Pharmacodynamic analysis of stress erythropoiesis: Change in erythropoietin receptor pool size following double phlebotomies in sheep

Biopharmaceutics and Drug Disposition

Volumn 32, Issue 3, 2011, Pages 131-139

  Saleh, Mohammad I ^a   Widness, John A ^b   Veng Pedersen, Peter ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Dosing optimization; Erythropoietin receptor; Pharmacodynamics; Pharmacokinetics; Sheep

Indexed keywords

ERYTHROPOIETIN RECEPTOR; HEMOGLOBIN; IODINE 125; RECOMBINANT ERYTHROPOIETIN;

ALGORITHM; ANEMIA; ANIMAL EXPERIMENT; ARTICLE; BLOOD VOLUME; ERYTHROPOIESIS; FEEDBACK SYSTEM; HEMOGLOBIN SYNTHESIS; NONHUMAN; PHLEBOTOMY; SHEEP; UPREGULATION;

ANIMALS; BODY WEIGHT; ERYTHROPOIESIS; ERYTHROPOIETIN, RECOMBINANT; HEMOGLOBINS; MODELS, BIOLOGICAL; PHLEBOTOMY; RECEPTORS, ERYTHROPOIETIN; SHEEP;

EID: 79953711418     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.743     Document Type: Article

References (38)

