메뉴 건너뛰기




Volumn 6, Issue 2, 2011, Pages 147-157

Is there evidence to support the use of direct Factor Xa inhibitors in coronary artery disease?

Author keywords

Apixaban; Clinical pharmacology; Clinical trials; Coronary artery disease; DX 9065a; Otamixaban; Preclinical pharmacology; Rivaroxaban; ZK 807834

Indexed keywords

2 [4 [(1 ACETIMIDOYL 3 PYRROLIDINYL)OXY]PHENYL] 3 (7 AMIDINO 2 NAPHTHYL)PROPIONIC ACID; ACETYLSALICYLIC ACID; ALTEPLASE; ANTIVITAMIN K; APIXABAN; ARGATROBAN; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A INHIBITOR; CLOPIDOGREL; DANAPAROID; EDOXABAN; ENOXAPARIN; EPTIFIBATIDE; FIBRINOGEN RECEPTOR ANTAGONIST; FIDEXABAN; FONDAPARINUX; FXV 673; HEPARIN; HIRULOG; LOW MOLECULAR WEIGHT HEPARIN; N ETHYL N [4 (4 PIPERIDINYL)BUTYRYL]GLYCYLASPARTYL 3 CYCLOHEXYLALANINAMIDE; OTAMIXABAN; PLACEBO; PRASUGREL; RAZAXABAN; RIVAROXABAN; RPR 130673; TIROFIBAN; UNCLASSIFIED DRUG; WARFARIN;

EID: 79953838461     PISSN: 15748871     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488711795177921     Document Type: Article
Times cited : (4)

References (65)
  • 1
    • 0037438875 scopus 로고    scopus 로고
    • Use of low-molecularweight heparins in the management of acute coronary artery syndromes and percutaneous coronary intervention
    • Wong GC, Giugliano RP, Antman EM. Use of low-molecularweight heparins in the management of acute coronary artery syndromes and percutaneous coronary intervention. JAMA 2003; 289: 331-42.
    • (2003) JAMA , vol.289 , pp. 331-342
    • Wong, G.C.1    Giugliano, R.P.2    Antman, E.M.3
  • 2
    • 79953848709 scopus 로고    scopus 로고
    • Daiichi Sankyo Co., Ltd:, (accessed 15.1). Available from
    • Daiichi Sankyo Co., Ltd: Priority Development Projects (accessed 15.1.2010). Available from: http://www.daiichisankyo.com/rd/project/ index.html
    • (2010) Priority Development Projects
  • 4
    • 0030727965 scopus 로고    scopus 로고
    • Antithrombotic and hemorrhagic effects of DX-9065a, a direct and selective factor Xa inhibitor: Comparison with a direct thrombin inhibitor and antithrombin III-dependent anticoagulants
    • Morishima Y, Tanabe K, Terada U, Hara T, Kunitada S. Antithrombotic and hemorrhagic effects of DX-9065a, a direct and selective factor Xa inhibitor: comparison with a direct thrombin inhibitor and antithrombin III-dependent anticoagulants. Thrombo Haemost 1997; 78: 1366-71.
    • (1997) Thrombo Haemost , vol.78 , pp. 1366-1371
    • Morishima, Y.1    Tanabe, K.2    Terada, U.3    Hara, T.4    Kunitada, S.5
  • 5
    • 0032864368 scopus 로고    scopus 로고
    • Tolerability, pharmacokinetics, and pharmacodynamics of DX-9065a, a new synthetic potent anticoagulant and specific factor Xa inhibitor, in healthy male volunteers
    • Murayama N, Tanaka M, Kunitada S, et al. Tolerability, pharmacokinetics, and pharmacodynamics of DX-9065a, a new synthetic potent anticoagulant and specific factor Xa inhibitor, in healthy male volunteers. Clin Pharmacol Ther 1999; 66: 258-64.
    • (1999) Clin Pharmacol Ther , vol.66 , pp. 258-264
    • Murayama, N.1    Tanaka, M.2    Kunitada, S.3
  • 6
    • 0036847576 scopus 로고    scopus 로고
    • Antithrombotic effects of DX-9065a, a direct factor Xa inhibitor: A comparative study in humans versus low molecular weight heparin
    • Simbo D, Osende J, Chen J, et al. Antithrombotic effects of DX-9065a, a direct factor Xa inhibitor: a comparative study in humans versus low molecular weight heparin. Thromb Haemost 2002; 88: 733-8.
