Unawareness of deficits in Alzheimer's disease: Role of the cingulate cortex

Brain

Volumn 134, Issue 4, 2011, Pages 1061-1076

  Amanzio, Martina ^a   Torta, Diana M E ^a   Sacco, Katiuscia ^a,b   Cauda, Franco ^a,b   D'Agata, Federico ^a,b   Duca, Sergio ^a,b   Leotta, Daniela ^c   Palermo, Sara ^a,c   Geminiani, Giuliano C ^a,b  

^a UNIVERSITY OF TURIN   (Italy)

^b Ospedale Koelliker   (Italy)

^c Martini Hospital   (Italy)

Author keywords

anterior cingulate cortex; early Alzheimer's disease; functional magnetic resonance; response inhibition task; unawareness of deficit

Indexed keywords

AGED; ALZHEIMER DISEASE; ANTERIOR CINGULATE; APATHY; APTITUDE TEST; ARTICLE; BEHAVIOR CHANGE; BRAIN FUNCTION; CEREBELLUM; CINGULATE GYRUS; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; LIMBIC CORTEX; MAJOR CLINICAL STUDY; MALE; MOOD CHANGE; NEUROPSYCHIATRY; OCCIPITAL CORTEX; PARIETAL LOBE; PHYSICAL PERFORMANCE; PREFRONTAL CORTEX; PRIORITY JOURNAL; PSYCHOPHYSIOLOGY; TASK PERFORMANCE; UNAWARENESS OF DEFICIT;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AWARENESS; BRAIN MAPPING; EXECUTIVE FUNCTION; FEMALE; GYRUS CINGULI; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LANGUAGE; MAGNETIC RESONANCE IMAGING; MALE; MEMORY; NEUROPSYCHOLOGICAL TESTS; PSYCHIATRIC STATUS RATING SCALES; QUESTIONNAIRES;

EID: 79953651361     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awr020     Document Type: Article

References (120)

