Possible role of the transglutaminases in the pathogenesis of alzheimer's disease and other neurodegenerative diseases

International Journal of Alzheimer's Disease

Volumn , Issue , 2011, Pages

  Martin, Antonio ^a   Gentile, Vittorio ^a   De Vivo, Giulia ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 1; ATAXIN 3; GAMMA GLUTAMYL HYDROLASE; GUANINE NUCLEOTIDE BINDING PROTEIN; MERCAPTAMINE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE;

ALZHEIMER DISEASE; CEREBROSPINAL FLUID; ENZYME ACTIVITY; HUNTINGTON CHOREA; MOLECULAR MECHANICS; OLIGOMERIZATION; PARKINSON DISEASE; PRIORITY JOURNAL; PROGRESSIVE SUPRANUCLEAR PALSY; PROTEIN MODIFICATION; REVIEW;

EID: 79953286790     PISSN: None     EISSN: 20900252     Source Type: Journal    
DOI: 10.4061/2011/865432     Document Type: Review

References (67)

1. Folk J. E., Mechanism and basis for specificity of transglutaminase- catalyzed epsilon-(gamma-glutamyl) lysine bond formation Advances in Enzymology and Related Areas of Molecular Biology 1983 54 1 56
2. Lorand L., Conrad S. M., Transglutaminases Molecular and Cellular Biochemistry 1984 58 1-2 9 35
3. Piacentini M., Martinet N., Beninati S., Folk J. E., Free and protein-conjugated polyamines in mouse epidermal cells. Effect of high calcium and retinoic acid Journal of Biological Chemistry 1988 263 8 3790 3794 (Pubitemid 18078968)
4. Kim C. Y., Quarsten H., Bergseng E., Khosla C., Sollid L. M., Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease Proceedings of the National Academy of Sciences of the United States of America 2004 101 12 4175 4179 (Pubitemid 38405902)
5. Fleckenstein B., Qiao S. W., Larsen M. R., Jung G., Roepstorff P., Sollid L. M., Molecular characterization of covalent complexes between tissue transglutaminase and gliadin peptides Journal of Biological Chemistry 2004 279 17 17607 17616 (Pubitemid 38560525)
6. Achyuthan K. E., Greenberg C. S., Identification of a guanosine triphosphate-binding site on guinea pig liver transglutaminase. Role of GTP and calcium ions in modulating activity Journal of Biological Chemistry 1987 262 4 1901 1906
7. Hasegawa G., Suwa M., Ichikawa Y., Ohtsuka T., Kumagai S., Kikuchi M., Sato Y., Saito Y., A novel function of tissue-type transglutaminase: protein disulphide isomerase Biochemical Journal 2003 373 3 793 803 (Pubitemid 36981089)
8. Lahav J., Karniel E., Bagoly Z., Sheptovitsky V., Dardik R., Inbal A., Coagulation factor XIII serves as protein disulfide isomerase Thrombosis and Haemostasis 2009 101 5 840 844
9. Iismaa S. E., Mearns B. M., Lorand L., Graham R. M., Transglutaminases and disease: lessons from genetically engineered mouse models and inherited disorders Physiological Reviews 2009 89 3 991 1023
10. Olaisen B., Gedde-Dahl T. Jr., Teisberg P., A structural locus for coagulation factor XIIIA (F13A) is located distal to the HLA region on chromosome 6p in man American Journal of Human Genetics 1985 37 1 215 220 (Pubitemid 15138693)
11. Yamanishi K., Inazawa J., Liew F. M., Nonomura K., Ariyama T., Yasuno H., Abe T., Doi H., Hirano J., Fukushima S., Structure of the gene for human transglutaminase 1 Journal of Biological Chemistry 1992 267 25 17858 17863
12. Gentile V., Davies P. J. A., Baldini A., The human tissue transglutaminase gene maps on chromosome 20q12 by in situ fluorescence hybridization Genomics 1994 20 2 295 297 (Pubitemid 24108413)
13. Wang M., Kim I. G., Steinert P. M., McBride O. W., Assignment of the human transglutaminase 2 (TGM2) and transglutaminase 3 (TGM3) genes to chromosome 20q11.2 Genomics 1994 23 3 721 722 (Pubitemid 24338670)
14. Gentile V., Grant F. J., Porta R., Baldini A., Localization of the human prostate transglutaminase (type IV) gene (TGM4) to chromosome 3p21.33-p22 by fluorescence in situ hybridization Genomics 1995 27 1 219 220
15. Grenard P., Bates M. K., Aeschlimann D., Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15: structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z Journal of Biological Chemistry 2001 276 35 33066 33078
