Slow absorption of conjugated linoleic acid in rat intestines, and similar absorption rates of 9c,11t-conjugated linoleic acid and 10t,12c-conjugated linoleic acid

Bioscience, Biotechnology and Biochemistry

Volumn 71, Issue 8, 2007, Pages 2034-2040

  Tsuzuki, Tsuyoshi ^a   Ikeda, Ikuo ^b  

^a MIYAGI UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Absorption; Conjugated fatty acid; Conjugated linoleic acid; Linoleic acid; Lymph

Indexed keywords

CONJUGATED FATTY ACIDS; CONJUGATED LINOLEIC ACID (CLA); LINOLEIC ACID; LYMPH;

ABSORPTION; CHEMICAL BONDS; FATTY ACIDS; ISOMERS; RATS; VEGETABLE OILS;

BIOLOGICAL ORGANS;

10,12 OCTADECADIENOIC ACID; 10,12-OCTADECADIENOIC ACID; 9,11 LINOLEIC ACID; 9,11-LINOLEIC ACID; CONJUGATED LINOLEIC ACID; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; INTESTINE ABSORPTION; KINETICS; LYMPH; METABOLISM; RAT; THORACIC DUCT;

ANIMALS; INTESTINAL ABSORPTION; KINETICS; LINOLEIC ACIDS, CONJUGATED; LYMPH; RATS; THORACIC DUCT;

CARTHAMUS TINCTORIUS; MUS; RATTUS;

EID: 36148934111     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.70238     Document Type: Article

References (29)

