DNA breakage and cell cycle checkpoint abrogation induced by a therapeutic thiopurine and UVA radiation

Oncogene

Volumn 29, Issue 27, 2010, Pages 3953-3963

  Brem, R ^a   Li, F ^a   Montaner, B ^a   Reelfs, O ^b   Karran, P ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b GUY S HOSPITAL   (United Kingdom)

Author keywords

cell cycle checkpoints; DNA breakage; skin cancer; thiopurines; UVA

Indexed keywords

CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; DNA; IMMUNOSUPPRESSIVE AGENT; MERCAPTOPURINE; PROTEASOME;

ARTICLE; CANCER RISK; CELL CYCLE; CELL CYCLE S PHASE; CELL SURVIVAL; COMET ASSAY; DNA DAMAGE; DNA STRAND BREAKAGE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOBLOTTING; IMMUNOSUPPRESSIVE TREATMENT; LIGHT DAMAGE; LOW ENERGY RADIATION; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SKIN CANCER; SUNLIGHT; ULTRAVIOLET A RADIATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL CYCLE; CHO CELLS; CRICETINAE; CRICETULUS; DNA BREAKS; DNA BREAKS, DOUBLE-STRANDED; DNA BREAKS, SINGLE-STRANDED; DNA REPAIR; DNA REPLICATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; HCT116 CELLS; HUMANS; PHOTOCHEMICAL PROCESSES; PROTEIN KINASES; THIOGUANINE; ULTRAVIOLET RAYS;

EID: 77954537733     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.140     Document Type: Article

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