Mechanisms controlling lipid accumulation and polyunsaturated fatty acid synthesis in oleaginous fungi

Chemical Papers

Volumn 65, Issue 2, 2011, Pages 97-103

  Laoteng, Kobkul ^a   Čertík, Milan ^b   Cheevadhanark, Supapon ^a  

^a KING MONGKUT'S UNIVERSITY OF TECHNOLOGY THONBURI   (Thailand)

^b SLOVAK UNIVERSITY OF TECHNOLOGY   (Slovakia)

Author keywords

fatty acid desaturation; gene expression; lipid accumulation; oleaginous fungi; polyunsaturated fatty acids

Indexed keywords

EID: 79954425444     PISSN: 03666352     EISSN: 13369075     Source Type: Journal    
DOI: 10.2478/s11696-010-0097-4     Document Type: Review

References (46)

1. A. Beopoulos J. Cescut R. Haddouche J.-L. Uribelarrea C. Molina-Jouve J.-M. Nicaud 2009 Yarrowia lipolytica as a model for bio-oil production Progress in Lipid Research 48 375 387 10.1016/j.plipres.2009.08.005 1:CAS:528: DC%2BD1MXht1WmsrvJ
2. 9- unsaturated fatty acids Journal of Biological Chemistry 235 337 345 1:CAS:528:DyaF3cXmvVyrsg%3D%3D
3. M. Certík L. Baltészová J. Sajbidor 1997 Lipid formation and γ-linolenic acid production by Mucorales fungi grown on sunflower oil Letters in Applied Microbiology 25 101 105 10.1046/j.1472-765X. 1997.00173.x
4. M. Certik J. Megova R. Horenitzky 1999 Effect of nitrogen sources on the activities of lipogenic enzymes in oleaginous fungus Cunninghamella echinulata The Journal of General Applied Microbiology 45 289 293 10.2323/jgam.45.289 1:CAS:528:DC%2BD3cXisVeksbg%3D (Pubitemid 30224101)
5. S. Y. Choi D. D. Y. Ryu J. S. Rhee 1982 Production of microbial lipid: Effects of growth rate and oxygen on lipid synthesis and fatty acid composition of Rhodotorula gracilis Biotechnology and Bioengineering 24 1165 1172 10.1002/bit.260240513 1:CAS:528:DyaL38XktVCls74%3D (Pubitemid 12099499)
6. S. D. Dyal L. Bouzidi S. S. Narine 2005 Maximizing the production of γ-linolenic acid in Mortierella ramanniana var. ramanniana as a function of pH, temperature and carbon source, nitrogen source, metal ions and oil supplementation Food Research International 38 815 829 10.1016/j.foodres.2005. 04.002 1:CAS:528:DC%2BD2MXlsVClsLo%3D (Pubitemid 40831753)
7. S. Fakas M. Galiotou-Panayotou S. Papanikolaou M. Komaitis G. Aggelis 2007 Compositional shifts in lipid fractions during lipid turnover in Cunninghamella echinulata Enzyme and Microbial Technology 40 1321 1327 10.1016/j.enzmictec.2006.10.005 1:CAS:528:DC%2BD2sXisl2ktrw%3D (Pubitemid 46356546)
8. S. Fakas S. Papanikolaou M. Galiotou-Panayotou M. Komaitis G. Aggelis 2006 Lipids of Cunninghamella echinulata with emphasis to γ-linolenic acid distribution among lipid classes Applied Microbiology and Biotechnology 73 676 683 10.1007/s00253-006-0506-3 1:CAS:528:DC%2BD28XhtF2ksLrO (Pubitemid 44748958)
9. L. Hansson M. Dostálek 1988 Effect of culture conditions on mycelial growth and production of γ-linolenic acid by the fungus Mortierella ramanniana Applied Microbiology and Biotechnology 28 240 246 10.1007/BF00250448 1:CAS:528:DyaL1cXktlGjtrs%3D
