Design and synthesis of several small-size HTLV-I protease inhibitors with different hydrophilicity profiles

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 8, 2011, Pages 2425-2429

  Nguyen, Jeffrey Tri ^a   Kato, Keiko ^a   Hidaka, Koushi ^a   Kumada, Henri Obadja ^a   Kimura, Tooru ^a   Kiso, Yoshiaki ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Adult T cell leukemia; Aspartic protease; HAM TSP; Human T cell lymphotropic virus; Inhibitor

Indexed keywords

KNI 10562; KNI 10605; KNI 10608; KNI 10635; KNI 10680; KNI 10752; KNI 10753; KNI 10756; KNI 10767; KNI 10768; KNI 10838; KNI 10856; KNI 10857; KNI 10858; KNI 10859; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHRONIC INFLAMMATION; DRUG DESIGN; DRUG SYNTHESIS; HUMAN T CELL LEUKEMIA VIRUS 1; HYDROPHILICITY; HYDROPHOBICITY; LYMPHOMA; SPINAL CORD DISEASE; T CELL LEUKEMIA; TROPICAL SPASTIC PARAPARESIS; VIRUS REPLICATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CATALYTIC DOMAIN; COMPUTER-AIDED DESIGN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HIV PROTEASE; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; PEPTIDE HYDROLASES; PEPTIDES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 79953286584     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.02.066     Document Type: Article

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