1. Davis JM, Arakawa T, Strickland TW, Yphantis DA. Characterization of recombinant human erythropoietin produced in Chinese hamster ovary cells. Biochemistry 1987; 26: 2633-2638. (Pubitemid 17081496)
2. Sawada K, Krantz SB, Dai CH, et al. Purification of human blood burst-forming units-erythroid and demonstration of the evolution of erythropoietin receptors. J Cell Physiol 1990; 142: 219-230.
3. Sawyer ST, Krantz SB, Goldwasser E. Binding and receptor-mediated endocytosis of erythropoietin in Friend virus-infected erythroid cells. J Biol Chem 1987; 262: 5554-5562.
4. Krzyzanski W, Wyska E. Pharmacokinetics and pharmacodynamics of erythropoietin receptor in healthy volunteers. Naunyn Schmiedebergs Arch Pharmacol 2008; 377: 637-645.
5. Mufson RA, Gesner TG. Binding and internalization of recombinant human erythropoietin in murine erythroid precursor cells. Blood 1987; 69: 1485-1490. (Pubitemid 17085312)
6. Freise KJ, Widness JA, Segar JL, Schmidt RL, Veng-Pdersen P. Increased erythropoietin elimination in fetal sheep following chronic phlebotomy. Pharm Res 2007; 24: 1653-1659. (Pubitemid 47206616)
7. Widness JA, Schmidt RL, Hohl RJ, et al. Change in erythropoietin pharmacokinetics following hematopoietic transplantation. Clin Pharmacol Ther 2007; 81: 873-879. (Pubitemid 46788298)
8. Chapel SH, Veng-Pedersen P, Schmidt RL, Widness JA. Receptor-based model accounts for phlebotomy-induced changes in erythropoietin pharmacokinetics. Exp Hematol 2001; 29: 425-431. (Pubitemid 32297667)
9. Chapel S, Veng-Pedersen P, Hohl RJ, Schmidt RL, McGuire EM, Widness JA. Changes in erythropoietin pharmacokinetics following busulfan-induced bone marrow ablation in sheep: evidence for bone marrow as a major erythropoietin elimination pathway. J Pharmacol Exp Ther 2001; 298: 820-824. (Pubitemid 32673436)
10. Nalbant D, Saleh M, Goldman FD, Widness JA, Veng-Pedersen P. Evidence of receptor-mediated elimination of erythropoietin by analysis of Epo receptor mRNA expression in bone marrow and erythropoietin clearance during anemia. J Pharmacol Exp Ther 2010; 333: 528-532.
11. Widness JA, Schmidt RL, Veng-Pedersen P, Modi NB, Sawyer ST. A sensitive and specific erythropoietin immunoprecipitation assay: application to pharmacokinetic studies. J Lab Clin Med 1992; 119: 285-294.
12. Widness JA, Teramo KA, Clemons GK, et al. Temporal response of immunoreactive erythropoietin to acute hypoxemia in fetal sheep. Pediatr Res 1986; 20: 15-19. (Pubitemid 16146313)
13. Veng-Pedersen P, Chapel S, Al-Huniti NH, et al. A differential pharmacokinetic analysis of the erythropoietin receptor population in newborn and adult sheep. J Pharmacol Exp Ther 2003; 306: 532-537. (Pubitemid 36886151)
14. Veng-Pedersen P, Widness JA, Pereira LM, Peters C, Schmidt RL, Lowe LS. Kinetic evaluation of nonlinear drug elimination by a disposition decomposition analysis. Application to the analysis of the nonlinear elimination kinetics of erythropoietin in adult humans. J Pharm Sci 1995; 84: 760-767.
15. Al-Huniti NH, Widness JA, Schmidt RL, Veng-Pedersen P. Pharmacokinetic/pharmacodynamic analysis of paradoxal regulation of erythropoietin production in acute anemia. J Pharmacol Exp Ther 2004; 310: 202-208. (Pubitemid 38812712)
16. Veng-Pedersen P, Chapel S, Al-Huniti NH, et al. Pharmacokinetic tracer kinetics analysis of changes in erythropoietin receptor population in phlebotomy-induced anemia and bone marrow ablation. Biopharm Drug Dispos 2004; 25: 149-156. (Pubitemid 38765288)
17. Holford N. Dosing in children. Clin Pharmacol Ther 2010; 87: 367-370.
18. Al-Huniti NH, Widness JA, Schmidt RL, Veng-Pedersen P. Pharmacodynamic analysis of changes in reticulocyte subtype distribution in phlebotomy-induced stress erythropoiesis. J Pharmacokinet Pharmacodyn 2005; 32: 359-376. (Pubitemid 41742189)
19. Landaw SA. Factors that accelerate or retard red blood cell senescence. Blood Cells 1988; 14: 47-67.
20. Freise KJ, Widness JA, Schmidt RL, Veng-Pedersen P. Modeling time variant distributions of cellular lifespans: increases in circulating reticulocyte lifespans following double phlebotomies in sheep. J Pharmacokinet Pharmacodyn 2008; 35: 285-323.
21. Krzyzanski W, Woo S, Jusko WJ. Pharmacodynamic models for agents that alter production of natural cells with various distributions of lifespans. J Pharmacokinet Pharmacodyn 2006; 33: 125-166.
22. Freise KJ, Widness JA, Veng-Pedersen P. Erythropoietic response to endogenous erythropoietin in premature very low birth weight infants. J Pharmacol Exp Ther 2010; 332: 229-237.
23. Koong LJ, Garrett WN, Rattray PV. A description of the dynamics of fetal growth in sheep. J Anim Sci 1975; 41: 1065-1068.
24. Kisker CT, Robillard JE, Clarke WR. Development of blood coagulation - a fetal lamb model. Pediatr Res 1981; 15: 1045-1050. (Pubitemid 11087055)
25. Jobe A, Jacobs H, Ikegami M, Berry D. Lung protein leaks in ventilated lambs: effects of gestational age. J Appl Physiol 1985; 58: 1246-1251. (Pubitemid 15033189)
26. Veng-Pedersen P. Curve fitting and modelling in pharmacokinetics and some practical experiences with NONLIN and a new program FUNFIT. J Pharmacokinet Biopharm 1977; 5: 513-531.
27. Neelakantan S, Widness JA, Schmidt RL, Veng-Pedersen P. Erythropoietin pharmacokinetic/pharmacodynamic analysis suggests higher doses in treating neonatal anemia. Pediatr Int 2009; 51: 25-32.
28. Woo S, Krzyzanski W, Duliege AM, Stead RB, Jusko WJ. Population pharmacokinetics and pharmacodynamics of peptidic erythropoiesis receptor agonist (ERA) in healthy volunteers. J Clin Pharmacol 2008; 48: 43-52. (Pubitemid 350292274)
29. Gross AW, Lodish HF. Cellular trafficking and degradation of erythropoietin and novel erythropoiesis stimulating protein (NESP). J Biol Chem 2006; 281: 2024-2032. (Pubitemid 43845790)
30. Becker V, Schilling M, Bachmann J, et al. Covering a broad dynamic range: information processing at the erythropoietin receptor. Science 2010; 328: 1404-1408.
31. Broudy VC, Nakamoto B, Lin N, Papayannopoulou T. Dynamics of erythropoietin receptor expression on erythropoietin-responsive murine cell lines. Blood 1990; 75: 1622-1626. (Pubitemid 20145747)
32. Bernaudin M, Marti HH, Roussel S, et al. A potential role for erythropoietin in focal permanent cerebral ischemia in mice. J Cereb Blood Flow Metab 1999; 19: 643-651. (Pubitemid 30161216)
33. Freise KJ, Widness JA, Schmidt RL, Veng-Pedersen P. Pharmacodynamic analysis of time-variant cellular disposition: reticulocyte disposition changes in phlebotomized sheep. J Pharmacokinet Pharmacodyn 2007; 34: 519-547. (Pubitemid 47038126)
34. Brugnara C. Use of reticulocyte cellular indices in the diagnosis and treatment of hematological disorders. Int J Clin Lab Res 1998; 28: 1-11.
35. Tucker E. Red cell life span in young and adult sheep. Res Vet Sci 1963; 4: 11-23.
36. Kaufman JS, Reda DJ, Fye CL, et al. Subcutaneous compared with intravenous epoetin in patients receiving hemodialysis. Department of Veterans Affairs Cooperative Study Group on Erythropoietin in Hemodialysis Patients. N Engl J Med 1998; 339: 578-583.
37. Ashai NI, Paganini EP, Wilson JM. Intravenous versus subcutaneous dosing of epoetin: a review of the literature. Am J Kidney Dis 1993; 22(2 Suppl 1): 23-31.
38. Brown MS, Jones MA, Ohls RK, Christensen RD. Single-dose pharmacokinetics of recombinant human erythropoietin in preterm infants after intravenous and subcutaneous administration. J Pediatr 1993; 122: 655-657. (Pubitemid 23093603)