Rap1 GTPases: An emerging role in the cardiovasculature

Life Sciences

Volumn 88, Issue 15-16, 2011, Pages 645-652

  Jeyaraj, Selvi C ^a   Unger, Nicholas T ^a   Chotani, Maqsood A ^a,b  

^a NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

cAMP; Epac; Rap1

Indexed keywords

ACTIN; BETA INTEGRIN; CALCIUM; CONNEXIN 43; CYCLIC AMP; DIACYLGLYCEROL; FIBROBLAST GROWTH FACTOR 2; GAP JUNCTION PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 7; PROTEIN C JUN; PROTEIN P22; RAP1 A PROTEIN; RAP1 PROTEIN; RAP1B PROTEIN; RAS PROTEIN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE; THROMBOSPONDIN; UNCLASSIFIED DRUG;

ADRENERGIC ACTIVITY; ANGIOGENESIS; APOPTOSIS; BLOOD VESSEL PERMEABILITY; CALCIUM SIGNALING; CARDIOVASCULAR SYSTEM; CELL ADHESION; CELL FUNCTION; CELL HOMING; CELL JUNCTION; CELL MIGRATION; CELL PROLIFERATION; CHEMOTAXIS; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART VENTRICLE HYPERTROPHY; HEMATOPOIETIC CELL; HUMAN; INTRACELLULAR SIGNALING; MACROPHAGE; MICROVASCULAR ENDOTHELIAL CELL; NEUTROPHIL; PHENOTYPE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; REGULATORY MECHANISM; REPERFUSION INJURY; SECOND MESSENGER; SHORT SURVEY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; STRESS FIBER; THROMBOCYTE; THROMBOSIS; VASCULAR RESISTANCE; VASOCONSTRICTION;

MURINAE;

EID: 79953268014     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2011.01.023     Document Type: Review

References (56)

