Quassin alters the immunological patterns of murine macrophages through generation of nitric oxide to exert antileishmanial activity

Journal of Antimicrobial Chemotherapy

Volumn 63, Issue 2, 2009, Pages 317-324

  Bhattacharjee, Surajit ^a   Gupta, Gaurav ^a   Bhattacharya, Parna ^a   Mukherjee, Asok ^a   Mujumdar, Suchandra Bhattacharyya ^a   Pal, Amita ^a   Majumdar, Subrata ^a  

^a BOSE INSTITUTE   (India)

Author keywords

Anti inflammatory cytokines; Leishmania donovani; NO; Pro inflammatory cytokines

Indexed keywords

HERBACEOUS AGENT; IMMUNOMODULATING AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE 2; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; MESSENGER RNA; QUASSIN; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMASTIGOTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTILEISHMANIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BAGG ALBINO MOUSE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DOWN REGULATION; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME REPRESSION; GENE EXPRESSION REGULATION; HOST RESISTANCE; IMMUNOMODULATION; LEISHMANIA DONOVANI; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TH1 CELL; TH2 CELL; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTIPROTOZOAL AGENTS; CELL SURVIVAL; CYTOKINES; FEMALE; IMMUNOLOGIC FACTORS; LEISHMANIA DONOVANI; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED BALB C; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; QUASSINS;

EID: 58849101311     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkn479     Document Type: Article

References (35)