1. Agnew SK, Morris RG. The heterogeneity of anosognosia for memory impairment in Alzheimer's disease: a review of the literature and a proposed model. Aging and Mental Health 1998; 2: 9-15.
2. Amanzio M, Geminiani G, Leotta D, Cappa S. Metaphor comprehension in Alzheimer's disease: novelty matters. Brain Lang 2008; 107: 1-10.
3. Amanzio M, Torta DME. Unawareness of deficits in Alzheimer's disease through a biopsychosocial perspective. In: Columbus F, editor. Metacognition: new research development. Hauppauge, New York: Nova Science Publishers; 2009. p. 239-53.
4. American Psychiatric Association. Diagnostic and statistical manual IV. Washington DC: American Psychiatric Association; 2000.
5. Aron AR, Robbins TW, Poldrack RA. Inhibition and the right inferior frontal cortex. Trends Cogn Sci 2004; 8: 170-7. (Pubitemid 38429927)
6. Aron AR, Schlaghecken F, Fletcher PC, Bullmore ET, Eimer M, Barker R, et al. Inhibition of subliminally primed responses is mediated by the caudate and thalamus: evidence from functional MRI and Huntington's disease. Brain 2003; 126: 713-23. (Pubitemid 36240871)
7. Assal F, Cummings JL. Neuropsychiatric symptoms in the dementias. Curr Opin Neurol 2002; 15: 445-50. (Pubitemid 34828121)
8. Auchus AP, Goldstein FC, Green J, Green RC. Unawareness of cognitive impairments in Alzheimer's disease. Neuropsychiatry Neuropsychol Beh Neurol 1994; 7: 25-9. (Pubitemid 24095080)
9. Baddeley AD. Working memory. Oxford: Clarendon Press; 1986.
10. Baddeley AD, Baddeley HA, Bucks RS, Wilcock GK. Attentional control in Alzheimer's disease. Brain 2001; 124: 1492-508. (Pubitemid 32726764)
11. Barch DM, Braver TS, Akbudak E, Conturo T, Ollinger J, Snyder A. Anterior cingulate cortex and response conflict: effects of response modality and processing domain. Cereb Cortex 2001; 11: 837-48. (Pubitemid 32800551)
12. Barrett AM, Eslinger PJ, Ballentine NH, Heilman KM. Unawareness of cognitive deficit (cognitive anosognosia) in probable AD and control subjects. Neurology 2005; 64: 693-9. (Pubitemid 40261900)
13. Bech P. The Bech-Rafaelsen Mania Scale in clinical trials of therapies for bipolar disorder: a 20-year review of its use as an outcome measure. CNS Drugs 2002; 16: 47-63. (Pubitemid 34151337)
14. Bech P, Rafaelsen OJ, Kramp P, Bolwig TG. The mania rating scale: scale construction and inter-observer agreement. Neuropharmacology 1978; 17: 430-1.
15. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. JRSS-B 1995; 57: 289-300.
16. Benoit M, Clairet S, Koulibaly PM, Darcourt J, Robert PH. Brain perfusion correlates of the apathy inventory dimensions of Alzheimer's disease. Int J Geriatr Psychiatry 2004; 19: 864-9. (Pubitemid 39242892)
17. Binder JR, Frost JA, Hammeke TA, Bellgowan PSF, Rao SM, Cox RW. Conceptual processing during the conscious resting state A functional MRI study. J Cogn Neurosci 1999; 11: 80-93. (Pubitemid 29224571)
18. Botvinick M, Nystrom LE, Fissell K, Carter CS, Cohen JD. Conflict monitoring versus selection-for-action in anterior cingulate cortex. Nature 1999; 402: 179-81.
19. Boynton GM, Engel SA, Glover GH, Heeger DJ. Linear systems analysis of functional magnetic resonance imaging in human V1. J Neurosci 1996; 16: 4207-21. (Pubitemid 26192416)
20. Braver TS, Barch DM, Gray JR, Molfese DL, Snyder A. Anterior cingulate cortex and response conflict: effects of frequency, inhibition and errors. Cereb Cortex 2001; 11: 825-36. (Pubitemid 32800550)
