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Volumn 6, Issue 10, 2008, Pages 1736-1741

Arterial antithrombotic and bleeding time effects of apixaban, a direct factor Xa inhibitor, in combination with antiplatelet therapy in rabbits

Author keywords

Apixaban; Arterial thrombosis; Aspirin; Clopidogrel; Direct factor Xa inhibitor; Hemostasis

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; APIXABAN; BLOOD CLOTTING FACTOR 10A INHIBITOR; CLOPIDOGREL;

EID: 52449130392     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2008.03092.x     Document Type: Article
Times cited : (46)

References (23)
  • 1
    • 18044378766 scopus 로고    scopus 로고
    • 12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis
    • 12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin Thromb Hemost 2005; 31: 195-204.
    • (2005) Semin Thromb Hemost , vol.31 , pp. 195-204
    • Savi, P.1    Herbert, J.-M.2
  • 2
    • 0035899289 scopus 로고    scopus 로고
    • Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK. Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 2001; 345: 494-502.
    • (2001) N Engl J Med , vol.345 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3    Chrolavicius, S.4    Tognoni, G.5    Fox, K.K.6
  • 3
    • 0036846734 scopus 로고    scopus 로고
    • Clopidogrel does not suppress blood markers of coagulation activation in aspirin-treated patients with non-ST-elevation acute coronary syndromes
    • Eikelboom JW, Weitz JI, Budaj A, Zhao F, Copland I, Maciejewski P, Johnston M, Yusuf S. Clopidogrel does not suppress blood markers of coagulation activation in aspirin-treated patients with non-ST-elevation acute coronary syndromes. Eur Heart J 2002; 23: 1771-9.
    • (2002) Eur Heart J , vol.23 , pp. 1771-1779
    • Eikelboom, J.W.1    Weitz, J.I.2    Budaj, A.3    Zhao, F.4    Copland, I.5    Maciejewski, P.6    Johnston, M.7    Yusuf, S.8
  • 4
    • 33645229796 scopus 로고    scopus 로고
    • Aspirin plus warfarin compared to aspirin alone after acute coronary syndromes: An updated and comprehensive meta-analysis of 25,307 patients
    • Andreotti F, Testa L, Biondi-Zoccai GG, Crea F. Aspirin plus warfarin compared to aspirin alone after acute coronary syndromes: An updated and comprehensive meta-analysis of 25,307 patients. Eur Heart J 2006; 27: 519-26.
    • (2006) Eur Heart J , vol.27 , pp. 519-526
    • Andreotti, F.1    Testa, L.2    Biondi-Zoccai, G.G.3    Crea, F.4
  • 5
    • 34447306023 scopus 로고    scopus 로고
    • Bleeding complications with warfarin use: A prevalent adverse effect resulting in regulatory action
    • Wysowski DK, Nourjah P, Swartz L. Bleeding complications with warfarin use: A prevalent adverse effect resulting in regulatory action. Arch Intern Med 2007; 167: 1414-9.
    • (2007) Arch Intern Med , vol.167 , pp. 1414-1419
    • Wysowski, D.K.1    Nourjah, P.2    Swartz, L.3
  • 6
    • 35848929515 scopus 로고    scopus 로고
    • Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl -4,5,6,7-tetrahydro -1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, e.cacious, and orally bioavailable inhibitor of blood coagulation factor Xa
    • Pinto DJ, Orwat MJ, Koch S, Rossi KA, Alexander RS, Smallwood A, Wong PC, Rendina AR, Luettgen JM, Knabb RM, He K, Xin B, Wexler RR, Lam PY. Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl -4,5,6,7-tetrahydro -1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, e.cacious, and orally bioavailable inhibitor of blood coagulation factor Xa. Med Chem 2007; 50: 5339-56.
    • (2007) J Med Chem , vol.50 , pp. 5339-5356
    • Pinto, D.J.1    Orwat, M.J.2    Koch, S.3    Rossi, K.A.4    Alexander, R.S.5    Smallwood, A.6    Wong, P.C.7    Rendina, A.R.8    Luettgen, J.M.9    Knabb, R.M.10    He, K.11    Xin, B.12    Wexler, R.R.13    Lam, P.Y.14
  • 7
  • 9
    • 42149159619 scopus 로고    scopus 로고
    • Apixaban, an oral direct, factor Xa inhibitor: Single-dose safety, pharmacokinetics and pharmacodynamics in healthy subjects
    • P-M-665
    • Frost C, Yu Z, Nepal S, Mosqueda-Garcia R, Shenker A. Apixaban, an oral direct, factor Xa inhibitor: Single-dose safety, pharmacokinetics and pharmacodynamics in healthy subjects. J Thromb Haemost 2007; 5:(Suppl. 2): P-M-665.
    • (2007) J Thromb Haemost , vol.5 , Issue.SUPPL. 2
