메뉴 건너뛰기




Volumn 353, Issue 1, 2011, Pages 1-9

Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin

Author keywords

Aging; Epithelial stem cell; Mdm2; P53

Indexed keywords

PROTEIN MDM2; PROTEIN P53;

EID: 79953747376     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2011.02.007     Document Type: Article
Times cited : (69)

References (44)
  • 2
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
    • Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 2005, 120(4):513-522.
    • (2005) Cell , vol.120 , Issue.4 , pp. 513-522
    • Campisi, J.1
  • 3
    • 0029171789 scopus 로고
    • Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene
    • Chen J., Lin J., Levine A.J. Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene. Mol. Med. 1995, 1(2):142-152.
    • (1995) Mol. Med. , vol.1 , Issue.2 , pp. 142-152
    • Chen, J.1    Lin, J.2    Levine, A.J.3
  • 5
    • 0031724593 scopus 로고    scopus 로고
    • Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
    • Freedman D.A., Levine A.J. Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6. Mol. Cell. Biol. 1998, 18(12):7288-7293.
    • (1998) Mol. Cell. Biol. , vol.18 , Issue.12 , pp. 7288-7293
    • Freedman, D.A.1    Levine, A.J.2
  • 6
    • 63349092825 scopus 로고    scopus 로고
    • A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres
    • Flores I., Blasco M.A. A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres. PLoS ONE 2009, 4(3):e4934.
    • (2009) PLoS ONE , vol.4 , Issue.3
    • Flores, I.1    Blasco, M.A.2
  • 8
    • 23844535164 scopus 로고    scopus 로고
    • Complicating the role of p53 in aging
    • Gentry A., Venkatachalam S. Complicating the role of p53 in aging. Aging Cell 2005, 4(3):157-160.
    • (2005) Aging Cell , vol.4 , Issue.3 , pp. 157-160
    • Gentry, A.1    Venkatachalam, S.2
  • 9
    • 0034282220 scopus 로고    scopus 로고
    • The MDM2 RING-finger domain is required to promote p53 nuclear export
    • Geyer R.K., Yu Z.K., Maki C.G. The MDM2 RING-finger domain is required to promote p53 nuclear export. Nat. Cell Biol. 2000, 2(9):569-573.
    • (2000) Nat. Cell Biol. , vol.2 , Issue.9 , pp. 569-573
    • Geyer, R.K.1    Yu, Z.K.2    Maki, C.G.3
  • 12
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt Y., Maya R., Kazaz A., Oren M. Mdm2 promotes the rapid degradation of p53. Nature 1997, 387(6630):296-299.
    • (1997) Nature , vol.387 , Issue.6630 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 13
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • Honda R., Tanaka H., Yasuda H. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 1997, 420(1):25-27.
    • (1997) FEBS Lett. , vol.420 , Issue.1 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 14
    • 35148847384 scopus 로고    scopus 로고
    • Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation
    • Itahana K., Mao H., Jin A., Itahana Y., Clegg H.V., Lindstrom M.S., Bhat K.P., Godfrey V.L., Evan G.I., Zhang Y. Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell 2007, 12:355-366.
    • (2007) Cancer Cell , vol.12 , pp. 355-366
    • Itahana, K.1    Mao, H.2    Jin, A.3    Itahana, Y.4    Clegg, H.V.5    Lindstrom, M.S.6    Bhat, K.P.7    Godfrey, V.L.8    Evan, G.I.9    Zhang, Y.10
  • 15
    • 0036182866 scopus 로고    scopus 로고
    • Molecular mechanisms of skin ageing
    • Jenkins G. Molecular mechanisms of skin ageing. Mech. Ageing Dev. 2002, 123(7):801-810.
    • (2002) Mech. Ageing Dev. , vol.123 , Issue.7 , pp. 801-810
    • Jenkins, G.1
  • 16
    • 0028834902 scopus 로고
    • Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
    • Jones S.N., Roe A.E., Donehower L.A., Bradley A. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 1995, 378(6553):206-208.
    • (1995) Nature , vol.378 , Issue.6553 , pp. 206-208
    • Jones, S.N.1    Roe, A.E.2    Donehower, L.A.3    Bradley, A.4
  • 17
    • 0028168643 scopus 로고
    • P53-deficient mice are extremely susceptible to radiation-induced tumorigenesis
