2-methoxyestradiol, an endogenous estrogen metabolite, sensitizes radioresistant MCF-7/FIR breast cancer cells through multiple mechanisms

International Journal of Radiation Oncology Biology Physics

Volumn 80, Issue 1, 2011, Pages 231-239

  Salama, Salama ^a,b   Diaz Arrastia, Concepcion ^a,b   Patel, Deepa ^a,b   Botting, Shaleen ^a,b   Hatch, Sandra ^b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

radiation; 2 Methoxyestradiol; Breast cancer; Radiosensitizer

Indexed keywords

2-METHOXYESTRADIOL; APOPTOSIS; BREAST CANCER; BREAST CANCER CELLS; CELL CYCLE; CELL LINES; CELL-CYCLE PROGRESSION; CLINICAL STUDY; CLONOGENIC SURVIVAL; DNA DAMAGES; DOWNSTREAM TARGET; IMMUNOBLOTTING; MCF-7 CELLS; MINIMAL EFFECTS; MULTIPLE LEVELS; RADIATION-INDUCED; RADIORESISTANCE; RADIOSENSITIZERS; REACTIVE OXYGEN SPECIES; SIGNALING PATHWAYS; SURVIVING FRACTIONS; TUMOR CELLS; UNDERLYING MECHANISM;

CELL CULTURE; CELL DEATH; CELL PROLIFERATION; DISEASES; FLOW CYTOMETRY; OXYGEN; PHOSPHORYLATION; RADIATION EFFECTS; RATING; SIGNALING; TRANSCRIPTION FACTORS;

RADIOTHERAPY;

2 METHOXYESTRADIOL; ESTROGEN DERIVATIVE; HISTONE H2AX; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL DEATH; CELL PROLIFERATION; CELL STRAIN FIR; CELL STRAIN MCF 7; CELL SURVIVAL; CLONOGENESIS; DNA DAMAGE; FLOW CYTOMETRY; GAMMA RADIATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; METABOLITE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIOSENSITIVITY; SENSITIZATION;

APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA DAMAGE; ESTRADIOL; FEMALE; GAMMA RAYS; HISTONES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NEOPLASM PROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR STEM CELL ASSAY;

EID: 79954421458     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.10.080     Document Type: Article

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