Alcohol facilitates CD1d loading, subsequent activation of NKT cells, and reduces the incidence of diabetes in NOD mice

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Buschard, Karsten ^a   Hansen, Axel Kornerup ^b   Jensen, Karen ^b   Lindenbergh Kortleve, Dicky J ^c   de Ruiter, Lilian F ^c   Krohn, Thomas C ^b   Hufeldt, Majbritt R ^b   Vogensen, Finn K ^b   Aasted, Bent ^b   Osterbye, Thomas ^a   Roep, Bart O ^d   de Haar, Colin ^c   Nieuwenhuis, Edward E ^e  

^a University of Copenhagen   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALPHA GALACTOSYLCERAMIDE; ALPHA2 INTEGRIN; CD1D ANTIGEN; CD3 ANTIGEN; DRINKING WATER; GAMMA INTERFERON; GLYCOLIPID; INTERLEUKIN 2; TRANSCRIPTION FACTOR FOXP3;

ALCOHOLIC BEVERAGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CECUM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; DRINKING BEHAVIOR; EPITHELIUM CELL; FEMALE; HELA CELL; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INTESTINE FLORA; LIPID TRANSPORT; LYMPHOCYTE ACTIVATION; MOUSE; NATURAL KILLER T CELL; NONHUMAN; NONOBESE DIABETIC MOUSE; OPEN FIELD TEST; REGULATORY T LYMPHOCYTE; ANIMAL; ANIMAL BEHAVIOR; CYTOLOGY; DENATURING GRADIENT GEL ELECTROPHORESIS; DIABETES MELLITUS; DOSE RESPONSE; DRUG EFFECT; FLOW CYTOMETRY; HUMAN; IMMUNOLOGY; METABOLISM; PROTEIN TRANSPORT;

BACTERIA (MICROORGANISMS); MUS;

ANIMALS; ANTIGENS, CD1D; BEHAVIOR, ANIMAL; DENATURING GRADIENT GEL ELECTROPHORESIS; DIABETES MELLITUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FEMALE; FLOW CYTOMETRY; HELA CELLS; HUMANS; MICE; MICE, INBRED NOD; NATURAL KILLER T-CELLS; PROTEIN TRANSPORT;

EID: 79953662870     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017931     Document Type: Article

References (34)