    • Kemp C.J., Wheldon T., Balmain A. p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis. Nat. Genet. 1994, 8(1):66-69.
    • (1994) Nat. Genet. , vol.8 , Issue.1 , pp. 66-69
    • Kemp, C.J.1    Wheldon, T.2    Balmain, A.3
  • 18
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by Mdm2
    • Kubbutat M.H., Jones S.N., Vousden K.H. Regulation of p53 stability by Mdm2. Nature 1997, 387(6630):299-303.
    • (1997) Nature , vol.387 , Issue.6630 , pp. 299-303
    • Kubbutat, M.H.1    Jones, S.N.2    Vousden, K.H.3
  • 20
    • 0348134742 scopus 로고    scopus 로고
    • Mono- versus polyubiquitination: differential control of p53 fate by Mdm2
    • Li M., Brooks C.L., Wu-Baer F., Chen D., Baer R., Gu W. Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science 2003, 302(5652):1972-1975.
    • (2003) Science , vol.302 , Issue.5652 , pp. 1972-1975
    • Li, M.1    Brooks, C.L.2    Wu-Baer, F.3    Chen, D.4    Baer, R.5    Gu, W.6
  • 21
    • 0035958574 scopus 로고    scopus 로고
    • Hdmx and Mdm2 can repress transcription activation by p53 but not by p63
    • Little N.A., Jochemsen A.G. Hdmx and Mdm2 can repress transcription activation by p53 but not by p63. Oncogene 2001, 20(33):4576-4580.
    • (2001) Oncogene , vol.20 , Issue.33 , pp. 4576-4580
    • Little, N.A.1    Jochemsen, A.G.2
  • 22
    • 0242658564 scopus 로고    scopus 로고
    • Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge
    • Liu Y., Lyle S., Yang Z., Cotsarelis G. Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge. J. Invest. Dermatol. 2003, 121(5):963-968.
    • (2003) J. Invest. Dermatol. , vol.121 , Issue.5 , pp. 963-968
    • Liu, Y.1    Lyle, S.2    Yang, Z.3    Cotsarelis, G.4
  • 24
    • 33845611951 scopus 로고    scopus 로고
    • Modeling the therapeutic efficacy of p53 restoration in tumors
    • Martins C.P., Brown-Swigart L., Evan G.I. Modeling the therapeutic efficacy of p53 restoration in tumors. Cell 2006, 127(7):1323-1334.
    • (2006) Cell , vol.127 , Issue.7 , pp. 1323-1334
    • Martins, C.P.1    Brown-Swigart, L.2    Evan, G.I.3
  • 26
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand J., Zambetti G.P., Olson D.C., George D., Levine A.J. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992, 69(7):1237-1245.
    • (1992) Cell , vol.69 , Issue.7 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 27
    • 0028823020 scopus 로고
    • Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
    • Montes de Oca Luna R., Wagner D.S., Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 1995, 378(6553):203-206.
    • (1995) Nature , vol.378 , Issue.6553 , pp. 203-206
    • Montes de Oca Luna, R.1    Wagner, D.S.2    Lozano, G.3
  • 28
    • 0032913444 scopus 로고    scopus 로고
    • Highly persistent label-retaining cells in the hair follicles of mice and their fate following induction of anagen
    • Morris R.J., Potten C.S. Highly persistent label-retaining cells in the hair follicles of mice and their fate following induction of anagen. J. Invest. Dermatol. 1999, 112(4):470-475.
    • (1999) J. Invest. Dermatol. , vol.112 , Issue.4 , pp. 470-475
    • Morris, R.J.1    Potten, C.S.2
  • 29
    • 59749096851 scopus 로고    scopus 로고
    • Isolation and culture of epithelial stem cells
    • Humana Press, J. Audet, W.L. Stanford (Eds.)
    • Nowak J.A., Fuchs E. Isolation and culture of epithelial stem cells. Stem Cells in Regenerative Medicine: Methods and Protocols 2009, 482:215-232. Humana Press. J. Audet, W.L. Stanford (Eds.).
    • (2009) Stem Cells in Regenerative Medicine: Methods and Protocols , vol.482 , pp. 215-232
    • Nowak, J.A.1    Fuchs, E.2
  • 30
    • 30944435091 scopus 로고    scopus 로고
    • Unleashing the power of p53: lessons from mice and men
    • Poyurovsky M.V., Prives C. Unleashing the power of p53: lessons from mice and men. Genes Dev. 2006, 20(2):125-131.
    • (2006) Genes Dev. , vol.20 , Issue.2 , pp. 125-131
    • Poyurovsky, M.V.1    Prives, C.2
  • 31
    • 33745594603 scopus 로고    scopus 로고
    • Lhx2 maintains stem cell character in hair follicles
