 90 400 404 18310769 10.1302/0301-620X.90B3.19544 1:STN:280:DC%2BD1c7ltlygsQ%3D%3D (Pubitemid 351428963)
28. Daugaard H, Elmengaard B, Lamberg A, Bechtold JE, Soballe K (2009) Osseointegration of implants inserted pressfit with parathyroid hormone as adjuvant therapy. In: European Federation of National Associations of Orthopaedics and Traumatology, 10th conference EFORT, June 3-6, Vienna, Austria
29. S Overgaard K Soballe H Jorgen G Gundersen 2000 Efficiency of systematic sampling in histomorphometric bone research illustrated by hydroxyapatite-coated implants: optimizing the stereological vertical-section design J Orthop Res 18 313 321 10815834 10.1002/jor.1100180221 1:STN:280:DC%2BD3c3ntlamtA%3D%3D (Pubitemid 30304762)
30. J Baas 2008 Adjuvant therapies of bone graft around non-cemented experimental orthopedic implants stereological methods and experiments in dogs Acta Orthop Suppl 79 1 43 19065776
31. K Gotfredsen E Budtz-Jorgensen LN Jensen 1989 A method for preparing and staining histological sections containing titanium implants for light microscopy Stain Technol 64 121 127 2480002 1:STN:280:DyaK3c%2FntVWjsw%3D%3D (Pubitemid 20176980)
32. Daugaard H, Elmengaard E, Andreassen T, Bechtold J, Soballe K (2009) Osseointegration of implants inserted pressfit with parathyroid hormone as adjuvant therapy. 10th European Federation of National Associations of Orthopaedics and Traumatology EFORT 2009
33. HJ Gundersen EB Jensen 1987 The efficiency of systematic sampling in stereology and its prediction J Microsc 147 229 263 3430576 1:STN:280: DyaL1c7hvVyltA%3D%3D
34. WJ Dhert CC Verheyen LH Braak JR de Wijn CP Klein K de Groot PM Rozing 1992 A finite element analysis of the push-out test: influence of test conditions J Biomed Mater Res 26 119 130 1577832 10.1002/jbm.820260111 1:STN:280:DyaK383ltVKrsg%3D%3D
35. T Sugiyama LK Saxon G Zaman A Moustafa A Sunters JS Price LE Lanyon 2008 Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice Bone 43 238 248 18539556 10.1016/j.bone.2008.04.012 1:CAS:528:DC%2BD1cXosVOitrc%3D
36. K Soballe 1993 Hydroxyapatite ceramic coating for bone implant fixation. Mechanical and histological studies in dogs Acta Orthop Scand Suppl 255 1 58 8237337 1:STN:280:DyaK2c%2FlsFKlug%3D%3D
37. AH Tashjian BA Chabner 2002 Commentary on clinical safety of recombinant human parathyroid hormone 1-34 in the treatment of osteoporosis in men and postmenopausal women J Bone Miner Res 17 1151 1161 12096828 10.1359/jbmr.2002. 17.7.1151 1:CAS:528:DC%2BD38XlsF2nurg%3D (Pubitemid 34680490)
38. WK Sietsema 1995 Animal models of cortical porosity Bone 17 297S 305S 8579932 1:STN:280:DyaK287hvFajtQ%3D%3D
39. R Brommage CE Hotchkiss CJ Lees MW Stancill JM Hock CP Jerome 1999 Daily treatment with human recombinant parathyroid hormone-(1-34), LY333334, for 1 year increases bone mass in ovariectomized monkeys J Clin Endocrinol Metab 84 3757 3763 10523026 10.1210/jc.84.10.3757 1:CAS:528:DyaK1MXms1Ohurc%3D (Pubitemid 30645237)
40. F Eitel F Klapp W Jacobson L Schweiberer 1981 Bone regeneration in animals and in man. A contribution to understanding the relative value of animal experiments to human pathophysiology Arch Orthop Trauma Surg 99 59 64 7316703 10.1007/BF00400911 1:STN:280:DyaL38%2FptVemsA%3D%3D (Pubitemid 12231752)