21. Bush G, Whalen PJ, Rosen BR, Jenike MA, McInerney SC, Rauch SL. The counting Stroop: an interference task specialized for functional neuroi-maging-validation study with functional MRI. Hum Brain Mapp 1998; 6: 270-82. (Pubitemid 28364523)
22. Carter CS, Braver TS, Barch DM, Botvinick MM, Noll D, Cohen JD. Anterior cingulate cortex, error detection, and the online monitoring of performance. Science 1998; 280: 747-9. (Pubitemid 28243351)
23. Casey BJ, Trainor RJ, Orendi JL, Schubert A, Nystrom LE, Giedd JN, et al. A Developmental Functional MRI Study of Prefrontal Activation during Performance of a Go-No-Go Task. J Cog Neurosci 1997; 9: 835-47. (Pubitemid 28025197)
24. Cavanna AE. The precuneus and consciousness. CNS Spectrums 2007; 12: 545-52. (Pubitemid 47195296)
25. Chikazoe J, Konishi S, Asari T, Jimura K, Miyashita Y. Activation of right inferior frontal gyrus during response inhibition across response modalities. J Cogn Neurosci 2007; 19: 69-80. (Pubitemid 46106024)
26. Clare L. Awareness in early-stage Alzheimer's disease: a review of methods and evidence. Br J Clin Psychol 2004a; 43: 177-96. (Pubitemid 38923510)
27. Clare L. The construction of awareness in early-stage Alzheimer's disease: a review of concepts and models. Br J Clin Psychol 2004 b; 43: 155-75. (Pubitemid 38923509)
28. Clarke DE, Reekum R, Simard M, Streiner DL, Freedman M, Conn D. Apathy in dementia: an examination of the psychometric properties of the apathy evaluation scale. J Neuropsychiatry Clin Neurosci 2007; 19: 57-64. (Pubitemid 46294446)
29. Cohen JD, Botvinick M, Carter CS. Anterior cingulate and prefrontal cortex: who's in control? Nat Neurosci 2000; 3: 421-3. (Pubitemid 30495619)
30. Corbetta M, Miezin FM, Dobmeyer S, Shulman GL, Petersen SE. Selective and divided attention during visual discriminations of shape, color, and speed: functional anatomy by positron emission tomography. J Neurosci 1991; 11: 2383-402.
31. Corbetta M, Shulman GL. Control of goal-directed and stimulus-driven attention in the brain. Nat Rev Neurosci 2002; 3: 201-15. (Pubitemid 135706590)
32. DeBettignies BH, Mahurin RK, Pirozzolo FJ. Insight for impairment in independent living skills in Alzheimer's disease and multi-infarct dementia. J Clin Exp Neuropsychol 1990; 12: 355-63. (Pubitemid 20203703)
33. Derbyshire SW, Vogt BA, Jones AK. Pain and Stroop interference tasks activate separate processing modules in anterior cingulate cortex. Exp Brain Res 1998; 118: 52-60. (Pubitemid 28052677)
34. Devinsky O, Morrell MJ, Vogt BA. Contributions of anterior cingulate cortex to behaviour. Brain 1995; 118 (Pt 1): 279-306.
35. Dickerson BC, Sperling RA. Large-scale functional brain network abnormalities in Alzheimer's disease: insight from functional neuroima-ging. Behav Neurol 2009; 21: 63-75.
36. Duara R, Grady C, Haxby J, Sundaram M, Cutler NR, Heston L, et al. Positron emission tomography in Alzheimer's disease. Neurology 1986; 36: 879-87. (Pubitemid 16098229)
37. Fernandez-Duque D, Baird J, Posner M. Executive attention and meta-cognitive regulation. Consciousness and Cognition 2000; 9: 288-307.
38. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-98.
39. Forman SD, Cohen JD, Fitzgerald M, Eddy WF, Mintun MA, Noll DC. Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold. Magn Reson Med 1995; 33: 636-47.
40. Fox MD, Corbetta M, Snyder AZ, Vincent JL, Raichle ME. Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems. Proc Natl Acad Sci USA 2006; 103: 10046-51. (Pubitemid 43993620)
41. Garavan H, Ross TJ, Stein EA. Right hemispheric dominance of inhibitory control: an event-related functional MRI study. Proc Natl Acad Sci USA 1999; 96: 8301-6. (Pubitemid 29328449)
