Virulence of Entamoeba histolytica: A challenge for human health research

Future Microbiology

Volumn 6, Issue 3, 2011, Pages 255-258

  Anaya Velázquez, Fernando ^a   Padilla Vaca, Felipe ^a  

^a UNIVERSITY OF GUANAJUATO   (Mexico)

Author keywords

biological activities; determinants of virulence; Entamoeba histolytica; pathogenesis; virulence factors

Indexed keywords

COMPLEMENTARY RNA; CYSTEINE PROTEINASE; LECTIN; MUCIN; TRANSCRIPTOME; VIRULENCE FACTOR;

ANTIBACTERIAL ACTIVITY; APOPTOSIS; EDITORIAL; ENTAMOEBA HISTOLYTICA; ERYTHROPHAGOCYTOSIS; GENE SILENCING; GENETIC RESISTANCE; HOST CELL; HUMAN; IMMUNE RESPONSE; INFLAMMATION; INTESTINE FLORA; MORBIDITY; MORTALITY; NONHUMAN; NUTRITIONAL STATUS; PARASITE VIRULENCE; PARASITOSIS; PATHOGENESIS; PRIORITY JOURNAL; TROPHOZOITE;

ENTAMOEBA HISTOLYTICA; ENTAMOEBIASIS; HUMANS; VIRULENCE; VIRULENCE FACTORS;

ENTAMOEBA HISTOLYTICA;

EID: 79953307506     PISSN: 17460913     EISSN: None     Source Type: Journal    
DOI: 10.2217/fmb.11.2     Document Type: Editorial

References (25)

1. Ali IK, Clark CG, Petri WA Jr: Molecular epidemiology of amebiasis. Infect. Genet. Evol. 8, 698-707 (2008).
2. Olivos-García A, Saavedra E, Ramos-Martínez E, Nequiz M, Pérez-Tamayo R: Molecular nature of virulence in Entamoeba histolytica. Infect. Genet. Evol. 9, 1033-1037 (2009).
3. Padilla-Vaca F, Anaya-Velázquez F: Insights into Entamoeba histolytica virulence modulation. Infect. Disord. Drug Targets 10, 242-250 (2010).
4. González A, Monterrubio D, Nequiz M et al.: Localization of Entamoeba histolytica amebopore in amebic liver abscesses in hamsters. Ann. NY Acad. Sci. 1149, 375-379 (2008).
5. Irmer H, Tillack M, Biller L et al.: Major cysteine peptidases of Entamoeba histolytica are required for aggregation and digestion of erythrocytes but are dispensable for phagocytosis and cytopathogenicity. Mol. Microbiol. 72, 658-667 (2009).
6. Sen A, Chatterjee NS, Akbar MA, Nandi N, Das P: The 29-kilodalton thiol-dependent peroxidase of Entamoeba histolytica is a factor involved in pathogenesis and survival of the parasite during oxidative stress. Eukaryot. Cell 6, 664-673 (2007).
7. Santi-Rocca J, Weber C, Guigon G, Sismeiro O, Coppée JY, Guillén N: The lysine- and glutamic acid-rich protein KERP1 plays a role in Entamoeba histolytica liver abscess pathogenesis. Cell Microbiol. 10, 202-217 (2008).
8. Freitas MA, Fernandes HC, Calixto VC et al.: Entamoeba histolytica: cysteine proteinase activity and virulence. Focus on cysteine proteinase 5 expression levels. Exp. Parasitol. 122, 306-309 (2009).
9. Mendoza-Macías CL, Barrios-Ceballos MP, Anaya-Velázquez F, Nakada-Tsukui K, Nozaki T, Padilla-Vaca F: Entamoeba histolytica: molecular cloning and characterization of a novel neutral sphingomyelinase. Exp. Parasitol. 125, 279-285 (2010).
10. He C, Nora GP, Schneider EL et al.: A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. J. Biol. Chem. 285, 18516-18527 (2010).
11. Ramos-Martínez E, Olivos-García A, Saavedra E et al.: Entamoeba histolytica: oxygen resistance and virulence. Int. J. Parasitol. 39, 693-702 (2009).
12. Davis PH, Zhang X, Guo J, Townsend RR, Stanley SL Jr: Comparative proteomic analysis of two Entamoeba histolytica strains with different virulence phenotypes identifies peroxiredoxin as an important component of amoebic virulence. Mol. Microbiol. 61, 1523-1532 (2006).
13. Biller L, Davis PH, Tillack M, Matthiesen J, Lotter H, Stanley SL Jr: Differences in the transcriptome signatures of two genetically related Entamoeba histolytica cell lines derived from the same isolate with different pathogenic properties. BMC Genomics 11, 63 (2010).
14. Ehrenkaufer GM, Singh U: Transcriptional regulatory networks in Entamoeba histolytica. Curr. Drug Targets 9, 931-937 (2008).
15. Gilchrist CA, Houpt E, Trapaidze N et al.: Impact of intestinal colonization and invasion on the Entamoeba histolytica transcriptome. Mol. Biochem. Parasitol. 147, 163-176 (2006).
16. Vicente JB, Ehrenkaufer GM, Saraiva LM, Teixeira M, Singh U: Entamoeba histolytica modulates a complex repertoire of novel genes in response to oxidative and nitrosative stresses: implications for amebic pathogenesis. Cell Microbiol. 11, 51-69 (2009).
17. Baxt LA, Rastew E, Bracha R, Mirelman D, Singh U: Downregulation of an Entamoeba histolytica rhomboid protease reveals roles in regulating parasite adhesion and phagocytosis. Eukaryot. Cell 9, 1283-1293 (2010).
18. Biller L, Schmidt H, Krause E et al.: Comparison of two genetically related Entamoeba histolytica cell lines derived from the same isolate with different pathogenic properties. Proteomics 9, 4107-4120 (2009).
19. Mirelman D, Anbar M, Bracha R: Trophozoites of Entamoeba histolytica epigenetically silenced in several genes are virulence-attenuated. Parasite 15, 266-274 (2008).
20. Lejeune M, Rybicka JM, Chadee K: Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica. Future Microbiol. 4, 105-118 (2009).
21. Mendoza-Macías CL, Barrios-Ceballos MP, de la Peña LP et al.: Entamoeba histolytica: effect on virulence, growth and gene expression in response to monoxenic culture with Escherichia coli 055. Exp. Parasitol. 121, 167-174 (2009).
22. Lorenzi HA, Puiu D, Miller JR et al.: New assembly, reannotation and analysis of the Entamoeba histolytica genome reveal new genomic features and protein content information. PLoS Negl. Trop. Dis. 4, E716 (2010).
23. Mirelman D, Ankri S, Katz U, Padilla-Vaca F, Bracha R: Pathogenesis of Entamoeba histolytica depends on the concerted action of numerous virulence factors. Arch. Med. Res. 31(4 Suppl.), S214-S215 (2000).
24. Bansal D, Ave P, Kerneis S et al.: An ex-vivo human intestinal model to study Entamoeba histolytica pathogenesis. PLoS Negl. Trop. Dis. 3, E551 (2009).
25. Solis CF, Santi-Rocca J, Perdomo D, Weber C, Guillén N: Use of bacterially expressed dsRNA to downregulate Entamoeba histolytica gene expression. PLoS ONE 4, E8424 (2009).