    • Rhee H., Polak L., Fuchs E. Lhx2 maintains stem cell character in hair follicles. Science 2006, 312(5782):1946-1949.
    • (2006) Science , vol.312 , Issue.5782 , pp. 1946-1949
    • Rhee, H.1    Polak, L.2    Fuchs, E.3
  • 33
    • 38048999665 scopus 로고    scopus 로고
    • Two faces of p53: aging and tumor suppression
    • Rodier F., Campisi J., Bhaumik D. Two faces of p53: aging and tumor suppression. Nucleic Acids Res. 2007, 35(22):7475-7484.
    • (2007) Nucleic Acids Res. , vol.35 , Issue.22 , pp. 7475-7484
    • Rodier, F.1    Campisi, J.2    Bhaumik, D.3
  • 34
    • 0035751937 scopus 로고    scopus 로고
    • Assessing TP53 status in human tumours to evaluate clinical outcome
    • Soussi T., Beroud C. Assessing TP53 status in human tumours to evaluate clinical outcome. Nat. Rev. Cancer 2001, 1(3):233-240.
    • (2001) Nat. Rev. Cancer , vol.1 , Issue.3 , pp. 233-240
    • Soussi, T.1    Beroud, C.2
  • 35
    • 0036195290 scopus 로고    scopus 로고
    • Generation of an Mdm2 conditional allele in mice
    • Steinman H.A., Jones S.N. Generation of an Mdm2 conditional allele in mice. Genesis 2002, 32(2):142-144.
    • (2002) Genesis , vol.32 , Issue.2 , pp. 142-144
    • Steinman, H.A.1    Jones, S.N.2
  • 36
    • 0035134022 scopus 로고    scopus 로고
    • Controls of hair follicle cycling
    • Stenn K.S., Paus R. Controls of hair follicle cycling. Physiol. Rev. 2001, 81(1):449-494.
    • (2001) Physiol. Rev. , vol.81 , Issue.1 , pp. 449-494
    • Stenn, K.S.1    Paus, R.2
  • 37
    • 0034682742 scopus 로고    scopus 로고
    • Involvement of follicular stem cells in forming not only the follicle but also the epidermis
    • Taylor G., Lehrer M.S., Jensen P.J., Sun T.T., Lavker R.M. Involvement of follicular stem cells in forming not only the follicle but also the epidermis. Cell 2000, 102(4):451-461.
    • (2000) Cell , vol.102 , Issue.4 , pp. 451-461
    • Taylor, G.1    Lehrer, M.S.2    Jensen, P.J.3    Sun, T.T.4    Lavker, R.M.5
  • 40
    • 33644826850 scopus 로고    scopus 로고
    • Aging and p53: getting it straight. A commentary on a recent paper by Gentry and Venkatachalam
    • Vijg J., Hasty P. Aging and p53: getting it straight. A commentary on a recent paper by Gentry and Venkatachalam. Aging Cell 2005, 4(6):331-333.
    • (2005) Aging Cell , vol.4 , Issue.6 , pp. 331-333
    • Vijg, J.1    Hasty, P.2
  • 41
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: the cell's response to p53
    • Vousden K.H., Lu X. Live or let die: the cell's response to p53. Nat. Rev. Cancer 2002, 2(8):594-604.
    • (2002) Nat. Rev. Cancer , vol.2 , Issue.8 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 42
    • 0035895602 scopus 로고    scopus 로고
    • MDM2 and MDMX can interact differently with ARF and members of the p53 family
    • Wang X., Arooz T., Siu W.Y., Chiu C.H., Lau A., Yamashita K., Poon R.Y. MDM2 and MDMX can interact differently with ARF and members of the p53 family. FEBS Lett. 2001, 490(3):202-208.
    • (2001) FEBS Lett. , vol.490 , Issue.3 , pp. 202-208
    • Wang, X.1    Arooz, T.2    Siu, W.Y.3    Chiu, C.H.4    Lau, A.5    Yamashita, K.6    Poon, R.Y.7
  • 43
    • 33644757727 scopus 로고    scopus 로고
    • Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development
    • Xiong S., Van Pelt C.S., Elizondo-Fraire A.C., Liu G., Lozano G. Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development. Proc. Natl Acad. Sci. USA 2006, 103(9):3226-3231.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.9 , pp. 3226-3231
    • Xiong, S.1    Van Pelt, C.S.2    Elizondo-Fraire, A.C.3    Liu, G.4    Lozano, G.5
  • 44
    • 0036195466 scopus 로고    scopus 로고
    • In utero activation of K5.CrePR1 induces gene deletion
    • Zhou Z., Wang D., Wang X.J., Roop D.R. In utero activation of K5.CrePR1 induces gene deletion. Genesis 2002, 32(2):191-192.
    • (2002) Genesis , vol.32 , Issue.2 , pp. 191-192
    • Zhou, Z.1    Wang, D.2    Wang, X.J.3    Roop, D.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.