Gene-gene and gene-environment interactions defining lipid-related traits

Current Opinion in Lipidology

Volumn 22, Issue 2, 2011, Pages 129-136

  Ordovás, José M ^a,b,c   Robertson, Ruairi ^a   Cléirigh, Ellen Ní ^a  

^a TUFTS UNIVERSITY   (United States)

^b CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^c IMDEA FOOD INSTITUTE   (Spain)

Author keywords

cardiovascular diseases; gene environment interactions; obesity; plasma lipoproteins

Indexed keywords

ABC TRANSPORTER A1; ACYL COENZYME A DESATURASE 1; ADIPONECTIN; APOENZYME; CYTOCHROME P450 2C19; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LINOLEOYL COENZYME A DESATURASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MITOGEN ACTIVATED PROTEIN KINASE; OLIVE OIL; POLYUNSATURATED FATTY ACID; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CORONARY ARTERY DISEASE; DISEASE COURSE; DYSLIPIDEMIA; EPISTASIS; EVOLUTIONARY ADAPTATION; GENE EXPRESSION; GENE INTERACTION; GENETIC ASSOCIATION; HUMAN; INSULIN SENSITIVITY; LIPID METABOLISM; LOW FAT DIET; METABOLIC SYNDROME X; NONHUMAN; NUT; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; CARDIOVASCULAR DISEASES; DISEASE MODELS, ANIMAL; ENVIRONMENT; EPIGENOMICS; HUMANS; LIPOPROTEINS; OBESITY;

EID: 79953766750     PISSN: 09579672     EISSN: 14736535     Source Type: Journal    
DOI: 10.1097/MOL.0b013e32834477a9     Document Type: Article

References (45)

