Functional comparison of esterified and free forms of conjugated linoleic acid in high-fat-diet-induced obese C57BL/6J mice

Journal of Agricultural and Food Chemistry

Volumn 58, Issue 21, 2010, Pages 11441-11447

  Kim, Jun Ho ^a   Pan, Jeong Hoon ^a   Park, Hui Gyu ^a   Yoon, Ho Geun ^b   Kwon, O Jun ^c   Kim, Tae Wan ^d   Shin, Dong Hoon ^a   Kim, Young Jun ^a  

^a Korea University   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c Gyeongbuk Regional Innovation Agency   (South Korea)

^d Andong National University   (South Korea)

Author keywords

oxidation; Conjugated linoleic acids; gene expression; lipogenesis; liver enlargement

Indexed keywords

ADIPOSE TISSUE; ALANINE AMINOTRANSFERASE; CHOLESTEROL LEVELS; COENZYME A; CONJUGATED LINOLEIC ACID; CONJUGATED LINOLEIC ACIDS; FATTY ACID SYNTHASE; FREE FATTY ACID; FREEFORMS; HIGH-FAT-DIET; LIPOGENESIS; LIVER LIPIDS; MALIC ENZYMES; STEROL REGULATORY ELEMENT-BINDING PROTEINS; TRIACYLGLYCEROLS; WHOLE BODY;

AMINO ACIDS; ANIMALS; BODY FLUIDS; GLYCEROL; LINOLEIC ACID; LIVER; NUTRITION; OXIDATION; TISSUE; UNSATURATED FATTY ACIDS;

GENE EXPRESSION;

CONJUGATED LINOLEIC ACID;

ADIPOSE TISSUE; ANIMAL; ARTICLE; C57BL MOUSE; CHEMISTRY; COMPARATIVE STUDY; ESTERIFICATION; FAT INTAKE; HUMAN; LIPID DIET; LIPOGENESIS; LIVER; MALE; METABOLISM; MOUSE; MOUSE MUTANT; OBESITY;

ADIPOSE TISSUE; ANIMALS; DIET, HIGH-FAT; DIETARY FATS; ESTERIFICATION; HUMANS; LINOLEIC ACIDS, CONJUGATED; LIPOGENESIS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY;

ANIMALIA; MUS;

EID: 78149293577     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf102164j     Document Type: Article

References (28)