    • (2002) Thromb Haemost , vol.88 , pp. 733-738
    • Simbo, D.1    Osende, J.2    Chen, J.3
  • 7
    • 0037150191 scopus 로고    scopus 로고
    • First experience with direct factor Xa inhibition in patients with stable coronary disease: A pharmacokinetic and pharmacodynamic evaluation
    • Dyke CK, Becker RC, Kleiman NS, et al. First experience with direct factor Xa inhibition in patients with stable coronary disease: a pharmacokinetic and pharmacodynamic evaluation. Circulation 2002; 105: 2385-91.
    • (2002) Circulation , vol.105 , pp. 2385-2391
    • Dyke, C.K.1    Becker, R.C.2    Kleiman, N.S.3
  • 8
    • 32044434887 scopus 로고    scopus 로고
    • XaNADU-1B Investigators. Effect of the novel direct factor Xa inhibitor DX-9065a on thrombin generation and inhibition among patients with stable atherosclerotic coronary artery disease
    • Becker RC, Alexander JH, Dyke C, et al. XaNADU-1B Investigators. Effect of the novel direct factor Xa inhibitor DX-9065a on thrombin generation and inhibition among patients with stable atherosclerotic coronary artery disease. Thromb Res 2006; 117: 439-46.
    • (2006) Thromb Res , vol.117 , pp. 439-446
    • Becker, R.C.1    Alexander, J.H.2    Dyke, C.3
  • 9
    • 4644316833 scopus 로고    scopus 로고
    • XaNADU-PCI PILOT Investigators. Initial experience with factor-Xa inhibition in percutaneous coronary intervention: The XaNADU-PCI Pilot
    • Alexander JH, Dyke CK, Yang H, et al. XaNADU-PCI PILOT Investigators. Initial experience with factor-Xa inhibition in percutaneous coronary intervention: the XaNADU-PCI Pilot. J Thromb Haemost 2004; 2: 234-41.
    • (2004) J Thromb Haemost , vol.2 , pp. 234-241
    • Alexander, J.H.1    Dyke, C.K.2    Yang, H.3
  • 10
    • 23944460642 scopus 로고    scopus 로고
    • XaNADU-ACS trial. First experience with direct, selective factor Xa inhibition in patients with non-ST-elevation acute coronary syndromes: Results of the XaNADU-ACS trial
    • Alexander JH, Yang H, Becker RC, et al. XaNADU-ACS trial. First experience with direct, selective factor Xa inhibition in patients with non-ST-elevation acute coronary syndromes: results of the XaNADU-ACS trial. J Thromb Haesmost 2005; 3: 439-47.
    • (2005) J Thromb Haesmost , vol.3 , pp. 439-447
    • Alexander, J.H.1    Yang, H.2    Becker, R.C.3
  • 11
    • 0032505156 scopus 로고    scopus 로고
    • Discovery of N-[2-[5-Amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridine-4-yl]-N methylglycine (ZK-807834): A potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa
    • Phillips GB, Buckman BO, Davey DD, et al. Discovery of N-[2-[5-Amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridine-4-yl]-N methylglycine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa. J Med Chem 1998; 41: 3557-62.
    • (1998) J Med Chem , vol.41 , pp. 3557-3562
    • Phillips, G.B.1    Buckman, B.O.2    Davey, D.D.3
  • 12
    • 33947302258 scopus 로고    scopus 로고
    • Potent arterial antithrombotic effect of direct factor-Xa inhibition with ZK-807834 administered to coronary artery disease patients
    • Zafar MU, Farkouh ME, Osende J, et al. Potent arterial antithrombotic effect of direct factor-Xa inhibition with ZK-807834 administered to coronary artery disease patients. Thromb Haemost 2007; 97: 485-92.
    • (2007) Thromb Haemost , vol.97 , pp. 485-492
    • Zafar, M.U.1    Farkouh, M.E.2    Osende, J.3
  • 13
    • 0037082373 scopus 로고    scopus 로고
    • Human in vitro pharmacodynamic profile of the selective Factor Xa inhibitor ZK-807834 (CI-1031)
    • Post JM, Sullivan ME, Abendschein D, Ewing J, Hinchman JW, Light DR. Human in vitro pharmacodynamic profile of the selective Factor Xa inhibitor ZK-807834 (CI-1031). Thromb Res 2002; 105: 347-52.
