α2-macroglobulin induces glial fibrillary acidic protein expression mediated by low-density lipoprotein receptor-related protein 1 in müller cells

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 2, 2011, Pages 778-786

  Barcelona, Pablo F ^a   Ortiz, Susana G ^a   Chiabrando, Gustavo A ^a   Sánchez, Maria C ^a  

^a UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 MACROGLOBULIN; GLIAL FIBRILLARY ACIDIC PROTEIN; JANUS KINASE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; RAP PROTEIN; STAT PROTEIN; STAT3 PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; LRP1 PROTEIN, MOUSE; STAT3 PROTEIN, MOUSE; TUMOR SUPPRESSOR PROTEIN; VIMENTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MOUSE; MUELLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RETINA BIPOLAR GANGLION CELL; RETINA GANGLION CELL; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CELL LINE; CHO CELL; CRICETULUS; DRUG EFFECT; FLUORESCENCE MICROSCOPY; GLIA; HAMSTER; IMMUNOHISTOCHEMISTRY; METABOLISM; RAT;

ALPHA-MACROGLOBULINS; ANIMALS; BLOTTING, WESTERN; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; IMMUNOHISTOCHEMISTRY; JANUS KINASES; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; NEUROGLIA; RATS; RECEPTORS, LDL; STAT3 TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEINS; VIMENTIN;

EID: 79953270992     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-5759     Document Type: Article

References (62)