1. Corella D, Ordovas JM. Nutrigenomics in cardiovascular medicine. Circ Cardiovasc Genet 2009; 2:637-651.
2. Flegal KM, CarrollMD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999-2008. JAMA 2010; 303:235-241.
3. Patel MD, Thompson PD. Phytosterols and vascular disease. Atherosclerosis 2006; 186:12-19.
4. Marotta F, Harada M, Minelli E, et al. Progression of atherosclerotic lesions in the arteries and related gene expression: protective effect of phytonutrients. Rejuvenation Res 2010; 13:242-245.
5. Kim JH, Pan JH, Park HG, et al. Functional comparison of esterified and free forms of conjugated linoleic acid in high-fat-diet-induced obese C57BL/6J mice. J Agric Food Chem 2010 [Epub ahead of print].
6. Fukuchi Y, Hiramitsu M, Okada M, et al. Lemon polyphenols suppress dietinduced obesity by up-regulation of mRNA levels of the enzymes involved in beta-oxidation in mouse white adipose tissue. J Clin Biochem Nutr 2008; 43:201-209.
7. Rideout TC, Harding SV, Jones PJ. Consumption of plant sterols reduces plasma and hepatic triglycerides and modulates the expression of lipid regulatory genes and de novo lipogenesis in C57BL/6J mice. Mol Nutr Food Res 2010; 54 (Suppl 1):S7-S13.
8. Camargo A, Ruano J, Fernandez JM, et al. Gene expression changes in mononuclear cells in patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil. BMC Genomics 2010; 11:253.
9. Ló pez-Miranda J, Pé rez-Jiménez F, Ros E, et al. Olive oil and health: summary of the II international conference on olive oil and health consensus report. Nutr Metab Cardiovasc Dis 2010:20: 284-294.
10. Razquin C, Martinez JA, Martinez-Gonzalez MA, et al. A Mediterranean diet rich in virgin olive oil may reverse the effects of the -174G/C IL6 gene variant on 3-year body weight change. Mol Nutr Food Res 2010; 54 (Suppl 1):S75-S82.
11. Murphy EF, Hooiveld GJ, Muller M, et al. The effect of trans-10, cis-12 conjugated linoleic acid on gene expression profiles related to lipid metabolism in human intestinal-like Caco-2 cells. Genes Nutr 2009; 4:103-112.
12. Silbernagel G, Fauler G, Hoffmann MM, et al. The associations of cholesterol metabolism and plasma plant sterols with all-cause and cardiovascular mortality. J Lipid Res 2010; 51:2384-2393.
13. Rubis B, Paszel A, Kaczmarek M, et al. Beneficial or harmful influence of phytosterols on human cells? Br J Nutr 2008; 100:1183-1191.
14. Weingartner O, Bohm M, Laufs U. Controversial role of plant sterol esters in the management of hypercholesterolaemia. Eur Heart J 2009; 30:404-409.
15. Lu Y, Feskens EJ, Dolle ME, et al. Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDLcholesterol concentrations in the Doetinchem Cohort Study. Am J Clin Nutr 2010; 92:258-265.
16. Delgado-Lista J, Perez-Martinez P, Perez-Jimenez F, et al. ABCA1 gene variants regulate postprandial lipid metabolism in healthy men. Arterioscler Thromb Vasc Biol 2010; 30:1051-1057.
17. Corella D, Peloso G, Arnett DK, et al. APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations. Arch Intern Med 2009; 169:1897-1906.
18. Corella D, Tai ES, Sorli JV, et al. Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene-saturated fat interaction. Int J Obes (Lond) 2010. [Epub ahead of print]
19. Yang YN, Wang XL, Ma YT, et al. Association of interaction between smoking and CYP 2C19-3 polymorphism with coronary artery disease in a Uighur population. Clin Appl Thromb Hemost 2010; 16:579-583.
20. Garcia-Rios A, Perez-Martinez P, Fuentes F, et al. Genetic variations at ABCG5/G8 genes modulate plasma lipids concentrations in patients with familial hypercholesterolemia. Atherosclerosis 2010; 210:486-492.
21. Junyent M, Tucker KL, Smith CE, et al. The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations depend on smoking habit in the Boston Puerto Rican Health Study. J Lipid Res 2009; 50:565-573.
22. Garenc C, Vohl MC, Bouchard C, Perusse L. LIPE C-60G influences the effects of physical activity on body fat and plasma lipid concentrations: the Quebec Family Study. Hum Genomics 2009; 3:157-168.
23. Smith CE, Arnett DK, Tsai MY, et al. Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study. Atherosclerosis 2009; 206:500-504.
24. Lanktree MB, Hegele RA. Gene-gene and gene-environment interactions: new insights into the prevention, detection and management of coronary artery disease. Genome Med 2009; 1:28.
25. Junyent M, Lee YC, Smith CE, et al. The effect of a novel intergenic polymorphism (rs11774572) on HDL-cholesterol concentrations depends on TaqIB polymorphism in the cholesterol ester transfer protein gene. Nutr Metab Cardiovasc Dis 2010; 20:34-40.
26. Junyent M, Tucker KL, Smith CE, et al. The effects of ABCG5/G8 polymorphisms on HDL-cholesterol concentrations depend on ABCA1 genetic variants in the Boston Puerto Rican Health Study. Nutr Metab Cardiovasc Dis 2010; 20:558-566.
27. Laurila PP, Naukkarinen J, Kristiansson K, et al. Genetic association and interaction analysis of USF1 and APOA5 on lipid levels and atherosclerosis. Arterioscler Thromb Vasc Biol 2010; 30:346-352.
28. Singmann P, Baumert J, Herder C, et al. Gene-gene interaction between APOA5 and USF1: two candidate genes for the metabolic syndrome. Obes Facts 2009; 2:235-242.
29. Fernandez-Morera JL, Rodriguez-Rodero S, Menendez-Torre E, Fraga MF. The possible role of epigenetics in gestational diabetes: cause, consequence, or both. Obstet Gynecol Int 2010; 2010:605163.
30. Ordovas JM, Smith CE. Epigenetics and cardiovascular disease. Nat Rev Cardiol 2010; 7:510-519.
31. Vucetic Z, Kimmel J, Totoki K, et al. Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes. Endocrinology 2010; 151:4756-4764.
32. Heerwagen MJ, Miller MR, Barbour LA, Friedman JE. Maternal obesity and fetal metabolic programming: a fertile epigenetic soil. Am J Physiol Regul Integr Comp Physiol 2010; 299:R711-R722.
33. Durbin RM, Abecasis GR, Altshuler DL, et al. A map of human genome variation from population-scale sequencing. Nature 2010; 467:1061-1073.
34. Teslovich TM, Musunuru K, Smith AV, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010; 466:707-713.
35. Wang K, Li M, Hakonarson H. Analysing biological pathways in genome-wide association studies. Nat Rev Genet 2010; 11:843-854.
36. Mohtat D, Susztak K. Fine tuning gene expression: the epigenome. Semin Nephrol 2010; 30:468-476.
37. Lister R, Pelizzola M, Dowen RH, et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 2009; 462:315-322.
38. Phillips CM, Goumidi L, Bertrais S, et al. Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome. J Lipid Res 2010; 51:1793-1800.
39. Warodomwichit D, Shen J, Arnett DK, et al. ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study. Obesity (Silver Spring) 2009; 17:510-517.
40. Ferguson JF, Phillips CM, Tierney AC, et al. Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. Am J Clin Nutr 2010; 91:794-801.
41. Ruixing Y, Yiyang L, Meng L, et al. Interactions of the apolipoprotein C-III 3238C>G polymorphism and alcohol consumption on serum triglyceride levels. Lipids Health Dis 2010; 9:86.
42. Phillips CM, Goumidi L, Bertrais S, et al. Additive effect of polymorphisms in the IL-6, LTA, and TNF-a genes and plasma fatty acid level modulate risk for the metabolic syndrome and its components. J Clin Endocrinol Metab 2010; 95:1386-1394.
43. Lairon D, Defoort C, Martin JC, et al. Nutrigenetics: links between genetic background and response to Mediterranean-type diets. Public Health Nutr 2009; 12:1601-1606.
44. Scott RA, Bailey ME, Moran CN, et al. FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males. Eur J Hum Genet 2010; 18:1339-1343.
45. Smith CE, Tucker KL, Lai CQ, et al. Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin. Obesity (Silver Spring) 2010; 18:327-332.