Isochronous assessment of cardiac metabolism and function in mice using hybrid PET/MRI

Journal of Nuclear Medicine

Volumn 51, Issue 8, 2010, Pages 1277-1284

  Büscher, Katharina ^a   Judenhofer, Martin S ^b   Kuhlmann, Michael T ^a   Hermann, Sven ^a   Wehrl, Hans F ^b   Schäfers, Klaus P ^a   Schäfers, Michael ^a   Pichler, Bernd J ^b   Stegger, Lars ^a,b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Cardiology (basic technical); Molecular imaging; Multimodal imaging; PET MRI; Small animals

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; HEART FUNCTION; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE METABOLISM; IMAGE PROCESSING; IMAGE QUALITY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; ALGORITHM; ANIMAL; C57BL MOUSE; HEART; HEART FUNCTION TEST; HEART MUSCLE; METABOLISM; PHYSIOLOGY; SCINTISCANNING; STATISTICAL ANALYSIS;

ALGORITHMS; ANIMALS; DATA INTERPRETATION, STATISTICAL; HEART; HEART FUNCTION TESTS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; MYOCARDIUM; POSITRON-EMISSION TOMOGRAPHY; VENTRICULAR FUNCTION, LEFT;

EID: 77956219244     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.110.076448     Document Type: Article

References (22)

1. Cherry SR. Multimodality in vivo imaging systems: twice the power or double the trouble? Annu Rev Biomed Eng. 2006;8:35-62.
2. Gerth HU, Juergens KU, Dirksen U, Gerss J, Schober O, Franzius C. Significant benefit of multimodal imaging: PET/CT compared with PET alone in staging and follow-up of patients with Ewing tumors. J Nucl Med. 2007;48:1932-1939. (Pubitemid 350237602)
3. Mawlawi O, Townsend DW. Multimodality imaging: an update on PET/CT technology. Eur J Nucl Med Mol Imaging. 2009;36(suppl):S15-S29.
4. Nahrendorf M, Zhang H, Hembrador S, et al. Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis. Circulation. 2008;117:379-387.
5. Garot J, Bluemke DA, Osman NF, et al. Fast determination of regional myocardial strain fields from tagged cardiac images using harmonic phase MRI. Circulation. 2000;101:981-988.
6. Wong K, Kelso R, Worthley S, Sanders P, Mazumdar J, Abbott D. Cardiac flow analysis applied to phase contrast magnetic resonance imaging of the heart. Ann Biomed Eng. 2009;37:1495-1515.
7. Frank LR, Lu K, Wong EC. Perfusion tensor imaging. Magn Reson Med. 2008;60:1284-1291.
8. Kim RJ, Wu E, Rafael A, et al. The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. N Engl J Med. 2000;343:1445-1453.
9. Judenhofer MS, Wehrl HF, Newport DF, et al. Simultaneous PET-MRI: a new approach for functional and morphological imaging. Nat Med. 2008;14: 459-465.
10. Catana C, Procissi D, Wu Y. Simultaneous in vivo positron emission tomography and magnetic resonance imaging. Proc Natl Acad Sci. 2008;105;3705-3710.
11. Raylman RR, Majewski S, Velan SS, et al. Simultaneous acquisition of magnetic resonance spectroscopy (MRS) data and positron emission tomography (PET) images with a prototype MR-compatible, small animal PET imager. J Magn Reson. 2007;186:305-310.
12. Yamamoto S, Hatazawa J, Imaizumi M, et al. A multi-slice dual layer MR-compatible animal PET system. IEEE Trans Nucl Sci. 2009;56:2706-2713.
13. Delso G, Ziegler S. PET/MRI system design. Eur J Nucl Med Mol Imaging. 2009;36(suppl):S86-S92.
14. Schäfers KP, Reader AJ, Kriens M, Knoess C, Schober O, Schäfers M. Performance evaluation of the 32-module quadHIDAC small-animal PET scanner. J Nucl Med. 2005;46:996-1004.
15. Yang Y, Rendig S, Siegel S, Newport DF, Cherry SR. Cardiac PET imaging in mice with simultaneous cardiac and respiratory gating. Phys Med Biol. 2005;50:2979-2989. (Pubitemid 40905180)
16. Schäfers KP, Lang N, Stegger L, Schober O, Schäfers M. Gated listmode acquisition with the quadHIDAC animal PET to image mouse hearts. Z Med Phys. 2006;16:60-66.
17. Loening AM, Gambhir SS. AMIDE: a free software tool for multimodality medical image analysis. Mol Imaging. 2003;2:131-137.
18. Stegger L, Heijman E, Schäfers KP, Nicolay K, Schäfers MA, Strijkers GJ. Quantification of left ventricular volumes and ejection fraction in mice using PET, compared with MRI. J Nucl Med. 2009;50:132-138.
19. van der Geest RJ, Lelieveldt BPF, Reiber JHC. Quantification in cardiac magnetic resonance imaging and computed tomography. In: Higgins CB, de Roos A, eds. MRI and CT of the Cardiovascular System. Philadelphia, PA: Lippincott Williams & Wilkins; 2006:91-106.
20. Sharir T, Germano G, Kavanagh PB, et al. Incremental prognostic value of post-stress left ventricular ejection fraction and volume by gated myocardial perfusion single photon emission computed tomography. Circulation. 1999;100:1035-1042.
21. Lertsburapa K, Ahlberg AW, Bateman TM, et al. Independent and incremental prognostic value of left ventricular ejection fraction determined by stress gated rubidium 82 PET imaging in patients with known or suspected coronary artery disease. J Nucl Cardiol. 2008;15:745-753.
22. Lutgens E, Daemen MJ, de Muinck ED, Debets J, Leenders P, Smits JF. Chronic myocardial infarction in the mouse: cardiac structural and functional changes. Cardiovasc Res. 1999;41:586-593.