16. Smethurst P. A., Griffin M., Measurement of tissue transglutaminase activity in a permeabilized cell system: its regulation by Ca2+ and nucleotides Biochemical Journal 1996 313 3 803 808
17. Nakaoka H., Perez D. M., Baek K. J., G h: a GTP-binding protein with transglutaminase activity and receptor signaling function Science 1994 264 5165 1593 1596
18. Gentile V., Porta R., Chiosi E., Spina A., Valente F., Pezone R., Davies P. J. A., Alaadik A., Illiano G., tTGase/G h protein expression inhibits adenylate cyclase activity in Balb-C 3T3 fibroblasts membranes Biochimica et Biophysica Acta 1997 1357 1 115 122 (Pubitemid 27239339)
19. Nanda N., Iismaa S. E., Owens W. A., Husain A., Mackay F., Graham R. M., Targeted inactivation of G/tissue transglutaminase II Journal of Biological Chemistry 2001 276 23 20673 20678
20. Mian S., El Alaoui S., Lawry J., Gentile V., Davies P. J. A., Griffin M., The importance of the GTP-binding protein tissue transglutaminase in the regulation of cell cycle progression FEBS Letters 1995 370 1-2 27 31
21. Thomazy V., Fesus L., Differential expression of tissue transglutaminase in human cells. An immunohistochemical study Cell and Tissue Research 1989 255 1 215 224 (Pubitemid 19017924)
22. Bailey C. D. C., Johnson G. V. W., Developmental regulation of tissue transglutaminase in the mouse forebrain Journal of Neurochemistry 2004 91 6 1369 1379 (Pubitemid 39658563)
23. Kim S. Y., Grant P., Lee J. H., Pant H. C., Steinert P. M., Differential expression of multiple transglutaminases in human brain. Increased expression and cross-linking by transglutaminases 1 and 2 in Alzheimer's disease Journal of Biological Chemistry 1999 274 43 30715 30721
24. Citron B. A., SantaCruz K. S., Davies P. J. A., Festoff B. W., Intron-exon swapping of transglutaminase mRNA and neuronal tau aggregation in Alzheimer's disease Journal of Biological Chemistry 2001 276 5 3295 3301
25. De Laurenzi V., Melino G., Gene disruption of tissue transglutaminase Molecular and Cellular Biology 2001 21 1 148 155
26. Lorand L., Graham R. M., Transglutaminases: crosslinking enzymes with pleiotropic functions Nature Reviews Molecular Cell Biology 2003 4 2 140 156 (Pubitemid 36172696)
27. Adams R. D., Victor M., Principles of Neurology 1993 New York, NY, USA McGraw-Hill
28. Selkoe D. J., Ihara Y., Salazar F. J., Alzheimer's disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea Science 1982 215 4537 1243 1245 (Pubitemid 12106489)
29. Grierson A. J., Johnson G. V. W., Miller C. C. J., Three different human tau isoforms and rat neurofilament light, middle and heavy chain proteins are cellular substrates for transglutaminase Neuroscience Letters 2001 298 1 9 12 (Pubitemid 32057202)
30. Dudek S. M., Johnson G. V. W., Transglutaminase catalyzes the formation of sodium dodecyl sulfate-insoluble, Alz-50-reactive polymers of Journal of Neurochemistry 1993 61 3 1159 1162 (Pubitemid 23241261)
31. Miller M. L., Johnson G. V. W., Transglutaminase cross-linking of the protein Journal of Neurochemistry 1995 65 4 1760 1770
32. Appelt D. M., Balin B. J., The association of tissue transglutaminase with human recombinant tau results in the formation of insoluble filamentous structures Brain Research 1997 745 1-2 21 31 (Pubitemid 27055742)
33. Singer S. M., Zainelli G. M., Norlund M. A., Lee J. M., Muma N. A., Transglutaminase bonds in neurofibrillary tangles and paired helical filament tau early in Alzheimer's disease Neurochemistry International 2002 40 1 17 30 (Pubitemid 34003555)
34. Appelt D. M., Kopen G. C., Boyne L. J., Balin B. J., Localization of transglutaminase in hippocampal neurons: implications for Alzheimer's disease Journal of Histochemistry and Cytochemistry 1996 44 12 1421 1427
35. Balin B. J., Loewy A. G., Appelt D. M., Analysis of transglutaminase- catalyzed isopeptide bonds in paired helical filaments and neurofibrillary tangles from Alzheimer's disease Methods in Enzymology 1999 309 172 186 (Pubitemid 29446449)
36. Wilhelmus M. M. M., Grunberg S. C. S., Bol J. G. J. M., Van Dam A. M., Hoozemans J. J. M., Rozemuller A. J. M., Drukarch B., Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain Brain Pathology 2009 19 4 612 622