42. Goebel R, Esposito F, Formisano E. Analysis of functional image analysis contest (FIAC) data with brainvoyager QX: from single-subject to cortically aligned group general linear model analysis and self-organizing group independent component analysis. Hum Brain Mapp 2006; 27: 392-401. (Pubitemid 43787637)
43. Goldstein RZ, Volkow ND, Wang GJ, Fowler JS, Rajaram S. Addiction changes orbitofrontal gyrus function: involvement in response inhibition. Neuroreport 2001; 12: 2595-9. (Pubitemid 32682228)
44. Green J, Goldstein FC, Sirockman BE, Green RC. Variable awareness of deficits in Alzheimer's disease. Neuropsychiatry Neuropsychol Beh Neurol 1993; 6: 159-65. (Pubitemid 23220666)
45. Gusnard DA, Raichle ME, Raichle ME. Searching for a baseline: functional imaging and the resting human brain. Nat Rev Neurosci 2001; 2: 685-94. (Pubitemid 33674814)
46. Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol 1959; 32: 50-5.
47. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 56-62.
48. Hannesdottir K, Morris RG. Primary and secondary anosognosia for memory impairment in patients with Alzheimer's disease. Cortex 2007; 43: 1020-30. (Pubitemid 47520456)
49. Hanyu H, Sato T, Akai T, Shimizu S, Hirao K, Kanetaka H, et al. Neuroanatomical correlates of unawareness of memory deficits in early Alzheimer's disease. Dement Geriatr Cogn Disord 2008; 25: 347-53. (Pubitemid 351562956)
50. Harwood DG, Sultzer DL, Feil D, Monserratt L, Freedman E, Mandelkern MA. Frontal lobe hypometabolism and impaired insight in Alzheimer disease. Am J Geriatr Psychiatry 2005; 13: 934-41. (Pubitemid 46638659)
51. Jagust WJ, Reed BR, Seab JP, Budinger TF. Alzheimer's disease. Age at onset and single-photon emission computed tomographic patterns of regional cerebral blood flow. Arch Neurol 1990; 47: 628-33. (Pubitemid 20183568)
52. Jorm A. Use of informants' reports to study memory changes in dementia. In: Backman L, editor. Memory functioning in dementia. Amsterdam: Elsevier Science Publishers BV; 1992.
53. Jorm AF, Christensen H, Henderson AS, Korten AE, Mackinnon AJ, Scott R. Complaints of cognitive decline in the elderly: a comparison of reports by subjects and informants in a community survey. Psychol Med 1994; 24: 365-74. (Pubitemid 24158850)
54. Kashiwa Y, Kitabayashi Y, Narumoto J, Nakamura K, Ueda H, Fukui K. Anosognosia in Alzheimer's disease: association with patient characteristics, psychiatric symptoms and cognitive deficits. Psychiatry Clin Neurosci 2005; 59: 697-704. (Pubitemid 43151663)
55. Kaszniak AW, Zak MG. On the neuropsychology of metamemory: Contributions from the study of amnesia and dementia. Learn Individ Differ 1996; 8: 355-81. (Pubitemid 126174996)
56. Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged. The index of Adl: a standardized measure of biological and psychosocial function. JAMA 1963; 185: 914-9.
57. Kawashima R, Satoh K, Itoh H, Ono S, Furumoto S, Gotoh R, et al. Functional anatomy of GO/NO-GO discrimination and response selec-tion-a PET study in man. Brain Res 1996; 728: 79-89. (Pubitemid 26254959)
58. Kiehl KA, Liddle PF, Hopfinger JB. Error processing and the rostral anterior cingulate: an event-related fMRI study. Psychophysiology 2000; 37: 216-23. (Pubitemid 30140286)
59. Konishi S, Nakajima K, Uchida I, Kikyo H, Kameyama M, Miyashita Y. Common inhibitory mechanism in human inferior prefrontal cortex revealed by event-related functional MRI. Brain 1999; 122 (Pt 5): 981-91. (Pubitemid 29219269)
