Diagnosing and monitoring seizures in the ICU: The role of continuous EEG for detection and management of seizures in critically ill patients

Current Clinical Neurology

Volumn , Issue , 2010, Pages 21-47

  Friedman, Daniel ^a   Hirsch, Lawrence J ^a  

^a Columbia University ^*  (United States)

Author keywords

Continuous EEG monitoring; Critical care; Intensive care unit; Neurotelemetry; Nonconvulsive seizures; Status epilepticus

Indexed keywords

BENZODIAZEPINE;

ALGORITHM; BRAIN HEMORRHAGE; BRAIN INJURY; COMPUTER ASSISTED TOMOGRAPHY; CRITICALLY ILL PATIENT; DIAGNOSTIC ACCURACY; ELECTRODE; ELECTROENCEPHALOGRAM; HUMAN; INTENSIVE CARE UNIT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATIENT MONITORING; PRIORITY JOURNAL; PROGNOSIS; REVIEW; RISK FACTOR; SAFETY; SEIZURE; SENSITIVITY AND SPECIFICITY;

EID: 79953717421     PISSN: 15590585     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60327-532-3_2     Document Type: Review

References (106)

1. Claassen J, Mayer SA, Kowalski RG, Emerson RG, Hirsch LJ (2004) Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. Neurology 62(10):1743-8
2. Jordan K (1999) Nonconvulsive status epilepticus in acute brain injury. J Clin Neurophysiol 16(4):332-40
3. Pandian JD, Cascino GD, So EL, Manno E, Fulgham JR (2004) Digital videoelectroencephalographic monitoring in the neurological-neurosurgical intensive care unit: clinical features and outcome. Arch Neurol 61(7):1090-4
4. Towne AR, Waterhouse EJ, Boggs JG et al (2000) Prevalence of nonconvulsive status epilepticus in comatose patients. Neurology 54(2):340-5
5. Privitera M, Hoffman M, Moore JL, Jester D (1994) EEG detection of nontonicclonic status epilepticus in patients with altered consciousness. Epilepsy Res 18(2):155-66
6. Young GB, Jordan KG, Doig GS (1996) An assessment of nonconvulsive seizures in the intensive care unit using continuous EEG monitoring: an investigation of variables associated with mortality. Neurology 47(1):83-9
7. Walker M, Cross H, Smith S et al (2005) Nonconvulsive status epilepticus: Epilepsy Research Foundation Workshop Reports. Epileptic Disord 7(3):253-96
8. Lowenstein DH, Aminoff MJ (1992) Clinical and EEG features of status epilepticus in comatose patients. Neurology 42(1):100-4
9. Kaplan PW (2002) Behavioral Manifestations of Nonconvulsive Status Epilepticus. Epilepsy Behav 3(2):122-39
10. Husain AM, Horn GJ, Jacobson MP (2003) Non-convulsive status epilepticus: usefulness of clinical features in selecting patients for urgent EEG. J Neurol Neurosurg Psychiatry 74(2):189-91
11. Jirsch J, Hirsch LJ (2007) Nonconvulsive seizures: developing a rational approach to the diagnosis and management in the critically ill population. Clin Neurophysiol 118(8):1660-70
12. Young GB, Ives JR, Chapman MG, Mirsattari SM (2006) A comparison of subdermal wire electrodes with collodion-applied disk electrodes in long-term EEG recordings in ICU. Clin Neurophysiol 117(6):1376-9
13. Mirsattari SM, Lee DH, Jones D, Bihari F, Ives JR (2004) MRI compatible EEG electrode system for routine use in the epilepsy monitoring unit and intensive care unit. Clin Neurophysiol 115(9):2175-80
14. Young GB, Campbell VC (1999) EEG monitoring in the intensive care unit: pitfalls and caveats. J Clin Neurophysiol 16(1):40
15. Hirsch LJ (2004) Continuous EEG monitoring in the intensive care unit: an overview. J Clin Neurophysiol 21(5):332-40
16. Snodgrass SM, Tsuburaya K, Ajmone-Marsan C (1989) Clinical significance of periodic lateralized epileptiform discharges: relationship with status epilepticus. J Clin Neurophysiol 6(2):159-72
17. Hirsch LJ, Claassen J, Mayer SA, Emerson RG (2004) Stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs): a common EEG phenomenon in the critically ill. Epilepsia 45(2):109-23
