Effect of different buffers on kinetic properties of human acetylcholinesterase and the interaction with organophosphates and oximes

Archives of Toxicology

Volumn 85, Issue 3, 2011, Pages 193-198

  Wille, T ^a   Thiermann, H ^a   Worek, F ^a  

^a BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

Author keywords

Acetylcholinesterase; Buffer; Inhibition; Kinetics; Organophosphorus compound; Reactivation

Indexed keywords

3 (N MORPHOLINO)PROPANE SULFONIC ACID; ACETYLCHOLINESTERASE; BUFFER; OBIDOXIME; ORGANOPHOSPHATE; OXIME DERIVATIVE; PARAOXONETHYL; PHOSPHATE; SARIN; SOMAN; TROMETAMOL; TYRODE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL INTERACTION; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME REACTIVATION; ERYTHROCYTE; HUMAN; HUMAN CELL; MICHAELIS MENTEN KINETICS; PRIORITY JOURNAL; PROTEIN INTERACTION;

ACETYLCHOLINESTERASE; BUFFERS; CHOLINESTERASE INHIBITORS; DRUG INTERACTIONS; ERYTHROCYTES; HUMANS; KINETICS; OXIMES; PARAOXON; PHOSPHORIC ACID ESTERS; SARIN; SOMAN;

EID: 79954415346     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-010-0578-9     Document Type: Article

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