Gα 12/13 induction of CYR61 in association with arteriosclerotic intimal hyperplasia: Effect of sphingosine-1-phosphate

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 31, Issue 4, 2011, Pages 861-869

  Kim, Young Mi ^a,b   Lim, Sung Chul ^c   Han, Chang Yeob ^a   Kay, Hee Yeon ^a,b   Cho, Il Je ^a   Ki, Sung Hwan ^a   Lee, Moo Yeol ^d   Kwon, Hyuck Moon ^e   Lee, Chang Ho ^f   Kim, Sang Geon ^a,b  

^a Research Institute of Pharmaceutical Sciences   (South Korea)

^b Seoul National University   (South Korea)

^c Chosun University   (South Korea)

^d Chonnam National University   (South Korea)

^e Yonsei University College of Medicine   (South Korea)

^f Hanyang University   (South Korea)

Author keywords

atherosclerosis; cysteine rich protein 61; G proteins; G 12 13; oncogenes; signal transduction; sphingosine 1 phosphate; vascular biology; vascular smooth muscle cell

Indexed keywords

ACETYLCYSTEINE; CYSTEINE RICH PROTEIN 61; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; MITOGEN ACTIVATED PROTEIN KINASE 10; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SPHINGOSINE 1 PHOSPHATE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR JUND;

ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; FEMORAL ARTERY; GENE SILENCING; MALE; NEOINTIMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRANSACTIVATION; UPREGULATION;

AGED; ANIMALS; ARTERIOSCLEROSIS; CELL MOVEMENT; CYSTEINE-RICH PROTEIN 61; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; HEK293 CELLS; HUMANS; HYPERPLASIA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LYSOPHOSPHOLIPIDS; MALE; MICE; MICE, INBRED ICR; MICE, KNOCKOUT; MIDDLE AGED; MUSCLE, SMOOTH, VASCULAR; MUTATION; NADPH OXIDASE; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SPHINGOSINE; TRANSCRIPTION FACTOR AP-1; TRANSFECTION; TUNICA INTIMA; UP-REGULATION;

EID: 79953761982     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.110.218552     Document Type: Article

References (37)