1. Arora PD, Conti MA, Ravid S, Sacks DB, Kapus A, Adelstein RS, et al. Rap1 activation in collagen phagocytosis is dependent on nonmuscle myosin II-A. Mol Biol Cell 2008;19(12):5032-46.
2. Bivona TG, Wiener HH, Ahearn IM, Silletti J, Chiu VK, Philips MR. Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion. J Cell Biol 2004;164(3):461-70. (Pubitemid 38174773)
3. Block JA, Sequeira W. Raynaud's phenomenon. Lancet 2001;357(9273):2042-8. (Pubitemid 32592397)
4. Bos JL. Linking Rap to cell adhesion. Curr Opin Cell Biol 2005;17(2):123-8. (Pubitemid 40380934)
5. Bos JL, de Rooij J, Reedquist KA. Rap1 signalling: adhering to new models. Nat Rev Mol Cell Biol 2001;2(5):369-77. (Pubitemid 33674049)
6. Bourne HR, Sanders DA, McCormick F. The GTPase superfamily: a conserved switch for diverse cell functions. Nature 1990;348(6297):125-32.
7. Carmona G, Chavakis E, Koehl U, Zeiher AM, Dimmeler S. Activation of Epac stimulates integrin-dependent homing of progenitor cells. Blood 2008;111(5):2640-6.
8. Carmona G, Gottig S, Orlandi A, Scheele J, Bauerle T, Jugold M, et al. Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis. Blood 2009;113(2):488-97.
9. 2C-adrenoceptor expression: role in serum induction in human arteriolar smooth muscle cells. Am J Physiol Heart Circ Physiol 2005;288(1):H69-76.
10. Chrzanowska-Wodnicka M, Smyth SS, Schoenwaelder SM, Fischer TH, White II GC. Rap1b is required for normal platelet function and hemostasis in mice. J Clin Invest 2005;115(3):680-7. (Pubitemid 40322242)
11. Chrzanowska-Wodnicka M, Kraus AE, Gale D, White 2nd GC, Vansluys J. Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice. Blood 2008;111(5):2647-56.
12. Chu H, Awasthi A, White 2nd GC, Chrzanowska-Wodnicka M, Malarkannan S. Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity. J Immunol 2008;181(5):3373-83.
13. Cullere X, Shaw SK, Andersson L, Hirahashi J, Luscinskas FW, Mayadas TN. Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood 2005;105(5):1950-5. (Pubitemid 40731777)
14. de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, et al. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 1998;396(6710):474-7. (Pubitemid 28553318)
15. de Rooij J, Rehmann H, van Triest M, Cool RH, Wittinghofer A, Bos JL. Mechanismof regulation of the Epac family of cAMP-dependent RapGEFs. J Biol Chem 2000;275(27):20829-36. (Pubitemid 30457676)
16. Dodge-Kafka KL, Soughayer J, Pare GC, Carlisle Michel JJ, Langeberg LK, Kapiloff MS, et al. The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature 2005;437(7058):574-8. (Pubitemid 41613557)
17. Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, et al. A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis. Blood 2009;114(20):4592-600.
18. Duchniewicz M, Zemojtel T, Kolanczyk M, Grossmann S, Scheele JS, Zwartkruis FJ. Rap1A-deficient T and B cells show impaired integrin-mediated cell adhesion. Mol Cell Biol 2006;26(2):643-53. (Pubitemid 43089775)
19. Ehses JA, Casilla VR, Doty T, Pospisilik JA, Winter KD, Demuth HU, et al. Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase. Endocrinology 2003;144(10):4433-45. (Pubitemid 37204843)
20. 2C- adrenoceptors and cold-induced constriction of cutaneous arteries. Am J Physiol Heart Circ Physiol 2007;293(3):H1955-61.
21. 2C-adrenoceptors. Am J Physiol Heart Circ Physiol 2008;295(1):H266-72.
22. 2- adrenergicr constriction of isolated arterioles in diffuse scleroderma. Arthritis Rheum 2000;43(8):1886-90.
23. Flavahan NA, Flavahan S, Mitra S, Chotani MA. The vasculopathy of Raynaud's phenomenon and scleroderma. Rheum Dis Clin North Am 2003;29(2):275-91 vi.
24. Guo FF, Kumahara E, Saffen D. A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2. J Biol Chem 2001;276(27):25568-81.
25. Hariharan IK, Carthew RW, Rubin GM. The Drosophila roughened mutation: activation of a rap homolog disrupts eye development and interferes with cell determination. Cell 1991;67(4):717-22. (Pubitemid 121001484)
26. Hassona MD, Abouelnaga ZA, Elnakish MT, Awad MM, Alhaj M, Goldschmidt-Clermont PJ, et al. Vascular hypertrophy-associated hypertension of profilin1 transgenic mouse model leads to functional remodeling of peripheral arteries. Am J Physiol Heart Circ Physiol 2010;298(6):H2112-20.
27. Hattori M, Minato N. Rap1 GTPase: functions, regulation, and malignancy. J Biochem 2003;134(4):479-84.
28. He Q, Harding P, LaPointe MC. PKA, Rap1, ERK1/2, and p90RSK mediate PGE2 and EP4 signaling in neonatal ventricular myocytes. Am J Physiol Heart Circ Physiol 2010;298(1):H136-43.
29. Karliner JS, Simpson PC. β-adrenoceptor and adenylate cyclase regulation in cardiac myocyte growth. Basic Res Cardiol 1988;83(6):655-63. (Pubitemid 19020711)
30. Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, et al. A family of cAMP-binding proteins that directly activate Rap1. Science 1998;282(5397):2275-9. (Pubitemid 29004080)
31. Kitayama H, Sugimoto Y, Matsuzaki T, Ikawa Y, Noda M. A ras-related gene with transformation suppressor activity. Cell 1989;56(1):77-84. (Pubitemid 19033515)
32. Kooistra MR, Corada M, Dejana E, Bos JL. Epac1 regulates integrity of endothelial cell junctions through VE-cadherin. FEBS Lett 2005;579(22):4966-72. (Pubitemid 41242837)
33. 2C-adrenergic smooth muscle constriction and alters thermosensitivity of cutaneous arteries. J Appl Physiol 2006;100(4):1230-7.
34. Kwak HJ, Park KM, Choi HE, Chung KS, Lim HJ, Park HY. PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways. Cell Signal 2008;20(5):803-14.
35. 2+ATPase isoform 3b and Rap 1b: interrelation and regulation in physiopathology. Biochem J 1998;332(Pt 1):173-81.
36. Li Y, Yan J, De P, Chang HC, Yamauchi A, Christopherson 2nd KW, et al. Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins. J Immunol 2007;179(12):8322-31.
37. 2+ transport in platelets: a new approach. Biochem J 1995;310(Pt 2):469-75.
38. Maridonneau-Parini I, de Gunzburg J. Association of Rap1 and Rap2 proteins with the specific granules of human neutrophils. Translocation to the plasma membrane during cell activation. J Biol Chem 1992;267(9):6396-402.
39. McConnachie G, Langeberg LK, Scott JD. AKAP signaling complexes: getting to the heart of the matter. Trends Mol Med 2006;12(7):317-23. (Pubitemid 44110003)
40. McLeod SJ, Shum AJ, Lee RL, Takei F, Gold MR. The Rap GTPases regulate integrin-mediated adhesion, cell spreading, actin polymerization, and Pyk2 tyrosine phosphorylation in B lymphocytes. J Biol Chem 2004;279(13):12009-19. (Pubitemid 38445762)
41. Moustafa-Bayoumi M, Alhaj MA, El-Sayed O, Wisel S, Chotani MA, Abouelnaga ZA, et al. Vascular hypertrophy and hypertension caused by transgenic overexpression of profilin 1. J Biol Chem 2007;282(52):37632-9.
42. Oestreich EA, Wang H, Malik S, Kaproth-Joslin KA, Blaxall BC, Kelley GG, et al. Epac-mediated activation of phospholipase Cε plays a critical role in β-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes. J Biol Chem 2007;282(8):5488-95. (Pubitemid 47093776)
43. 2+ release in the heart by activation of protein kinase Cε and calcium-calmodulin kinase II. J Biol Chem 2009;284(3):1514-22.
44. Ohba Y, Ikuta K, Ogura A, Matsuda J, Mochizuki N, Nagashima K, et al. Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis. EMBO J 2001;20(13):3333-41. (Pubitemid 32634341)
45. Paganini S, Guidetti GF, Catricala S, Trionfini P, Panelli S, Balduini C, et al. Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins. Biochimie 2006;88(3-4):285-95.
46. Panchatcharam M, Miriyala S, Yang F, Leitges M, Chrzanowska-Wodnicka M, Quilliam LA, et al. Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by β3 integrin signaling. Int J Biochem Cell Biol 2010;42(6):965-74.
47. Raaijmakers JH, Bos JL. Specificity in Ras and Rap signaling. J Biol Chem 2009;284(17):10995-9.
48. Rangarajan S, Enserink JM, Kuiperij HB, de Rooij J, Price LS, Schwede F, et al. Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the β2-adrenergic receptor. J Cell Biol 2003;160(4):487-93. (Pubitemid 36254387)
49. Sakurai A, Fukuhara S, Yamagishi A, Sako K, Kamioka Y, Masuda M, et al. MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion. Mol Biol Cell 2006;17(2):966-76. (Pubitemid 43191128)
50. Schmidt M, Evellin S, Weernink PA, von Dorp F, Rehmann H, Lomasney JW, et al. A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase. Nat Cell Biol 2001;3(11):1020-4. (Pubitemid 34428748)
51. Sehrawat S, Cullere X, Patel S, Italiano Jr J, Mayadas TN. Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function. Mol Biol Cell 2008;19(3):1261-70. (Pubitemid 351481837)
52. Somekawa S, Fukuhara S, Nakaoka Y, Fujita H, Saito Y, Mochizuki N. Enhanced functional gap junction neoformation by protein kinase A-dependent and Epac-dependent signals downstream of cAMP in cardiac myocytes. Circ Res 2005;97(7):655-62. (Pubitemid 41416334)
53. Tsai IC, Amack JD, Gao ZH, Band V, Yost HJ, Virshup DM. A Wnt-CKIε-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein. Dev Cell 2007;12(3):335-47.
54. Yan J, Li F, Ingram DA, Quilliam LA. Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions. Mol Cell Biol 2008;28(18):5803-10.
55. York RD, Molliver DC, Grewal SS, Stenberg PE, McCleskey EW, Stork PJ. Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1. Mol Cell Biol 2000;20(21):8069-83.
56. Zemojtel T, Duchniewicz M, Zhang Z, Paluch T, Luz H, Penzkofer T, et al. Retrotransposition and mutation events yield Rap1 GTPases with differential signalling capacity. BMC Evol Biol 2010;10:55.