Regulation of cysteine dioxygenase degradation is mediated by intracellular cysteine levels and the ubiquitin-26 S proteasome system in the living rat

Biochemical Journal

Volumn 394, Issue 1, 2006, Pages 267-273

  Dominy Jr , John E ^a   Hirschberger, Lawrence L ^a   Coloso, Relicardo M ^a   Stipanuk, Martha H ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

Cysteine; Dioxygenase; Liver; Proteasome; Ubiquitin; Ubiquitin 26 S proteasome system

Indexed keywords

BIOLOGICAL ORGANS; CELLS; OXIDATION; PROTEINS; TOXICITY;

CYSTEINE; DIOXYGENASE; LIVER; PROTEASOME; UBIQUITIN; UBIQUITIN-26 S PROTEASOME SYSTEM;

ENZYMES;

CYSTEINE; DIOXYGENASE; PROTEASOME; PROTEASOME INHIBITOR; UBIQUITIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; ENZYME ANALYSIS; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME METABOLISM; ENZYME REGULATION; ENZYME STABILITY; LIVER; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; UBIQUITINATION;

ANIMALS; CELLS, CULTURED; CYSTEAMINE; CYSTEINE; CYSTEINE DIOXYGENASE; HEPATOCYTES; LIVER; MALE; OLIGOPEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; UBIQUITIN;

ANIMALIA; MAMMALIA;

EID: 32944454336     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20051510     Document Type: Article

References (35)

