Effects of alfacalcidol on mechanical properties and collagen cross-links of the femoral diaphysis in glucocorticoid-treated rats

Calcified Tissue International

Volumn 88, Issue 4, 2011, Pages 314-324

  Saito, Mitsuru ^a   Marumo, Keishi ^a   Ushiku, Chikara ^a   Kato, Soki ^a   Sakai, Sadaoki ^b   Hayakawa, Naohiko ^b   Mihara, Masahiko ^b   Shiraishi, Ayako ^b  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Alfacalcidol; Bone quality; Bone strength; Collagen cross links; Glucocorticoid; Osteoporosis

Indexed keywords

ALFACALCIDOL; CALCIUM; COLLAGEN; PREDNISOLONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE DENSITY; BONE LEVEL; BONE METABOLISM; BONE STRENGTH; CALCIUM BLOOD LEVEL; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CORTICAL BONE; CORTICOSTEROID THERAPY; DIAPHYSIS; DOSE RESPONSE; DRUG ANTAGONISM; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; FEMUR; MALE; NONHUMAN; PREVENTIVE MEDICINE; PRIORITY JOURNAL; PROTEIN CROSS LINKING; RAT; TREATMENT DURATION;

ANIMALS; BODY WEIGHT; BONE AND BONES; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; COLLAGEN; CROSS-LINKING REAGENTS; DIAPHYSES; FEMUR; GLUCOCORTICOIDS; HYDROXYCHOLECALCIFEROLS; MALE; OSTEOPOROSIS; PREDNISOLONE; RATS; RATS, WISTAR; STRESS, MECHANICAL;

EID: 79954419460     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-011-9472-6     Document Type: Article

References (50)