1. Chin, S. F.; Liu, W.; Storkson, J. M.; Ha, Y. L.; Pariza, M. W. Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens J. Food Compos. Anal. 1992, 5, 185-197
2. Ha, Y. L.; Grimm, N. K.; Pariza, M. W. Newly recognized anticarcinogenic fatty acids: identification and quantification in natural and processed cheeses J. Agric. Food Chem. 1989, 37, 75-81
3. Belury, M. A. Dietary conjugated linoleic acid in health: physiological effects and mechanisms of action Annu. Rev. Nutr. 2002, 22, 505-531
4. Ha, Y. L.; Storkson, J.; Pariza, M. W. Inhibition of benzo(a)pyrene- induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid Cancer Res. 1990, 50, 1097-1101
5. Ntambi, J. M.; Choi, Y.; Park, Y.; Peters, J. M.; Pariza, M. W. Effects of conjugated linoleic acid on immune responses, body composition and stearoyl-CoA desaturase Can. J. Appl. Physiol. 2002, 27, 617-628
6. Clement, L.; Poirier, H.; Niot, I.; Bocher, V.; Guerre-Millo, M.; Krief, S.; Staels, B.; Besnard, P. Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse J. Lipid Res. 2002, 43, 1400-1409
7. Park, Y.; Storkson, J. M.; Albright, K. J.; Liu, W.; Pariza, M. W. Evidence that the trans-10, cis-12 isomer of conjugated linoleic acid induces body composition changes in mice Lipids 1999, 34, 235-241 (Pubitemid 29169626)
8. Kelley, D. S.; Bartolini, G. L.; Warren, J. M.; Simon, V. A.; Mackey, B. E.; Erickson, K. L. Contrasting effects of t10,c12-and c9,t11-conjugated linoleic acid isomers on the fatty acid profiles of mouse liver lipids Lipids 2004, 39, 135-141
9. Ferramosca, A.; Savy, V.; Conte, L.; Colombo, S.; Einerhand, A. W. C.; Zara, V. Conjugated linoleic acid and hepatic lipogenesis in mouse: role of the mitochondrial citrate carrier J. Lipid Res. 2006, 47, 1994-2003
10. Porsgaard, T.; Xu, X.; Mu, H. The form of dietary conjugated linoleic acid does not influence plasma and liver triacylglycerol concentrations in syrian golden hamsters J. Nutr. 2006, 136, 2201-2206
11. Terpstra, A. H. M.; Javadi, M.; Beynen, A. C.; Kocsis, S.; Lankhorst, A. E.; Lemmens, A. G.; Mohede, I. C. M. Dietary conjugated linoleic acids as free fatty acids and triacylglycerols similarly effect body composition and energy balance in mice J. Nutr. 2003, 133, 3181-3186
12. Rahman, S. M.; Wang, Y. M.; Yotsumoto, H.; Cha, J. Y.; Han, S. Y.; Inoue, S.; Yanagita, T. Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and β-oxidation of fatty acid in OLETF rats Nutrition 2001, 17, 385-390
13. Kim, J. H.; Jeong, W. S.; Kim, I. H.; Kim, H. J.; Kim, S. H.; Kang, G. H.; Lee, H. G.; Yoon, H. G.; Ham, H. J.; Kim, Y. J. Effect of an oil by-product from conjugated linoleic acid (CLA) purification on CLA accumulation and lipogenic genes expression in broilers J. Agric. Food Chem. 2009, 57, 2397-2404
14. Murase, T.; Mizuno, T.; Omachi, T.; Onizawa, K.; Komine, Y.; Kondo, H.; Hase, T.; Tokimitsu, I. Dietary diacylglycerol suppresses high fat and high sucrose diet-induced body fat accumulation in C57BL/6J mice J. Lipid. Res. 2001, 42, 372-378
15. Yu, X. X.; Mao, W.; Zhong, A.; Schow, P.; Brush, J.; Sherwood, S. W.; Adams, S. H.; Pan, G. Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation FASEB J. 2000, 14, 1611-1618
16. Kim, S.; Sohn, I.; Ahn, J. I.; Lee, K. H.; Lee, Y. S.; Lee, Y. S. Hepatic gene expression profiles in a long-term high-fat diet-induced obesity mouse model Gene 2004, 340, 99-109
17. Ide, T. Interaction of fish oil and conjugated linoleic acid in affecting hepatic activity of lipogenic enzymes and gene expression in liver and adipose tissue Diabetes 2005, 54, 412-423
18. db mice J. Oleo Sci. 2001, 50, 883-888
19. Macarulla, M. T.; Fernandez-Quintela, A.; Zabala, A.; Navarro, V.; Echevarria, E.; Churruca, I.; Rodriguez, V. M.; Portillo, M. P. Effects of conjugated linoleic acid on liver composition and fatty acid oxidation are isomer-dependent in hamster Nutrition 2005, 21, 512-519
20. Takahashi, Y.; Kushiro, M.; Shinohara, K.; Ide, T. Activity and mRNA levels of enzymes involved in hepatic fatty acid synthesis and oxidation in mice fed conjugated linoleic acid Biochim. Biophys. Acta 2003, 1631, 265-273
21. Gregoire, F. M.; Zhang, Q.; Smith, S. J.; Tong, C.; Ross, D.; Lopez, H.; West, D. B. Diet-induce obesity and hepatic gene expression alterations in C57BL/6J and ICAM-1-deficient mice Am. J. Physiol. Endocrinol. Metabol. 2002, 282, E703-E713
22. Innis, S.; Dyer, R.; Lien, E. Formula containing randomized fats with palmitic acid (16:0) in the 2-position increases 16:0 in the 2-position of the plasma and chylomicron triglycerides in formula-fed piglets to levels approaching those of piglets fed sow's milk J. Nutr. 1997, 127, 1362-1370
23. Lien, E. L.; Boyle, F. G.; Yumhas, R.; Tomarelli, R. M.; Quilan, P. The effect of triglyceride positional distribution on fatty acid absorption in rats J. Pediatr. Gastroenterol. Nutr. 1997, 25, 167-174
24. Fernie, C. E.; Dupont, I. E.; Scruel, O.; Carpentier, Y. A.; Sebedio, J. L.; Scrimgeour, C. M. Relative absorption of conjugated linoleic acid as triacyglycerol, free fatty acid and ethyl ester in a functional food matrix Eur. J. Lipid Sci. Technol. 2004, 106, 347-354
25. Kim, J. H.; Choi, N.-J.; Park, H. G.; Kim, I. H.; Lee, H. G.; Song, M. K.; Whang, K. Y.; Kim, Y. J. Utilization of oil by-product from the purification process of conjugated linoleic acid as feeding supplements for the accumulation of conjugated linoleic acid in the egg yolk Poult. Sci. 2008, 87, 64-70
26. DeLany, J. P.; West, D. B. Changes in body composition with conjugated linoleic acid J. Am. Col. Nutr. 2000, 19, 487S-493S
27. Ribot, J.; Portillo, M. P.; Picó, C.; Macarulla, M. T.; Palou, A. Effects of trans-10, cis-12 conjugated linoleic acid on the expression of uncoupling proteins in hamsters fed an atherogenic diet Br. J. Nutr. 2007, 97, 1074-1082
28. Reeves, P. G.; Nielsen, F. H.; Fahey, G. C. AIN-93 purified diet for laboratory rodents; final reports for the American Institute of Nutrition ad hoc writing committee on the reformation of the AIN-73A rodent diet J. Nutr. 1993, 123, 1939-1951