1. Andine, P., Orwar, O., Jacobson, I., Sandberg, M. and Hagberg, H. (1991) Extracellular acidic sulfur-containing amino acids and gamma-glutamyl peptides in global ischemia: postischemic recovery of neuronal activity is paralleled by a tetrodotoxin-sensitive increase in cysteine sulfinate in the CA1 of the rat hippocampus. J. Neurochem. 57, 230-236
2. Lehmann, A. (1987) Alterations in hippocampal extracellular amino acids and purine catabolites during limbic seizures induced by folate injections into the rabbit amygdala. Neuroscience 22, 573-578
3. Lehmann, A., Hagberg, H., Orwar, O. and Sandberg, M. (1993) Cysteine sulphinate and cysteate: mediators of cysteine toxicity in the neonatal rat brain? Eur. J. Neurosci. 5, 1398-1412
4. Bradley, H., Gough, A., Sokhi, R. S., Hassell, A., Waring, R. and Emery, P. (1994) Sulfate metabolism is abnormal in patients with rheumatoid arthritis. Confirmation by in vivo biochemical findings. J. Rheumatol. 21, 1192-1196
5. Heafield, M. T., Fearn, S., Steventon, G. B., Waring, R. H., Williams, A. C. and Sturman, S. G. (1990) Plasma cysteine and sulphate levels in patients with motor neurone, Parkinson's and Alzheimer's disease. Neurosci. Lett. 110, 216-220
6. Gordon, C., Bradley, H., Waring, R. H. and Emery, P. (1992) Abnormal sulphur oxidation in systemic lupus erythematosus. Lancet 339, 616-617
7. El-Khairy, L., Vollset, S. E., Refsum, H. and Ueland, P. M. (2003) Plasma total cysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine Study. Am. J. Clin. Nutr. 77, 467-472
8. Karlsen, R. L. and Pedersen, O. O. (1982) A morphological study of the acute toxicity of L-cysteine on the retina of young rats. Exp. Eye Res. 34, 467-472
9. Garcia, R. A. and Stipanuk, M. H. (1992) The splanchnic organs, liver and kidney have unique roles in the metabolism of sulfur amino acids and their metabolites in rats. J. Nutr. 122, 1693-1701
10. Bella, D. L., Hahn, C. and Stipanuk, M. H. (1999) Effects of nonsulfur and sulfur amino acids on the regulation of hepatic enzymes of cysteine metabolism. Am. J. Physiol. 277, E144-E153
11. Bella, D. L., Hirschberger, L. L., Hosokawa, Y. and Stipanuk, M. H. (1999) Mechanisms involved in the regulation of key enzymes of cysteine metabolism in rat liver in vivo. Am. J. Physiol. 276, E326-E335
12. Kwon, Y. H. and Stipanuk, M. H. (2001) Cysteine regulates expression of cysteine dioxygenase and gamma-glutamylcysteine synthetase in cultured rat hepatocytes. Am. J. Physiol. Endocrinol. Metab. 280, E804-E815
13. Bella, D. L., Kwon, Y. H., Hirschberger, L. L. and Stipanuk, M. H. (2000) Post-transcriptional regulation of cysteine dioxygenase in rat liver. Adv. Exp. Med. Biol. 483, 71-85
14. Stipanuk, M. H., Hirschberger, L. L., Londono, M. P., Cresenzi, C. L. and Yu, A. F. (2004) The ubiquitin-proteasome system is responsible for cysteine-responsive regulation of cysteine dioxygenase concentration in liver. Am. J. Physiol. Endocrinol. Metab. 286, E439-E448
15. Fischer, D., Gang, G., Pritts, T. and Hasselgren, P. O. (2000) Sepsis-induced muscle proteolysis is prevented by a proteasome inhibitor in vivo. Biochem. Biophys. Res. Commun. 270, 215-221
16. Stipanuk, M. H., Londono, M., Lee, J. I., Hu, M. and Yu, A. F. (2002) Enzymes and metabolites of cysteine metabolism in nonhepatic tissues of rats show little response to changes in dietary protein or sulfur amino acid levels. J. Nutr. 132, 3369-3378
17. Yamaguchi, K., Hosokawa, Y., Kohashi, N., Kori, Y., Sakakibara, S. and Ueda, I. (1978) Rat liver cysteine dioxygenase (cysteine oxidase). Further purification, characterization, and analysis of the activation and inactivation J. Biochem. (Tokyo) 83, 479-491
18. Stipanuk, M. H., Londono, M., Hirschberger, L. L., Hickey, C., Thiel, D. J. and Wang, L. (2004) Evidence for expression of a single distinct form of mammalian cysteine dioxygenase. Amino Acids 26, 99-106
19. Pfeiffer, C. M., Huff, D. L. and Gunter, E. W. (1999) Rapid and accurate HPLC assay for plasma total homocysteine and cysteine in a clinical laboratory setting. Clin. Chem. 45, 290-292
20. Chu, F. F. and Doyle, D. (1985) Turnover of plasma membrane proteins in rat hepatoma cells and primary cultures of rat hepatocytes. J. Biol. Chem. 260, 3097-3107
21. Drake, M. R., De La Rosa, J. and Stipanuk, M. H. (1987) Metabolism of cysteine in rat hepatocytes. Evidence for cysteinesulphinate-independent pathways. Biochem. J. 244, 279-286
22. de la Rosa, J., Drake, M. R. and Stipanuk, M. H. (1987) Metabolism of cysteine and cysteinesulfinate in rat and cat hepatocytes. J. Nutr. 117, 549-558
23. de la Rosa, J. and Stipanuk, M. H. (1985) Evidence for a rate-limiting role of cysteinesulfinate decarboxylase activity in taurine biosynthesis in vivo. Comp. Biochem. Physiol. B 81, 565-571
24. Bagley, P. J., Hirschberger, L. L. and Stipanuk, M. H. (1995) Evaluation and modification of an assay procedure for cysteine dioxygenase activity: high-performance liquid chromatography method for measurement of cysteine sulfinate and demonstration of physiological relevance of cysteine dioxygenase activity in cysteine catabolism. Anal. Biochem. 227, 40-48
25. Kasai, T., Ogo, Y., Otobe, Y. and Kiriyama, S. (1992) Accumulation of hypotaurine in tissues and urine of rats fed an excess methionine diet. J. Nutr. Sci. Vitaminol. (Tokyo) 38, 93-101
26. Oja, S. S. and Kontro, P. (1981) Oxidation of hypotaurine in vitro by mouse liver and brain tissues. Biochim. Biophys. Acta 677, 350-357
27. Stipanuk, M. H. and Rotter, M. A. (1984) Metabolism of cysteine, cysteinesulfinate and cysteinesulfonate in rats fed adequate and excess levels of sulfur-containing amino acids. J. Nutr. 114, 1426-1437
28. Coloso, R. M., Hirschberger, L. L., Dominy, J. E., Lee, J. and and Stipanuk, M. H. (2006) Cysteamine dioxygenase: evidence for the physiological conversion of cysteamine to hypotaurine in rat and mouse tissues. Adv. Exp. Med. Biol., in the press
29. Ciechanover, A. (2005) Proteolysis: from the lysosome to ubiquitin and the proteasome. Nat. Rev. Mol. Cell. Biol. 6, 79-87
30. Ciechanover, A. and Ben-Saadon, R. (2004) N-terminal ubiquitination: more protein substrates join in. Trends Cell. Biol. 14, 103-106
31. Lafaye, A., Junot, C., Pereira, Y., Lagniel, G., Tabet, J., Ezan, E. and Labarre, J. (2005) Combined proteome and metabolite-profiling analyses reveal surprising insights into yeast sulfur metabolism. J. Biol. Chem. 280, 24723-24730
32. Fuachon, M., Lagniel, G., Aude, J. C., Lombardia, L., Soularue, P., Petat, C., Marguerie, G., Sentenac, A., Werner, M. and Labarre, J. (2002) Sulfur sparing in the yeast proteome in response to sulfur demand. Mol. Cell 9, 713-723
33. Nikiforova, V., Freitag, J., Kempa, S., Adamik, M., Hesse, H. and Hoefgen, R. (2003) Transcriptome analysis of sulfur depletion in Arabidopsis thaliana: interlacing biosynthetic pathways provides response specificity. Plant J. 33, 633-650
34. Hansen, J. and Johannesen, P. F. (2000) Cysteine is essential for transcriptional regulation of the sulfur assimilation genes in Saccharomyces cerevisiae. Mol. Gen. Genet. 263, 535-542
35. Ono, B.-I., Naito, K., Shirahige, Y.-I. and Yamamoto, M. (1991) Regulation of cystathionine γ-lyase in Sacchammyces cerevisiae. Yeast 7, 843-848