    • Frost, C.1    Yu, Z.2    Nepal, S.3    Mosqueda-Garcia, R.4    Shenker, A.5
  • 10
    • 36348978071 scopus 로고    scopus 로고
    • The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement
    • Lassen MR, Davidson BL, Gallus A, Pineo G, Ansell J, Deitchman D. The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement. J Thromb Haemost 2007; 5: 2368-75.
    • (2007) J Thromb Haemost , vol.5 , pp. 2368-2375
    • Lassen, M.R.1    Davidson, B.L.2    Gallus, A.3    Pineo, G.4    Ansell, J.5    Deitchman, D.6
  • 11
    • 47649098524 scopus 로고    scopus 로고
    • Efficacy and safety of the oral direct factor Xa inhibitor apixaban for symptomatic deep-vein thrombosis. The Botticelli DVT dose-ranging study
    • On behalf of the Botticelli investigators, the writing committee
    • On behalf of the Botticelli investigators, the writing committee, Büller H, Deitchman D, Prins M, Segers A. Efficacy and safety of the oral direct factor Xa inhibitor apixaban for symptomatic deep-vein thrombosis. The Botticelli DVT dose-ranging study. J Thromb Haemost 2008; 6: 1313-8.
    • (2008) J Thromb Haemost , vol.6 , pp. 1313-1318
    • Büller, H.1    Deitchman, D.2    Prins, M.3    Segers, A.4
  • 17
    • 33750485039 scopus 로고    scopus 로고
    • Arterial antithrombotic effects of aspirin, heparin, enoxaparin and clopidogrel alone, or in combination, in the rat
    • Daykin HJ, Sturgeon SA, Jones C, Wright CE. Arterial antithrombotic effects of aspirin, heparin, enoxaparin and clopidogrel alone, or in combination, in the rat. Thromb Res 2006; 118: 755-62.
    • (2006) Thromb Res , vol.118 , pp. 755-762
    • Daykin, H.J.1    Sturgeon, S.A.2    Jones, C.3    Wright, C.E.4
  • 19
    • 26044459888 scopus 로고    scopus 로고
    • The antithrombotic effect of melagatran in combination with clopidogrel and/or aspirin (carotid artery primary thrombosis study)
    • Hong TT, Huang J, Driscoll E, Lucchesi BR. The antithrombotic effect of melagatran in combination with clopidogrel and/or aspirin (carotid artery primary thrombosis study). J Cardiovasc Pharmacol 2005;46: 526-33.
    • (2005) J Cardiovasc Pharmacol , vol.46 , pp. 526-533
    • Hong, T.T.1    Huang, J.2    Driscoll, E.3    Lucchesi, B.R.4
  • 20
    • 34249705694 scopus 로고    scopus 로고
    • Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/ or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits
    • Wong PC, Crain EJ, Watson CA, Wexler RR, Lam PY, Quan ML, Knabb RM. Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/ or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits. J Thromb Thrombolysis 2007; 24: 43-51.
    • (2007) J Thromb Thrombolysis , vol.24 , pp. 43-51
    • Wong, P.C.1    Crain, E.J.2    Watson, C.A.3    Wexler, R.R.4    Lam, P.Y.5    Quan, M.L.6    Knabb, R.M.7
  • 21
    • 0041829444 scopus 로고    scopus 로고
    • Oral ximelagatran for secondary prophylaxis after myocardial infarction: The ESTEEM randomised controlled trial
    • ESTEEM Investigators
    • Wallentin L, Wilcox RG, Weaver WD, Emanuelsson H, Goodvin A, Nyström P, Bylock A; ESTEEM Investigators. Oral ximelagatran for secondary prophylaxis after myocardial infarction: The ESTEEM randomised controlled trial. Lancet 2003; 362: 789-97.
    • (2003) Lancet , vol.362 , pp. 789-797
    • Wallentin, L.1    Wilcox, R.G.2    Weaver, W.D.3    Emanuelsson, H.4    Goodvin, A.5    Nyström, P.6    Bylock, A.7
  • 22
    • 33746899054 scopus 로고    scopus 로고
    • The challenges of new drugs benefits and risks analysis: Lessons from the ximelagatran FDA Cardiovascular Advisory Committee
    • Boudes PF. The challenges of new drugs benefits and risks analysis: lessons from the ximelagatran FDA Cardiovascular Advisory Committee. Contemp Clin Trials 2006; 27: 432-40.
    • (2006) Contemp Clin Trials , vol.27 , pp. 432-440
    • Boudes, P.F.1
  • 23
    • 37349074069 scopus 로고    scopus 로고
    • Efficacy and safety of fondaparinux in patients with acute coronary syndromes
    • Bassand JP, Richard-Lordereau I, Cadroy Y. Efficacy and safety of fondaparinux in patients with acute coronary syndromes. Expert Rev Cardiovasc Ther 2007; 5: 1013-26.
    • (2007) Expert Rev Cardiovasc Ther , vol.5 , pp. 1013-1026
    • Bassand, J.P.1    Richard-Lordereau, I.2    Cadroy, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.