Synthesis and characterization of a cell-permeable bimodal contrast agent targeting β-galactosidase

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 8, 2011, Pages 2529-2540

  Keliris, Aneta ^a   Ziegler, Thomas ^b   Mishra, Ritu ^a   Pohmann, Rolf ^a   Sauer, Martin G ^c   Ugurbil, Kamil ^a   Engelmann, Jörn ^a  

^a MAX PLANCK INSTITUTE FOR BIOLOGICAL CYBERNETICS   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

d Galactopyranose; Cellular imaging; Gadolinium complex; Intracellular MRI contrast agent; Solid phase synthesis

Indexed keywords

2,3,4 TRI O ACETYL 6 O (3 BENZYLOXYCARBONYLAMIDOPROPYL) 1 THIO BETA DEXTRO GALACTOPYRANOSIDE; BETA GALACTOSIDASE; CONTRAST MEDIUM; FLUORESCEIN; GADOTERIC ACID; GALACTOSE; PEPTIDE; PHENYL 1 THIO BETA DEXTRO GALACTOPYRANOSIDE; PHENYL 2,3,4 TRI O (4 METHOXYBENZYL) 6 HYDROXY 1 THIO BETA DEXTRO GALACTOPYRANOSIDE; PHENYL 2,3,4 TRI O (4 METHOXYBENZYL) 6 O (3 BENZYLOXYCARBONYLAMINOPROPYL) 1 THIO BETA DEXTRO GALACTOPYRANOSIDE; PHENYL 2,3,4 TRI O (4 METHOXYBENZYL) 6 O (TERT BUTYLDIMETHYLSILOXYPROPYL) 1 THIO BETA DEXTRO GALACTOPYRANOSIDE; PHENYL 6 (O TERT BUTYLDIMETHYLSILYL) 1 THIO BETA DEXTRO GALACTOPYRANOSIDE; PHENYL 6 O (3 BENZYLOXYCARBONYLAMIDOPROPYL) 1 THIO BETA DEXTRO GALACTOPYRANOSIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; DRUG UPTAKE; ENZYME DEFICIENCY; GLIOMA CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL CHEMISTRY; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT;

ANIMALS; BETA-GALACTOSIDASE; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; CONTRAST MEDIA; FLUORESCEIN; GALACTOSE; GLIOMA; HETEROCYCLIC COMPOUNDS; MAGNETIC RESONANCE IMAGING; MICROSCOPY, FLUORESCENCE; ORGANOMETALLIC COMPOUNDS; PEPTIDE FRAGMENTS; RATS; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

RATTUS;

EID: 79954419552     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.03.023     Document Type: Article

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