Molecular mechanism of pancreatic β-cell adaptive proliferation: Studies during pregnancy in rats and in vitro

Endocrine

Volumn 39, Issue 2, 2011, Pages 118-127

  Chen, Guofang ^a,c   Liu, Cuiping ^a   Xue, Ying ^a,b   Mao, Xiaodong ^a   Xu, Kuanfeng ^a   Liu, Chao ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b NORTHERN JIANGSU PEOPLE S HOSPITAL   (China)

^c MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

Author keywords

Gene chips; Pancreatic islet cell; Pregnancy; Proliferation

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; BETA CATENIN; BETA CELL TRANSLOCATION GENE 2 PROTEIN; CELL PROTEIN; MESSENGER RNA; MYC PROTEIN; NUCLEAR PROTEIN; NUCLEAR PROTEIN 1; PROLACTIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION PROFILING; IN VITRO STUDY; MICROARRAY ANALYSIS; NONHUMAN; PANCREAS ISLET BETA CELL; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 79953650081     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-010-9421-6     Document Type: Article

References (30)

1. A.E. Butler, J. Janson, S. Bonner-Weir, R. Ritzel, R.A. Rizza, P.C. Butler, β-Cell deficit, increased β-cell apoptosis in humans with type 2 diabetes. Diabetes 52, 102-110 (2003)
2. E.A. Ryan, B.W. Paty, P.A. Senior, D. Bigam, E. Alfadhli, N.M. Kneteman, Five-year follow-up after clinical islet transplantation. Diabetes 54, 2060-2069 (2005)
3. S. Bonner-Weir, G.C. Weir, New sources of pancreatic beta-cells. Nat. Biotechnol. 23, 857-861 (2005)
4. I. Swenne, Glucose-stimulated DNA replication in the pancreatic islets during the development of the rat fetus. Diabetes 34, 803-807 (1985)
5. S. Georgia, A. Bhushan, Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J. Clin. Invest. 114, 963-968 (2004)
6. Y. Dor, J. Brown, O.I. Martinez, D.A. Melton, Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429, 41-46 (2004)
7. E. Akbay, M.B. Tiras, I. Yetkin, F. Toruner, R. Ersoy, S. Uysal, Insulin secretion and insulin sensitivity in normal pregnancy and gestational diabetes mellitus. Gynecol. Endocrinol. 17(2), 137-142 (2003)
8. E.A. Ryan, Hormones and insulin resistance during pregnancy. Lancet 362(9398), 1777-1778 (2003)
9. A.M. Svensson, B. Bodin, A. Andersson, L. Jansson, Pancreatic islet blood flow during pregnancy in the rat: an increased islet mass is associated with decreased islet blood flow. J. Endocrinol. 180(3), 409-415 (2004)
10. M. Johansson, G. Mattsson, A. Andersson, L. Jansson, P.O. Carlsson, Islet endothelial cells, pancreatic beta-cell proliferation: studies in vitro, during pregnancy in adult rats. Endocrinology 147(5), 2315-2324 (2006)
11. Y. Xue, C.P. Liu, Y. Xu, Q.X. Yuan, X.D. Mao, G.F. Chen, C. Liu, Study on pancreatic islet adaptation, gene expression during pregnancy in rats. Endocrine 37, 83-97 (2010)
12. L.C. Alonso, T. Yokoe, P. Zhang, D.K. Scott, S.K. Kim, C.P. O'Donnell, Glucose infusion in mice a new model to induce β-cell replication. Diabetes 56, 1792-1801 (2007)
13. S. Fatrai, L. Elghazi, N. Balcazar, C. Cras-Meneur, I. Krits, H. Kiyokawa, Akt induces β-cell proliferation by regulating cyclin D1, cyclin D2, p21 levels, cyclin-dependent kinase-4 activity. Diabetes 55, 318-325 (2006)
14. S.K. Chakrabarti, R.G. Mirmira, Transcription factors direct the development and function of pancreatic β cells. TEM 14, 782-841 (2003)
15. E. Edlund, Factors controlling pancreatic cell differentiation and function. Diabetologia 44, 1071-1079 (2001)
16. T. Hai, M.G. Hartman, The molecular biology and nomenclature of the ATF/CREB family of transcription factors: ATF proteins and homeostasis. Gene 273, 1-11 (2001)
17. A.E. Allen-Jennings, M.G. Hartman, G.J. Kociba, T. Hai, The roles of ATF3 in glucose homeostasis: a transgenic mouse model with liver dysfunction and defects in endocrine pancreas. J. Biol. Chem 276, 29507-29514 (2001)
18. M.G. Hartman, D. Lu, M.L. Kim, G.J. Kociba, T. Shukri, J. Buteau, Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Mol. Cell. Biol. 24, 5721-5732 (2004)
19. A.K. Busch, D. Cordery, G.S. Denyer, T.J. Biden, Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function. Diabetes 51, 977-987 (2002)
20. K. Tamura, B. Hua, S. Adachi, I. Guney, J. Kawauchi, M. Morioka, Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation. EMBO 24, 2590-2601 (2005)
21. L.C. Murtaugh, A.C. Law, Y. Dor, D.A. Melton, β-Catenin is essential for pancreatic acinar but not islet development. Development 132, 4663-4674 (2005)
22. S. Papadopoulou, H. Edlund, Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function. Diabetes 54, 2844-2851 (2005)
23. P.W. Heiser, J. Lau, M.M. Taketo, P.L. Herrera, M. Hebrok, Stabilization of b-catenin impacts pancreas growth. Development 133, 2023-2032 (2006)
24. I.C. Rulifson, S.K. Karnik, P.W. Heiser, D. Berge, H. Chen, X. Gu, Wnt signaling regulates pancreatic β cell proliferation. PNAS 104(15), 6247-6252 (2007)
25. G.V. Mallo, F. Fiedler, E.L. Calvo, E.M. Ortiz, S. Vasseur, V. Keim, Cloning and expression of the rat p8 cDNA, a new gene activated in pancreas during the acute phase of pancreatitis, pancreatic development, and regeneration, and which promotes cellular growth. J. Biol. Chem 272, 32360-32369 (1997)
26. Y. Motoo, J.L. Iovanna, G.V. Mallo, S.B. Su, M.J. Xie, N. Sawabu, P8 expression is induced in acinar cells during chronic pancreatitis. Dig. Dis. Sci. 46, 1640-1646 (2001)
27. G. Path, A. Opel, M. Gehlen, V. Rothhammer, M.D. Brendel, R.G. Bretzel, Glucose-dependent expansion of pancreatic β-cells by the protein p8 in vitro and in vivo. Am. J. Physiol. Endocrinol. Metab 291, 1168-1176 (2006)
28. S. Wang, A.J. Dibenedetto, R.N. Pittman, Genes induced in programmed cell death of neuronal PC12 cells and developing sympathetic neurons in vivo. Dev. Biol. 188, 322-336 (1997)
29. L.E. Stout, N.V. Bhagroo, R.L. Sorenson, Distinctive roles for prolactin and growth hormone in the activation of signal transducer and activator of transcription 5 in pancreatic islets of langerhans. Endocrinology 145(9), 4162-4175 (2004)
30. Y. Fujinaka, K. Takane, H. Yamashita, R.C. Vasavada, Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation. J. Biol. Chem 282(42), 30707-30717 (2007)