    • (2002) Thromb Res , vol.105 , pp. 347-352
    • Post, J.M.1    Sullivan, M.E.2    Abendschein, D.3    Ewing, J.4    Hinchman, J.W.5    Light, D.R.6
  • 14
    • 0034021684 scopus 로고    scopus 로고
    • Effects of ZK-807834, a novel inhibitor of factor Xa, on arterial and venous thrombosis in rabbits
    • Abendschein DR, Baum PK, Martin DJ, et al. Effects of ZK-807834, a novel inhibitor of factor Xa, on arterial and venous thrombosis in rabbits. J Cardiovasc Pharmacol 2000; 35: 796-805.
    • (2000) J Cardiovasc Pharmacol , vol.35 , pp. 796-805
    • Abendschein, D.R.1    Baum, P.K.2    Martin, D.J.3
  • 15
    • 0035824736 scopus 로고    scopus 로고
    • The antithrombotic effects of CI-1031 (ZK-807834) and enoxaparin in a canine electrolytic injury model of arterial and venous thrombosis
    • McClanahan TB, Hicks GW, Morrison AL, et al The antithrombotic effects of CI-1031 (ZK-807834) and enoxaparin in a canine electrolytic injury model of arterial and venous thrombosis. Eur J Pharmacol 2001; 432: 187-94.
    • (2001) Eur J Pharmacol , vol.432 , pp. 187-194
    • McClanahan, T.B.1    Hicks, G.W.2    Morrison, A.L.3
  • 16
    • 0035146488 scopus 로고    scopus 로고
    • A novel synthetic inhibitor of factor Xa decreases early reocclusion and improves 24-h patency after coronary fibrinolysis in dogs
    • Abendschein DR, Braum PK, Verhallen P, Eisenberg PR, Sullivan ME, Light DR. A novel synthetic inhibitor of factor Xa decreases early reocclusion and improves 24-h patency after coronary fibrinolysis in dogs. J Pharmacol Exp Ther 2001; 296: 567-72.
    • (2001) J Pharmacol Exp Ther , vol.296 , pp. 567-572
    • Abendschein, D.R.1    Braum, P.K.2    Verhallen, P.3    Eisenberg, P.R.4    Sullivan, M.E.5    Light, D.R.6
  • 17
    • 13244289984 scopus 로고    scopus 로고
    • Inhibition and reversal of platelet-rich arterial thrombus in vivo: Direct vs indirect factor Xa inhibition
    • nd, Miller RS, et al. Inhibition and reversal of platelet-rich arterial thrombus in vivo: direct vs indirect factor Xa inhibition. J Thromb Haemost 2004; 2: 2162-9.
    • (2004) J Thromb Haemost , vol.2 , pp. 2162-2169
    • Karnicki, K.1    McBane II, R.D.2    Miller, R.S.3
  • 18
    • 0035880858 scopus 로고    scopus 로고
    • Pharmacological characterization of a novel factor Xa inhibitor, FXV673
    • Chu V, Brown K, Colussi D, et al. Pharmacological characterization of a novel factor Xa inhibitor, FXV673. Thromb Res 2001; 103: 309-24.
    • (2001) Thromb Res , vol.103 , pp. 309-324
    • Chu, V.1    Brown, K.2    Colussi, D.3
  • 19
    • 0034914281 scopus 로고    scopus 로고
    • Role of short-term inhibition of factor Xa by FXV673 in arterial passivation: A study in a chronic model of thrombosis in conscious dogs
    • Rebello SS, Kasiewski CJ, Wang W, et al. Role of short-term inhibition of factor Xa by FXV673 in arterial passivation: a study in a chronic model of thrombosis in conscious dogs. J Cardiovasc Pharmacol 2001; 38:299-97
    • (2001) J Cardiovasc Pharmacol , vol.38 , pp. 299-297
    • Rebello, S.S.1    Kasiewski, C.J.2    Wang, W.3
  • 20
    • 0034887402 scopus 로고    scopus 로고
    • Antithrombotic efficacy of a novel factor Xa inhibitor, FXV673, in a canine model of coronary artery thrombosis
    • Rebello SS, Bentley RG, Morgan SR, et al. Antithrombotic efficacy of a novel factor Xa inhibitor, FXV673, in a canine model of coronary artery thrombosis. Br J Pharmacol 2001; 133: 1190-8.
    • (2001) Br J Pharmacol , vol.133 , pp. 1190-1198
    • Rebello, S.S.1    Bentley, R.G.2    Morgan, S.R.3
  • 21
    • 29244439893 scopus 로고    scopus 로고
    • Pharmacodynamic markers in the early clinical assessment of otamixaban, a direct factor Xa inhibitor
    • Paccaly A, Ozoux ML, Chu V, et al. Pharmacodynamic markers in the early clinical assessment of otamixaban, a direct factor Xa inhibitor. Thromb Haemost 2005; 94; 1156-1163.