18. Hirsch LJ, Pang T, Claassen J et al (2008) Focal motor seizures induced by alerting stimuli in critically ill patients. Epilepsia 49(6):968-73
19. Vespa PM, Nuwer MR, Juhász C et al (1997) Early detection of vasospasm after acute subarachnoid hemorrhage using continuous EEG ICU monitoring. Electroencephalogr Clin Neurophysiol 103(6):607-15
20. Kull LL, Emerson RG (2005) Continuous EEG monitoring in the intensive care unit: technical and staffing considerations. J Clin Neurophysiol 22(2):107
21. Shellhaas RA, Soaita AI, Clancy RR (2007) Sensitivity of amplitude-integrated electroencephalography for neonatal seizure detection. Pediatrics 120(4):770-7
22. Kolls BJ, Husain AM (2007) Assessment of hairline EEG as a screening tool for nonconvulsive status epilepticus. Epilepsia 48(5):959-65
23. Scheuer ML, Wilson SB (2004) Data analysis for continuous EEG monitoring in the ICU: seeing the forest and the trees. J Clin Neurophysiol 21(5):353-78
24. Claassen J, Hirsch LJ, Kreiter KT et al (2004) Quantitative continuous EEG for detecting delayed cerebral ischemia in patients with poor-grade subarachnoid hemorrhage. Clin Neurophysiol 115(12):2699-710
25. Toet MC, van der Meij W, de Vries LS, Uiterwaal CS, van Huffelen KC (2002) Comparison between simultaneously recorded amplitude integrated electroencephalogram (cerebral function monitor) and standard electroencephalogram in neonates. Pediatrics 109(5):772-9
26. Eisenberg HM, Frankowski RF, Contant CF, Marshall LF, Walker MD (1988) High-dose barbiturate control of elevated intracranial pressure in patients with severe head injury. J Neurosurg 69(1):15-23
27. Simmons LE, Riker RR, Prato BS, Fraser GL (1999) Assessing sedation during intensive care unit mechanical ventilation with the Bispectral Index and the Sedation-Agitation Scale. Crit Care Med 27(8):1499-504
28. Prichep LS, Gugino LD, John ER et al (2004) The Patient State Index as an indicator of the level of hypnosis under general anaesthesia. Br J Anaesth 92(3):393-9
29. Bauerle K, Greim CA, Schroth M, Geisselbrecht M, Kobler A, Roewer N (2004) Prediction of depth of sedation and anaesthesia by the NarcotrendTM EEG monitor. Br J Anaesth 92(6):841-5
30. Roustan JP, Valette S, Aubas P, Rondouin G, Capdevila X (2005) Can electroencephalographic analysis be used to determine sedation levels in critically ill patients? In: IARS: 1141-1151
31. Abou Khaled KJ, Hirsch LJ (2006) Advances in the management of seizures and status epilepticus in critically ill patients. Crit Care Clin 22(4):637-59
32. Clancy RR, Legido A, Lewis D (1988) Occult neonatal seizures. Epilepsia 29(3):256-61
33. Jette N, Claassen J, Emerson RG, Hirsch LJ (2006) Frequency and predictors of nonconvulsive seizures during continuous electroencephalographic monitoring in critically ill children. Arch Neurol 63(12):1750-5
34. Vespa P (2005) Continuous EEG monitoring for the detection of seizures in traumatic brain injury, infarction, and intracerebral hemorrhage: "to detect and protect". J Clin Neurophysiol 22(2):99-106
35. DeLorenzo RJ, Waterhouse EJ, Towne AR et al (1998) Persistent nonconvulsive status epilepticus after the control of convulsive status epilepticus. Epilepsia 39(8):833-40
36. Oddo M, Carrera E, Claassen J, Mayer SA, Hirsch LJ. (2009) Continuous Electroencephalography in the Medical Intensive Care Unit. Crit Care Medicine 37(6): 2051-2056
37. Young GB (2000) The EEG in Coma. J Clin Neurophysiol 17(5):473
38. Kaplan PW (2004) The EEG in metabolic encephalopathy and coma. J Clin Neurophysiol 21(5):307-18
39. Chong DJ, Hirsch LJ (2005) Which EEG patterns warrant treatment in the critically ill? Reviewing the evidence for treatment of periodic epileptiform discharges and related patterns. J Clin Neurophysiol 22(2):79-91
