Cysteine is the metabolic signal responsible for dietary regulation of hepatic cysteine dioxygenase and glutamate cysteine ligase in intact rats

Journal of Nutrition

Volumn 133, Issue 9, 2003, Pages 2697-2702

  Cresenzi, Carrie L ^a   Lee, Jeong In ^a   Stipanuk, Martha H ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

Cysteine; Cysteine dioxygenase; Glutamate cysteine ligase; Glutathione; Homocysteine; Methionine

Indexed keywords

AMINO ACID; CYSTATHIONINE GAMMA LYASE; CYSTEINE; CYSTEINE DIOXYGENASE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HOMOCYSTEINE; METHIONINE; OXYGENASE; PROPARGYLGLYCINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DIETARY INTAKE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; IN VIVO STUDY; LIVER CELL; MALE; METABOLISM; NONHUMAN; PROTEIN DIET; RAT;

ANIMALIA;

EID: 0042920806     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/133.9.2697     Document Type: Article

References (27)

1. Karlsen, R. L., Grofova, I., Malthe-Sorenssen, D. & Fonnum, F. (1981) Morphological changes in rat brain induced by L-cysteine injection in newborn animals. Brain Res. 208: 167-180.
2. Mathisen, G. A., Fonnum, F. & Paulsen, R. E. (1996) Contributing mechanisms for cysteine excitotoxicity in cultured cerebellar granule cells. Neurochem. Res. 21: 293-298.
3. Pedersen, O. O. & Karlsen, R. L. (1980) The toxic effect of L-cysteine on the rat retina. A morphological and biochemical study. Investig. Ophthalmol. Vis. Sci. 19: 886-892.
4. Sandberg, M., Orwar, O. & Hehmann, A. (1991) L-Cysteine toxicity: effects on non-sulfur amino acids, sulfur-containing excitatory amino acids and γ-glutamyl peptides in the immature brain. J. Neurochem. 57: S152.
5. El-Khairy, L., Vollset, S. E., Refsum, H. & Ueland, P. M. (2003) Plasma total cysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine Study. Am. J. Clin. Nutr. 77: 467-72.
6. El-Khairy, L., Ueland, P. M., Nygård, O., Refsum, H. & Vollset, S. E. (1999) Lifestyle and cardiovascular disease risk factors as determinants of total cysteine in plasma: the Hordaland Homocysteine Study. Am. J. Clin. Nutr. 70: 1016-1024.
7. Bagley, P. J. & Stipanuk, M. H. (1995) Rats fed a low protein diet supplemented with sulfur amino acids have increased cysteine dioxygenase activity and increased taurine production in hepatocytes. J. Nutr. 125: 933-940.
8. Bella, D. L., Hahn, C. & Stipanuk, M. H. (1999) Effects of non-sulfur and sulfur amino acids on the regulation of hepatic enzymes of cysteine metabolism. Am. J. Physiol. 277: E144-E153.
9. Bella, D. L., Hirschberger, L. L., Hosokawa, Y. & Stipanuk, M. H. (1999) The mechanisms involved in the regulation of key enzymes of cysteine metabolism in rat liver in vivo. Am. J. Physiol. 276: E326-E335.
10. Bella, D. L. & Stipanuk, M. H. (1995) Effects of protein, methionine, or chloride on acid-base balance and on cysteine catabolism. Am. J. Physiol. 269: E910-E917.
11. Stipanuk, M. H., Londono, M., Lee, J. I., Hu, M. & Yu, A. F. (2002) Enzymes and metabolites of cysteine metabolism in nonhepatic tissues of rats show little response to changes in dietary protein or sulfur amino acid levels. J. Nutr. 132: 3369-3378.
12. Stipanuk M. H., Londono M & Hirschberger L. L. (2003) Cysteine-responsive regulation of hepatic cysteine dioxygenase by the ubiquitin-proteasome system. FASEB J. 17: A737 (abs.).
13. Kwon, Y. H. & Stipanuk, M. H. (2001) Cysteine regulates expression of cysteine dioxygenase and gamma-glutamylcysteine synthetase in cultured rat hepatocytes. Am. J. Physiol. 280: E804-E815.
14. Reeves, P. G. Nielsen, F. H. & Fahey, G. C., Jr. (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr. 123: 1939-1951.
15. Gaitonde, M. K. (1967) A spectrophotometric method for the direct determination of cysteine in the presence of other naturally occurring amino acids. Biochem. J. 104: 627-633.
16. Viña, J., Gimenez, A., Puertes, I. R., Gasco, E. & Viña, J. (1992) Impairment of cysteine synthesis from methionine in rats exposed to surgical stress. Br. J. Nutr. 68: 421-429.
17. Yan, C. C. & Huxtable, R. J. (1996) Effects of monocrotaline, a pyrrolizidine alkaloid, on glutathione metabolism in the rat. Biochem. Pharmacol. 51: 375-379.
18. Fariss, M. W. & Reed, D. J. (1987) High performance liquid chromatography of thiols and disulfides: dinitrophenol derivatives. Methods Enzymol. 143: 101-109.
19. Stipanuk, M. H., Bagley, P. J. Coloso, R. M. & Banks, M. F. (1992) Metabolism of cysteine to taurine by rat hepatocytes. Adv. Exp. Med. Biol. 315: 413-421.
20. Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J. & Klenk, D. C. (1985) Measurement of protein using bicinchoninic acid. Anal. Biochem. 150: 76-85.
21. Sullivan, D. M. & Hoffman, J. L. (1983) Fractionation and kinetic properties of rat liver and kidney methionine adenosyltransferase isozymes. Biochemistry 22: 1641-1645.
22. Stipanuk, M. H. (1986) Metabolism of sulfur-containing amino acids. Annu. Rev. Nutr. 6: 179-209.
23. Stipanuk, M. H. (1999) Homocysteine, cysteine, and taurine. In: Modern Nutrition in Health and Disease, 9th ed. (Shils, M. E., Olson, J. A., Shike, M. & Ross, A. C., eds.), pp. 543-558. Williams and Wilkins, Baltimore, MD.
24. Drake, M. R., De La Rosa, J. & Stipanuk, M. H. (1987) Metabolism of cysteine in rat hepatocytes. Biochem. J. 244: 279-286.
25. National Research Council (1978) Nutrient Requirements of Laboratory Animals, pp. 13-16. National Academy of Sciences, Washington, DC.
26. Bella, D. L., Kwon, Y. H. & Stipanuk, M. H. (1996) Variations in dietary, protein but not in dietary fat plus cellulose or carbohydrate levels affect cysteine metabolism in rat isolated hepatocytes. J. Nutr. 126: 2179-2187.
27. Stipanuk, M. H., Coloso, R. M., Garcia, R.A.G. & Banks, M. F. (1992) Cysteine concentration regulates cysteine metabolism to glutathione, sulfate and taurine in rat hepatocytes. J. Nutr. 122: 420-427.