    • (2005) Thromb Haemost , vol.94 , pp. 1156-1163
    • Paccaly, A.1    Ozoux, M.L.2    Chu, V.3
  • 22
    • 29644437323 scopus 로고    scopus 로고
    • Pharmacokinetics of otamixaban, a direct factor Xa inhibitor, in healthy male subjects: Pharmacokinetic model development for phase 2/3 simulation of exposure
    • Paccaly A, Frick A, Rohatagi S, et al. Pharmacokinetics of otamixaban, a direct factor Xa inhibitor, in healthy male subjects: pharmacokinetic model development for phase 2/3 simulation of exposure. J Clin Pharmacol 2006; 46: 37-44.
    • (2006) J Clin Pharmacol , vol.46 , pp. 37-44
    • Paccaly, A.1    Frick, A.2    Rohatagi, S.3
  • 23
    • 33645534679 scopus 로고    scopus 로고
    • Anti-coagulant and antiplatelet effects are maintained following coadministration of otamixaban, a direct factor Xa inhibitor, and acetylsalicylic acid
    • Hinder M, Frick A, Rosenburg R, et al. Anti-coagulant and antiplatelet effects are maintained following coadministration of otamixaban, a direct factor Xa inhibitor, and acetylsalicylic acid. Thromb Haemost 2006; 95:224-8.
    • (2006) Thromb Haemost , vol.95 , pp. 224-228
    • Hinder, M.1    Frick, A.2    Rosenburg, R.3
  • 24
    • 16844382064 scopus 로고    scopus 로고
    • Anticoagulant and antiplatelet effects are maintained following coadministration of otamixaban, a direct factor Xa inhibitor, with tirofibran in healthy volunteers
    • Hinder M, Paccaly A, Frick A, et al. Anticoagulant and antiplatelet effects are maintained following coadministration of otamixaban, a direct factor Xa inhibitor, with tirofibran in healthy volunteers. Thromb Haemost 2005; 93: 794-5.
    • (2005) Thromb Haemost , vol.93 , pp. 794-795
    • Hinder, M.1    Paccaly, A.2    Frick, A.3
  • 25
    • 33845536606 scopus 로고    scopus 로고
    • Direct and rapid inhibition of factor Xa by otamixaban: A pharmacokinetic and pharmacodynamic investigation in patients with coronary artery disease
    • Hinder M, Frick A, Jordaan P, et al. Direct and rapid inhibition of factor Xa by otamixaban: a pharmacokinetic and pharmacodynamic investigation in patients with coronary artery disease. Clin Pharmacol Ther 2006; 80: 691-702.
    • (2006) Clin Pharmacol Ther , vol.80 , pp. 691-702
    • Hinder, M.1    Frick, A.2    Jordaan, P.3
  • 26
    • 34249025394 scopus 로고    scopus 로고
    • Randomized, doubleblind, dose-ranging study of otamixaban, a novel, parenteral, shortacting direct factor Xa inhibitor, in percutaneous coronary intervention-The SEPIA-PCI trial
    • Cohen M, Bhatt DL, Alexander JH, et al. Randomized, doubleblind, dose-ranging study of otamixaban, a novel, parenteral, shortacting direct factor Xa inhibitor, in percutaneous coronary intervention-The SEPIA-PCI trial. Circulation 2007; 115: 2642-51.
    • (2007) Circulation , vol.115 , pp. 2642-2651
    • Cohen, M.1    Bhatt, D.L.2    Alexander, J.H.3
  • 27
    • 69949096467 scopus 로고    scopus 로고
    • Otamixaban for the treatment of patients with non-ST-elevation acute coronary syndromes (SEPIA-AC1 TIMI 42): A randomised, double-blind, active-controlled, phase 2 trial
    • Sabatine MS, Antman EM, Widimsky P, et al. Otamixaban for the treatment of patients with non-ST-elevation acute coronary syndromes (SEPIA-AC1 TIMI 42): a randomised, double-blind, active-controlled, phase 2 trial. Lancet 2009; 374: 787-95.
    • (2009) Lancet , vol.374 , pp. 787-795
    • Sabatine, M.S.1    Antman, E.M.2    Widimsky, P.3
  • 28
    • 79953875371 scopus 로고    scopus 로고
    • (Accessed 10/2) Available from
    • Otamixaban (Accessed 10/22010) Available from http://clinicaltrials.gov/ct2/results?term=otamixaban
    • (2010) Otamixaban
  • 29
    • 20144374942 scopus 로고    scopus 로고
    • /-dimethylaminomethy)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly, potent, selective, and orally bioavailable factor Xa inhibitor
    • /-dimethylaminomethy)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly, potent, selective, and orally bioavailable factor Xa inhibitor. J Med Chem 2005; 48: 1729-44.