40. Reiher J, Rivest J, Grand'Maison F, Leduc CP (1991) Periodic lateralized epileptiform discharges with transitional rhythmic discharges: association with seizures. Electroencephalogr Clin Neurophysiol 78(1):12-7
41. Husain AM, Mebust KA, Radtke RA (1999) Generalized periodic epileptiform discharges: etiologies, relationship to status epilepticus, and prognosis. J Clin Neurophysiol 16(1):51-8
42. Pohlmann-Eden B, Hoch DB, Cochius JI, Chiappa KH (1996) Periodic lateralized epileptiform discharges-a critical review. J Clin Neurophysiol 13(6):519-30
43. Handforth A, Cheng JT, Mandelkern MA, Treiman DM (1994) Markedly increased mesiotemporal lobe metabolism in a case with PLEDs: further evidence that PLEDs are a manifestation of partial status epilepticus. Epilepsia 35(4):876-81
44. Assal F, Papazyan JP, Slosman DO, Jallon P, Goerres GW (2001) SPECT in periodic lateralized epileptiform discharges (PLEDs): a form of partial status epilepticus? Seizure 10(4):260-5
45. Bozkurt MF, Saygi S, Erbas B (2002) SPECT in a patient with postictal PLEDs: is hyperperfusion evidence of electrical seizure? Clin Electroencephalogr 33(4):171-3
46. Terzano MG, Parrino L, Mazzucchi A, Moretti G (1986) Confusional states with periodic lateralized epileptiform discharges (PLEDs): a peculiar epileptic syndrome in the elderly. Epilepsia 27(4):446-57
47. Westmoreland BF, Klass DW, Sharbrough FW (1986) Chronic periodic lateralized epileptiform discharges. Arch Neurol 43(5):494-6
48. Brenner RP (2002) Is it status? Epilepsia 43(Suppl 3):103-13
49. Fountain NB, Waldman WA (2001) Effects of benzodiazepines on triphasic waves: implications for nonconvulsive status epilepticus. J Clin Neurophysiol 18(4):345-52
50. Drislane FW, Lopez MR, Blum AS, Schomer DL (2008) Detection and treatment of refractory status epilepticus in the intensive care unit. J Clin Neurophysiol 25(4):181-6
51. Claassen J, Jette N, Chum F et al (2007) Electrographic seizures and periodic discharges after intracerebral hemorrhage. Neurology 69(13):1356-65
52. Claassen J, Hirsch LJ, Frontera JA et al (2006) Prognostic significance of continuous EEG monitoring in patients with poor-grade subarachnoid hemorrhage. Neurocrit Care 4(2):103-12
53. Jaitly R, Sgro JA, Towne AR, Ko D, DeLorenzo RJ (1997) Prognostic value of EEG monitoring after status epilepticus: a prospective adult study. J Clin Neurophysiol 14(4):326-34
54. Frohlich F, Bazhenov M, Sejnowski TJ (2008) Pathological effect of homeostatic synaptic scaling on network dynamics in diseases of the cortex. J Neurosci 28(7):1709
55. Aminoff MJ (1998) Do nonconvulsive seizures damage the brain?-No. Arch Neurol 55(1):119-20
56. Young GB, Jordan KG (1998) Do Nonconvulsive seizures damage the brain?-Yes. Arch Neurol 55(1):117-9
57. Vespa PM, Nuwer MR, Nenov V et al (1999) Increased incidence and impact of nonconvulsive and convulsive seizures after traumatic brain injury as detected by continuous electroencephalographic monitoring. J Neurosurg 91(5):750-60
58. Shneker BF, Fountain NB (2003) Assessment of acute morbidity and mortality in nonconvulsive status epilepticus. Neurology 61(8):1066-73
59. Bottaro FJ, Martinez OA, Pardal MM, Bruetman JE, Reisin RC (2007) Nonconvulsive status epilepticus in the elderly: a case-control study. Epilepsia 48(5):966-72
60. Litt B, Wityk RJ, Hertz SH et al (1998) Nonconvulsive status epilepticus in the critically ill elderly. Epilepsia 39(11):1194-202
61. Meldrum BS, Vigouroux RA, Brierley JB (1973) Systemic factors and epileptic brain damage Prolonged seizures in paralyzed, artificially ventilated baboons. Arch Neurol 29(2):82-7
62. Holmes GL (2002) Seizure-induced neuronal injury: animal data. Neurology 59(9 Suppl 5):S3-6
63. Krsek P, Mikulecka A, Druga R et al (2004) Long-term behavioral and morphological consequences of nonconvulsive status epilepticus in rats. Epilepsy Behav 5(2):180-91
