Extended side chain analogues of 8-aminoquinolines: Synthesis and evaluation of antiprotozoal, antimicrobial, β-hematin inhibition, and cytotoxic activities

MedChemComm

Volumn 2, Issue 4, 2011, Pages 300-307

  Kaur, Kirandeep ^a   Jain, Meenakshi ^a   Khan, Shabana I ^b,c   Jacob, Melissa R ^b   Tekwani, Babu L ^b,c   Singh, Savita ^a   Singh, Prati Pal ^a   Jain, Rahul ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 AMINOQUINOLINE DERIVATIVE; BETA HEMATIN; HEMATIN; N (5 AMINOPENTAN 2 YL) N' [4 [(2 TERT BUTYL 6 METHOXYQUINOLIN 8 YL)AMINO]PENTYL]PENTANE 1,4 DIAMINE; N (5 AMINOPENTAN 2 YL) N' [4 [(5 BUTOXY 4 ETHYL 6 METHOXYQUINOLIN 8 YL)AMINO]PENTYL]PENTANE 1,4 DIAMINE; N (5 AMINOPENTAN 2 YL) N' [4 [(6 METHOXYQUINOLIN 8 YL)AMINO]PENTYL]PENTANE 1,4 DIAMINE; N (5 AMINOPENTAN 2 YL) N' [4 [[4 [(2 TERT BUTYL 6 METHOXYQUINOLIN 8 YL)AMINO]PENTYL]AMINO]PENTYL]PENTANE 1,4 DIAMINE; N (5 AMINOPENTAN 2 YL) N' [4 [[4 [(5 BUTOXY 4 ETHYL 6 METHOXYQUINOLIN 8 YL)AMINO]PENTYL]AMINO]PENTYL]PENTANE 1,4 DIAMINE; N (5 AMINOPENTAN 2 YL) N' [4 [[4 [(6 METHOXYQUINOLIN 8 YL) AMINO]PENTYL]AMINO]PENTYL]PENTANE 1,4 DIAMINE; N (5 AMINOPENTAN 2 YL) N' [4 [[4 [[4 ETHYL 6 METHOXY 5 (PENTYLOXY)QUINOLIN 8 YL]AMINO]PENTYL]AMINO]PENTYL]PENTANE 1,4 DIAMINE; N (5 AMINOPENTAN 2 YL) N' [4 [[4 ETHYL 6 METHOXY 5 (PENTYLOXY)QUINOLIN 8 YL]AMINO]PENTYL]PENTANE 1,4 DIAMINE; N1 (5 AMINOPENTAN 2 YL) N4 (2 TERT BUTYL 6 METHOXYQUINOLIN 8 YL)PENTANE 1,4 DIAMINE; N1 (5 AMINOPENTAN 2 YL) N4 (5 BUTOXY 4 ETHYL 6 METHOXYQUINOLIN 8 YL)PENTANE 1,4 DIAMINE; N1 (5 AMINOPENTAN 2 YL) N4 (6 METHOXYQUINOLIN 8 YL)PENTANE 1,4 DIAMINE; N1 (5 AMINOPENTAN 2 YL) N4 [4 ETHYL 6 METHOXY 5 (OCTYLOXY)QUINOLIN 8 YL]PENTANE 1,4 DIAMINE; N1 (5 AMINOPENTAN 2 YL) N4 [4 ETHYL 6 METHOXY 5 (PENTYLOXY)QUINOLIN 8 YL]PENTANE 1,4 DIAMINE; PRIMAQUINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ANTIMICROBIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA KRUSEI; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; HEME SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LEISHMANIA DONOVANI; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM INTRACELLULARE; NONHUMAN; PLASMODIUM BERGHEI INFECTION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROMASTIGOTE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

FUNGI; MUS; PLASMODIUM FALCIPARUM;

EID: 79953906869     PISSN: 20402503     EISSN: 20402511     Source Type: Journal    
DOI: 10.1039/c0md00267d     Document Type: Article

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