1. TP van Staa HG Leufkens C Cooper 2002 The epidemiology of corticosteroid-induced osteoporosis:a meta-analysis Osteoporos Int 13 777 787 12378366 10.1007/s001980200108 (Pubitemid 36336722)
2. FN Ton SC Gunawardene H Lee RM Neer 2005 Effects of low-dose prednisone on bone metabolism J Bone Miner Res 20 464 470 15746991 10.1359/JBMR.041125 1:CAS:528:DC%2BD2MXis1Knu7o%3D (Pubitemid 40293495)
3. D Patschan K Loddenkemper F Buttgereit 2001 Molecular mechanisms of glucocorticoid-induced osteoporosis Bone 29 498 505 11728918 10.1016/S8756-3282(01)00610-X 1:CAS:528:DC%2BD3MXos1KnsbY%3D (Pubitemid 33124290)
4. E Canalis 2005 Mechanisms of glucocorticoid action in bone Curr Osteoporos Rep 3 98 102 16131429 10.1007/s11914-005-0017-7
5. E Canalis AM Delany 2002 Mechanisms of glucocorticoid action in bone Ann N Y Acad Sci 966 73 81 12114261 10.1111/j.1749-6632.2002.tb04204.x 1:CAS:528:DC%2BD38XlvVWmsbk%3D (Pubitemid 34729163)
6. RN de Nijs JW Jacobs WF Lems RF Laan A Algra AM Huisman E Buskens CE de Laet AC Oostveen PP Geusens GA Bruyn BA Dijkmans JW Bijlsma STOP Investigators 2006 Alendornate or alfacacidol in glucocorticoid-induced osteoporosis N Engl J Med 355 675 684 16914703 10.1056/NEJMoa053569
7. 3 analoges: a review with meta-analysis of randomized controlled trials including organ transplantation studies Osteoporos Int 15 589 602 15138667 10.1007/s00198-004-1614-5 (Pubitemid 39121106)
8. JA Clowes N Peel R Eastell 2001 Glucocorticoid-induced osteoporosis Curr Osteoporos Rep 13 326 332 1:CAS:528:DC%2BD3MXnt1Slt78%3D (Pubitemid 32831827)
9. NIH Consensus Development Panel 2001 Osteoporosis prevention, diagnosis, and therapy JAMA 285 785 795 10.1001/jama.285.6.785
10. EP Paschalis E Shane G Lyritis G Skarantavos R Mendelsohn AL Boskey 2004 Bone fragility and collagen cross-links J Bone Miner Res 19 2000 2004 15537443 10.1359/jbmr.040820 (Pubitemid 41109925)
11. S Viguet-Carrin P Garnero PD Delmas 2006 The role of collagen in bone strength Osteoporos Int 17 319 336 16341622 10.1007/s00198-005-2035-9 1:CAS:528:DC%2BD28XislCrtro%3D
12. L Knott AJ Bailey 1998 Collagen cross-links in mineralizing tissues: a review of their chemistry, function, and clinical relevance Bone 22 181 287 9514209 10.1016/S8756-3282(97)00279-2 1:CAS:528:DyaK1cXitVGktrw%3D (Pubitemid 28127472)
13. M Saito K Marumo 2010 Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus Osteoporos Int 21 195 214 19760059 10.1007/s00198-009-1066-z 1:CAS:528:DC%2BC3cXjtl2ntg%3D%3D
14. M Saito K Fujii Y Mori K Marumo 2006 Role of collagen enzymatic and glycation induced cross-links as a determinant of bone quality in spontaneously diabetic WBN/Kob rats Osteoporos Int 17 1514 1523 16770520 10.1007/s00198-006- 0155-5 1:CAS:528:DC%2BD28XpsFWls78%3D (Pubitemid 44387486)
15. M Saito K Marumo S Soshi Y Kida C Ushiku A Shinohara 2010 Raloxifene ameliorates detrimental enzymatic and non-enzymatic collagen cross-links and bone strength in rabbits with hyperhomocysteinemia Osteoporos Int 21 655 666 19484165 10.1007/s00198-009-0980-4 1:CAS:528:DC%2BC3cXivVGqtbw%3D
16. M Saito K Fujii S Soshi T Tanaka 2006 Reductions in degree of mineralization and enzymatic collagen cross-links and increases in glycation induced pentosidine in the femoral neck cortex in cases of femoral neck fracture Osteoporos Int 17 986 995 16552468 10.1007/s00198-006-0087-0 1:CAS:528:DC%2BD28XltlOju74%3D (Pubitemid 43864852)
17. M Saito K Fujii K Marumo 2006 Degree of mineralization-related collagen crosslinking in the femoral neck cancellous bone in cases of hip fracture and controls Calcif Tissue Int 79 160 168 16969591 10.1007/s00223-006-0035-1 1:CAS:528:DC%2BD28XpvFalsLs%3D (Pubitemid 44440444)
18. Y Kuboki A Kudo M Mizuno M Kawamura 1992 Time-dependent changes of collagen cross-links and their precursors in the culture of osteogenic cells Calcif Tissue Int 50 473 480 1596783 10.1007/BF00296780 1:STN:280: DyaK383ot1Cluw%3D%3D