    • (2005) J Med Chem , vol.48 , pp. 1729-1744
    • Quan, M.L.1    Lam, P.Y.2    Pinto, D.J.3
  • 31
    • 35848929515 scopus 로고    scopus 로고
    • Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa
    • Pinto DJ, Orwat MJ, Koch S, et al. Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa. J Med Chem 2007; 50: 5339-56.
    • (2007) J Med Chem , vol.50 , pp. 5339-5356
    • Pinto, D.J.1    Orwat, M.J.2    Koch, S.3
  • 32
    • 64849114048 scopus 로고    scopus 로고
    • Apixaban, an oral direct factor Xa inhibitor, inhibits human clotbound factor Xa activity in vitro
    • Jiang X, Crain EJ, Luettgen JM, Schumacher WA, Wong PC. Apixaban, an oral direct factor Xa inhibitor, inhibits human clotbound factor Xa activity in vitro. Thromb Haemost 2009; 101: 780-2.
    • (2009) Thromb Haemost , vol.101 , pp. 780-782
    • Jiang, X.1    Crain, E.J.2    Luettgen, J.M.3    Schumacher, W.A.4    Wong, P.C.5
  • 33
    • 42149172523 scopus 로고    scopus 로고
    • Apixaban, an oral, direct and highly selective factor Xa inhibitor: In vitro, antithrombotic and antihemostatic studies
    • Wong PC, Crain Ej, Xin B, et al. Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies. J Thromb Haemost 2008; 6: 820-9.
    • (2008) J Thromb Haemost , vol.6 , pp. 820-829
    • Wong, P.C.1    Crain, E.J.2    Xin, B.3
  • 34
    • 52449130392 scopus 로고    scopus 로고
    • Arterial antithrombotic and bleeding time effects of apixaban, a direct factor Xa inhibitor, in combination with antiplatelet therapy in rabbits
    • Wong PC, Watson CA, Crain EJ. Arterial antithrombotic and bleeding time effects of apixaban, a direct factor Xa inhibitor, in combination with antiplatelet therapy in rabbits. J Thromb Haemost 2008; 6: 1736-41.
    • (2008) J Thromb Haemost , vol.6 , pp. 1736-1741
    • Wong, P.C.1    Watson, C.A.2    Crain, E.J.3
  • 35
    • 76749166335 scopus 로고    scopus 로고
    • In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies
    • Wang L, Zhang D, Raghavan N, et al. In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies. Drug Metab Dispos 2010; 38(3): 448-58.
    • (2010) Drug Metab Dispos , vol.38 , Issue.3 , pp. 448-458
    • Wang, L.1    Zhang, D.2    Raghavan, N.3
  • 36
    • 58149458160 scopus 로고    scopus 로고
    • Apixaban metabolism and pharmacokinetics after oral administration to humans
    • Raghavan N, Forst CE, Yu Z, et al. Apixaban metabolism and pharmacokinetics after oral administration to humans. Drug Metab Dispos 2009; 37: 74-81.
    • (2009) Drug Metab Dispos , vol.37 , pp. 74-81
    • Raghavan, N.1    Forst, C.E.2    Yu, Z.3
  • 37
    • 36348978071 scopus 로고    scopus 로고
    • The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thrombolysis in patients following total knee replacement
    • Lassen MR, Davidson BL, Gallus A, Pineo G, Ansell J, Deitchman D. The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thrombolysis in patients following total knee replacement. J Thromb Haemost 2007; 5: 2368-75.
    • (2007) J Thromb Haemost , vol.5 , pp. 2368-2375
    • Lassen, M.R.1    Davidson, B.L.2    Gallus, A.3    Pineo, G.4    Ansell, J.5    Deitchman, D.6
  • 38
    • 47649098524 scopus 로고    scopus 로고
    • Efficacy and safety of the oral direct factore Xa inhibitor apixaban for symptomatic deep vein thrombosis. The Botticelli DVT dose-ranging study
    • Botticelli Investigators, the writing committee
    • Botticelli Investigators, the writing committee, Buller H, Deitchman D, Prins M, Segers A. Efficacy and safety of the oral direct factore Xa inhibitor apixaban for symptomatic deep vein thrombosis. The Botticelli DVT dose-ranging study. J Thromb Haemost 2008; 6:1313-8.