1. Marmot MG, Rose G, Shipley MJ, Thomas BJ, (1981) Alcohol and mortality: a U-shaped curve. Lancet 1: 580-583.
2. Klatsky AL, Friedman GD, (1995) Alcohol and longevity. Am J Public Health 85: 16-18.
3. Rimm EB, Williams P, Fosher K, Criqui M, Stampfer MJ, (1999) Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. Brit Med J 319: 1523-1528.
4. Koppes LL, Dekker JM, Hendriks HF, Bouter LM, Heine RJ, (2005) Moderate alcohol consumption lowers the risk of type 2 diabetes: a meta-analysis of prospective observational studies. Diabetes Care 28: 719-725.
5. Kang L, Sebastian BM, Pritchard MT, Pratt BT, Previs SF, et al. (2007) Chronic ethanol-induced insulin resistance is associated with macrophage infiltration into adipose tissue and altered expression of adipocytokines. Alcohol Clin Exp Res 31: 1581-1588.
6. Razay G, Heaton KW, (1997) Moderate alcohol consumption has been shown previously to improve insulin sensitivity in men. Brit Med J 314: 443-444.
7. Ting JW, Lautt WW, (2006) The effect of acute, chronic, and prenatal ethanol exposure on insulin sensitivity. Pharmacol Ther 111: 346-373.
8. Pai JK, Hankinson SE, Thadhani R, Rifai N, Pischon T, et al. (2006) Moderate alcohol consumption and lower levels of inflammatory markers in US men and women. Atherosclerosis 186: 113-120.
9. Volpato S, Pahor M, Ferrucci L, Simonsick EM, Guralnik JM, et al. (2004) Relationship of alcohol intake with inflammatory markers and plasminogen activator inhibitor-1 in well-functioning older adults: the Health, Aging, and Body Composition study. Circulation 109: 607-612.
10. Maraldi C, Volpato S, Kritchevsky SB, Cesari M, Andresen E, et al. (2006) Impact of inflammation on the relationship among alcohol consumption, mortality, and cardiac events: the health, aging, and body composition study. Arch Intern Med 166: 1490-1497.
11. Zeng Z, Castano AR, Segelke BW, Stura EA, Peterson PA, et al. (1997) Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove. Science 277: 339-345.
12. Porcelli SA, Modlin RL, (1999) The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids. Annu Rev Immunol 17: 297-329.
13. Liu R, La CA, Bai XF, Jee Y, Price M, et al. (2005) Cooperation of invariant NKT cells and CD4+CD25+ T regulatory cells in the prevention of autoimmune myasthenia. J Immunol 175: 7898-7904.
14. Hong S, Wilson MT, Serizawa I, Wu L, Singh N, et al. (2001) The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat Med 7: 1052-1056.
15. Sharif S, Arreaza GA, Zucker P, Mi QS, Sondhi J, et al. (2001) Activation of natural killer T cells by alpha-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes. Nat Med 7: 1057-1062.
16. Buschard K, Hanspers K, Fredman P, Reich EP, (2001) Treatment with sulfatide or its precursor, galactosylceramide, prevents diabetes in NOD mice. Autoimmunity 34: 9-17.
17. Hansen AK, Ling F, Kaas A, Funda DP, Farlov H, et al. (2006) Diabetes preventive gluten-free diet decreases the number of caecal bacteria in non-obese diabetic mice. Diabetes Metab Res Rev 22: 220-225.
18. Colgan SP, Pitman RS, Nagaishi T, Mizoguchi A, Mizoguchi E, et al. (2003) Intestinal heat shock protein 110 regulates expression of CD1d on intestinal epithelial cells. J Clin Invest 112: 745-754.
19. Hufeldt A, Nielsen D, Vogensen F, Midtvedt T, Hansen A, et al. (2010) Variation in the gut microbiota of laboratory mice is related to both genetic and environmental factors. Comparative Medicine 60: 336-342.
20. Jayawardena-Wolf J, Benlagha K, Chiu YH, Mehr R, Bendelac A, (2001) CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity 15: 897-908.
21. Vaarala O, Atkinson MA, Neu J, (2008) The "perfect storm" for type 1 diabetes: the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity. Diabetes 57: 2555-2562.
22. Chen L, Nyomba BL, (2004) Whole body insulin resistance in rat offspring of mothers consuming alcohol during pregnancy or lactation: comparing prenatal and postnatal exposure. J Appl Physiol 96: 167-172.
23. Atkinson MA, Leiter EH, (1999) The NOD mouse model of type 1 diabetes: as good as it gets? Nat Med 5: 601-604.
24. Popova S, Rehm J, Patra J, Zatonski W, (2007) Comparing alcohol consumption in central and eastern Europe to other European countries. Alcohol Alcohol 42: 465-473.
25. Kallberg H, Jacobsen S, Bengtsson C, Pedersen M, Padyukov L, et al. (2009) Alcohol consumption is associated with decreased risk of rheumatoid arthritis: results from two Scandinavian case-control studies. Ann Rheum Dis 68: 222-227.
26. Gombert JM, Herbelin A, Tancrede-Bohin E, Dy M, Carnaud C, et al. (1996) Early quantitative and functional deficiency of NK1+-like thymocytes in the NOD mouse. Eur J Immunol 26: 2989-2998.
27. van der Vliet HJ, von Blomberg BM, Nishi N, Reijm M, Voskuyl AE, et al. (2001) Circulating V(alpha24+) Vbeta11+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage. Clin Immunol 100: 144-148.
28. Wilson SB, Kent SC, Patton KT, Orban T, Jackson RA, et al. (1998) Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. Nature 391: 177-181.
29. Shi FD, Flodstrom M, Balasa B, Kim SH, Van Gunst K, et al. (2001) Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse. Proc Natl Acad Sci U S A 98: 6777-6782.
30. Falcone M, Facciotti F, Ghidoli N, Monti P, Olivieri S, et al. (2004) Up-regulation of CD1d expression restores the immunoregulatory function of NKT cells and prevents autoimmune diabetes in nonobese diabetic mice. J Immunol 172: 5908-5916.
31. Blomqvist M, Kaas A, Mansson JE, Formby B, Rynmark BM, et al. (2003) Developmental expression of the type I diabetes related antigen sulfatide and sulfated lactosylceramide in mammalian pancreas. J Cell Biochem 89: 301-310.
32. Beaudoin L, Laloux V, Novak J, Lucas B, Lehuen A, (2002) NKT cells inhibit the onset of diabetes by impairing the development of pathogenic T cells specific for pancreatic beta cells. Immunity 17: 725-736.
33. Lau AH, Abe M, Thomson AW, (2006) Ethanol affects the generation, cosignaling molecule expression, and function of plasmacytoid and myeloid dendritic cell subsets in vitro and in vivo. J Leukoc Biol 79: 941-953.
34. Novak J, Beaudoin L, Griseri T, Lehuen A, (2005) Inhibition of T cell differentiation into effectors by NKT cells requires cell contacts. J Immunol 174: 1954-1961.