60. Krabbendam L, de Vugt ME, Derix MM, Jolles J. The behavioural assessment of the dysexecutive syndrome as a tool to assess executive functions in schizophrenia. Clin Neuropsychol 1999; 13: 370-5. (Pubitemid 30040148)
61. Lancaster JL, Rainey LH, Summerlin JL, Freitas CS, Fox PT, Evans AC, et al. Automated labeling of the human brain: a preliminary report on the development and evaluation of a forward-transform method. Hum Brain Mapp 1997; 5: 238-42. (Pubitemid 27375521)
62. Lancaster JL, Woldorff MG, Parsons LM, Liotti M, Freitas CS, Rainey L, et al. Automated Talairach atlas labels for functional brain mapping. Hum Brain Mapp 2000; 10: 120-31. (Pubitemid 30456920)
63. Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 1969; 9: 179-86.
64. Levy R, Dubois B. Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cereb Cortex 2006; 16: 916-28. (Pubitemid 43992442)
65. Leys D, Steinling M, Petit H, Salomez JL, Gaudet Y, Ovelacq E, et al. Alzheimer's disease: study by single photon emission tomography (Hm PAO Tc99m). Rev Neurol 1989; 145: 443-50. (Pubitemid 19164677)
66. Liddle PF, Kiehl KA, Smith AM. Event-related fMRI study of response inhibition. Hum Brain Mapp 2001; 12: 100-9. (Pubitemid 32120708)
67. Litvan I, Agid Y, Calne D, Campbell G, Dubois B, Duvoisin RC, et al. Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology 1996; 47: 1-9. (Pubitemid 26243849)
68. Litvan I, Agid Y, Goetz C, Jankovic J, Wenning GK, Brandel JP, et al. Accuracy of the clinical diagnosis of corticobasal degeneration: a clinicopathologic study. Neurology 1997; 48: 119-25. (Pubitemid 27039529)
69. Litvan I, Bhatia KP, Burn DJ, Goetz CG, Lang AE, McKeith I, et al. Movement disorders society scientific issues committee report: SIC task force appraisal of clinical diagnostic criteria for Parkinsonian disorders. Mov Disord 2003; 18: 467-86. (Pubitemid 36656531)
70. Loebel JP, Dager SR, Berg G, Hyde TS. Fluency of speech and self-awareness of memory deficit in Alzheimer's disease. Int J Geriatric Psychiatry 1990; 5: 41-5. (Pubitemid 20081806)
71. Lopez OL, Becker JT, Somsak D, Dew MA, DeKosky ST. Awareness of cognitive deficits and anosognosia in probable Alzheimer's disease. Eur Neurol 1994; 34: 277-82. (Pubitemid 24265499)
72. Mangone CA, Hier DB, Gorelick PB, Ganellen RJ, Langenberg P, Boarman R, et al. Impaired insight in Alzheimer's disease. J Geriatr Psychiatry Neurol 1991; 4: 189-93.
73. Marin RS. Apathy: concept, syndrome, neural mechanisms, and treatment. Semin Clin Neuropsychiatry 1996; 1: 304-14.
74. Marin RS, Biedrzycki RC, Firinciogullari S. Reliability and validity of the apathy evaluation scale. Psychiatry Res 1991; 38: 143-62.
75. Marshall GA, Monserratt L, Harwood D, Mandelkern M, Cummings JL, Sultzer DL. Positron emission tomography metabolic correlates of apathy in Alzheimer disease. Arch Neurol 2007; 64: 1015-20. (Pubitemid 47048003)
76. McGlynn SM, Schacter DL. Unawareness of deficits in neuropsy-chological syndromes. J Clin Exp Neuropsychol 1989; 11: 143-205.
77. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-44. (Pubitemid 14076461)
78. Michon A, Deweer B, Pillon B, Agid Y, Dubois B. Relation of anosognosia to frontal lobe dysfunction in Alzheimer's disease. J Neurol Neurosurg Psychiatry 1994; 57: 805-9. (Pubitemid 24214960)
79. Migliorelli R, Teson A, Sabe L, Petracca G, Petracchi M, Leiguarda R, et al. Anosognosia in Alzheimer's disease: a study of associated factors. J Neuropsychiatry Clin Neurosci 1995; 7: 338-44.
