Simultaneous quantification of 5-FU, 5-FUrd, 5-FdUrd, 5-FdUMP, dUMP and TMP in cultured cell models by LC-MS/MS

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 27, 2009, Pages 2937-2944

  Carli, Delphine ^a,b,e   Honorat, Mylène ^c,d,g   Cohen, Sabine ^a,b,f   Megherbi, Mehdi ^a,b,e   Vignal, Bruno ^a,b,f   Dumontet, Charles ^c,d,g   Payen, Léa ^c,d,g,h   Guitton, Jérôme ^a,b,c,d,e,h  

^a HOSPICES CIVILS DE LYON   (France)

^b CENTRE HOSPITALIER LYON SUD   (France)

^c UNIVERSITÉ DE LYON   (France)

^d UNIVERSITÉ LYON 1   (France)

^e Laboratoire de ciblage thérapeutique en cancérologie   (France)

^f Laboratoire de biochimie toxicologieFrance   (France)

^g CENTRE LÉON BÉRARD   (France)

^h ISPBL   (France)

Author keywords

5 FdUMP; 5 FU; Intracellular; Mass spectrometry; Metabolite

Indexed keywords

5-FDUMP; 5-FLUOROURACIL (5-FU); 5-FU; ABC TRANSPORTER; AMMONIUM FORMATE; ANALYTES; ATLANTIS; CELLULAR PROTEINS; CULTURE MEDIUM; CULTURED CELL; DEOXYURIDINE; ELECTROSPRAY INTERFACES; EXPERIMENTAL CONDITIONS; EXTRACTION RECOVERY; FREEZE-THAW CYCLES; IN-CELL; INTER-ASSAY VARIABILITY; INTRACELLULAR; INTRACELLULAR PRODUCTION; ISOCRATIC MODES; LC-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MATRIX EFFECTS; MOBILE PHASE; MONOPHOSPHATES; RUNTIMES; SOLID-PHASE EXTRACTION;

AMMONIUM COMPOUNDS; BIOMOLECULES; BODY FLUIDS; CELL MEMBRANES; CHROMATOGRAPHIC ANALYSIS; EXTRACTION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLISM; METABOLITES; METHANOL; NUCLEIC ACIDS; PHASE INTERFACES; THERMOMECHANICAL PULPING PROCESS;

CELL CULTURE;

ABC TRANSPORTER; AMMONIUM FORMATE; CELL PROTEIN; DEOXYURIDINE PHOSPHATE; FLOXURIDINE; FLOXURIDINE PHOSPHATE; FLUOROURACIL; METHANOL; THYMIDINE PHOSPHATE;

ACCURACY; ARTICLE; CELL CULTURE; CELL SECRETION; CHROMATOGRAPHY; CONTROLLED STUDY; ELECTROSPRAY; EXTRACTION; HUMAN; HUMAN CELL; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRECIPITATION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; TEMPERATURE SENSITIVITY; VALIDATION STUDY;

CELL LINE; CELL LINE, TUMOR; CHROMATOGRAPHY, LIQUID; DEOXYURACIL NUCLEOTIDES; DRUG STABILITY; FLOXURIDINE; FLUORODEOXYURIDYLATE; FLUOROURACIL; HUMANS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; THYMIDINE MONOPHOSPHATE;

EID: 69749128176     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.07.004     Document Type: Article

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