64. Lothman EW, Bertram EH, Bekenstein JW, Perlin JB (1989) Self-sustaining limbic status epilepticus induced by 'continuous' hippocampal stimulation: electrographic and behavioral characteristics. Epilepsy Res 3(2):107-19
65. Cavazos JE, Das I, Sutula TP (1994) Neuronal loss induced in limbic pathways by kindling: evidence for induction of hippocampal sclerosis by repeated brief seizures. J Neurosci 14(5 Pt 2):3106-21
66. Kotloski R, Lynch M, Lauersdorf S, Sutula T (2002) Repeated brief seizures induce progressive hippocampal neuron loss and memory deficits. Prog Brain Res 135:95-110
67. Saffen DW, Cole AJ, Worley PF, Christy BA, Ryder K, Baraban JM (1988) Convulsant-induced increase in transcription factor messenger RNAs in rat brain. Proc Natl Acad Sci U S A 85(20):7795-9
68. Zhou JL, Shatskikh TN, Liu X, Holmes GL (2007) Impaired single cell firing and long-term potentiation parallels memory impairment following recurrent seizures. Eur J NeuroSci 25(12):3667-77
69. Dube C, Chen K, Eghbal-Ahmadi M, Brunson K, Soltesz I, Baram TZ (2000) Prolonged febrile seizures in the immature rat model enhance hippocampal excitability long term. Ann Neurol 47(3):336-44
70. DeGiorgio CM, Tomiyasu U, Gott PS, Treiman DM (1992) Hippocampal pyramidal cell loss in human status epilepticus. Epilepsia 33(1):23-7
71. Rabinowicz AL, Correale J, Boutros RB, Couldwell WT, Henderson CW, DeGiorgio CM (1996) Neuron-specific enolase is increased after single seizures during inpatient video/EEG monitoring. Epilepsia 37(2):122-5
72. DeGiorgio CM, Gott PS, Rabinowicz AL, Heck CN, Smith TD, Correale JD (1996) Neuron-specific enolase, a marker of acute neuronal injury, is increased in complex partial status epilepticus. Epilepsia 37(7):606-9
73. Palmio J, Keranen T, Alapirtti T et al (2008) Elevated serum neuron-specific enolase in patients with temporal lobe epilepsy: A video-EEG study. Epilepsy Res 81(2-3):155-60
74. DeGiorgio CM, Heck CN, Rabinowicz AL, Gott PS, Smith T, Correale J (1999) Serum neuron-specific enolase in the major subtypes of status epilepticus. Neurology 52(4):746-9
75. Vespa P, Prins M, Ronne-Engstrom E et al (1998) Increase in extracellular glutamate caused by reduced cerebral perfusion pressure and seizures after human traumatic brain injury: a microdialysis study. J Neurosurg 89(6):971-82
76. Vespa PM, Miller C, McArthur D, et al. Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis. Critical care medicine 2007
77. Vespa P, Martin NA, Nenov V et al (2002) Delayed increase in extracellular glycerol with post-traumatic electrographic epileptic activity: support for the theory that seizures induce secondary injury. Acta Neurochir Suppl 81:355-7
78. Vespa PM, O'Phelan K, Shah M et al (2003) Acute seizures after intracerebral hemorrhage: a factor in progressive midline shift and outcome. Neurology 60(9):1441-6
79. Hartings JA, Williams AJ, Tortella FC (2003) Occurrence of nonconvulsive seizures, periodic epileptiform discharges, and intermittent rhythmic delta activity in rat focal ischemia. Exp Neurol 179(2):139-49
80. Williams AJ, Tortella FC, Lu XM, Moreton JE, Hartings JA (2004) Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia. J Pharmacol Exp Ther 311(1):220-7
81. Johnson DW, Hogg JP, Dasheiff R, Yonas H, Pentheny S, Jumao-as A (1993) Xenon/CT cerebral blood flow studies during continuous depth electrode monitoring in epilepsy patients. AJNR 14(1):245-52
82. Gabor AJ, Brooks AG, Scobey RP, Parsons GH (1984) Intracranial pressure during epileptic seizures. Electroencephalogr Clin Neurophysiol 57(6):497-506
83. Marienne JP, Robert G, Bagnat E (1979) Post-traumatic acute rise of ICP related to subclinical epileptic seizures. Acta Neurochir Suppl (Wien) 28(1):89-92
84. Fabricius M, Fuhr S, Bhatia R et al (2006) Cortical spreading depression and peri-infarct depolarization in acutely injured human cerebral cortex. Brain 129(Pt 3):778-90
