Age-related efficacy of parathyroid hormone on osseointegration in the rat

Clinical Oral Implants Research

Volumn 20, Issue 4, 2009, Pages 400-405

  Mair, Birgit ^b   Tangl, Stefan ^b   Feierfeil, Johannes ^b   Skiba, Daniela ^b   Watzek, Georg ^b   Gruber, Reinhard ^a,b  

^a Vienna Austria Austrian Cluster of Tissue Regeneration ^*  (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Aging; Implants; Osseointegration; PTH; Rat

Indexed keywords

PARATHYROID HORMONE; TITANIUM;

AGING; ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; BONE REGENERATION; COMPARATIVE STUDY; DRUG ADMINISTRATION; FEMALE; JAW; METHODOLOGY; PHYSIOLOGY; RAT; TIBIA; TOOTH IMPLANTATION; WISTAR RAT;

AGING; ALVEOLAR PROCESS; ANALYSIS OF VARIANCE; ANIMALS; BONE REGENERATION; DENTAL IMPLANTATION, ENDOSSEOUS; DENTAL IMPLANTS; DRUG ADMINISTRATION SCHEDULE; FEMALE; OSSEOINTEGRATION; PARATHYROID HORMONE; RATS; RATS, WISTAR; TIBIA; TITANIUM;

EID: 62249210947     PISSN: 09057161     EISSN: 16000501     Source Type: Journal    
DOI: 10.1111/j.1600-0501.2008.01658.x     Document Type: Article

References (32)