19. K Uzawa WJ Grzesik T Nishiura SA Kuznetsov PG Robey DA Brenner M Yamauchi 1999 Differential expression of human lysyl hydroxylase genes, lysyl hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro J Bone Miner Res 14 1272 1280 10457259 10.1359/jbmr.1999.14.8.1272 1:CAS:528:DyaK1MXltlylsbo%3D (Pubitemid 29368289)
20. M Yamauchi EP Katz 1993 The post-translational chemistry and molecular packing of mineralizing tendon collagens Connect Tissue Res 29 81 98 8403898 10.3109/03008209309014236 1:STN:280:DyaK2c%2FgslyjtQ%3D%3D
21. M Saito S Soshi K Fujii 2003 Effect of hyper- and microgravity on collagen post-translational controls of MC3T3-E1 osteoblasts J Bone Miner Res 18 1695 1705 12968680 10.1359/jbmr.2003.18.9.1695 1:CAS:528:DC%2BD3sXnsVymu7g%3D (Pubitemid 37022929)
22. M Saito S Sohsi T Tanaka K Fujii 2004 Intensity-related differences in collagen post-translational modification in MC3T3-E1 osteoblasts after exposure to low and high intensity pulsed ultrasound Bone 35 644 655 15336600 10.1016/j.bone.2004.04.024 1:CAS:528:DC%2BD2cXntFChurk%3D (Pubitemid 39141865)
23. H Oxlund M Barckman G Ortoft TT Andreassen 1995 Reduced concentrations of collagen cross-links are associated with reduced strength of bone Bone 17 4 Suppl 365S 371S 8579939 1:CAS:528:DyaK2MXptlKjtrY%3D
24. H Oxlund L Mosekilde G Ortoft 1996 Reduced concentration of collagen reducible crosslinks in human trabecular bone with respect to age and osteoporosis Bone 19 448 479
25. X Banse TJ Sims AJ Bailey 2002 Mechanical properties of adult vertebral cancellous bone: correlation with collagen intermolecular cross-links J Bone Miner Res 17 1621 1628 12211432 10.1359/jbmr.2002.17.9.1621 1:CAS:528: DC%2BD38XntlSrsL8%3D
26. 3 in the physiologically active metabolite of vitamin D3 Endocr Rev 6 491 511 3000754 10.1210/edrv-6-4-491 1:CAS:528:DyaL28XltVWmtg%3D%3D
27. K Hara Y Akiyama I Ohkawa T Tajima 1993 Effects of menatetrenone on prednisolone-induced bone loss in rats Bone 14 813 818 8155403 10.1016/8756-3282(93)90309-X 1:CAS:528:DyaK2cXivV2rsbs%3D (Pubitemid 24012689)
28. Y Tanaka T Nakamura S Nishida K Suzuki K Sato S Takeda Y Nishii 1996 Effects of synthetic vitamin D analog, ED-71, on bone dynamics and strength in cancellous and cortical bone in prednisolone-treated rats J Bone Miner Res 11 325 336 8852943 10.1002/jbmr.5650110306 1:CAS:528:DyaK28Xit1Cgurc%3D (Pubitemid 26076382)
29. A Shiraishi S Takeda T Masaki Y Higuchi Y Uchiyama N Kubodera K Sato K Ikeda T Nakamura T Matsumoto E Ogata 2000 Alfacalcidol inhibits bone resorption and stimulates formation in an ovariectomized rat model of osteoporosis: distinct actions from estrogen J Bone Miner Res 15 770 779 10780869 10.1359/jbmr.2000.15.4.770 1:CAS:528:DC%2BD3cXisFWmt7w%3D (Pubitemid 30174031)
30. A Shiraishi M Ito N Hayakawa N Kubota N Kubodera E Ogata 2006 Calcium supplementation does not reproduce the pharmacological efficacy of alfacalcidol for the treatment of osteoporosis in rats Calcif Tissue Int 78 152 161 16525749 10.1007/s00223-005-0014-y 1:CAS:528:DC%2BD28XislCqt7g%3D
31. T Katsumata T Nakamura H Ohnishi T Sakurawa 1995 Intermittent cyclical etidronate treatment maintains the mass, structure and the mechanical property of bone in ovariectomized rats J Bone Miner Res 10 921 931 7572316 10.1002/jbmr.5650100613 1:CAS:528:DyaK2MXms1Srtrk%3D
32. M Saito K Marumo K Fujii N Ishioka 1997 Single column high-performance liquid chromatographic-fluorescence detection of immature, mature and senescent cross-links of collagen Anal Biochem 253 26 32 9356137 10.1006/abio.1997.2350 1:CAS:528:DyaK2sXnsVegsbk%3D (Pubitemid 27490600)
33. TP van Staa RF Laan IP Barton S Cohen DM Reid C Cooper 2003 Bone density threshold and other predictors of vertebral fracture in patients receiving oral glucocorticoid therapy Arthritis Rheum 48 3224 3229 14613287 10.1002/art.11283 (Pubitemid 37409336)