80. Migneco O, Benoit M, Koulibaly PM, Dygai I, Bertogliati C, Desvignes P, et al. Perfusion brain SPECT and statistical parametric mapping analysis indicate that apathy is a cingulate syndrome: a study in Alzheimer's disease and nondemented patients. Neuroimage 2001; 13: 896-902. (Pubitemid 32848334)
81. Mimura M, Yano M. Memory impairment and awareness of memory deficits in early-stage Alzheimer's disease. Rev Neurosci 2006; 17: 253-66.
82. Mitchell JP, Heatherton TF, Macrae CN. Distinct neural systems subserve person and object knowledge. Proc Natl Acad Sci USA 2003; 99: 15238-43. (Pubitemid 35334640)
83. Mograbi DC, Brown RG, Morris RG. Anosognosia in Alzheimer's disease- the petrified self. Conscious Cogn 2009; 18: 989-1003.
84. Morris R, Hannesdottir GK. Loss of "awareness" in Alzheimer's disease. In: Morris RG, Becker JT, editors. Cognitive Neuropsychology of Alzheimer's. Oxford: Oxford University Press; 2004.
85. Mullen R, Howard R, David A, Levy R. Insight in Alzheimer's disease. Int J Geriatr Psychiatry 1996; 11: 645-51. (Pubitemid 26241743)
86. Nakata H, Sakamoto K, Ferretti A, Gianni Perrucci M, Del Gratta C, Kakigi R, et al. Somato-motor inhibitory processing in humans: an event-related functional MRI study. Neuroimage 2008; 39: 1858-66.
87. Norman DA, Shallice T. Attention to action: willed and automatic control of behavior. San Diego: San Diego: University of California; 1980.
88. Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 1971; 9: 97-113.
89. Ott BR, Fogel BS. Measurement of depression in dementia: self vs clinician rating. Int J Geriatr Psychiatry 1992; 7: 899-904. (Pubitemid 23007116)
90. Ott BR, Noto RB, Fogel BS. Apathy and loss of insight in Alzheimer's disease: a SPECT imaging study. J Neuropsychiatry Clin Neurosci 1996; 8: 41-6. (Pubitemid 26044699)
91. Pardo JV, Pardo PJ, Janer KW, Raichle ME. The anterior cingulate cortex mediates processing selection in the Stroop attentional conflict paradigm. Proc Natl Acad Sci USA 1990; 87: 256-9.
92. Picard N, Strick PL. Motor areas of the medial wall: a review of their location and functional activation. Cereb Cortex 1996; 6: 342-53. (Pubitemid 26161547)
93. Reed BR, Jagust WJ, Coulter L. Anosognosia in Alzheimer's disease: relationships to depression, cognitive function, and cerebral perfusion. J Clin Exp Neuropsychol 1993; 15: 231-44. (Pubitemid 23156209)
94. Reisberg B, Ferris SH, de Leon MJ, Crook T. The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry 1982; 139: 1136-9. (Pubitemid 12051593)
95. Reitan RM, Wolfson D. A selective and critical review of neuropsycho-logical deficits and the frontal lobes. Neuropsychol Rev 1994; 4: 161-98.
96. Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. Am J Psychiatry 1984; 141: 1356-64.
97. Rubia K, Russell T, Bullmore ET, Soni W, Brammer MJ, Simmons A, et al. An fMRI study of reduced left prefrontal activation in schizophrenia during normal inhibitory function. Schizophr Res 2001; 52: 47-55. (Pubitemid 32947047)
98. Ryan JJ, Tree HA, Morris J, Gontkovsky ST. Wechsler Adult Intelligence Scale-III inter-subtest scatter: a comparison of brain-damaged patients and normal controls. J Clin Psychol 2006; 62: 1319-26. (Pubitemid 44569378)
99. Salmon E, Ruby P, Perani D, Kalbe E, Laureys S, Adam S, et al. Two aspects of impaired consciousness in Alzheimer's disease. Prog Brain Res 2005; 150: 287-98. (Pubitemid 41381560)
100. Salmon E, Perani D, Herholz K, Marique P, Kalbe E, Holthoff V, et al. Neural correlates of anosognosia for cognitive impairment in Alzheimer's Disease. Hum Brain Mapp 2006; 27: 588-97. (Pubitemid 44078930)