    • (2008) J Thromb Haemost , vol.6 , pp. 1313-1318
    • Buller, H.1    Deitchman, D.2    Prins, M.3    Segers, A.4
  • 39
    • 67649563209 scopus 로고    scopus 로고
    • Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: Results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial
    • APPRAISE Steering Committee and Investigators
    • APPRAISE Steering Committee and Investigators, Alexander JH, Becker RC, Bhatt DL, et al. Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial. Circulation 2009; 119: 2877-85.
    • (2009) Circulation , vol.119 , pp. 2877-2885
    • Alexander, J.H.1    Becker, R.C.2    Bhatt, D.L.3
  • 40
    • 77956057303 scopus 로고    scopus 로고
    • (Accessed 19/1) Available at
    • Phase III Acute Coronary Syndrome (APPRAISE-2). (Accessed 19/1/2010) Available at: http://clinicaltrials.gov/ct2/show/ NCT00831441?term=apixaban&rank=16
    • (2010) Phase III Acute Coronary Syndrome (APPRAISE-2)
  • 41
    • 24944536065 scopus 로고    scopus 로고
    • Discovery of the novel antithromboin agent 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide (BAY 59-7939): An oral, direct factor Xa inhibitor
    • Roehrig S, Straub A, Pohlmann J, et al. Discovery of the novel antithromboin agent 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor. J Med Chem 2005; 48: 5900-8.
    • (2005) J Med Chem , vol.48 , pp. 5900-5908
    • Roehrig, S.1    Straub, A.2    Pohlmann, J.3
  • 42
    • 22844442726 scopus 로고    scopus 로고
    • In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939-an oral direct factor Xa inhibitor
    • Perzborn E, Strassburger J, Wilmen A, et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939-an oral direct factor Xa inhibitor. J Thromb Haemost 2005; 3: 514-21.
    • (2005) J Thromb Haemost , vol.3 , pp. 514-521
    • Perzborn, E.1    Strassburger, J.2    Wilmen, A.3
  • 43
    • 66449099711 scopus 로고    scopus 로고
    • Metabolism and excretion of rivaroxaban, an oral, direct factor Xa inhibitor, in rats, dogs, and humans
    • Weinz C, Schwarz T, Kubitza D, Mueck W, Lang D. Metabolism and excretion of rivaroxaban, an oral, direct factor Xa inhibitor, in rats, dogs, and humans. Drug Metab Dispos 2009; 37: 1056-64.
    • (2009) Drug Metab Dispos , vol.37 , pp. 1056-1064
    • Weinz, C.1    Schwarz, T.2    Kubitza, D.3    Mueck, W.4    Lang, D.5
  • 44
    • 25844525489 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor
    • Kubitza D, Becka M, Voith B, Zuehlsdorf M, Wensing G. Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor. Clin Pharmacol Ther 2005; 78: 412-21.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 412-421
    • Kubitza, D.1    Becka, M.2    Voith, B.3    Zuehlsdorf, M.4    Wensing, G.5
  • 45
    • 29144518504 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939-an oral, direct Factor Xa inhibitor-after multiple dosing in healthy male subjects
    • Kubitza D, Becka M, Wensing G, Voith B, Zuehlsdorf M. Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939-an oral, direct Factor Xa inhibitor-after multiple dosing in healthy male subjects. Eur J Clin Pharmacol 2005; 61: 873-80.
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 873-880
    • Kubitza, D.1    Becka, M.2    Wensing, G.3    Voith, B.4    Zuehlsdorf, M.5
  • 46
    • 28444474155 scopus 로고    scopus 로고
    • For the ODIXa-knee study group. BAY 59-7939: An oral, direct factor Xa inhibitor for the prevention of venous thromboembolism. A phase II doseranging study
    • Turpie AG, Fisher WD, Bauer KA, et al. For the ODIXa-knee study group. BAY 59-7939: an oral, direct factor Xa inhibitor for the prevention of venous thromboembolism. A phase II doseranging study. J Thromb Haemost 2005; 3: 2479-86.
    • (2005) J Thromb Haemost , vol.3 , pp. 2479-2486
    • Turpie, A.G.1    Fisher, W.D.2    Bauer, K.A.3
  • 47
    • 45949103416 scopus 로고    scopus 로고
    • RECORD3 investigators. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee anthroplasty
    • Lassen MR, Ageno W, Borris LC, et al. RECORD3 investigators. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee anthroplasty. N Engl J Med 2008; 358: 2776-86.