41. J Aerssens S Boonen G Lowet J Dequeker 1998 Interspecies differences in bone composition, density, and quality: potential implications for in vivo bone research Endocrinology 139 663 670 9449639 10.1210/en.139.2.663 1:CAS:528:DyaK1cXns12lsA%3D%3D (Pubitemid 28513217)
42. J Reeve 1996 PTH: a future role in the management of osteoporosis? J Bone Miner Res 11 440 445 8992874 10.1002/jbmr.5650110404 1:CAS:528: DyaK28XisF2gsrc%3D
43. H Oxlund C Ejersted TT Andreassen O Torring MH Nilsson 1993 Parathyroid hormone (1-34) and (1-84) stimulate cortical bone formation both from periosteum and endosteum Calcif Tissue Int 53 394 399 8293353 1:CAS:528:DyaK2cXitV2is7k%3D (Pubitemid 23335226)
44. RW Boyce CL Paddock AF Franks ML Jankowsky EF Eriksen 1996 Effects of intermittent hPTH(1-34) alone and in combination with 1, 25(OH)2D3 or risedronate on endosteal bone remodeling in canine cancellous and cortical bone J Bone Miner Res 11 600 613 9157775 10.1002/jbmr.5650110508 1:CAS:528: DyaK28XjtVGksrs%3D (Pubitemid 26123912)
45. YF Ma YY Chen K Ijiri, et al. 1997 PTH in combination with risedronate in aged beagle dogs resulted in bone balance similar to PTH alone Bone 20 99
46. L Zhang HE Takahashi J Inoue T Tanizawa N Endo N Yamamoto M Hori 1997 Effects of intermittent administration of low dose human PTH(1-34) on cancellous and cortical bone of lumbar vertebral bodies in adult beagles Bone 21 501 506 9430239 10.1016/S8756-3282(97)00198-1 1:CAS:528:DyaK1cXktVShtA%3D%3D (Pubitemid 28029692)
47. GJ Pettway JA Meganck AJ Koh ET Keller SA Goldstein LK McCauley 2008 Parathyroid hormone mediates bone growth through the regulation of osteoblast proliferation and differentiation Bone 42 806 818 18234576 10.1016/j.bone.2007. 11.017 1:CAS:528:DC%2BD1cXjs1Whu7s%3D
48. T Nakazawa A Nakajima K Shiomi H Moriya TA Einhorn M Yamazaki 2005 Effects of low-dose, intermittent treatment with recombinant human parathyroid hormone (1-34) on chondrogenesis in a model of experimental fracture healing Bone 37 711 719 16143574 10.1016/j.bone.2005.06.013 1:CAS:528:DC%2BD2MXhtFeiu7bM (Pubitemid 41476394)
49. R Skripitz TT Andreassen P Aspenberg 2000 Parathyroid hormone (1-34) increases the density of rat cancellous bone in a bone chamber. A dose-response study J Bone Joint Surg Br 82 138 141 10697330 10.1302/0301-620X.82B1.9729 1:STN:280:DC%2BD3c7mtVCjsQ%3D%3D (Pubitemid 30060142)
50. RE Jung CH Hammerle V Kokovic FE Weber 2007 Bone regeneration using a synthetic matrix containing a parathyroid hormone peptide combined with a grafting material Int J Oral Maxillofac Implants 22 258 266 17465351
51. TT Andreassen GE Willick P Morley JF Whitfield 2004 Treatment with parathyroid hormone hPTH(1-34), hPTH(1-31), and monocyclic hPTH(1-31) enhances fracture strength and callus amount after withdrawal fracture strength and callus mechanical quality continue to increase Calcif Tissue Int 74 351 356 15255072 10.1007/s00223-003-0093-6 1:CAS:528:DC%2BD2cXjslWrtLk%3D (Pubitemid 38480859)
52. R Dayer I Badoud R Rizzoli P Ammann 2007 Defective implant osseointegration under protein undernutrition: prevention by PTH or pamidronate J Bone Miner Res 22 1526 1533 17563238 10.1359/jbmr.070610 1:CAS:528: DC%2BD2sXhtFyhu7nE (Pubitemid 351229323)