37. Jeitner T. M., Matson W. R., Folk J. E., Blass J. P., Cooper A. J. L., Increased levels of -glutamylamines in Huntington disease CSF Journal of Neurochemistry 2008 106 1 37 44 (Pubitemid 351850209)
38. Dudek S. M., Johnson G. V. W., Transglutaminase facilitates the formation of polymers of the -amyloid peptide Brain Research 1994 651 1-2 129 133 (Pubitemid 24222858)
39. Hartley D. M., Zhao C., Speier A. C., Woodard G. A., Li S., Li Z., Walz T., Transglutaminase induces protofibril-like amyloid -protein assemblies that are protease-resistant and inhibit long-term potentiation Journal of Biological Chemistry 2008 283 24 16790 16800
40. Citron B. A., Suo Z., SantaCruz K., Davies P. J. A., Qin F., Festoff B. W., Protein crosslinking, tissue transglutaminase, alternative splicing and neurodegeneration Neurochemistry International 2002 40 1 69 78 (Pubitemid 34003559)
41. Junn E., Ronchetti R. D., Quezado M. M., Kim S. Y., Mouradian M. M., Tissue transglutaminase-induced aggregation of -synuclein: implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies Proceedings of the National Academy of Sciences of the United States of America 2003 100 4 2047 2052 (Pubitemid 36254571)
42. Zemaitaitis M. O., Lee J. M., Troncoso J. C., Muma N. A., Transglutaminase-induced cross-linking of tau proteins in progressive supranuclear palsy Journal of Neuropathology and Experimental Neurology 2000 59 11 983 989
43. Zemaitaitis M. O., Kim S. Y., Halverson R. A., Troncoso J. C., Lee J. M., Muma N. A., Transglutaminase activity, protein, and mRNA expression are increased in progressive supranuclear palsy Journal of Neuropathology and Experimental Neurology 2003 62 2 173 184 (Pubitemid 36176952)
44. Iuchi S., Hoffner G., Verbeke P., Djian P., Green H., Oligomeric and polymeric aggregates formed by proteins containing expanded polyglutamine Proceedings of the National Academy of Sciences of the United States of America 2003 100 5 2409 2414 (Pubitemid 36297512)
45. Gentile V., Sepe C., Calvani M., Melone M. A. B., Cotrufo R., Cooper A. J. L., Blass J. P., Peluso G., Tissue transglutaminase-catalyzed formation of high-molecular-weight aggregates in vitro is favored with long polyglutamine domains: a possible mechanism contributing to CAG-triplet diseases Archives of Biochemistry and Biophysics 1998 352 2 314 321 (Pubitemid 28368600)
46. Kahlem P., Green H., Djian P., Transglutaminase action imitates Huntington's disease: selective polymerization of huntingtin containing expanded polyglutamine Molecular Cell 1998 1 4 595 601 (Pubitemid 128374695)
47. Karpuj M. V., Garren H., Slunt H., Price D. L., Gusella J., Becher M. W., Steinman L., Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington's disease brain nuclei Proceedings of the National Academy of Sciences of the United States of America 1999 96 13 7388 7393 (Pubitemid 29299671)
48. Verhoef L. G., Lindsten K., Masucci M. G., Dantuma N. P., Aggregate formation inhibits proteasomal degradation of polyglutamine proteins Human Molecular Genetics 2002 11 22 2689 2700
49. MacDonald M. E., Ambrose C. M., Duyao M. P., Myers R. H., Lin C., Srinidhi L., Barnes G., Taylor S. A., James M., Groot N., MacFarlane H., Jenkins B., Anderson M. A., Wexler N. S., Gusella J. F., Bates G. P., Baxendale S., Hummerich H., Kirby S., A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes Cell 1993 72 6 971 983 (Pubitemid 23110238)
50. Banfi S., Chung M. Y., Kwiatkowski T. J., Ranum L. P. W., McCall A. E., Chinault A. C., Orr H. T., Zoghbi H. Y., Mapping and cloning of the critical region for the spinocerebellar ataxia type 1 gene (SCA1) in a yeast artificial chromosome contig spanning 1.2 Mb Genomics 1993 18 3 627 635 (Pubitemid 24021081)
51. Sanpei K., Takano H., Igarashi S., Sato T., Oyake M., Sasaki H., Wakisaka A., Tashiro K., Ishida Y., Ikeuchi T., Koide R., Saito M., Sato A., Tanaka T., Hanyu S., Takiyama Y., Nishizawa M., Shimizu N., Nomura Y., Segawa M., Iwabuchi K., Eguchi I., Tanaka H., Takahashi H., Tsuji S., Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT Nature Genetics 1996 14 3 277 284