101. Sebastian MV, Menor J, Elosua MR. Attentional dysfunction of the central executive in AD: evidence from dual task and perseveration errors. Cortex 2006; 42: 1015-20. (Pubitemid 46017206)
102. Shibata K, Narumoto J, Kitabayashi Y, Ushijima Y, Fukui K. Correlation between anosognosia and regional cerebral blood flow in Alzheimer's disease. Neurosci Lett 2008; 435: 7-10.
103. Snow AL, Norris MP, Doody R, Molinari VA, Orengo CA, Kunik ME. Dementia Deficits Scale. Rating self-awareness of deficits. Alzheimer Dis Assoc Disord 2004; 18: 22-31.
104. Spinnler H, Tognoni G. Standardizzazione e taratura italiana di test neuropsicologici. Ital J Neurol Sci 1987; 8.
105. Starkstein SE, Garau ML, Cao A. Prevalence and clinical correlates of disinhibition in dementia. Cogn Behav Neurol 2004; 17: 139-47. (Pubitemid 39238361)
106. Starkstein SE, Jorge R, Mizrahi R, Adrian J, Robinson RG. Insight and danger in Alzheimer's disease. Eur J Neurol 2007; 14: 455-60. (Pubitemid 46481175)
107. Starkstein SE, Jorge R, Mizrahi R, Robinson RG. A diagnostic formulation for anosognosia in Alzheimer's disease. J Neurol Neurosurg Psychiatry 2006; 77: 719-25. (Pubitemid 43837195)
108. Starkstein SE, Migliorelli R, Teson A, Petracca G, Chemerinsky E, Manes F, et al. Prevalence and clinical correlates of pathological affective display in Alzheimer's disease. J Neurol Neurosurg Psychiatry 1995; 59: 55-60.
109. Starkstein SE, Petracca G, Chemerinski E, Kremer J. Syndromic validity of apathy in Alzheimer's disease. Am J Psychiatry 2001; 158: 872-7. (Pubitemid 32547615)
110. Starkstein SE, Sabe L, Chemerinski E, Jason L, Leiguarda R. Two domains of anosognosia in Alzheimer's disease. J Neurol Neurosurg Psychiatry 1996; 61: 485-90. (Pubitemid 26394906)
111. Stuss DT, Anderson V. The frontal lobes and theory of mind: developmental concepts from adult focal lesion research. Brain Cogn 2004; 55: 69-83. (Pubitemid 38591431)
112. Stuss DT, Levine B. Adult clinical neuropsychology: lessons from studies of the frontal lobes. Annu Rev Psychol 2002; 53: 401-33.
113. Stuss DT, Picton TW, Alexander MP. Counsciousness, self-awareness and the frontal lobes. In: Stuss DT, Knight RT, editors. Princuples of frontal lobe function. New York: Oxford University Press; 2001.
114. Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain: 3-dimensional proportional system-an approach to cerebral imaging. New York: Thieme Medical Publishers; 1988.
115. Vasterling JJ, Seltzer B, Foss JW, Vanderbrook V. Unawareness of deficits in Alzheimer's disease: domain-specific differences and disease correlates. Neuropsych Neuropsychol Behav Neurol 1995; 8: 26-32.
116. Verhey FR, Jolles J, Ponds RW, Rozendaal N, Plugge LA, de Vet RC, et al. Diagnosing dementia: a comparison between a monodisciplinary and a multidisciplinary approach. J Neuropsychiatry Clin Neurosci 1993; 5: 78-85. (Pubitemid 23073815)
117. Vogel A, Hasselbalch S, Gade A, Ziebell M, Waldemar G. Cognitive and functional neuroimaging correlate for anosognosia in mild cognitive impairment and Alzheimer's disease. Int J Geriatric Psych 2005; 20: 238-46. (Pubitemid 40426024)
118. Vogt BA, Devinsky O. Topography and relationships of mind and brain. Prog Brain Res 2000; 122: 11-22. (Pubitemid 30114466)
119. Wilson BA, Alderman N, Burguess PW, Emslie H, Evans JJ. Behavioural assessment of the dysexecutive syndrome (BADS). Bury St. Edmunds, UK: Thames Valley Test Company; 1996.
120. Zakzanis KK, Mraz R, Graham SJ. An fMRI study of the trail making test. Neuropsychologia 2005; 43: 1878-86. (Pubitemid 41317404)