Conjugated linoleic acid depresses the Δ9 desaturase index and stearoyl coenzyme A desaturase enzyme activity in porcine subcutaneous adipose tissue

Journal of Animal Science

Volumn 80, Issue 8, 2002, Pages 2110-2115

  Smith, S B ^a,c   Hively, T S ^a   Cortese, G M ^a   Han, J J ^a   Chung, K Y ^a   Castenada P ^a   Gilbert, C D ^a   Adams, V L ^a   Mersmann, H J ^b  

^a TEXAS A AND M UNIVERSITY   (United States)

^b CHILDREN S NUTRITION RESEARCH CENTER   (United States)

^c 2471 TAMU   (United States)

Author keywords

Acyl CoA Desaturase; Conjugated Dienes; Fatty Acids; Piglets

Indexed keywords

RODENTIA; SUIDAE; SUS SCROFA; ZEA MAYS;

ACYL COENZYME A DESATURASE; CORN OIL; FAT; FATTY ACID; LINOLEIC ACID;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL; ANIMAL FOOD; ARTICLE; CHEMISTRY; ENZYMOLOGY; FAT INTAKE; MALE; METABOLISM; RANDOMIZATION; SWINE; TALLOW;

ADIPOCYTES; ADIPOSE TISSUE; ANIMAL FEED; ANIMALS; CORN OIL; DIETARY FATS; FATS; FATTY ACIDS; LINOLEIC ACID; MALE; RANDOM ALLOCATION; STEAROYL-COA DESATURASE; SWINE;

EID: 0036688332     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.1093/ansci/80.8.2110     Document Type: Article

References (28)

