Pharmacodynamic analysis of time-variant cellular disposition: Reticulocyte disposition changes in phlebotomized sheep

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 34, Issue 4, 2007, Pages 519-547

  Freise, Kevin J ^a   Widness, John A ^b   Schmidt, Robert L ^b   Veng Pedersen, Peter ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Anemia; Cellular transformations; Endogenous pharmacodynamics; Erythropoiesis; Erythropoietin; Hemapoietic cells; Hemoglobin production; Reticulocyte maturation; Time varient kinetics

Indexed keywords

ERYTHROPOIETIN; HEMOGLOBIN;

ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; BLOOD VOLUME; CELL FUNCTION; CELL MATURATION; CELL STIMULATION; CELL SURVIVAL; CELL TRANSFORMATION; ERYTHROCYTE; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; HEMATOPOIETIC CELL; HEMOGLOBIN BLOOD LEVEL; HEMOGLOBIN DETERMINATION; HEMOGLOBIN SYNTHESIS; IRON BINDING CAPACITY; IRON BLOOD LEVEL; NONHUMAN; PHLEBOTOMY; PRIORITY JOURNAL; RETICULOCYTE; RETICULOCYTE COUNT; SHEEP; STATISTICAL SIGNIFICANCE;

ALGORITHMS; ANIMALS; ERYTHROID PROGENITOR CELLS; ERYTHROPOIESIS; ERYTHROPOIETIN; HEMOGLOBINS; MODELS, BIOLOGICAL; PHLEBOTOMY; RETICULOCYTES; SHEEP;

EID: 34447134083     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10928-007-9056-2     Document Type: Article

References (35)