    • (2008) N Engl J Med , vol.358 , pp. 2776-2786
    • Lassen, M.R.1    Ageno, W.2    Borris, L.C.3
  • 48
    • 65549169515 scopus 로고    scopus 로고
    • RECORD 4 investigators. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): A randomised trial
    • Turpie AG, Lassen MR, Davidson BL, et al. RECORD 4 investigators. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial. Lancet 2009; 373:1673-80.
    • (2009) Lancet , vol.373 , pp. 1673-1680
    • Turpie, A.G.1    Lassen, M.R.2    Davidson, B.L.3
  • 49
    • 33644867218 scopus 로고    scopus 로고
    • And ODIXa-HIP Study Investigators. Oral, direct, Factor Xa inhibition with BAY 59-7939 for the prevention of venous thromboembolism after total hip re placement
    • Eriksson BI, Borris L, Dahl OE, et al. And ODIXa-HIP Study Investigators. Oral, direct, Factor Xa inhibition with BAY 59-7939 for the prevention of venous thromboembolism after total hip re placement. J Thromb Haemost 2006; 4: 121-8.
    • (2006) J Thromb Haemost , vol.4 , pp. 121-128
    • Eriksson, B.I.1    Borris, L.2    Dahl, O.E.3
  • 50
    • 34250651947 scopus 로고    scopus 로고
    • Dose-escalation study of rivaroxaban (BAY 59-7939)-an oral, direct Factor Xa inhibitor-for the prevention of thromboembolism in patients undergoing total hip replacement
    • Eriksson BI, Borris LC, Dahl OE, et al. Dose-escalation study of rivaroxaban (BAY 59-7939)-an oral, direct Factor Xa inhibitor-for the prevention of thromboembolism in patients undergoing total hip replacement. Thromb Res 2007; 120: 685-93.
    • (2007) Thromb Res , vol.120 , pp. 685-693
    • Eriksson, B.I.1    Borris, L.C.2    Dahl, O.E.3
  • 51
    • 45949099359 scopus 로고    scopus 로고
    • For the RECORD1 study group. Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty
    • Eriksson BI, Borris LC, Friedman RJ, et al. For the RECORD1 study group. Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty. N Engl J Med 2008; 358:2765-75.
    • (2008) N Engl J Med , vol.358 , pp. 2765-2775
    • Eriksson, B.I.1    Borris, L.C.2    Friedman, R.J.3
  • 52
    • 46049106502 scopus 로고    scopus 로고
    • Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: A double-blind, randomised controlled trial. RECORD2 Investigators
    • Kakar AK, Brenner B, Dahl OE, et al. Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled trial. RECORD2 Investigators. Lancet 2008; 372: 31-9.
    • (2008) Lancet , vol.372 , pp. 31-39
    • Kakar, A.K.1    Brenner, B.2    Dahl, O.E.3
  • 53
    • 34447317298 scopus 로고    scopus 로고
    • ODIXa-DVT Study Investigators. Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor (BAY 59-7939): The ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in Patients With Acute Symptomatic Deep-Vein Thrombosis) study
    • Agnelli G, Gallus A, Goldhaber SZ, et al. ODIXa-DVT Study Investigators. Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor (BAY 59-7939): the ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in Patients With Acute Symptomatic Deep-Vein Thrombosis) study. Circulation 2007; 116: 180-7.
    • (2007) Circulation , vol.116 , pp. 180-187
    • Agnelli, G.1    Gallus, A.2    Goldhaber, S.Z.3
  • 54
    • 53849123533 scopus 로고    scopus 로고
    • On behalf of the Einstein-DVT Dose-Ranging Study Investigators. A dose-ranging study evaluating once-daily oral administration of the factor Xa inhibitor rivaroxaban in the treatment of patients with acute symptomatic deep vein thrombosis: The Einstein-DVT Dose-Ranging Study
    • Buller HR, Lensing AWA, Prins MH, et al. on behalf of the Einstein-DVT Dose-Ranging Study Investigators. A dose-ranging study evaluating once-daily oral administration of the factor Xa inhibitor rivaroxaban in the treatment of patients with acute symptomatic deep vein thrombosis: the Einstein-DVT Dose-Ranging Study. Blood 2008; 112: 2242-7.
    • (2008) Blood , vol.112 , pp. 2242-2247
    • Buller, H.R.1    Lensing, A.W.A.2    Prins, M.H.3
  • 55
    • 67649562905 scopus 로고    scopus 로고
    • ATLAS ACS-TIMI 46 study group. Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46); a randomised, double-blind, phase II trial
    • Mega JL, Braunwald E, Mohanavelu S, et al. ATLAS ACS-TIMI 46 study group. Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46); a randomised, double-blind, phase II trial. Lancet 2009; 374: 29-38.