1. Ha, Y. L., Grimm, N. K., and Pariza, M. W., Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid. Carcinogenesis, 8, 1881-1887 (1987).
2. Lee, K. N., Kritchevsky, D., and Pariza, M. W., Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis, 108, 19-25 (1994).
3. Park, Y., Albright, K. J., Storkson, J. M., Liu, W., Cook, M. E., and Pariza, M. W., Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids, 34, 243-248 (1999).
4. Ip, C., Chin, S. F., Scimeca, J. A., and Pariza, M. W., Mammary tumor prevention by conjugated dienoic derivative of linoleic acid. Cancer Res., 51, 6118-6124 (1991).
5. Igarashi, M., and Miyazawa, T., The growth inhibitory effect of conjugated linoleic acid on a human hepatoma cell line, HepG2, is induced by a change in fatty acid metabolism, but not the facilitation of lipid peroxidation in the cells. Biochim. Biophys. Acta, 1530, 162-171 (2001).
6. Larsen, T. M., Toubro, S., and Astrup, A., Efficacy and safety of dietary supplements containing CLA for the treatment of obesity: evidence from animal and human studies. J. Lipid Res., 44, 2234-2241 (2003).
7. Gaullier, J. M., Halse, J., Hoye, K., Kristiansen, K., Fagertun, H., Vik, H., and Gudmundsen, O., Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. J. Nutr., 135, 778-784 (2005).
8. Hopkins, C. Y., Fatty acids with conjugated unsaturation. In "Topics in Lipid Chemistry," ed. Gunstone, F. D., ELEK Science, London, pp. 37-87 (1972).
9. Badami, R. C., and Patil, K. B., Structure and occurrence of unusual fatty acids in minor seed oils. Prog. Lipid Res., 19, 119-153 (1981).
10. Lopez, A., and Gerwick, W. H., Two new icosapentaeinoic acids from the temperate red seaweed Ptilota filicina. J. Agardh. Lipids, 22, 190-194 (1987).
11. Burgess, J. R., de la Rosa, R. I., Jacobs, R. S., and Butler, A., A new eicosapentaenoic acid formed from arachidonic acid in the coralline red algae Bossiella orbigniana. Lipids, 26, 162-165 (1991).
12. Mikhailova, M. V., Bemis, D. L., Wise, M. L., Gerwick, W. H., Norris, J. N., and Jacobs, R. S., Structure and biosynthesis of novel conjugated polyene fatty acids from the marine green alga Anadyomene stellate. Lipids, 30, 583-589 (1995).
13. Tsuzuki, T., Tokuyama, Y., Igarashi, M., and Miyazawa, T., Tumor growth suppression by α-eleostearic acid, a linolenic acid isomer with a conjugated triene system, via lipid peroxidation. Carcinogenesis, 25, 1417-1425 (2004).
14. Tsuzuki, T., Igarashi, M., and Miyazawa, T., Conjugated eicosapentanoic acid inhibits transplanted tumor growth via membrane lipid peroxidation in nude mice. J. Nutr., 134, 1162-1166 (2004).
15. Tsuzuki, T., Tanaka, K., Kuwahara, S., and Miyazawa, T., Synthesis of the conjugated trienes 5E,7E,9E,14Z, 17Z-eicosapentaenoic acid and 5Z,7E,9E,14Z, 17Z-eicosapentaenoic acid, and their induction of apoptosis in DLD-1 colorectal adenocarcinoma human cells. Lipids, 40, 147-154 (2005).
16. Tsuzuki, T., Kambe, T., Shibata, A., Kawakami, Y., Nakagawa, K., and Miyazawa, T., Conjugated EPA activates mutant p53 via lipid peroxidation and induces p53-dependent apoptosis in DLD-1 colorectal adenocarcinoma human cells. Biochim. Biophys. Acta, 1771, 20-30 (2007).
17. Tsuzuki, T., Igarashi, M., Komai, M., and Miyazawa, T., A metabolic conversion of 9, 11, 13-eleostearic acid (18:3) to 9, 11-conjugated linoleic acid (18:2) in the rat. J. Nutr. Sci. Vitaminol., 49, 195-200 (2003).
18. Sugano, M., Tsujita, A., Yamasaki, M., Yamada, K., Ikeda, I., and Kritchevsky, D., Lymphatic recovery, tissue distribution, and metabolic effects of conjugated linoleic acid in rats. J. Nutr. Biochem., 8, 38-43 (1997).
19. Martin, J. C., Sebedio, J. L., Caselli, C., Pimont, C., Martine, L., and Bernard, A., Lymphatic delivery and in vitro pancreatic lipase hydrolysis of glycerol esters of conjugated linoleic acids in rats. J. Nutr., 130, 1108-1114 (2000).
20. Tsuzuki, T., Kawakami, Y., Abe, R., Nakagawa, K., Koba, K., Imamura, J., Iwata, T., Ikeda, I., and Miyazawa, T., Conjugated linolenic acid is slowly absorbed in rat intestine, but quickly converted to conjugated linoleic acid. J. Nutr., 136, 2153-2159 (2006).
21. Igarashi, M., Tsuzuki, T., Kambe, T., and Miyazawa, T., Recommended methods of fatty acid methylester preparation for conjugated dienes and trienes in food and biological samples. J. Nutr. Sci. Vitaminol., 50, 121-128 (2004).
22. Tsuzuki, T., Igarashi, M., Iwata, T., Yamauchi-Sato, Y., Yamamoto, T., Ogita, K., Suzuki, T., and Miyazawa, T., Oxidation rate of conjugated linoleic acid and conjugated linolenic acid is slowed by triacylglycerol esterification and α-tocopherol. Lipids, 39, 475-480 (2004).
23. Folch, J., Lees, M., and Sloane-Stanley, G. H., A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem., 226, 497-509 (1957).
24. Tsuzuki, T., Tokuyama, Y., Igarashi, M., Nakagawa, K., Ohsaki, Y., Komai, M., and Miyazawa, T., α-Eleostearic acid (9Z11E13E-18:3) is quickly converted to conjugated linoleic acid (9Z11E-18:2) in rats. J. Nutr., 134, 2634-2639 (2004).
25. Pariza, M. W., Park, Y., and Cook, M. E., The biologically active isomers of conjugated linoleic acid. Prog. Lipid Res., 40, 283-298 (2001).
26. Evans, M. E., Brown, J. M., and McIntosh, M. K., Isomer-specific effects of conjugated linoleic acid (CLA) on adiposity and lipid metabolism. J. Nutr. Biochem., 13, 508-516 (2002).
27. Nagao, K., Wang, Y. M., Inoue, N., Han, S. Y., Buang, Y., Noda, T., Kouda, N., Okamatsu, H., and Yanagita, T., The 10 trans, 12 cis isomer of conjugated linoleic acid promotes energy metabolism in OLETF rats. Nutrition, 19, 652-656 (2003).
28. Masso-Welch, P. A., Zangani, D., Ip, C., Vaughan, M. M., Shoemaker, S. F., McGee, S. O., and Ip, M. M., Isomers of conjugated linoleic acid differ in their effects on angiogenesis and survival of mouse mammary adipose vasculature. J. Nutr., 134, 299-307 (2004).
29. Hargrave, K. M., Azain, M. J., and Miner, J. L., Dietary coconut oil increases conjugated linoleic acid-induced body fat loss in mice independent of essential fatty acid deficiency. Biochim. Biophys. Acta, 1737, 52-60 (2005).