Bone: From a reservoir of minerals to a regulator of energy metabolism

Kidney International

Volumn 79, Issue SUPPL. 121, 2011, Pages

  Confavreux, Cyrille B ^a,b  

^a University of Lyon Claude Bernard   (France)

^b EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

blood glucose; bone; energy metabolism; fibroblast growth factor 23; leptin; osteocalcin; serotonin

Indexed keywords

INSULIN; LEPTIN; OSTEOCALCIN; OSTEOPROTEGERIN; ACTIVATING TRANSCRIPTION FACTOR 4; SEROTONIN; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2;

ADRENERGIC SYSTEM; BONE MASS; BONE REMODELING; CALCIUM HOMEOSTASIS; CHRONIC KIDNEY DISEASE; ENERGY METABOLISM; HORMONE RELEASE; HUMAN; HYPOTHALAMUS; INSULIN RELEASE; INSULIN SENSITIVITY; OSTEOBLAST; OSTEOLYSIS; PRIORITY JOURNAL; REVIEW; SEROTONINERGIC NERVE CELL; CELL PROLIFERATION; ESP GENE; GENE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

EID: 79953267465     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2011.25     Document Type: Review

References (32)

1. Moe S, Drüeke T, Cunningham J et al. Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 2006; 69: 1945-1953. (Pubitemid 43924257)
2. Williams ME. Chronic kidney disease/bone and mineral metabolism: the imperfect storm. Semin Nephrol 2009; 29: 97-104.
3. Karsenty G. Convergence between bone and energy homeostases: leptin regulation of bone mass. Cell Metab 2006; 4: 341-348. (Pubitemid 44645074)
4. Dardeno TA, Chou SH, Moon HS et al. Leptin in human physiology and therapeutics. Front Neuroendocrinol 2010; 31: 377-393.
5. Magni P, Dozio E, Galliera E et al. Molecular aspects of adipokine-bone interactions. Curr Mol Med 2010; 10: 522-532.
6. Lee NK, Sowa H, Hinoi E et al. Endocrine regulation of energy metabolism by the skeleton. Cell 2007; 130: 456-469. (Pubitemid 47208519)
7. Ducy P, Amling M, Takeda S et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 2000; 100: 197-207. (Pubitemid 30064908)
8. Visitsunthorn U, Prete P. Reflex sympathetic dystrophy of the lower extremity: a complication of herpes zoster with dramatic response to propranolol. West J Med 1981; 135: 62-66. (Pubitemid 11011596)
9. Pasco JA, Henry MJ, Sanders KM et al. b-Adrenergic blockers reduce the risk of fracture partly by increasing bone mineral density: Geelong Osteoporosis Study. J Bone Miner Res 2004; 19: 19-24. (Pubitemid 41295133)
10. Reid IR, Gamble GD, Grey AB et al. b-Blocker use, BMD, and fractures in the study of osteoporotic fractures. J Bone Miner Res 2005; 20: 613-618. (Pubitemid 40393069)
11. Schlienger RG, Kraenzlin ME, Jick SS et al. Use of b-blockers and risk of fractures. JAMA 2004; 292: 1326-1332.
12. Turker S, Karatosun V, Gunal I. b-Blockers increase bone mineral density. Clin Orthop Relat Res 2006; 443: 73-74. (Pubitemid 44324936)
13. Takeda S, Elefteriou F, Levasseur R et al. Leptin regulates bone formation via the sympathetic nervous system. Cell 2002; 111: 305-317. (Pubitemid 35345151)
14. Balthasar N, Coppari R, McMinn J et al. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 2004; 42: 983-991. (Pubitemid 38798236)
15. Richards JB, Papaioannou A, Adachi JD et al. Effect of selective serotonin reuptake inhibitors on the risk of fracture. Arch Intern Med 2007; 167: 188-194. (Pubitemid 46148067)
16. Yadav VK, Oury F, Suda N et al. A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell 2009; 138: 976-989.
17. 2A receptors: a positron emission tomography study in healthy individuals. Neurosci Lett 1999; 261: 139-142. (Pubitemid 29104964)
18. Mann JJ, McBride PA, Brown RP et al. Relationship between central and peripheral serotonin indexes in depressed and suicidal psychiatric inpatients. Arch Gen Psychiatry 1992; 49: 442-446.
19. Ferron M, Hinoi E, Karsenty G et al. Osteocalcin differentially regulates b cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci USA 2008; 105: 5266-5270. (Pubitemid 351738545)
20. Kindblom JM, Ohlsson C, Ljunggren O et al. Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men. J Bone Miner Res 2009; 24: 785-791.
21. Leslie WD, Weiler HA, Lix LM et al. Body composition and bone density in Canadian White and Aboriginal women: the First Nations Bone Health Study. Bone 2008; 42: 990-995.
22. Confavreux CB. Interactions between bone tissue and energy metabolism. Joint Bone Spine 2010; 77: 287-289.
23. Confavreux CB, Levine RL, Karsenty G. A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms. Mol Cell Endocrinol 2009; 310: 21-29.
24. Yoshizawa T, Hinoi E, Jung DY et al. The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts. J Clin Invest 2009; 119: 2807-2817.
25. Gross DN, van den Heuvel AP, Birnbaum MJ. The role of FoxO in the regulation of metabolism. Oncogene 2008; 27: 2320-2336. (Pubitemid 351501783)
26. Rached MT, Kode A, Silva BC et al. FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. J Clin Invest 2010; 120: 357-368.
27. Ferron M, Wei J, Yoshizawa T et al. Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell 2010; 142: 296-308.
28. 3 synthesis in leptin-deficient ob/ob mice. J Bone Miner Res 2010; 25: 1711-1723.
29. McCullough PA, Agrawal V, Danielewicz E et al. Accelerated atherosclerotic calcification and Mönckeberg's sclerosis: a continuum of advanced vascular pathology in chronic kidney disease. Clin J Am Soc Nephrol 2008; 3: 1585-1598.
30. McCullough PA, Chinnaiyan KM, Agrawal V et al. Amplification of atherosclerotic calcification and Mö nckeberg's sclerosis: a spectrum of the same disease process. Adv Chronic Kidney Dis 2008; 15: 396-412.
31. Bacchetta J, Boutroy S, Guebre-Egziabher F et al. The relationship between adipokines, osteocalcin and bone quality in chronic kidney disease. Nephrol Dial Transplant 2009; 24: 3120-3125.
32. Petchey WG, Hickman IJ, Duncan E et al. The role of 25-hydroxyvitamin D deficiency in promoting insulin resistance and inflammation in patients with chronic kidney disease: a randomised controlled trial. BMC Nephrol 2009; 10: 41.