10. K. Higashiyama K. Murakami H. Tsujimura N. Matsumoto S. Fujikawa 1999 Effect of dissolved oxygen on the morphology of an arachidonic acid production by Mortierella alpina 1S-4 Biotechnology and Bioengineering 63 442 448 10.1002/(SICI)1097-0290(19990520)63:4<442::AID-BIT7>3.0.CO;2-9 1:CAS:528:DyaK1MXit12isbY%3D (Pubitemid 29157047)
11. S. Jeennor K. Laoteng M. Tanticharoen S. Cheevadhanarak 2006 Comparative fatty acid profiling of Mucor rouxii under different stress conditions FEMS Microbiology Letters 259 60 66 10.1111/j.1574-6968.2006.00242.x 1:CAS:528:DC%2BD28Xlt1Cjt74%3D
12. R. P. Jones 1989 Biological principles for the effects of ethanol Enzyme Microbiology and Technology 11 130 153 10.1016/0141-0229(89)90073-2 1:CAS:528:DyaL1MXhsFSqtbg%3D (Pubitemid 19076655)
13. Y. Kamisaka S. Mishra T. Nakahara 1997 Purification and characterization of diacylglycerol acyltransferase from the lipid body fraction of an oleaginous fungus Journal of Biochemistry 121 1107 1114 1:CAS:528:DyaK2sXktlKgtbg%3D (Pubitemid 27290526)
14. Y. Kamisaka T. Yokochi T. Nakahara O. Suzuki 1990 Incorporation of linoleic acid and its conversion to γ-linolenic acid in fungi Lipids 25 54 60 10.1007/BF02562428 1:CAS:528:DyaK3cXhtFGmsLk%3D (Pubitemid 20049255)
15. A. Kendrick C. Ratledge 1996 Cessation of polyunsaturated fatty acid formation in four selected filamentous fungi when grown on plant oils Journal of the American Oil Chemists' Society 73 431 435 10.1007/BF02523914 1:CAS:528:DyaK28XisVersr4%3D (Pubitemid 126547278)
16. S. Khoomrung K. Laoteng S. Jitsue S. Cheevadhanarak 2008 Significance of fatty acid supplementation on profiles of cell growth, fatty acid, and gene expression of three desaturases in Mucor rouxii Applied Microbiology and Biotechnology 80 499 506 10.1007/s00253-008-1569-0 1:CAS:528:DC%2BD1cXhtVSjtLbF
17. Y. Koike H. J. Cai K. Higashiyama S. Fujikawa E. Y. Park 2001 Effect of consumed carbon to nitrogen ratio of mycelial morphology and arachidonic acid production in cultures of Mortierella alpina Journal of Bioscience and Bioengineering 91 382 389 10.1263/jbb.91.382 1:CAS:528:DC%2BD3MXksFGmsrc%3D (Pubitemid 32476316)
18. 9-desaturase gene is transcriptionally regulated during cell growth and by low temperature Molecular Cell Biology Research Communications 1 36 43 10.1006/mcbr.1999.0107 1:CAS:528:DyaK1MXksFelu74%3D (Pubitemid 129532290)
19. Laoteng, K., & Certik, M. (2010). Biotechnological production and application of high-value microbial oils. In J. Krause, & O. Fleischer (Eds.), Industrial fermentation: Food processes, nutrient sources and production strategies (Food Science and Technology (pp. 187-215). Hauppauge, NY, USA: Nova Science Publisher, Inc.
20. K. Laoteng S. Jitsue Y. Dandusitapunth S. Cheevadhanarak 2008 Ethanol-induced changes in expression profiles of cell growth, fatty acid and desaturase genes of Mucor rouxii Fungal Genetics and Biology 45 61 67 10.1016/j.fgb.2007.04.006 1:CAS:528:DC%2BD2sXhtlamu7bM (Pubitemid 350110405)