    • (2009) Lancet , vol.374 , pp. 29-38
    • Mega, J.L.1    Braunwald, E.2    Mohanavelu, S.3
  • 56
    • 35448932027 scopus 로고    scopus 로고
    • Effects of the oral, direct factor Xa inhibitor rivaroxaban on platelet-induced thrombin generation and prothrombinase activity
    • Graff J, von Hentig N, Misselwitz F, et al. Effects of the oral, direct factor Xa inhibitor rivaroxaban on platelet-induced thrombin generation and prothrombinase activity. J Clin Pharmacol 2007; 47:1398-407.
    • (2007) J Clin Pharmacol , vol.47 , pp. 1398-1407
    • Graff, J.1    von Hentig, N.2    Misselwitz, F.3
  • 57
    • 33747068794 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacodynamics, and pharmacokinetics of rivaroxaban-and oral, direct factor Xa inhibitor-are not affected by aspirin
    • Kubitza D, Becka M, Mueck W, Zuehlsdorf M. Safety, tolerability, pharmacodynamics, and pharmacokinetics of rivaroxaban-and oral, direct factor Xa inhibitor-are not affected by aspirin. J Clin Pharmacol 2006; 46: 981-90.
    • (2006) J Clin Pharmacol , vol.46 , pp. 981-990
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Zuehlsdorf, M.4
  • 58
    • 33846448135 scopus 로고    scopus 로고
    • Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects
    • Kubitza D, Becka M, Zuehlsdorf M, Mueck W. Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects. J Clin Pharmacol 2007; 47: 218-26.
    • (2007) J Clin Pharmacol , vol.47 , pp. 218-226
    • Kubitza, D.1    Becka, M.2    Zuehlsdorf, M.3    Mueck, W.4
  • 60
    • 3042782723 scopus 로고    scopus 로고
    • Enoxaparin vs unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes managed with an intended early invasive strategy: Primary results of the SYNERGY randomized trial
    • Ferguson JJ, Califf RM, Antman EM, et al. Enoxaparin vs unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes managed with an intended early invasive strategy: primary results of the SYNERGY randomized trial. JAMA 2004; 292: 45-54.
    • (2004) JAMA , vol.292 , pp. 45-54
    • Ferguson, J.J.1    Califf, R.M.2    Antman, E.M.3
  • 61
    • 3042820414 scopus 로고    scopus 로고
    • Safety and efficacy of enoxaparin vs unfractionated heparin in patients with non-STsegment elevation acute coronary syndromes who receive tirofibran and aspirin: A randomized controlled trial
    • Blazing MA, de Lemos JA, White HD, et al. Safety and efficacy of enoxaparin vs unfractionated heparin in patients with non-STsegment elevation acute coronary syndromes who receive tirofibran and aspirin: a randomized controlled trial. JAMA 2004; 292: 55-64.
    • (2004) JAMA , vol.292 , pp. 55-64
    • Blazing, M.A.1    de Lemos, J.A.2    White, H.D.3
  • 62
    • 33751221316 scopus 로고    scopus 로고
    • Bivalirudin for patients with acute coronary syndromes
    • Stone GW, McLaurin BT, Cox DA, et al. Bivalirudin for patients with acute coronary syndromes. N Engl J Med 2006; 355: 2203-2216.
    • (2006) N Engl J Med , vol.355 , pp. 2203-2216
    • Stone, G.W.1    McLaurin, B.T.2    Cox, D.A.3
  • 63
    • 33645498094 scopus 로고    scopus 로고
    • Comparison of fondaparinux and enoxaparin in acute coronary syndromes
    • The Fifth Organization to Assess Strategies in Acute Ischemic Syndromes Investigators
    • The Fifth Organization to Assess Strategies in Acute Ischemic Syndromes Investigators. Comparison of fondaparinux and enoxaparin in acute coronary syndromes. N Engl J Med 2006; 354: 1454-1476.
    • (2006) N Engl J Med , vol.354 , pp. 1454-1476
  • 64
    • 67649448944 scopus 로고    scopus 로고
    • Rivaroxaban in acute coronary syndromes: Too soon to know
    • Gurm HS, Eagle K. Rivaroxaban in acute coronary syndromes: too soon to know. Lancet 2009; 374: 3-4.
    • (2009) Lancet , vol.374 , pp. 3-4
    • Gurm, H.S.1    Eagle, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.