1. Eng LF, Ghirnikar RS. GFAP and astrogliosis. Brain Pathol. 1994; 4:229-237.
2. Sarthy V, Ripps H, eds. Reactive gliosis. In: Sarthy V, Ripps H, eds. Perspectives in Vision Research. New York: Kluwer Academic/ Plenum Publishers; 2001:198-215
3. Lewis GP, Fisher SK. Upregulation of glial fibrillary acidic protein in response to retinal injury: its potential role in glial remodeling and a comparison to vimentin expression. Int Rev Cytol. 2003; 230:263-290.
4. Caicedo A, Espinosa-Heidmann DG, Pina Y, Hernandez EP, Cousins SW. Blood-derived macrophages infiltrate the retina and activate Muller glial cells under experimental choroidal neovascularization. Exp Eye Res. 2005;81:38-47.
5. Lewis GP, Matsumoto B, Fisher SK. Changes in the organization and expression of cytoskeletal proteins during retinal degeneration induced by retinal detachment. Invest Ophthalmol Vis Sci. 1995;36:2404-2416.
6. Sethi CS, Lewis GP, Fisher SK, et al. Glial remodeling and neural plasticity in human retinal detachment with proliferative vitreo-retinopathy. Invest Ophthalmol Vis Sci. 2005;46:329-342.
7. Wang Y, Smith SB, Ogilvie JM, McCool DJ, Sarthy V. Ciliary neurotrophic factor induces glial fibrillary acidic protein in retinal Muller cells through the JAK/STAT signal transduction pathway. Curr Eye Res. 2002;24:305-312.
8. Shi Z, Rudzinski M, Meerovitch K, et al. Alpha2-macroglobulin is a mediator of retinal ganglion cell death in glaucoma. J Biol Chem. 2008;283:29156-29165.
9. Mizutani M, Gerhardinger C, Lorenzi M. Muller cell changes in human diabetic retinopathy. Diabetes. 1998;47:445-449
10. Birkenmeier G. Targetting the proteinase inhibitor and immune modulatory function of human a2-macroglobulin. Mod Asp Immu-nobiol. 2001;2:32-36.
11. Sottrup-Jensen L, Stepanik TM, Kristensen T, et al. Primary structure of human alpha 2-macroglobulin, V: the complete structure. J Biol Chem. 1984;259:8318-8327.
12. Hussain MM, Strickland DK, Bakillah A. The mammalian low-density lipoprotein receptor family. Annu Rev Nutr. 1999;19:141-172.
13. Herz J, Strickland DK. LRP: a multifunctional scavenger and signaling receptor. J Clin Invest. 2001;108:779-784.
14. Bacskai BJ, Xia MQ, Strickland DK, Rebeck GW, Hyman BT. The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors. Proc Natl Acad Sci U S A. 2000;97:11551-11556.
15. Qiu Z, Strickland DK, Hyman BT, Rebeck GW. alpha 2-Macroglob-ulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neurons. J Biol Chem. 2002;277:14458-14466.
16. Bonacci GR, Caceres LC, Sanchez MC, Chiabrando GA. Activated alpha(2)-macroglobulin induces cell proliferation and mitogen-ac-tivated protein kinase activation by LRP-1 in the J774 macrophage-derived cell line. Arch Biochem Biophys. 2007;460:100-106.
17. Sanchez MC, Barcelona PF, Luna JD, et al. Low-density lipoprotein receptor-related protein-1 (LRP-1) expression in a rat model of oxygen-induced retinal neovascularization. Exp Eye Res. 2006;83: 1378-1385.
18. Sanchez MC, Luna JD, Barcelona PF, et al. Effect of retinal laser photocoagulation on the activity of metalloproteinases and the alpha(2)-macroglobulin proteolytic state in the vitreous of eyes with proliferative diabetic retinopathy. Exp Eye Res. 2007;85: 644-650.
19. Penn JS, Thum LA, Rhem MN, Dell SJ. Effects of oxygen rearing on the electroretinogram and GFA-protein in the rat. Invest Ophthal-mol Vis Sci. 1988;29:1623-1630.
20. Fitzgerald ME, Vana BA, Reiner A. Evidence for retinal pathology following interruption of neural regulation of choroidal blood flow: Muller cells express GFAP following lesions of the nucleus of Edinger-Westphal in pigeons. Curr Eye Res. 1990;9:583-598.
21. Osborne NN, Block F, Sontag KH. Reduction of ocular blood flow results in glial fibrillary acidic protein (GFAP) expression in rat retinal Muller cells. Vis Neurosci. 1991;7:637-639.
22. Smith LE, Wesolowski E, McLellan A, et al. Oxygen-induced reti-nopathy in the mouse. Invest Ophthalmol Vis Sci. 1994;35:101- 111.
23. Hayashi H, Campenot RB, Vance DE, Vance JE. Apolipoprotein E-containing lipoproteins protect neurons from apoptosis via a signaling pathway involving low-density lipoprotein receptor-related protein-1. J Neurosci. 2007;27:1933-1941.
24. Limb GA, Salt TE, Munro PM, Moss SE, Khaw PT. In vitro characterization of a spontaneously immortalized human Muller cell line (MIO-M1). Invest Ophthalmol Vis Sci. 2002;43:864-869.
25. Umapathy NS, Li W, Mysona BA, Smith SB, Ganapathy V. Expression and function of glutamine transporters SN1 (SNAT3) and SN2 (SNAT5) in retinal Muller cells. Invest Ophthalmol Vis Sci. 2005; 46:3980-3987.
26. Ceschin DG, Sanchez MC, Chiabrando GA. Insulin induces the low density lipoprotein receptor-related protein 1 (LRP1) degradation by the proteasomal system in J774 macrophage-derived cells. J Cell Biochem. 2009;106:372-380.
27. FitzGerald DJ, Fryling CM, Zdanovsky A, et al. Pseudomonas exotoxin-mediated selection yields cells with altered expression of low-density lipoprotein receptor-related protein. J Cell Biol. 1995; 129:1533-1541.
28. Chiabrando G, Bonacci G, Sanchez C, Ramos A, Zalazar F, Vides MA. A procedure for human pregnancy zone protein (and human alpha 2-macroglobulin) purification using hydrophobic interaction chromatography on phenyl-sepharose CL-4B column. Protein Expr Purif. 1997;9:399-406.
29. Chiabrando GA, Sanchez MC, Skornicka EL, Koo PH. Low-density lipoprotein receptor-related protein mediates in PC12 cell cultures the inhibition of nerve growth factor-promoted neurite outgrowth by pregnancy zone protein and alpha2-macroglobulin. J Neurosci Res. 2002;70:57-64.
30. Bu G, Geuze HJ, Strous GJ, Schwartz AL. 39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein. EMBO J. 1995;14:2269-2280.