52. Pujana M. A., Volpini V., Estivill X., Large CAG/CTG repeat templates produced by PCR, usefulness for the DIRECT method of cloning genes with CAG/CTG repeat expansions Nucleic Acids Research 1998 26 5 1352 1353 (Pubitemid 28291712)
53. Fletcher C. F., Lutz C. M., O'Sullivan T. N., Shaughnessy J. D., Hawkes R., Frankel W. N., Copeland N. G., Jenkins N. A., Absence epilepsy in tottering mutant mice is associated with calcium channel defects Cell 1996 87 4 607 617 (Pubitemid 26386935)
54. Vincent J. B., Neves-Pereira M. L., Paterson A. D., Yamamoto E., Parikh S. V., Macciardi F., Gurling H. M. D., Potkin S. G., Pato C. N., Macedo A., Kovacs M., Davies M., Lieberman J. A., Meltzer H. Y., Petronis A., Kennedy J. L., An unstable trinucleotide-repeat region on chromosome 13 implicated in spinocerebellar ataxia: a common expansion locus American Journal of Human Genetics 2000 66 3 819 829 (Pubitemid 30470485)
55. Holmes S. E., O'Hearn E., Margolis R. L., Why is SCA12 different from other SCAs? Cytogenetic and Genome Research 2003 100 1-4 189 197 (Pubitemid 37467806)
56. Imbert G., Trottier Y., Beckmann J., Mandel J. L., The gene for the TATA binding protein (TBP) that contains a highly polymorphic protein coding CAG repeat maps to 6q27 Genomics 1994 21 3 667 668 (Pubitemid 24189907)
57. La Spada A. R., Wilson E. M., Lubahn D. B., Harding A. E., Fischbeck K. H., Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy Nature 1991 352 6330 77 79 (Pubitemid 21896702)
58. Onodera O., Oyake M., Takano H., Ikeuchi T., Igarashi S., Tsuji S., Molecular cloning of a full-length cDNA for dentatorubral-pallidoluysian atrophy and regional expressions of the expanded alleles in the CNS American Journal of Human Genetics 1995 57 5 1050 1060
59. Griffith O. W., Larsson A., Meister A., Inhibition of -glutamylcysteine synthetase by cystamine; an approach to a therapy of 5-oxoprolinuria (pyroglutamic aciduria) Biochemical and Biophysical Research Communications 1977 79 3 919 925 (Pubitemid 8236083)
60. Igarashi S., Koide R., Shimohata T., Yamada M., Hayashi Y., Takano H., Date H., Oyake M., Sato T., Sato A., Egawa S., Ikeuchi T., Tanaka H., Nakano R., Tanaka K., Hozumi I., Inuzuka T., Takahashi H., Tsuji S., Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch Nature Genetics 1998 18 2 111 117 (Pubitemid 28082456)
61. Karpuj M. V., Becher M. W., Springer J. E., Chabas D., Youssef S., Pedotti R., Mitchell D., Steinman L., Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine Nature Medicine 2002 8 2 143 149 (Pubitemid 34155125)
62. Dedeoglu A., Kubilus J. K., Jeitner T. M., Matson S. A., Bogdanov M., Kowall N. W., Matson W. R., Cooper A. J. L., Ratan R. R., Beal M. F., Hersch S. M., Ferrante R. J., Therapeutic effects of cystamine in a murine model of Huntington's disease Journal of Neuroscience 2002 22 20 8942 8950 (Pubitemid 35379064)
63. Lesort M., Lee M., Tucholski J., Johnson G. V. W., Cystamine inhibits caspase activity: implications for the treatment of polyglutamine disorders Journal of Biological Chemistry 2003 278 6 3825 3830 (Pubitemid 36801110)
64. Hadjivassiliou M., Aeschlimann P., Strigun A., Sanders D. S., Woodroofe N., Aeschlimann D., Autoantibodies in gluten ataxia recognize a novel neuronal transglutaminase Annals of Neurology 2008 64 3 332 343
65. Krasnikov B. F., Kim S. Y., McConoughey S. J., Ryu H., Xu H., Stavrovskaya I., Iismaa S. E., Mearns B. M., Ratan R. R., Blass J. P., Gibson G. E., Cooper A. J. L., Transglutaminase activity Is present in highly purified nonsynaptosomal mouse brain and liver mitochondria Biochemistry 2005 44 21 7830 7843 (Pubitemid 40740766)
66. Mastroberardino P. G., Iannicola C., Nardacci R., Bernassola F., De Laurenzi V., Melino G., Moreno S., Pavone F., Oliverio S., Fesus L., Piacentini M., 'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease Cell Death and Differentiation 2002 9 9 873 880 (Pubitemid 35023603)
67. Davies J. E., Rose C., Sarkar S., Rubinsztein D. C., Cystamine suppresses polyalanine toxicity in a mouse model of oculopharyngeal muscular dystrophy Science Translational Medicine 2010 2 34 34 40