1. Hoffman R, Benz EJ Jr, Shattil SJ, Furie B, Cohen HJ, Silberstein LE, McGlave P (2005) Hematology: basic principles and applications, 4th edn. Elsevier Inc, USA
2. Brugnara C (1998) Use of reticulocyte cellular indices in the diagnosis and treatment of hematological disorders. Int J Clin Lab Res 28:1-11
3. Brugnara C (2000) Reticulocyte cellular indices: a new approach in the diagnosis of anemias and monitoring of erythropoietic function. Crit Rev Clin Lab Sci 37:93-130
4. Hillman RS, Ault KA, Rinder HM (2005) Hematology in clinical practice, 4th edn. McGraw-Hill Companies, Inc, USA
5. Riley RS, Ben-Ezra JM, Tidwell A, Romagnoli G (2002) Reticulocyte analysis by flow cytometry and other techniques. Hematol Oncol Clin North Am 16:373-420, vii
6. Hirose A, Yamane T, Shibata H, Kamitani T, Hino M (2005) Automated analyzer evaluation of reticulocytes in bone marrow and peripheral blood of hematologic disorders. Acta Haematol 114:141-145
7. Watanabe K, Kawai Y, Takeuchi K, Shimizu N, Iri H, Ikeda Y, Houwen B (1994) Reticulocyte maturity as an indicator for estimating qualitative abnormality of erythropoiesis. J Clin Pathol 47:736-739
8. Pradella M, Cavill I, d'Onofrio G (1996) Assessing erythropoiesis and the effect of erythropoietin therapy in renal disease by reticulocyte counting. Clin Lab Haematol 18:35-37
9. Aulesa C, Ortega JJ, Jou JM, Colomer E, Montero J, Olano E, Remacha AF, Martino R, Yoldi F, Escribano I (1994) Flow cytometric reticulocyte quantification in the evaluation of hematologic recovery-Spanish multicentric study-group for hematopoietic recovery. Euro J Haematol 53:293-297
10. Davis BH, Bigelow NC (1989) Flow cytometric reticulocyte quantification using thiazole orange provides clinically useful reticulocyte maturity index. Arch Pathol Lab Med 113:684-689
11. Batjer JD, Riddell K, Fritsma GA (1994) Predicting bone-marrow transplant engraftment by automated flow cytometric reticulocyte analysis. Lab Med 25:22-26
12. Dubner D, Perez MD, Barboza M, Sorrentino M, Robinson A, Gisone P (2002) Prognosis and bone marrow recovery indicators in bone marrow transplantation after total body irradiation. Med Buenos Aires 62:555-561
13. Noronha JFA, De Souza CA, Vigorito AC, Aranha FJP, Zulli R, Miranda ECM, Grotto HZW (2003) Immature reticulocytes as an early predictor of engraftment in autologous and allogeneic bone marrow transplantation. Clin Lab Haematol 25:47-54
14. Houwen B (1992) Reticulocyte maturation. Blood Cells 18:167-186
15. Jandl JH (1996) Blood: textbook of hematology, 2nd edn. Little, Brown and Company, USA
16. Veng-Pedersen P, Chapel, Schmidt RL, Al-Huniti NH, Cook RT, Widness JA (2002) An integrated pharmacodynamic analysis of erythropoietin, reticulocyte, and hemoglobin responses in acute anemia. Pharm Res 19:1630-1635
17. Chapel SH, Veng-Pedersen P, Schmidt RL, Widness JA (2000) A pharmacodynamic analysis of erythropoietin-stimulated reticulocyte response in phlebotomized sheep. J Pharmacol Exp Ther 295:346-351
18. Krzyzanski W, Jusko WJ, Wacholtz MC, Minton N, Cheung WK (2005) Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after multiple subcutaneous doses in healthy subjects. Eur J Pharm Sci 26:295-306
19. Ramakrishnan R, Cheung WK, Farrell F, Joffee L, Jusko WJ (2003) Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after intravenous and subcutaneous dose administration in cynomolgus monkeys. J Pharmacol Exp Ther 306:324-331
20. Ramakrishnan R, Cheung WK, Wacholtz MC, Minton N, Jusko WJ (2004) Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after single and multiple doses in healthy volunteers. J Clin Pharmacol 44:991-1002
21. Krzyzanski W, Ramakrishnan R, Jusko WJ (1999) Basic pharmacodynamic models for agents that alter production of natural cells. J Pharmacokinet Biopharm 27:467-489
22. Krzyzanski W, Woo S, Jusko WJ (2006) Pharmacodynamic models for agents that alter production of natural cells with various distributions of lifespans. J Pharmacokinet Pharmacodyn 33:125-166
23. Al-Huniti NH, Widness JA, Schmidt RL, Veng-Pedersen P (2005) Pharmacodynamic analysis of changes in reticulocyte subtype distribution in phlebotomy-induced stress erythropoiesis. J Pharmacokinet Pharmacodyn 32:359-376
24. Widness JA, Veng-Pedersen P, Modi NB, Schmidt RL, Chestnut DH (1992) Developmental differences in erythropoietin pharmacokinetics: Increased clearance and distribution in fetal and neonatal sheep. J Pharmacol Exp Therapeut 261:977-984
25. Peters C, Georgieff MK, Alarcon PAd, Cook RT, Burmeister LF, Lowe LS, Widness JA (1996) Effect of chronic erythropoietin administration on plasma iron in newborn lambs. Biol Neonate 70:218-228
26. Hutchinson MF, deHoog FR (1985) Smoothing noise data with spline functions. Numer Math 47:99-106
27. Mock DM, Lankford GL, Burmeister LF, Strauss RG (1997) Circulating red cell volume and red cell survival can be accurately determined in sheep using the [14C]cyanate label. Pediatr Res 41:916-921
28. Veng-Pedersen P (1977) Curve fitting and modelling in pharmacokinetics and some practical experiences with NONLIN and a new program FUNFIT. J Pharmacokinet Biopharm 5:513-531
29. Hairer E, Norsett SP, Wanner G (1993) Solving ordinary differential equations I: nonstiff problems, 2nd edn. Springer-Verlag, Berlin
30. Akaike H (1974) Automatic control: a new look at the statistical model identification. IEEE Trans 19:716-723
31. Hillman RS, Finch CA (1967) Erythropoiesis: normal and abnormal. Semin Hematol 4:327-336
32. Hillman RS (1969) Characteristics of marrow production and reticulocyte maturation in normal man in response to anemia. J Clin Invest 48:443-453
33. Shimada A (1975) The maturation of reticulocytes. II. Life-span of red cells originating from stress reticulocytes. Acta Med Okayama 29:283-289
34. Stohlman F Jr (1961) Humoral regulation of erythropoiesis. VII. Shortened survival of erythrocytes produced by erythropoietine or severe anemia. Proc Soc Exp Biol Med 107:884-887
35. Krantz SG, Parks HR (2002) The implicit function theorem: history, theory, and applications. Birkhauser, Boston