Rational design, synthesis, and characterization of novel inhibitors for human β1,4-galactosyltransferase

Journal of Medicinal Chemistry

Volumn 48, Issue 19, 2005, Pages 6054-6065

  Takaya, Kenji ^a   Nagahori, Noriko ^a   Kurogochi, Masaki ^a   Furuike, Tetsuya ^a   Miura, Nobuaki ^a   Monde, Kenji ^a   Lee, Yuan Chuan ^b   Nishimura, Shin Ichiro ^a,c  

^a HOKKAIDO UNIVERSITY   (Japan)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 1,4 GALACTOSYLTRANSFERASE; ENZYME INHIBITOR; GALACTOSYLTRANSFERASE; INDOLE DERIVATIVE; MANGANESE; TRYPTOPHAN; UNCLASSIFIED DRUG; URIDINE 5' [6 AMINO [2 [(7 BROMOMETHYL 2 NAPHTHYL)METHOXYCARBONYLMETHOXY]ETHOXY]ACETYL 6 DEOXY ALPHA DEXTRO GALACTOPYRANOSYL]DIPHOSPHATE; URIDINE 5' [6 O [10 (2 NAPHTHYL) 3,6,9 TRIOXADECANYL] ALPHA DEXTRO GALACTOPYRANOSYL]DIPHOSPHATE; URIDINE DIPHOSPHATE GALACTOSE;

AFFINITY LABELING; CARBON NUCLEAR MAGNETIC RESONANCE; COMPUTER SIMULATION; CONFERENCE PAPER; DRUG CONFORMATION; DRUG DESIGN; DRUG MECHANISM; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVE SITE; GLYCOSYLATION; MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; PROTON NUCLEAR MAGNETIC RESONANCE; TIME OF FLIGHT MASS SPECTROMETRY; X RAY CRYSTALLOGRAPHY;

AFFINITY LABELS; BINDING SITES; DRUG DESIGN; GALACTOSYLTRANSFERASES; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRYPTOPHAN; URIDINE DIPHOSPHATE SUGARS;

EID: 24944524827     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0504297     Document Type: Conference Paper

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