Loss of JNK2 increases intestinal tumor susceptibility in Apc1638+/- mice with dietary modulation

Carcinogenesis

Volumn 32, Issue 4, 2011, Pages 584-588

  Bi, Xiuli ^a,b   Pohl, Nicole M ^a   Yin, Zhinan ^c   Yang, Wancai ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b LIAONING UNIVERSITY   (China)

^c NANKAI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BETA CATENIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MUTANT PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM INTAKE; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CONTROLLED STUDY; DIET; GENE INACTIVATION; GENE INTERACTION; INFLAMMATION; INTESTINE TUMOR; LIPID DIET; LIPID METABOLISM; MOUSE; NONHUMAN; OBESITY; PHOSPHATE INTAKE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; VITAMIN INTAKE; WEIGHT GAIN;

ANIMALS; BETA CATENIN; BODY WEIGHT; DIET; DISEASE SUSCEPTIBILITY; GENES, APC; INFLAMMATION; INTESTINAL NEOPLASMS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 9; PPAR GAMMA;

EID: 79953712615     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq275     Document Type: Article

References (40)

1. Davis,R.J. (2000) Signal transduction by the JNK group of MAP kinases. Cell, 103, 239-252.
2. Johnson,G.L. et al. (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science, 298, 1911-1912.
3. Sabapathy,K. et al. (2004) Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol. Cell, 15, 713-725.
4. Hu,D. et al. (2008) c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/β-catenin signaling through GSK3β pathway. Carcinogenesis, 29, 2317-2324.
5. Tong,C. et al. (2007) c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression. Am. J. Pathol., 171, 297-303.
6. She,Q.B. et al. (2002) Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res., 62, 1343-1348.
7. Chen,N. et al. (2001) Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice. Cancer Res., 61, 3908-3912.
8. Wu,X. et al. (2008) Rac1 activation controls nuclear localization of β-catenin during canonical Wnt signaling. Cell, 133, 340-353.
9. Saadeddin,A. et al. (2009) The links between transcription, β-catenin/JNK signaling, and carcinogenesis. Mol. Cancer Res., 7, 1189-1196.
10. Rui,Y. et al. (2007)Aβ-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev. Cell, 13, 268-282.
11. Nateri,A.S. et al. (2005) Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature, 437, 281-285.
12. Liao,G. et al. (2006) Jun NH2-terminal kinase (JNK) prevents nuclear β-catenin accumulation and regulates axis formation in Xenopus embryos. Proc. Natl Acad. Sci. USA, 103, 16313-16318.
13. Lee,M.H. et al. (2009) JNK phosphorylates β-catenin and regulates adherens junctions. FASEB J., 23, 3874-3883.
14. Hu,D. et al. (2009) GSK3( is involved in JNK2-mediated β-catenin inhibition. PLoS One, 4, e6640.
15. Fodde,R. et al. (1994) A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc. Natl Acad. Sci. USA, 91, 8969-8973.
16. Yang,W. et al. (2001) Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of aWestern-style high-risk diet by altering cell maturation in the intestinal mucosal. Cancer Res., 61, 565-569.
17. Yang,D.D. et al. (1998) Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. Immunity, 9, 575-585.
18. Yang,W. et al. (2005) p27kip1 in intestinal tumorigenesis and chemoprevention in the mouse. Cancer Res., 65, 9363-9368.
19. Bi,X. et al. (2010) Black raspberries inhibit intestinal tumorigenesis in Apc1638+/- and Muc2-/- mouse models of colorectal cancer. Cancer Prev. Res. (Phila.), 3, 1443-1450.
20. Moser,A.R. et al. (1990) A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science, 247, 322-324.
21. Klaus,A. et al. (2008) Wnt signalling and its impact on development and cancer. Nat. Rev. Cancer, 8, 387-398.
22. Aoki,K. et al. (2007) Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene. J. Cell Sci., 120, 3327-3335.
23. Nathke,I. (2006) Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC. Nat. Rev. Cancer, 6, 967-974.
24. Hirosumi,J. et al. (2002) A central role for JNK in obesity and insulin resistance. Nature, 420, 333-336.
25. Singh,R. et al. (2009) Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance. Hepatology, 49, 87-96.
26. Newmark,H.L. et al. (1990) Colonic hyperplasia and hyperproliferation induced by a nutritional stress diet with four components of Western-style diet. J. Natl Cancer Inst., 82, 491-496.
27. Newmark,H.L. et al. (1991) Colonic hyperproliferation induced in rats and mice by nutritional-stress diets containing four components of a human Western-style diet (series 2). Am. J. Clin. Nutr., 54, 209S-214S.
28. Yang,W. et al. (2003) Targeted inactivation of p27kip1 is sufficient for large and small intestinal tumorigenesis in the mouse, which can be augmented by a Western-style high-risk diet. Cancer Res., 63, 4990-4996.
29. Augenlicht,L.H. et al. (2002) Environment-gene interactions in intestinal cancer. Eur. J. Cancer Prev., 11 (suppl. 2), S12-S17.
30. Yang,K. et al. (2005) Dietary components modify gene expression: implications for carcinogenesis. J. Nutr., 135, 2710-2714.
31. Kawai,M. et al. (2010) PPARgamma: a circadian transcription factor in adipogenesis and osteogenesis. Nat. Rev. Endocrinol., 6, 629-636.
32. Murtaugh,M.A. et al. (2005) Interactions of peroxisome proliferator-activated receptor {gamma} and diet in etiology of colorectal cancer. Cancer Epidemiol. Biomarkers Prev., 14, 1224-1229.
33. Slattery,M.L. et al. (2005) PPARgamma, energy balance, and associations with colon and rectal cancer. Nutr. Cancer, 51, 155-161.
34. Gong,Z. et al. (2005) The PPAR{gamma} Pro12Ala polymorphism and risk for incident sporadic colorectal adenomas. Carcinogenesis, 26, 579-585.
35. Wong,N.A. et al. (2002) B-catenin-a linchpin in colorectal carcinogenesis? Am. J. Pathol., 160, 389-401.
36. Zhu,Y. et al. (1995) Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms. Proc. Natl Acad. Sci. USA, 92, 7921-7925.
37. Fajas,L. et al. (1997) The organization, promoter analysis, and expression of the human PPARgamma gene. J. Biol. Chem., 272, 18779-18789.
38. Danese,S. et al. (2010) Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer. Oncogene, 29, 3313-3323.
39. Terzic,J. et al. (2010) Inflammation and colon cancer. Gastroenterology, 138, 2101-2114e5.
40. Yang,K. et al. (2008) Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation. Cancer Res., 68, 7313-7322.