1. Chappuis F, Sundar S, Hailu A et al. Visceral leishmaniasis: What are the needs for diagnosis, treatment and control? Nat Rev Microbiol 2007; 5: 873-82.
2. Coler RN, Reed SG. Second-generation vaccines against leishmaniasis. Trends Parasitol 2005; 21: 244-9.
3. Desjeux P. Global control and Leishmania HIV co-infection. Clin Dermatol 1999; 17: 317-25.
4. Croft SL, Seifert K, Yardley V. Current scenario of drug development for leishmaniasis. Indian J Med Res 2006; 123: 399-410.
5. Berman JD. Experimental chemotherapy of leishmaniasis - a critical review. In: Chang KP, Bray R, eds. Leishmaniasis. New York: Elsevier, 1985; 111-38.
6. McGreevey PB, Marsden PD. American trypanosomiasis and leishmaniasis. In: Campbell WC, Rew RS, eds. Chemotherapy of Parasitic Diseases. New York: Plenum Publishing Corp., 1986; 115-27.
7. Kayser O, Kiderlen AF, Folkens U et al. In vitro leishmanicidal activity of aurones. Planta Med 1999; 65: 316-9.
8. Clark EP. Quassin I. The preparation and purification of quassin and neoquassin, with information concerning their molecular formulas. J Am Chem Soc 1937; 59: 927-31.
9. Polonsky J. Quassinoid bitter principles. Fortschr Chem Org Naturst 1973; 30: 101-50.
10. Robins JR, Morgan MR, Rhodes MJ et al. An enzyme-linked immunosorbent assay for quassin and closely related metabolites. Anal Biochem 1984; 136: 145-56.
11. Jiwajinda S, Santisopasri V, Murakami A et al. In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia. J Ethnopharmacol 2002; 82: 55-8. Erratum in: J Ethnopharmacol 2003; 85: 173.
12. Trager W, Polonsky J. Antimalarial activity of quassinoids against chloroquine-resistant Plasmodium falciparum in vitro. Am J Trop Med Hyg 1981; 30: 531-7.
13. Morré DJ, Zeichhardt H, Maxeiner HG et al. Effect of the quassinoids glaucarubolone and simalikalactone D on growth of cells permanently infected with feline and human immunodeficiency viruses and on viral infections. Life Sci 1998; 62: 213-9.
14. Klocke JA, Arisawa M, Handa SS et al. Growth inhibitory, insecticidal and antifeedant effects of some antileukemic and cytotoxic quassinoids on two species of agricultural pests. Experientia 1985; 41: 379-82.
15. Wright CW, O'Neill MJ, Phillipson JD et al. Use of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of quassinoids. Antimicrob Agents Chemother 1988; 32: 1725-9.
16. Toma W, Gracioso Jde S, de Andrade FD et al. Antiulcerogenic activity of four extracts obtained from the bark wood of Quassia amara L. (Simaroubaceae). Biol Pharm Bull 2002; 25: 1151-5.
17. Lang'at-Thoruwa C, Kirby GC, Phillipson JD et al. Enhancement of the antiplasmodial activity of quassin by transformation into a γ-lactone. J Nat Prod 2003; 66: 1486-9.
18. Hart TD, Vickerman K, Coombs GH et al. Simple method for purifyimg L. mexicana amastigotes in large numbers. Parasitology 1981; 82: 345-55.
19. Fahey JT, Tracey KJ, Olson PT et al. Macrophage inflammatory protein 1 modulates macrophage function. J Immunol 1992; 148 2764-9.
20. Das L, Datta N, Bandyopadhyay S et al. Successful therapy of lethal murine visceral leishmaniasis with cystatin involves up-regulation of nitric oxide and a favorable T cell response. J Immunol 2001; 166: 4020-8.
21. Ghose AC, Mookerjee A, Sengupta K et al. Therapeutic and prophylactic uses of protein A in the control of Leishmania donovani infection in experimental animals. Immunol Lett 1999; 65: 175-81.
22. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63.
23. Green LC, Wagner DA, Glogowski J et al. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 1982; 126: 131-8.
24. Hibbs JB Jr, Taintor RR, Vavrin Z et al. Nitric oxide: A cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun 1988; 157: 87-94. Erratum in: Biochem Biophys Res Commun 1989; 158: 624.
25. Schreck R, Baeuerle PA. Assessing oxygen radicals as mediators in activation of inducible eukaryotic transcription factor NF-κB. Methods Enzymol 1994; 234: 151-63.
26. Majumdar S, Kane LH, Rossi MW et al. Protein kinase C iso-types and signal-transduction in human neutrophils: Selective substrate specificity of calcium-dependent β-PKC and novel calcium-independent nPKC. Biochim Biophys Acta 1993; 1176: 276-86.
27. Das S, Bhattacharyya S, Ghosh S et al. Signal transduction mechanism in human neutrophil: Comparative study between the ζ and β-protein kinase.C isotypes. Mol Cell Biochem 2000; 203: 143-51.
28. Ghosh S, Bhattacharyya. S, Sirkar M et al. Leishmania donovani suppresses activated protein 1 and NF-κB activation in host macrophages via ceramide generation: Involvement of extracellular signal-regulated kinase. Infect Immun 2002; 70: 6828-38.
29. Amer AO, Swanson MS. Phagosome of one's own: A microbial guide to life in the macrophage. Curr Opin Microbiol 2002; 5: 56-61.
30. Gantt KR, Goldman TL, McComick ML et al. Oxidative responses of human and murine macrophages during phagocytosis of Leishmania chagasi. J Immunol 2001; 167: 893-901.
31. Rogers KA, Dekrey GK, Mbow ML et al. Type 1 and type 2 responses to Leishmania major. FEMS Microbiol Lett 2002; 209: 1-7.
32. Diefenbach A, Schindler H, Rollinghoff M et al. Requirement for type 2 NO synthase for IL-12 signaling in innate immunity. Science 1999; 284: 951-5.
33. Taylor A, Murray HW. Intracellular antimicrobial activity in the absence of interferon-γ: Effect of interleukin-12 in experimental visceral leishmaniasis in interferon-γ gene-disrupted mice. J Exp Med 1997; 185: 1231-9.
34. Shiloh MU, Nathan CF. Antimicrobial mechanisms of macrophages. In: Gordon S, ed., Phagocytosis: The Host. Stamford: JAI Press Inc., 1999; 5: 407-38.
35. Prive C, Descoteaux A. Leishmania donovani promastigotes evade the activation of mitogen-activated protein kinases p38, c-Jun N-terminal kinase and extracellular signal-regulated kinase-1/2 during infection of naive macrophages. Eur J Immunol 2000; 8: 2235-44.