34. K Hayashi M Yamamoto Y Murakawa M Yamauchi H Kaji T Yamaguchi T Sugimoto 2009 Bone fragility in male glucocorticoid-induced osteoporosis is not defined by bone mineral density Osteoporos Int 20 1889 1894 19387764 10.1007/s00198-009-0901-6 1:STN:280:DC%2BD1MjgsFymsw%3D%3D
35. NE Lane W Yao M Balooch RK Nalla G Balooch S Habelitz JH Kinney LF Bonewald 2006 Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebo-treated or estrogen-deficient mice J Bone Miner Res 21 466 476 16491295 10.1359/JBMR.051103 1:CAS:528:DC%2BD28XisFGqurY%3D
36. H Oxlund L Mosekilde G Ortoft 1996 Reduced concentration of collagen reducible crosslinks in human trabecular bone with respect to age and osteoporosis Bone 19 479 484 8922646 10.1016/S8756-3282(96)00283-9 1:CAS:528:DyaK28XnsVakt7k%3D (Pubitemid 26396151)
37. P Atsawasuwan Y Mochida D Parisuthiman D Parisuthiman M Yamauchi 2005 Expression of lysyl oxidase isoforms in MC3T3-E1 osteoblastic cells Biochem Biophys Res Commun 327 1042 1046 15652501 10.1016/j.bbrc.2004.12.119 1:CAS:528:DC%2BD2MXksFGnsQ%3D%3D (Pubitemid 40137973)
38. SC Benson PA LuValle 1998 Inhibition of lysyl oxidase and prolyl hydroxylase activity in glucocorticoid treated rats Biochem Biophys Res Commun 99 557 562 10.1016/0006-291X(81)91781-2
39. EJ Feres-Filho YJ Choi X Han TE Takala PC Trackman 1995 Pre- and post-translational regulation of lysyl oxidase by transforming growth factor-beta 1 in osteoblastic MC3T3-E1 cells J Biol Chem 270 30797 30803 8530522 10.1074/jbc.270.51.30797 1:CAS:528:DyaK28XhtFKrtg%3D%3D (Pubitemid 26005149)
40. M Centrella TL McCarthy E Canalis 1991 Glucocorticoid regulation of transforming growth factor beta 1 activity and binding in osteoblast-enriched cultures from fetal rat bone Mol Cell Biol 11 4490 4496 1875934 1:CAS:528:DyaK3MXlsFSqt7g%3D (Pubitemid 21895845)
41. AM Delany D Durant E Canalis 2001 Glucocorticoid suppression of IGF I transcription in osteoblasts Mol Endocrinol 15 1781 1789 11579210 10.1210/me.15.10.1781 1:CAS:528:DC%2BD3MXnt12isbY%3D (Pubitemid 32939308)
42. K Reiser P Summers JF Medrano R Rucker J Last R McDonald 1996 Effects of elevated circulating IGF-1 on the extracellular matrix in high-growth C57BL/6 J mice Am J Physiol Regul Integr Comp Physiol 271 R696 R703 1:CAS:528: DyaK28XmtFaqu7c%3D
43. J Iwamoto A Seki T Takeda Y Sato H Yamada CL Shen JK Yeh 2006 Comparative effects of risedronate and calcitriol on cancellous bone in rats with glucocorticoid-induced osteopenia J Nutr Sci Vitaminol 52 21 27 16637226 10.3177/jnsv.52.21 1:CAS:528:DC%2BD28XisFKqsLk%3D
44. 3 regulates collagen quality in an osteoblastic cell culture system Biochem Biophys Res Commun 377 674 678 18930711 10.1016/j.bbrc.2008.10.036 1:CAS:528:DC%2BD1cXhtlykt7bL
45. S Pornprasertsuk R Wagner WR Duarte Y Mochida M Yamauchi 2005 Overexpression of lysyl hydroxylase-2b leads to defective collagen fibrillogenesis and matrix mineralization J Bone Miner Res 20 81 87 15619673 10.1359/JBMR.041026 1:CAS:528:DC%2BD2MXptValsA%3D%3D (Pubitemid 41716222)
46. 3 modulates glucocorticoid-induced alteration in serum bone Gla protein and bone histomorphometry Endocrinology 120 531 536 3492365 10.1210/endo-120-2-531 1:CAS:528:DyaL2sXps12ntg%3D%3D (Pubitemid 17020404)
47. IR Reid JM Katz HK Ibbertson DH Gray 1986 The effects of hydrocortisone, parathyroid hormone and the bisphosphonate, APD, on bone resorption in neonatal mouse calvaria Calcif Tissue Int 38 38 43 3079651 10.1007/BF02556593 1:CAS:528:DyaL28XhvVSgsLY%3D (Pubitemid 16187012)
48. SF Hodgson 1990 Corticosteroid-induced osteoporosis Endocrinol Metab Clin North Am 19 95 111 2192870 1:CAS:528:DyaK3MXnsFantg%3D%3D (Pubitemid 20142109)
49. 3 on osteopenia induced by prednisolone in adult rats Calcif Tissue Int 34 253 257 6809286 10.1007/BF02411246 1:CAS:528:DyaL38XksFCnsLs%3D (Pubitemid 12060436)
50. A Shiraishi S Higashi H Ohkawa N Kubodera T Hirasawa I Ezawa K Ikeda E Ogata 2006 The advantage of alfacalcidol over vitamin D in the treatment of osteoporosis Calcif Tissue Int 65 311 316 10.1007/s002239900704