High content imaging-based assay to classify estrogen receptor-α ligands based on defined mechanistic outcomes

Gene

Volumn 477, Issue 1-2, 2011, Pages 42-52

  Ashcroft, F J ^a   Newberg, J Y ^a   Jones, E D ^a   Mikic, I ^b   Mancini, M A ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b ACCELRYS INC   (United States)

Author keywords

Chromatin; Endocrine disruptor; High throughput microscopy; Nuclear structure; Systems biology; Transcription

Indexed keywords

ENDOCRINE DISRUPTOR; ESTROGEN RECEPTOR ALPHA; LIGAND; TRANSCRIPTION FACTOR;

ARTICLE; CELL ASSAY; CHROMATIN; CONTROLLED STUDY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MICROSCOPY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; RECEPTOR OCCUPANCY;

BLOTTING, WESTERN; CELL LINE, TUMOR; CLUSTER ANALYSIS; ENDOCRINE DISRUPTORS; ESTRADIOL; ESTROGEN ANTAGONISTS; ESTROGEN RECEPTOR ALPHA; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; MICROSCOPY, FLUORESCENCE; PHENOLS; PRINCIPAL COMPONENT ANALYSIS; PROMOTER REGIONS, GENETIC; RALOXIFENE; REPRODUCIBILITY OF RESULTS; TAMOXIFEN;

EID: 79953673206     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2011.01.009     Document Type: Article

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