21. K. Laoteng R. Ruenwai M. Tanticharoen S. Cheevadhanarak 2005 Genetic modification of essential fatty acids biosythesis in Hansenula polymorpha FEMS Microbiology Letters 245 169 178 10.1016/j.femsle.2005.03.006 1:CAS:528:DC%2BD2MXis1Kgtbc%3D (Pubitemid 40410691)
22. K. D. Lardizabal J. T. Mai N. W. Wagner A. Wyrick T. Voelker D. J. Hawkins 2001 DGAT2 is a new diacylglycerol acyltransferase gene family: Purification, cloning, and expression in insect cells of two polypeptides from Mortierella ramanniana with diacylglycerol acyltransferase activity The Journal of Biological Chemistry 276 38862 38869 10.1074/jbc.M106168200 1:CAS:528:DC%2BD3MXnvVenur4%3D
23. T. Lopes da Silva H. M. Pinheiro J. C. Roseiro 2003 Stress-induced morphological and physiological changes in γ-linolenic acid production by Mucor fragilis in batch and continuous cultures Enzyme and Microbial Technology 32 880 888 10.1016/S0141-0229(03)00061-9 1:CAS:528:DC%2BD3sXktFGmu74%3D (Pubitemid 36589031)
24. 6 fatty acid desaturases from Mucor circinelloides Applied Microbiology and Biotechnology 62 362 368 10.1007/s00253-003-1326-3 1:CAS:528:DC%2BD3sXmslCmu7c%3D (Pubitemid 37214918)
25. P. Mishra S. Kaur 1991 Lipids as modulators of ethanol tolerance in yeast Applied Microbiology and Biotechnology 34 697 702 10.1007/BF00169336 1:CAS:528:DyaK3MXitVeiurc%3D
26. S. Mishra S. P. Dwivedi N. Dwivedi A. Kumar A. Rawat Y. Kamisaka 2009 A molecular model for diacylglycerol acyltransferase from Mortierella ramanniana var angulispora. Bioinformation 3 394 398
27. F. Muhid W. N. N. W. Nawi A. J. A. Kader W. M. W. Yusoff A. A. Hamid 2008 Effects of metal ion concentrations on lipid and gamma linolenic acid production by Cunninghamella sp. 2A1 OnLine Journal of Biological Sciences 8 62 67 10.3844/ojbsci.2008.62.67 1:CAS:528:DC%2BD1MXmvVyj
28. 6-desaturase of Mucor rouxii FEBS Letters 579 2744 2748 10.1016/j.febslet.2005.04.010 1:CAS:528:DC%2BD2MXjvVOgs7o%3D (Pubitemid 40615687)
29. 5 fusion proteins The Biochemical Journal 328 717 718 1:CAS:528:DyaK2sXotVGgtbc%3D
30. 12-desaturase gene in Saccharomyces cerevisiae Biochemical and Biophysical Research Communications 263 47 51 10.1006/bbrc.1999.1258 1:CAS:528:DyaK1MXlvVWqtLk%3D (Pubitemid 29443637)
31. M. G. Pillai M. Certik T. Nakahara Y. Kamisaka 1998 Characterization of triacylglycerol biosynthesis in subcellular fractions of an oleaginous fungus, Mortierella ramanniana var angulispora. Biochimica et Biophysica Acta 1393 128 136 1:CAS:528:DyaK1cXkvFOntbo%3D (Pubitemid 28495597)
32. C. Ratledge 2004 Fatty acid biosynthesis in microorganisms being used for single cell oil production Biochimie 86 807 815 10.1016/j.biochi.2004.09.017 1:CAS:528:DC%2BD2cXhtVKksLbK (Pubitemid 39602760)
33. C. Ratledge 2002 Regulation of lipid accumulation in oleaginous micro-organisms Biochemical Society Transactions 30 1047 1050 10.1042/BST0301047 1:CAS:528:DC%2BD38XovF2isbo%3D (Pubitemid 36002403)
34. R. Ruenwai S. Cheevadhanarak K. Laoteng 2009 Overexpression of acetyl-CoA carboxylase gene of Mucor rouxii enhanced fatty acid content in Hansenula polymorpha Molecular Biotechnology 42 327 332 10.1007/s12033-009-9155-y 1:CAS:528:DC%2BD1MXns1Cnsbc%3D