1. Ross JS, Stagliano NE, Donovan MJ, Breitbart RE, Ginsburg GS. Atherosclerosis: a cancer of the blood vessels? Am J Clin Pathol. 2001; 116(suppl):S97-S107.
2. Ramos KS, Partridge CR. Atherosclerosis and cancer: flip sides of the neoplastic response in mammalian cells? Cardiovasc Toxicol. 2005;5: 245-255. (Pubitemid 41506866)
3. Isner JM. Cancer and atherosclerosis: the broad mandate of angiogenesis. Circulation. 1999;99:1653-1655. (Pubitemid 29162474)
4. Hager M, Mikuz G, Haufe H, Kolbitsch C, Moser KB, Moser PL. Association between atherosclerosis and urothelial tumors of the renal pelvis. World J Urol. 2008;26:375-379.
5. Hager M, Mikuz G, Bartsch G, Kolbitsch C, Moser PL. The association between local atherosclerosis and prostate cancer. BJU Int. 2007;99: 46-48. (Pubitemid 44915617)
6. Nguyen N, Kuliopulos A, Graham RA, Covic L. Tumor-derived Cyr61 (CCN1) promotes stromal matrix metalloproteinase-1 production and protease-activated receptor 1-dependent migration of breast cancer cells. Cancer Res. 2006;66:2658-2665.
7. Mo FE, Muntean AG, Chen CC, Stolz DB, Watkins SC, Lau LF. CYR61 (CCN1) is essential for placental development and vascular integrity. Mol Cell Biol. 2002;22:8709-8720. (Pubitemid 35397184)
8. Kireeva ML, MO FE, Yang GP, Lau LF. Cyr61, a product of a growth factor-inducible immediate-early gene, promotes cell proliferation, migration, and adhesion. Mol Cell Biol. 1996;16:1326-1334. (Pubitemid 26095602)
9. Bai T, Chen CC, Lau LF. Matricellular protein CCN1 activates a proinflammatory genetic program in murine macrophages. J Immunol. 2010; 184:3223-3232.
10. Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA. Expression cDNA cloning of a transforming gene encoding the wild-type G12 gene product. Mol Cell Biol. 1993;13:762-768. (Pubitemid 23040240)
11. Kelly P, Stemmle LN, Madden JF, Fields TA, Daaka Y, Casey PJ. A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion. J Biol Chem. 2006;281:26483-26490. (Pubitemid 44401857)
12. Liu SC, Jen YM, Jiang SS, Chang JL, Hsiung CA, Wang CH, Juang JL. G 12-mediated pathway promotes invasiveness of nasopharyngeal carcinoma by modulating actin cytoskeleton reorganization. Cancer Res. 2009;69:6122-6130.
13. Grzelinski M, Pinkenburg O, Büch T, Gold M, Stohr S, Kalwa H, Gudermann T, Aigner A. Critical role of G 12 and G 13 for human small cell lung cancer cell proliferation in vitro and tumor growth in vivo. Clin Cancer Res. 2010;16:1402-1415.
14. Gu JL, Muller S, Mancino V, Offermanns S, Simon MI. Interaction of Ga12 with Ga13 and Gaq signaling pathways. Proc Natl Acad Sci USA. 2002;99:9352-9357.
15. Offermanns S, Mancino V, Revel JP, Simon MI. Vascular system defects and impaired cell chemokinesis as a result of G 13 deficiency. Science. 1997;275:533-536. (Pubitemid 27051909)
16. Offermanns S, Laugwitz KL, Spicher K, Schultz G. G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets. Proc Natl Acad Sci USA. 1994;91:504-508.
17. Gohla A, Harhammer R, Schultz G. The G-protein G13 but not G12 mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho. J Biol Chem. 1998;273:4653-4659. (Pubitemid 28103211)
18. Spiegel S, Milstien S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol. 2003;4:397-407. (Pubitemid 36565571)
19. Lee MY, San Martin A, Mehta PK, Dikalova AE, Garrido AM, Datla SR, Lyons E, Krause KH, Banfi B, Lambeth JD, Lassègue B, Griendling KK. Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation. Arterioscler Thromb Vasc Biol. 2009;29:480-487.
20. Vogt S, Grosse R, Schultz G, Offermanns S. Receptor-dependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11. J Biol Chem. 2003;278:28743-28749. (Pubitemid 36935782)
21. Bartholin L, Wessner LL, Chirgwin JM, Guise TA. The human Cyr61 gene is a transcriptional target of transforming growth factor in cancer cells. Cancer Lett. 2007;246:230-236. (Pubitemid 44970515)
22. Lassègue B, Sorescu D, Szöcs K, Yin Q, Akers M, Zhang Y, Grant SL, Lambeth JD, Griendling KK. Novel gp91(phox) homologues in vascular smooth muscle cells: nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Circ Res. 2001;88: 888-894. (Pubitemid 32441466)
23. Lee SJ, Yang JW, Cho IJ, Kim WD, Cho MK, Lee CH, Kim SG. The gep oncogenes, G 12 and G 13, upregulate the transforming growth factor-β1 gene. Oncogene. 2009;28:1230-1240.
24. Latinkic BV, O'Brien TP, Lau LF. Promoter function and structure of the growth factor-inducible immediate early gene cyr61. Nucleic Acids Res. 1991;19:3261-3267. (Pubitemid 21912679)
25. Kim KH, Min YK, Baik JH, Lau LF, Chaqour B, Chung KC. Expression of angiogenic factor Cyr61 during neuronal cell death via the activation of c-Jun N-terminal kinase and serum response factor. J Biol Chem. 2003;278:13847-13854. (Pubitemid 36799923)
26. Wamhoff BR, Lynch KR, Macdonald TL, Owens GK. Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol. 2008;28:1454-1461.
27. Lee SJ, Lee WH, Ki SH, Kim YM, Lee SJ, Lee CH, Kim SG. G 13 regulates methacholine-induced contraction of bronchial smooth muscle via phosphorylation of MLC20. Biochem Pharmacol. 2009;77: 1497-1505.
28. Tsai MS, Bogart DF, Castaneda JM, Li P, Lupu R. Cyr61 promotes breast tumorigenesis and cancer progression. Oncogene. 2002;21:8178-8185. (Pubitemid 35454421)
29. Hilfiker A, Hilfiker-Kleiner D, Fuchs M, Kaminski K, Lichtenberg A, Rothkö tter HJ, Schieffer B, Drexler H. Expression of CYR61, an angiogenic immediate early gene, in arteriosclerosis and its regulation by angiotensin II. Circulation. 2002;106:254-260. (Pubitemid 34761308)
30. Matsumae H, Yoshida Y, Ono K, Togi K, Inoue K, Furukawa Y, Nakashima Y, Kojima Y, Nobuyoshi M, Kita T, Tanaka M. CCN1 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model. Arterioscler Thromb Vasc Biol. 2008;28:1077-1083.
31. French KJ, Schrecengost RS, Lee BD, Zhuang Y, Smith SN, Eberly JL, Yun JK, Smith CD. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003;63:5962-5969. (Pubitemid 37187498)
32. Daum G, Grabski A, Reidy MA. Sphingosine 1-phosphate: a regulator of arterial lesions. Arterioscler Thromb Vasc Biol. 2009;29: 1439-1443.
33. Clempus RE, Griendling KK. Reactive oxygen species signaling in vascular smooth muscle cells. Cardiovasc Res. 2006;71:216-225.
34. Cevik MO, Katsuyama M, Kanda S, Kaneko T, Iwata K, Ibi M, Matsuno K, Kakehi T, Cui W, Sasaki M, Yabe-Nishimura C. The AP-1 site is essential for the promoter activity of NOX1/NADPH oxidase, a vascular superoxide-producing enzyme: possible involvement of the ERK1/ 2-JunB pathway. Biochem Biophys Res Commun. 2008;374:351-355.
35. Han JS, Macarak E, Rosenbloom J, Chung KC, Chaqour B. Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways. Eur J Biochem. 2003;270:3408-3421. (Pubitemid 37011633)
36. Kunz M, Moeller S, Koczan D, Lorenz P, Wenger RH, Glocker MO, Thiesen HJ, Gross G, Ibrahim SM. Mechanisms of hypoxic gene regulation of angiogenesis factor Cyr61 in melanoma cells. J Biol Chem. 2003;278:45651-45660. (Pubitemid 37432707)
37. Fromm C, Coso OA, Montaner S, Xu N, Gutkind JS. The small GTPbinding protein Rho links G protein-coupled receptors and G 12 to the serum response element and to cellular transformation. Proc Natl Acad Sci USA. 1997;94:10098-10103.