Generation of an Mdm2 conditional allele in mice

Genesis

Volumn 32, Issue 2, 2002, Pages 142-144

  Steinman, Heather A ^a   Jones, Stephen N ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; PROTEIN MDM2; PROTEIN P53;

ALLELE; ARTICLE; BREEDING METHOD; CARCINOGENESIS; CHIMERA; EMBRYO DEATH; GENE CASSETTE; GENE FUNCTION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC RECOMBINATION; NULL ALLELE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTO ONCOGENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; TRANSACTIVATION; TRANSGENIC MOUSE;

ANIMALS; INTEGRASES; MICE; MICE, TRANSGENIC; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; VIRAL PROTEINS;

MUS MUSCULUS; RODENTIA;

EID: 0036195290     PISSN: 1526954X     EISSN: None     Source Type: Journal    
DOI: 10.1002/gene.10035     Document Type: Article

References (11)

1. Cre-mediated somatic site-specific recombination in mice
2. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
3. The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2
4. Genomic organization of the mouse double minute 2 gene
5. Over-expression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis
6. Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53
7. Mdm2 deletion does not alter growth characteristics of p53-deficient embryo fibroblasts
8. Characterization of the 5′ and 3′ untranslated regions in murine mdm2 mRNAs
9. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
10. Regulation of p53 function
11. Control of p53 ubiquitination and nuclear export by MDM2 and ARF