31. Liu X, Wang D, Liu Y, et al. Neuronal-driven angiogenesis: role of NGF in retinal neovascularization in an oxygen-induced retinopa-thy model. Invest Ophthalmol Vis Sci. 51: 3749-3757.
32. Eisenfeld AJ, Bunt-Milam AH, Saari JC. Uveoretinitis in rabbits following immunization with interphotoreceptor retinoid-binding protein. Exp Eye Res. 1987;44:425-438.
33. Saari JC, Crabb JW. Focus on molecules: cellular retinaldehyde-binding protein (CRALBP). Exp Eye Res. 2005;81:245-246.
34. Herz J. The LDL receptor gene family: (un)expected signal transducers in the brain. Neuron. 2001;29:571-581.
35. Misra UK, Gawdi G, Pizzo SV. Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4,5-trisphosphate in macrophages. Arch Biochem Biophys. 1999;372:238-247.
36. Barnes H, Ackermann EJ, van der Geer P. v-Src induces Shc binding to tyrosine 63 in the cytoplasmic domain of the LDL receptor-related protein 1. Oncogene. 2003;22:3589-3597.
37. Strickland DK, Ranganathan S. Diverse role of LDL receptor-related protein in the clearance of proteases and in signaling. J Thromb Haemost. 2003;1:1663-1670.
38. Hu K, Yang J, Tanaka S, Gonias SL, Mars WM, Liu Y. Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression. J Biol Chem. 2006;281:2120-2127.
39. Caceres LC, Bonacci GR, Sanchez MC, Chiabrando GA. Activated alpha2 macroglobulin induces matrix metalloproteinase 9 expression by low density lipoprotein receptor-related protein 1 through MAPK-ERK1/2 and NF-kappaB activation in macrophage derived cell lines. J Cell Biochem. 2010;111:607-617.
40. Chu CT, Pizzo SV. alpha 2-Macroglobulin, complement, and biologic defense: antigens, growth factors, microbial proteases, and receptor ligation. Lab Invest. 1994;71:792-812.
41. Barcelona P, Luna J, Chiabrando G, et al. Immunohistochemical localization of low density lipoprotein receptor-related protein 1 and alpha(2)-macroglobulin in retinal and choroidal tissue of pro-liferative retinopathies. Exp Eye Res. 2010;91:264-272.
42. Ahmed F, Brown KM, Stephan DA, Morrison JC, Johnson EC, Tomarev SI. Microarray analysis of changes in mRNA levels in the rat retina after experimental elevation of intraocular pressure. Invest Ophthalmol Vis Sci. 2004;45:1247-1258.
43. Yamane K, Minamoto A, Yamashita H, et al. Proteome analysis of human vitreous proteins. Mol Cell Proteomics. 2003;2:1177-1187.
44. Birkenmeier G, Osman AA, Kopperschlager G, Mothes T. Epitope mapping by screening of phage display libraries of a monoclonal antibody directed against the receptor binding domain of human alpha2-macroglobulin. FEBS Lett. 1997;416:193-196.
45. Fabrizi C, Businaro R, Lauro GM, Starace G, Fumagalli L. Activated alpha2-dmacroglobulin increases beta-amyloid (25-35)-induced toxicity in LAN5 human neuroblastoma cells. Exp Neurol. 1999; 155:252-259.
46. Kovacs DM. alpha2-macroglobulin in late-onset Alzheimer's disease. Exp Gerontol. 2000;35:473-479.
47. Fabrizi C, Businaro R, Lauro GM, Fumagalli L. Role of alpha2-macroglobulin in regulating amyloid beta-protein neurotoxicity: protective or detrimental factor? J Neurochem. 2001;78:406-412.
48. Herz J. LRP: a bright beacon at the blood-brain barrier. J Clin Invest. 2003;112:1483-1485.
49. Bu G, Cam J, Zerbinatti C. LRP in amyloid-beta production and metabolism. Ann N Y Acad Sci. 2006;1086:35-53.
50. Lee PG, Koo PH. Rat alpha(2)-macroglobulin inhibits NGF-pro-moted neurite outgrowth, TrK phosphorylation, and gene expression of pheochromocytoma PC12 cells. J Neurosci Res. 1999;57: 872-883.
51. Skornicka EL, Shi X, Koo PH. Comparative binding of biotinylated neurotrophins to alpha(2)-macroglobulin family of proteins: relationship between cytokine-binding and neuro-modulatory activities of the macroglobulins. J Neurosci Res. 2002;67:346-353.
52. LaMarre J, Wollenberg GK, Gonias SL, Hayes MA. Cytokine binding and clearance properties of proteinase-activated alpha 2-macro-globulins. Lab Invest. 1991;65:3-14.
53. Borth W. Alpha 2-macroglobulin, a multifunctional binding protein with targeting characteristics. FASEB J. 1992;6:3345-3353.
54. Feige JJ, Negoescu A, Keramidas M, Souchelnitskiy S, Chambaz EM. Alpha 2-macroglobulin: a binding protein for transforming growth factor-beta and various cytokines. Horm Res. 1996;45:227-232.
55. Mantuano E, Mukandala G, Li X, Campana WM, Gonias SL. Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling. J Biol Chem. 2008;283:19904-19911.
56. Shi Y, Mantuano E, Inoue G, Campana WM, Gonias SL. Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway. Sci Signal. 2009;2: ra18.
57. Asplin IR, Wu SM, Mathew S, Bhattacharjee G, Pizzo SV. Differential regulation of the fibroblast growth factor (FGF) family by alpha(2)-macroglobulin: evidence for selective modulation of FGF-2-induced angiogenesis. Blood. 2001;97:3450-3457.
58. Mathew S, Arandjelovic S, Beyer WF, Gonias SL, Pizzo SV. Characterization of the interaction between alpha2-macroglobulin and fibroblast growth factor-2: the role of hydrophobic interactions. Biochem J. 2003;374:123-129.
59. Wolf BB, Gonias SL. Neurotrophin binding to human alpha 2-mac-roglobulin under apparent equilibrium conditions. Biochemistry. 1994;33:11270-11277.
60. Liebl DJ, Koo PH. Comparative binding of neurotrophins (NT-3, CNTF and NGF) and various cytokines to alpha 2-macroglobulin. Biochem Biophys Res Commun. 1993;193:1255-1261.
61. Chaum E. Retinal neuroprotection by growth factors: a mechanistic perspective. J Cell Biochem. 2003;88:57-75.
62. Fischer AJ, Omar G, Eubanks J, McGuire CR, Dierks BD, Reh TA. Different aspects of gliosis in retinal Muller glia can be induced by CNTF, insulin, and FGF2 in the absence of damage. Mol Vis. 2004;10:973-986.