85. Fabricius M, Fuhr S, Willumsen L et al (2008) Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brain. Clin Neurophysiol 119(9):1973-84
86. Sundt TM Jr, Sharbrough FW, Anderson RE, Michenfelder JD (1974) Cerebral blood flow measurements and electroencephalograms during carotid endarterectomy. J Neurosurg 41(3):310-20
87. Sundt TM Jr, Sharbrough FW, Piepgras DG, Kearns TP, Messick JM Jr, O'Fallon WM (1981) Correlation of cerebral blood flow and electroencephalographic changes during carotid endarterectomy: with results of surgery and hemodynamics of cerebral ischemia. Mayo Clin Proc 56(9):533-43
88. Sharbrough FW, Messick JM Jr, Sundt TM Jr (1973) Correlation of continuous electroencephalograms with cerebral blood flow measurements during carotid endarterectomy. Stroke; a journal of cerebral circulation 4(4):674-83
89. Zampella E, Morawetz RB, McDowell HA et al (1991) The importance of cerebral ischemia during carotid endarterectomy. Neurosurgery 29(5):727-30 discussion 30-31
90. Arnold M, Sturzenegger M, Schaffler L, Seiler RW (1997) Continuous intraoperative monitoring of middle cerebral artery blood flow velocities and electroencephalography during carotid endarterectomy. A comparison of the two methods to detect cerebral ischemia. Stroke; a journal of cerebral circulation 28(7):1345-50
91. Astrup J, Siesjo BK, Symon L (1981) Thresholds in cerebral ischemia - the ischemic penumbra. Stroke; a journal of cerebral circulation 12(6):723-5
92. Jordan KG (2004) Emergency EEG and continuous EEG monitoring in acute ischemic stroke. J Clin Neurophysiol 21(5):341-52
93. Claassen J, Hirsch LJ, Emerson RG, Mayer SA (2002) Treatment of refractory status epilepticus with pentobarbital, propofol, or midazolam: a systematic review. Epilepsia 43(2):146-53
94. Jordan KG (1999) Continuous EEG monitoring in the neuroscience intensive care unit and emergency department. J Clin Neurophysiol 16(1):14
95. Gotman J (1999) Automatic detection of seizures and spikes. J Clin Neurophysiol 16(2):130
96. Agarwal R, Gotman J, Flanagan D, Rosenblatt B (1998) Automatic EEG analysis during long-term monitoring in the ICU. Electroencephalogr Clin Neurophysiol 107(1):44-58
97. Shah AK, Agarwal R, Carhuapoma JR, Loeb JA (2006) Compressed EEG pattern analysis for critically ill neurological-neurosurgical patients. Neurocrit Care 5(2): 124-33
98. Adams DC, Heyer EJ, Emerson RG et al (1995) The reliability of quantitative electroencephalography as an indicator of cerebral ischemia. Anesth Analg 81(1):80-3
99. Wartenberg KE, Schmidt JM, Mayer SA (2007) Multimodality monitoring in neurocritical care. Crit Care Clin 23(3):507-38
100. Hartings JA, Rolli ML, Lu XC, Tortella FC (2003) Delayed secondary phase of peri-infarct depolarizations after focal cerebral ischemia: relation to infarct growth and neuroprotection. J Neurosci 23(37):11602-10
101. Dohmen C, Sakowitz OW, Fabricius M et al (2008) Spreading depolarizations occur in human ischemic stroke with high incidence. Ann Neurol 63:720-728
102. Dreier JP, Woitzik J, Fabricius M et al (2006) Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations. Brain 129(12):3224
103. Waziri AE, Arif H, Oddo M et al (2007) Early experience with a cortical depth electrode for ICU neurophysiological monitoring in patients with acute brain injury. Epilepsia 48(s6):125
104. Jordan KG (1995) Neurophysiologic monitoring in the neuroscience intensive care unit. Neurol Clin 13(3):579-626
105. Vespa PM, Nenov V, Nuwer MR (1999) Continuous EEG Monitoring in the Intensive Care Unit: Early Findings and Clinical Efficacy. J Clin Neurophysiol 16(1):1
106. Friedman DE, Schevon C, Emerson RG, Hirsch LJ (2008) Cyclic electrographic seizures in critically ill patients. Epilepsia 49(2):281-7