1. Akerstrom, G., Hellman, P., Hessman, O., Segersten, U. Westin, G. (2005) Parathyroid glands in calcium regulation and human disease. Annals of the New York Academy of Sciences 1040 : 53 58.
2. Alkhiary, Y.M., Gerstenfeld, L.C., Krall, E., Westmore, M., Sato, M., Mitlak, B.H. Einhorn, T.A. (2005) Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (pth 1-34). The Journal of Bone and Joint Surgery 87 : 731 741.
3. Almeida, M., Han, L., Martin-Millan, M., Plotkin, L.I., Stewart, S.A., Roberson, P.K., Kousteni, S., O'Brien, C.A., Bellido, T., Parfitt, A.M., Weinstein, R.S., Jilka, R.L. Manolagas, S.C. (2007) Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. The Journal of Biological Chemistry 282 : 27285 97.
4. Andreassen, T.T., Ejersted, C. Oxlund, H. (1999) Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures. Journal of Bone and Mineral Research 14 : 960 968.
5. Berglundh, T., Abrahamsson, I., Lang, N.P. Lindhe, J. (2003) De novo alveolar bone formation adjacent to endosseous implants. Clinical Oral Implants Research 14 : 251 262.
6. Carano, R.A. Filvaroff, E.H. (2003) Angiogenesis and bone repair. Drug Discovery Today 8 : 980 989.
7. Diamond, A.G., Gonterman, R.M., Anderson, A.L., Menon, K., Offutt, C.D., Weaver, C.H., Philbrick, W.M. Foley, J. (2006) Parathyroid hormone hormone-related protein and the pth receptor regulate angiogenesis of the skin. The Journal of Investigative Dermatology 126 : 2127 2134.
8. Donahue, H.J., Zhou, Z., Li, Z. McCauley, L.K. (1997) Age-related decreases in stimulatory g protein-coupled adenylate cyclase activity in osteoblastic cells. The American Journal of Physiology 273 : E776 E781.
9. Donath, K. (1988) Die Trenn-Dünnschliff-Technik zur Herstellung histologischer Präparate von nicht schneidbaren Geweben und Materialien. Der Präparator 34 : 197 206.
10. Friedl, G., Turner, R.T., Evans, G.L. Dobnig, H. (2007) Intermittent parathyroid hormone (pth) treatment and age-dependent effects on rat cancellous bone and mineral metabolism. Journal of Orthopaedic Research 25 : 1454 64.
11. Gruber, R., Koch, H., Doll, B.A., Tegtmeier, F., Einhorn, T.A. Hollinger, J.O. (2006) Fracture healing in the elderly patient. Experimental Gerontology 41 : 1080 1093.
12. Hak, D.J., Makino, T., Niikura, T., Hazelwood, S.J., Curtiss, S. Reddi, A.H. (2006) Recombinant human bmp-7 effectively prevents non-union in both young and old rats. Journal of Orthopaedic Research 24 : 11 20.
13. Henriksen, K., Leeming, D.J., Byrjalsen, I., Nielsen, R.H., Sorensen, M.G., Dziegiel, M.H., Martin, T.J., Christiansen, C., Qvist, P. Karsdal, M.A. (2007) Osteoclasts prefer aged bone. Osteoporosis International 18 : 751 759.
14. Hodsman, A.B., Bauer, D.C., Dempster, D.W., Dian, L., Hanley, D.A., Harris, S.T., Kendler, D.L., McClung, M.R., Miller, P.D., Olszynski, W.P., Orwoll, E. Yuen, C.K. (2005) Parathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use. Endocrine Reviews 26 : 688 703.
15. Jung, R.E., Cochran, D.L., Domken, O., Seibl, R., Jones, A.A., Buser, D. Hammerle, C.H. (2007) The effect of matrix bound parathyroid hormone on bone regeneration. Clinical Oral Implants Research 18 : 319 325.
16. Katzburg, S., Lieberherr, M., Ornoy, A., Klein, B.Y., Hendel, D. Somjen, D. (1999) Isolation and hormonal responsiveness of primary cultures of human bone-derived cells: gender and age differences. Bone 25 : 667 673.
17. Knopp, E., Troiano, N., Bouxsein, M., Sun, B.H., Lostritto, K., Gundberg, C., Dziura, J. Insogna, K. (2005) The effect of aging on the skeletal response to intermittent treatment with parathyroid hormone. Endocrinology 146 : 1983 1990.
18. Koh, A.J., Demiralp, B., Neiva, K.G., Hooten, J., Nohutcu, R.M., Shim, H., Datta, N.S., Taichman, R.S. McCauley, L.K. (2005) Cells of the osteoclast lineage as mediators of the anabolic actions of parathyroid hormone in bone. Endocrinology 146 : 4584 4596.
19. Komatsu, D.E., Bosch-Marce, M., Semenza, G.L. Hadjiargyrou, M. (2007) Enhanced bone regeneration associated with decreased apoptosis in mice with partial hif-1alpha deficiency. Journal of Bone and Mineral Research 22 : 366 374.
20. Komatsubara, S., Mori, S., Mashiba, T., Nonaka, K., Seki, A., Akiyama, T., Miyamoto, K., Cao, Y., Manabe, T. Norimatsu, H. (2005) Human parathyroid hormone (1-34) accelerates the fracture healing process of woven to lamellar bone replacement and new cortical shell formation in rat femora. Bone 36 : 678 687.
21. Laczko, J. Levai, G. (1975) A simple differential staining method for semi-thin sections of ossifying cartilage and bone tissues embedded in epoxy resin. Mikroskopie 31 : 1 4.
22. Murray, T.M., Rao, L.G., Divieti, P. Richard Bringhurst, F. (2005) Parathyroid hormone secretion and action: evidence for discrete receptors for the carboxyl-terminal region and related biological actions of carboxyl-terminal ligands. Endocrine Reviews 26 : 78 113.
23. Nakajima, A., Shimoji, N., Shiomi, K., Shimizu, S., Moriya, H., Einhorn, T.A. Yamazaki, M. (2002) Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34). Journal of Bone and Mineral Research 17 : 2038 2047.
24. Neer, R.M., Arnaud, C.D., Zanchetta, J.R., Prince, R., Gaich, G.A., Reginster, J.Y., Hodsman, A.B., Eriksen, E.F., Ish-Shalom, S., Genant, H.K., Wang, O. Mitlak, B.H. (2001) Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. The New England Journal of Medicine 344 : 1434 1441.
25. Riggs, B.L. Melton, L.J. 3rd. (1995) The worldwide problem of osteoporosis: insights afforded by epidemiology. Bone 17 : 505S 511S.
26. Rivard, A., Fabre, J.E., Silver, M., Chen, D., Murohara, T., Kearney, M., Magner, M., Asahara, T. Isner, J.M. (1999) Age-dependent impairment of angiogenesis. Circulation 99 : 111 120.
27. Seebach, C., Skripitz, R., Andreassen, T.T. Aspenberg, P. (2004) Intermittent parathyroid hormone (1-34) enhances mechanical strength and density of new bone after distraction osteogenesis in rats. Journal of Orthopaedic Research 22 : 472 478.
28. Shirota, T., Tashiro, M., Ohno, K. Yamaguchi, A. (2003) Effect of intermittent parathyroid hormone (1-34) treatment on the bone response after placement of titanium implants into the tibia of ovariectomized rats. International Journal of Oral and Maxillofacial Surgery 61 : 471 480.
29. Skripitz, R., Andreassen, T.T. Aspenberg, P. (2000) Strong effect of pth (1-34) on regenerating bone: a time sequence study in rats. Acta Orthopaedica Scandinavica 71 : 619 624.
30. Skripitz, R. Aspenberg, P. (2004) Parathyroid hormone - a drug for orthopedic surgery? Acta Orthopaedica Scandinavica 75 : 654 662.
31. Skripitz, R., Bohling, S., Ruther, W. Aspenberg, P. (2005) Stimulation of implant fixation by parathyroid hormone (1-34) - a histomorphometric comparison of pmma cement and stainless steel. Journal of Orthopaedic Research 23 : 1266 1270.
32. Takeshita, F., Murai, K., Ayukawa, Y. Suetsugu, T. (1997) Effects of aging on titanium implants inserted into the tibiae of female rats using light microscopy, sem, and image processing. Journal of Biomedical Materials Research 34 : 1 8.