35. 12-desaturase genes modulates fatty acid composition in Mucor rouxii Applied Microbiology and Biotechnology 86 327 334 10.1007/s00253-009- 2338-4 1:CAS:528:DC%2BC3cXhvFKnsLw%3D
36. J. Sajbidor M. Koželouhov Certík 1992 Influence of some metal ions on the lipid content and arachidonic acid production by Mortierella sp Folia Microbiologica 37 404 406 10.1007/BF02899897
37. I. Serrano T. Lopes da Silva J. C. Roseiro 2001 Ethanolinduced dimorphism and lipid composition changes in Mucor fragilis CCMI 142 Letters in Applied Microbiology 33 89 93 10.1046/j.1472-765X.2001.00958.x 1:CAS:528: DC%2BD3MXlslWnurs%3D (Pubitemid 32625740)
38. D. M. Sokolov A. A. Sharyshev T. V. Finogenova 1995 Subcellular location of enzymes mediating glucose metabolism in various groups of yeasts Biochemistry (Moscow) 60 1325 1331
39. Y. Song J. P. Wynn Y. Li D. Grantham C. Ratledge 2001 A pre-genetic study of the isoforms of malic enzyme associated with lipid accumulation in Mucor circinelloides Microbiology 147 1507 1515 1:CAS:528:DC%2BD3MXkslSqsbw%3D (Pubitemid 32544815)
40. X. Wan Y. Zhang P. Wang F. Huang H. Chen M. Jiang 2009 Production of gamma-linolenic acid in Pichia pastoris by expression of a delta-6 desaturase gene from Cunninghamella echinulata Journal of Microbiology and Biotechnology 19 1098 1102 10.4014/jmb.0902.071 1:CAS:528:DC%2BD1MXhsVyhsb3P
41. D. Wang M. Li D. Wei Y. Cai Y. Zhang L. Xing 2007 Identification and functional characterization of the delta 6-fatty acid desaturase gene from Thamnidium elegans The Journal of Eukaryotic Microbiology 54 110 117 10.1111/j.1550-7408.2006.00136.x 1:CAS:528:DC%2BD2sXis1Sls70%3D (Pubitemid 46184550)
42. O. P. Ward A. Singh 2005 Omega-3/6 fatty acids: Alternative sources of production Process Biochemistry 40 3627 3652 10.1016/j.procbio.2005.02.020 1:CAS:528:DC%2BD2MXhtFWnt7%2FI (Pubitemid 41446464)
43. J. P. Wynn A. A. Hamid Y. Li C. Ratledge 2001 Biochemical events leading to the diversion of carbon into storage lipids in the oleaginous fungi Mucor circinelloides and Mortierella alpina Microbiology 147 2857 2864 1:CAS:528:DC%2BD3MXnslGltr8%3D (Pubitemid 32976326)
44. J. P. Wynn C. Ratledge 2000 Evidence that the ratelimiting step for the biosynthesis of arachidonic acid in Mortierella alpina is at the level of the 18:3 to 20:3 elongase Microbiology 146 2325 2331 1:CAS:528:DC%2BD3cXmslGkt7c%3D
45. J. P. Wynn C. Ratledge 1997 Malic enzyme is a major source of NADPH for lipid accumulation by Aspergillus nidulans Microbiology 143 253 257 10.1099/00221287-143-1-253 1:CAS:528:DyaK2sXptFygtQ%3D%3D (Pubitemid 27072980)
46. Y. Zhang I. P. Adams C. Ratledge 2007 Malic enzyme: the controlling activity for lipid production? Overexpression of malic enzyme in Mucor circienelloides leads to a 2.5-fold increase in lipid accumulation Microbiology 153 2013 2025 10.1099/mic.0.2006/002683-0 1:CAS:528:DC%2BD2sXot1Wlt7g%3D (Pubitemid 47074057)