1. Azain, M. J., D. B. Hausman, M. B. Sisk, W. P. Flatt, and D. E. Jewell. 2000. Dietary conjugated linoleic acid reduces rat adipose cell size rather than cell number. J. Nutr. 130:1548-1554.
2. Choi, Y., Y. C. Kim, Y. B. Han, Y. Park, M. W. Pariza, and J. M. Ntambi. 2000. The trans-10,cis-12 isomer of conjugated linoleic acid downregulates stearoyl-CoA desaturase 1 gene expression in 3T3-L1 adipocytes. J. Nutr. 130:1920-1924.
3. Choi, Y., Y. Park, M. W. Pariza, and J. M. Ntambi. 2001. Regulation of stearoyl-CoA desaturase activity by the trans-10,cis-12 isomer of conjugated linoleic acid. Biochem. Biophys. Res. Commun. 284:689-693.
4. 9-desaturase in the production of cis-9, trans-11 CLA. J. Nutr. Biochem. 12:622-630.
5. Etherton, T. D., E. H. Thompson, and C. E. Allen. 1977. Improved techniques for studies of cellularity and metabolism. J. Lipid Res. 18:552-557.
6. Folch, J., M. Lees, and G. H. S. Stanley. 1957. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226:497-509.
7. 9- desaturase activity in rat liver microsomes. Biochim. Biophys. Acta 962:330-336.
8. Joo, S. T., J. I. Lee, Y. L. Ha, and G. B. Park. 2002. Effects of dietary conjugated linoleic acid on fatty acid composition, lipid oxidation, color, and water-holding capacity of pork loin. J. Anim. Sci. 80:108-112.
9. Klingenberg, I. L., D. A. Knabe, and S. B. Smith. 1995. Lipid metabolism in pigs fed tallow or high-oleic acid sunflower oil. Comp. Biochem. Physiol. 110B:183-192.
10. Lee, K. N., M. W. Pariza, and J. M. Ntambi. 1998. Conjugated linoleic acid decreases hepatic stearoyl-CoA desaturase mRNA expression. Biochem. Biophys. Res. Commun. 248:817-821.
11. Martin, G. S., D. K. Lunt, K. G. Britain, and S. B. Smith. 1999. Postnatal development of stearoyl coenzyme A desaturase gene expression and adiposity in bovine subcutaneous adipose tissue. J. Anim. Sci. 77:630-636.
12. Mir, Z, M. L. Rushfeldt, P. S. Mir, L. J. Paterson, and R. J. Weselake. 2000. Effect of dietary supplementation with either conjugated linoleic acid (CLA) or linoleic acid rich oil on the CLA content of lamb tissues. Small Ruminant Res. 36:25-31.
13. Morrison, W. R., and L. M. Smith. 1964. Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol. J. Lipid Res. 5:600-607.
14. Ntambi, J. M., S. A. Buhrow, K. H. Kaestner, R. J. Christy, E. Sibley, Y. J. Kelly, and M. D. Lane. 1988. Differentiation-induced gene expression in 3T3-L1 preadipocytes. J. Biol. Chem. 263:17291-17300.
15. Pariza, M. W., Y. Park, and M. E. Cook. 2001. The biologically active isomers of conjugated linoleic acid. Prog. Lipid Res. 40:283-298.
16. Pariza, M. W., Y. Park, S. Kim, K. Sugimoto, K. Albright, W.-Liu, J. Storkson, and M. E. Cook. 1997. Mechanism of body fat reduction by conjugated linoleic acid. FASEB J. 11:A139 (Abstr.).
17. Park, Y., J. M. Storkson, J. M. Ntambi, M. E. Cook, C. J. Sih, and M. W. Pariza. 2000. Inhibition of hepatic stearoyl-CoA desaturase activity by trans-10,cis-12 conjugated linoleic acid and its derivatives. Biochem. Biophys. Acta 1486:285-292.
18. Periago, J. L. M. L. Pita, M. A. Sanchez del Castillo, G. Caamano, and M. D. Suarez. 1989. Changes in lipid composition of liver microsomes and fatty acyl-CoA desaturase activities induced by medium chain triglyceride feeding. Lipids 24:383-388.
19. Poulos, S. P., M. Sisk, D. B. Hausman, M. J. Azain, and G. J. Hausman. 2001. Pre- postnatal dietary conjugated linoleic acid alters adipose tissue development, body weight gain and body composition in Sprague-Dawley rats. J. Nutr. 131:2722-2731.
20. Prior, R. L. 1983. Lipogenesis and adipose tissue cellularity in steers switched from alfalfa hay to high concentrate diets. J. Anim. Sci. 56:483-489.
21. Ramsay, T. G., C. M. Evock-Clover, N. C. Steele, and M. J. Azain. 2001. Dietary conjugated linoleic acid alters fatty acid composition of pig skeletal muscle and fat. J. Anim. Sci. 79:2152-2161.
22. Satory, D. L., and S. B. Smith. 1999. Conjugated linoleic acid inhibits proliferation but stimulates lipid filling of murine 3T3-L1 preadipocytes. J. Nutr. 129:92-97.
23. Sisk, M. B., D. B. Hausman, R. J. Martin, and M. J. Azain. 2001. Dietary conjugated linoleic acid reduces adiposity in lean but not obese Zucker rats. J. Nutr. 131:1668-1674.
24. Smith, S. B., H. J. Mersmann, E. O. Smith, and K. G. Britain. 1999. Stearoyl-coenzyme A desaturase gene expression during growth in adipose tissue from obese and crossbred pigs. J. Anim. Sci. 77:1710-1716.
25. St. John, L. C., D. K. Lunt, and S. B. Smith. 1991. Fatty acid elongation and desaturation enzyme activities of bovine lives and subcutaneous adipose tissue microsomes. J. Anim. Sci. 69:1064-1073.
26. Sturdivant, C. A., D. K. Lunt, G. C. Smith, and S. B. Smith. 1992. Fatty acid composition of subcutaneous and intramuscular adipose tissues and M. longissimus dori of Wagyu cattle. Meat Sci. 32:449-458.
27. Wiegand, B. R., F. C. Parrish, Jr., J. E. Swan, S. T. Larsen, and T. J. Baas. 2001. Conjugated linoleic acid improves feed efficiency, decreases subcutaneous fat, and improves certain aspects of meat quality in Stress-Genotype pigs. J. Anim. Sci. 79:2187-2196.
28. Wiegand, B. R., J. C. Sparks, F. C. Parrish, Jr., and D. R. Zimmerman. 2002. Duration of feeding conjugated linoleic acid influences growth performance, carcass traits, and meat quality of finishing barrows. J. Anim. Sci. 80:637-643.